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  • Search results for: 'btk inhibitor 1 hydrochloride'

Search results for: 'btk inhibitor 1 hydrochloride'

Items 351-360 of 1082

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  1. Bestatin
    A2575 Bestatin
    Target: Aminopeptidases
    Summary: Aminopeptidase inhibitor
      insoluble in H2O; insoluble in EtOH; ≥12.34 mg/mL
  2. THZ1
    A8882 THZ1
     12 Citation
    Target: Cyclin-Dependent Kinases
    Summary: Covalent CDK7 inhibitor,potent and selective
      ≥28.3 mg/mL
  3. Efavirenz
    B1119 Efavirenz
    Target: HIV-1 reverse transcriptase
    Summary: Reverse transcriptase inhibitor
      insoluble in H2O; ≥15.55 mg/mL
  4. BMS-509744
    A3250 BMS-509744
    Target: ITK
    Summary: Itk inhibitor,potent and selective
      Soluble in DMSO
  5. Azilsartan
    B2210 Azilsartan
    Target: Angiotensin AT1 Receptors
    Summary: Potent angiotensin II type 1 (AT1) receptor inverse agonist
      insoluble in EtOH; insoluble in H2O; ≥16.95 mg/mL
  6. Apogossypolone (ApoG2)
    A4200 Apogossypolone (ApoG2)
     2 Citation
    Target: Bcl-2|Bcl-xl|Mcl-1
    Summary: Bcl-2 inhibitor,nonpeptidic small molecule
      ≥24.55 mg/mL
  7. Poloxin
    A3732 Poloxin
    Target: PLK
    Summary: PLK1 inhibitor
      insoluble in H2O; ≥14.85 mg/mL
  8. BGJ398
    A3014 BGJ398
     1 Citation
    Target: FGFR
    Summary: FGFR inhibitor ,potent and selective
      insoluble in H2O; insoluble in EtOH; ≥7 mg/mL
  9. GW441756
    B2297 GW441756
     1 Citation
    Target: Trk Receptors
    Summary: TrkA inhibitor,potent and selective
      insoluble in H2O; insoluble in EtOH; ≥13.75 mg/mL
  10. Ki8751
    A1821 Ki8751
    Target: VEGFR
    Summary: VEGFR-2 inhibitor,potent and selective
      ≥23.45 mg/mL

Items 351-360 of 1082

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  1. Signaling Pathways 1031item
  2. Natural Products 13item
  3. Other Products 1 item
  4. Peptides 1 item
  5. Probes & Dyes 2item
  6. Peptides & Proteins 1 item
  7. Lab Reagents 13item
Specificity
  1. Selective 754item
  2. Non-Selective 6item
Reversibility
  1. Reversible 55item
  2. Irreversible 31item
Target
  1. Caspases 9item
  2. Cyclin-Dependent Kinases 25item
  3. Adenosine A2A Receptors 1 item
  4. Proteasome 12item
  5. Cathepsins 9item
  6. Histone Deacetylases (HDACs) 33item
  7. Inhibitor of apoptosis proteins (IAP) 3item
  8. Akt 13item
  9. Bcl-2 9item
  10. PI3K 36item
  11. CXCR 4item
  12. Raf 13item
  13. Aurora Kinases 20item
  14. Bcl-xl 2item
  15. CSF-1R 4item
  16. Glycoproteins 1 item
  17. p97 1 item
  18. Gap Junctions 1 item
  19. MDM2 2item
  20. EZH2 4item
  21. mTOR 20item
  22. Bromodomains 6item
  23. AP-1 3item
  24. MMP 8item
  25. Thymidine Phosphorylases 1 item
  26. Androgen Receptors 5item
  27. Peptidylprolyl isomerases 1 item
  28. Acyl coenzyme A: cholesterol acyltransferases 1 item
  29. Myosin II ATPases 1 item
  30. DT-diaphorases 1 item
  31. Voltage-gated Potassium (KV) Channels 1 item
  32. MER 1 item
  33. FLT3 19item
  34. GSK-3 10item
  35. Factor Xa 4item
  36. LPA Receptors 3item
  37. P-glycoprotein (P-gp) 5item
  38. PLK 10item
  39. Chk 7item
  40. Eph Receptors 2item
  41. VEGFR 40item
  42. PDGFR 25item
  43. c-Kit 13item
  44. RET 4item
  45. IRAK 1 item
  46. Bromodomain-containing proteins(BRDs) 1 item
  47. Phosphodiesterases (PDEs) 16item
  48. Mcl-1 6item
  49. Hydrolase 1 item
  50. Thymidylate Synthase 3item
  51. p38 10item
  52. PKB 1 item
  53. JNK 4item
  54. SGK 1 item
  55. Bcr-Abl 13item
  56. Kynurenine-3-monooxygenase 1 item
  57. MEK 13item
  58. PORCN 1 item
  59. DOT1L 3item
  60. FGFR 17item
  61. Nrf2 2item
  62. Insulin-like growth factor receptors(IGFRs) 1 item
  63. CGRP receptors 1 item
  64. Pim 4item
  65. GABAB Receptors 1 item
  66. Liver X receptors (LXRs) 1 item
  67. Glucagon-like peptide 1 (GLP-1) receptors 2item
  68. Sir2-like Family Deacetylases (Sirtuins) 4item
  69. Voltage-gated Sodium (NaV) Channels 1 item
  70. Deubiquitinating enzymes (DUBs) 3item
  71. PP1 1 item
  72. PP2A 1 item
  73. Smoothened 4item
  74. Eukaryotic elongation factors 1 item
  75. Neuraminidases (NA) 2item
  76. MET 7item
  77. Src 14item
  78. Trk Receptors 6item
  79. Integrins 1 item
  80. Aminopeptidases 4item
  81. NMDA Receptors 2item
  82. STAT 10item
  83. ATP Citrate Lyases 1 item
  84. Microtubules/Tubulins 6item
  85. Estrogen and Related Receptors 2item
  86. EGFR 23item
  87. Hedgehog 1 item
  88. Reverse Transcriptases 6item
  89. ROCK 9item
  90. BTK 1 item
  91. RIP kinases 1 item
  92. Monocyte chemotactic proteins 1 item
  93. PAK 3item
  94. Hypoxia Inducible Factors (HIFs) 2item
  95. Tankyrases 1 item
  96. Inositol Phosphatases 1 item
  97. FAK 7item
  98. BMP and Other Activin Receptors 3item
  99. JAK 20item
  100. p300 1 item
  101. Stearoyl-CoA 9-desaturase (SCD-1) 2item
  102. Syk 7item
  103. Progesterone Receptors 1 item
  104. EZH1 2item
  105. DNA-PK 7item
  106. HSP90 12item
  107. AMPK 3item
  108. Gutathione S-transferase 1 item
  109. CCR 2item
  110. PDHK 1 item
  111. Angiotensin AT2 Receptors 2item
  112. Notch 1 item
  113. S-nitrosoglutathione reductase 1 item
  114. CFTR 2item
  115. TNKS 1 item
  116. Topoisomerases 16item
  117. Cytochrome P450 (CYP450) 10item
  118. thrombin 1 item
  119. Ksp 2item
  120. Renin 1 item
  121. Influenza viruses 1 item
  122. ErbB 5item
  123. S6 kinases 1 item
  124. Toll-like receptors (TLRs) 4item
  125. Adenosine Kinases 2item
  126. Actin 1 item
  127. Serine Proteases 2item
  128. DNA Methyltransferases 4item
  129. Survivin 1 item
  130. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  131. ERK 8item
  132. HMG-CoA Reductases 6item
  133. c-MET 8item
  134. BMI-1 1 item
  135. PKC 14item
  136. Calpains 5item
  137. Ubiquitin-specific proteases 1 item
  138. M1 Receptors 1 item
  139. HCV Proteases 3item
  140. Ca2 /calmodulin-dependent protein kinases (CaMKs) 7item
  141. MLK3 1 item
  142. O-GlcNAcase 1 item
  143. CREBBP 1 item
  144. EP300 1 item
  145. Protease-Activated Receptors 1 item
  146. Lyn 2item
  147. SGLT 1 item
  148. RAD51 2item
  149. Trypsins 1 item
  150. HER2 3item
  151. Pyk2 3item
  152. USP 1 item
  153. 5-HT2 Receptors 7item
  154. LRRK2 6item
  155. Voltage-gated Calcium Channels (CaV) 2item
  156. Calcium chelator 1 item
  157. DGAT 2item
  158. Insulin and Insulin-like Receptors 4item
  159. PARP 7item
  160. CB1 Receptors 3item
  161. Pyruvate dehydrogenases (PDH) 2item
  162. ALK 10item
  163. ROS1 2item
  164. Sphingosine kinases (SphKs) 3item
  165. Trypsin 1 item
  166. Chymotrypsin 1 item
  167. Kallikrein 1 item
  168. Trypsinogen 1 item
  169. Monocarboxylate transporters (MCTs) 2item
  170. CETP 2item
  171. Dehydrogenase 1 item
  172. PKG 2item
  173. PKA 6item
  174. Myosin light chain kinases (MLCKs) 2item
  175. GPR30 1 item
  176. HIV-1 gp120 1 item
  177. D1 and D5 Receptors 1 item
  178. D2 Receptors 4item
  179. D3 Receptors 2item
  180. 5-HT1 Receptors 2item
  181. 5-HT7 Receptors 1 item
  182. MELK 1 item
  183. Serotonin reuptake 1 item
  184. Insulin-like growth factors (IGFs) 1 item
  185. CSF1R 1 item
  186. Bromodomain and Extra-Terminal motif (BET) 1 item
  187. Lactate Dehydrogenases (LDH) 2item
  188. MK2 2item
  189. Fatty-acid-binding proteins (FABPs) 1 item
  190. 5-HT3 Receptors 2item
  191. Angiotensin-Converting Enzymes (ACEs) 6item
  192. Tie-2 5item
  193. RSK 3item
  194. p70 S6K 1 item
  195. Free Fatty Acid Receptors 1 item
  196. phosphatases 2item
  197. Autophagy 4item
  198. ATM/ATR 5item
  199. COX 12item
  200. YAP 1 item
  201. CK1 1 item
  202. CK2 3item
  203. HIPK2 1 item
  204. HIPK3 1 item
  205. HIV Integrases 2item
  206. Pregnane X Receptors 1 item
  207. Squalene epoxidases 3item
  208. PRAK 1 item
  209. MAPKAP-K2 1 item
  210. Delayed rectifier outward potassium current (IKr) 1 item
  211. GpIIb/IIIa receptor 1 item
  212. Guanine nucleotide exchange factors (GEFs) 1 item
  213. 20S proteasomal chymotrypsin 1 item
  214. Geranylgeranyltransferase I 1 item
  215. Farnesyltransferase 1 item
  216. Nampt 3item
  217. eIF4F 1 item
  218. Cdc42 1 item
  219. SRPK1 1 item
  220. P2X Receptors 2item
  221. Glutaminases 2item
  222. Carbonic Anhydrases 7item
  223. Ron 1 item
  224. G9a 1 item
  225. BLM 1 item
  226. HSV 2item
  227. NADPH Oxidases 3item
  228. Glutamate (Metabotropic) Group I Receptors 1 item
  229. Calcium-activated chloride channels (CaCC) 1 item
  230. GPR35 1 item
  231. Aldehyde Dehydrogenases 2item
  232. Synthases/Synthetases 2item
  233. MAGL 2item
  234. Leukotriene and Related Receptors 1 item
  235. Histamine H1 Receptors 5item
  236. Sigma Receptors 1 item
  237. Na /K ATPases 3item
  238. P110 1 item
  239. Hck 2item
  240. Inositol-requiring enzyme 1 (IRE1) 2item
  241. Na /K /Cl- Symporters (NKCCs) 2item
  242. GABAA Receptors 1 item
  243. Phospholipases 1 item
  244. Monoamine oxidases (MAOs) 1 item
  245. Organic anion transporters (OATs) 1 item
  246. TRP Channel 3item
  247. RNA Polymerases 3item
  248. Norepinephrine transporter 1 item
  249. 5-HT Transporters 3item
  250. Xanthine oxidoreductases 1 item
  251. Dihydroorotate dehydrogenase 1 item
  252. Guanylyl Cyclases 1 item
  253. Histone Demethylases 2item
  254. MNK 2item
  255. 5-Lipoxygenases 1 item
  256. NO Donors / Precursors 2item
  257. CB2 Receptors 2item
  258. HIV-1 reverse transcriptase 1 item
  259. IL Receptors 2item
  260. CCL2 1 item
  261. Noradrenaline reuptake 1 item
  262. Norepinephrine transporters 1 item
  263. 15-lipoxygenases 1 item
  264. Calcium-Activated Potassium (KCa) Channels 2item
  265. AChE 3item
  266. Insulin Receptors 1 item
  267. IRG-1R 1 item
  268. cAMP 1 item
  269. Sulfonylurea receptors 1 item
  270. Cdc2-like kinase (Clk) 1 item
  271. eEF-2 1 item
  272. Inward Rectifier Potassium (Kir) Channels 3item
  273. CRTH2 1 item
  274. Cdc7 1 item
  275. Nuclear Receptors 1 item
  276. CMV 1 item
  277. ZAP-70 1 item
  278. Catechol O-Methyltransferase (COMT) 2item
  279. fibrinolysis 1 item
  280. Angiotensin AT1 Receptors 3item
  281. D4 Receptors 1 item
  282. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  283. NMDA receptor 1 item
  284. HBV Proteases 1 item
  285. Hydroxylases 2item
  286. Flk-1 1 item
  287. Papains 1 item
  288. Protein Arginine Methyltransferases 1 item
  289. IMPDH 1 item
  290. Na /Ca2 Exchangers (NCXs) 1 item
  291. NAE 2item
  292. Ubiquitin-activating Enzyme E1 2item
  293. SUMOylation 1 item
  294. ATGL 1 item
  295. BACE 1 item
  296. Cytidine deaminases 1 item
  297. angiogenesis 1 item
  298. Glucagon Receptors 1 item
  299. 15-PGDH 1 item
  300. DPP-4 5item
  301. PP4 1 item
  302. c-RET 3item
  303. Nonstructural protein 5B (NS5B) 1 item
  304. guanylyl cyclase 2item
  305. ETA Receptors 2item
  306. ETB Receptors 1 item
  307. p70 rsk 3item
  308. voltage-gated chloride channels 1 item
  309. FPTase 1 item
  310. dopamine receptor 1 item
  311. 5-HT1 Receptor 2item
  312. 5-HT2 Receptor 1 item
  313. Microtubule/Tubulin 1 item
  314. VEGFR3/FLT4 1 item
  315. NTRK1/TRKA 1 item
  316. CSF-1R/c-Fms 1 item
  317. Tryptophan hydroxylases (TPH) 2item
  318. ADAMs 1 item
  319. NMPRTase 1 item
  320. Bfl-1 1 item
  321. TAM kinase 1 item
  322. p53-MDM2 interaction 1 item
  323. nuclear export 1 item
  324. CRM1 1 item
  325. PTP 1 item
  326. KDR 2item
  327. Fyn kinase 1 item
  328. Trypsin-like protease 1 item
  329. AXL 1 item
  330. Glyoxalase I 1 item
  331. ERAD 1 item
  332. Dipeptidyl-peptidase II 1 item
  333. p53 5item
  334. metalloprotease 1 item
  335. HDAC 2item
  336. Antifungal 1 item
  337. 5-HT receptors 1 item
  338. sodium channel 3item
  339. c-Fms tyrosine kinase 1 item
  340. human lyase 1 item
  341. insulin 1 item
  342. Ub-conjugating enzyme (E2) complex 1 item
  343. Smoothened receptor 1 item
  344. cysteine protease 2item
  345. PPAR 1 item
  346. IKK 1 item
  347. MSK 1 item
  348. gp120-CD4 interaction 1 item
  349. HCV polymerase 2item
  350. Ftase 1 item
  351. PC-PLC 2item
  352. Elastases 1 item
  353. ATP synthase 1 item
  354. Glucosidases 1 item
  355. Vitamin D receptors (VDRs) 1 item
  356. Antibiotic 4item
  357. Mer tyrosine kinase 1 item
  358. Hec1 1 item
  359. neprilysin 1 item
  360. Calcium-Sensing Receptors (CaSRs) 2item
  361. GLI 1 item
  362. decarboxylase 1 item
  363. Stem Cell Differentiation 1 item
  364. PP2A/Nkd interaction 1 item
  365. HMGCR 1 item
  366. ErbB-2 1 item
  367. adrenergic receptor 2item
  368. HIV 1 item
  369. 5-HT4 Receptor 1 item
  370. TRPA 1 item
  371. sterol demethylase 1 item
  372. PDK-1 1 item
  373. GAPDH 1 item
  374. Histone Acetyltransferases (HATs) 2item
  375. complex I of the mitochondrial electron transport chain 1 item
  376. F1 Fo-ATPase 1 item
  377. Prk 1 item
  378. potassium channel 1 item
  379. calcium channel 1 item
  380. Ribonucleotide Reductases 1 item
  381. Trx 1 item
  382. Tyrosinases 1 item
  383. Neurokinin receptor 1 item
  384. HSP70 1 item
  385. ICAM 1 item
  386. ITK 1 item
  387. HIF-PH 1 item
  388. troponin 1 item
  389. NUAK 1 item
  390. Rho 1 item
  391. Aryl hydrocarbon receptors (AHRs) 1 item
  392. Ubiquitin E3 Ligases 1 item
  393. DCLK2 1 item
  394. FAAH 1 item
  395. PTK 1 item
  396. integrase 1 item
  397. NOS 2item
  398. TYK2 2item
  399. MUSK 1 item
  400. MAP3K 1 item
  401. GPR3 1 item
  402. Adenosine Deaminases 2item
  403. mitochondrial pyruvate carrier (MPC) 1 item
  404. DNA gyrase 1 item
  405. prolactin secretion 1 item
  406. gonadotropin release 1 item
  407. DprE 1 item
  408. Vitamin D 1 item
  409. carnitine reabsorption 1 item
  410. Histamine receptors 1 item
  411. GluR 1 item
  412. 5-HT receptor 1 item
  413. dopamine receptors 1 item
  414. AMPA receptor 1 item
  415. 5-alpha Reductases 1 item
  416. Flk1 2item
  417. SAPK 1 item
  418. p21 1 item
  419. Prostaglandin synthesis 1 item
  420. Protein Tyrosine Phosphatases 1 item
  421. alkaline phosphatases 1 item
  422. ATPases 1 item
  423. glutamate release 1 item
  424. PAFR 1 item
  425. Aromatases 2item
  426. DHFR 1 item
  427. GARFT 1 item
  428. 5-HT 1 item
  429. FGR 1 item
  430. YES 2item
  431. Fyn 2item
  432. ARG 1 item
  433. Autotaxin 1 item
  434. UCH 1 item
  435. RHA 1 item
  436. HCV NS3-4A protease 1 item
  437. TRPC channel 1 item
  438. PKD 1 item
  439. Pyruvate kinases 1 item
  440. Thioredoxin Reductases 1 item
  441. enoyl-acyl-carrier protein reductase 1 item
  442. SHIP 1 item
  443. MCL1 1 item
  444. Bcl-w 1 item
  445. glutathione peroxidase 4 1 item
  446. S-adenosylhomocysteine hydrolase 1 item
  447. Rho-kinase 1 item
  448. tropomyosin receptor kinase 1 item
  449. LSD 1 item
  450. DDX3 1 item
  451. PRMT 1 item
  452. ACE 1 item
  453. GLP 1 item
  454. SK 1 item
  455. MST 1 item
  456. PPK 1 item
  457. c-Syk 1 item
  458. CDK1/CyclinB 1 item
  459. NHE 1 item
  460. IDO 2item
  461. Tph 1 item
  462. PIM1 kinase 1 item
  463. phospholipase A2 1 item
  464. reverse transcriptase 1 item
  465. GABAA receptor 1 item
  466. epoxide hydrolase 1 item
  467. Serotonin (5-HT) reuptake 1 item
  468. Cholesterol absorption 1 item
  469. Vascular Disrupting Agents (VDA) 1 item
  470. Androgen Receptor 1 item
  471. Substance P/NK1 Receptor 1 item
  472. gp120/CD4 1 item
  473. ATM 1 item
  474. Sirtuin 1 item
  475. NE 1 item
  476. CRF1 Receptors 1 item
  477. PIKfyve 1 item
  478. Bax 1 item
  479. Glycogen Phosphorylases 1 item
  480. MTH1 1 item
  481. PTEN 1 item
  482. Insulin Receptor 1 item
  483. NS3/4a Proteases 1 item
  484. Ca2 -ATPases 1 item
  485. p90 S6K 1 item
  486. Dynamins 1 item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 3item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 5item
  7. Acute Myeloid Leukemia 26item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Bacterial Infectios 1 item
  13. Biliary Cancer 1 item
  14. Bladder Cancer 11item
  15. Bladder Carcinoma 4item
  16. Bladder Diseases 2item
  17. B-lymphoid Malignancies 1 item
  18. Brain Injuries Studies 3item
  19. Breast Cancer 120item
  20. Cancer 530item
  21. Candida Peritonitis 1 item
  22. Candidemia 1 item
  23. Castration-resistant Prostate Cancer 1 item
  24. Cervical Cancer 6item
  25. Cholangiocarcinoma 2item
  26. Chronic Lymphocytic Leukemia 8item
  27. Chronic Myeloproliferative Disorders 1 item
  28. Clear Cell Renal Cell Carcinoma 2item
  29. Cocaine-Related Disorders 2item
  30. Colon Cancer 43item
  31. Colon Carcinoma 7item
  32. Colorectal Cancer 40item
  33. Depression 2item
  34. Diabetes 7item
  35. Diffuse Large B-cell Lymphoma 1 item
  36. Dyskinesia 1 item
  37. Dyslipidemia 2item
  38. Epilepsy 4item
  39. Erectile Dysfunction 4item
  40. Friedreich's Ataxia 2item
  41. Fungal Infection 1 item
  42. Fungi 1 item
  43. Glioblastoma 33item
  44. Glioma 18item
  45. HCV 4item
  46. Heart Failure 6item
  47. Hepatic Cancer 2item
  48. Hepatitis C 4item
  49. Hepatocellular Carcinoma 8item
  50. HIV 14item
  51. HIV Infections 11item
  52. Hypercholesterolemia 3item
  53. Immunological Diseases 1 item
  54. Inflammation 1 item
  55. Inflammatory Bowel Disease 1 item
  56. Inflammatory Diseases 19item
  57. Influenza 3item
  58. Kidney Injury Studies 3item
  59. Leukemia 26item
  60. Liver Cancer 3item
  61. Lung Cancer 43item
  62. Lung Carcinoma 4item
  63. Lymphoma 31item
  64. Mantle Cell Lymphoma 2item
  65. Medulloblastoma 1 item
  66. Melanoma 35item
  67. Mixed Lineage Leukemia 3item
  68. Multidrug Resistance Studies 1 item
  69. Multiple Myeloma 22item
  70. Myelofibrosis 2item
  71. Myeloma 7item
  72. Narcolepsy 1 item
  73. Neuroblastoma 14item
  74. Neurocognitive Disorders 1 item
  75. Neuronal Protection 1 item
  76. Non-small Cell Lung Cancer 26item
  77. Non-small Cell Lung Carcinoma 2item
  78. Obsessive-Compulsive Disorder 1 item
  79. Osteoporosis 2item
  80. Ovarian Cancer 35item
  81. Pancreatic Cancer 49item
  82. Pancreatic Carcinoma 3item
  83. Pentacyclic Triterpenoid 1 item
  84. Prostate Cancer 56item
  85. Psoriasis 4item
  86. Psoriasis Vulgaris 1 item
  87. Pulmonary Arterial Hypertension 2item
  88. Pulmonary Fibrosis 2item
  89. Renal Cancer 4item
  90. Renal Cell Carcinoma 9item
  91. Rheumatoid Arthritis 14item
  92. Sarcoma 1 item
  93. Schizophrenia 10item
  94. Sleep Disorders 2item
  95. Soft Tissue Sarcoma 1 item
  96. Squamous Cell Carcinoma 2item
  97. Testicular Cancer 2item
  98. Thyroid Cancer 6item
  99. Tuberculosis 4item
  100. Type 2 Diabetes 18item