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  • Search results for: 'cdk4 inhibitor'

Search results for: 'cdk4 inhibitor'

Items 111-120 of 775

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  1. Crenolanib (CP-868596)
    A8307 Crenolanib (CP-868596)
     1 Citation
    Target: FLT3|PDGFR
    Summary: PDGFR-β inhibitor,potent and selective
      ≥22.2 mg/mL
  2. ML167
    B3707 ML167
    Target: Clk
    Summary: Clk4 inhibitor,highly selective
      insoluble in EtOH; insoluble in H2O; ≥16.75 mg/mL
  3. LY2801653
    A3573 LY2801653
    Target: MET
    Summary: MET inhibitor
      ≥27.65 mg/mL
  4. NH125
    A8814 NH125
     1 Citation
    Target: eEF-2
    Summary: Selective eEF-2 kinase inhibitor
      ≥25.9 mg/mL
  5. GKT137831
    B4763 GKT137831
     1 Citation
    Target: NADPH Oxidases
    Summary: dual NADPH oxidase Nox1/Nox4 inhibitor
      ≥39.5 mg/mL
  6. VE-822
    B1383 VE-822
     2 Citation
    Target: ATM/ATR
    Summary: ATR inhibitor
      ≥50 mg/mL
  7. THZ1 Hydrochloride
    B4736 THZ1 Hydrochloride
    Target: Cyclin-Dependent Kinases
    Summary: CDK7 inhibitor
      ≥30.13 mg/mL
  8. MS436
    B1012 MS436
    Target: Bromodomains
    Summary: BRD4 inhibitor
      insoluble in H2O; insoluble in EtOH; ≥19.15 mg/mL
  9. IWR-1-endo
    B2306 IWR-1-endo
     1 Citation
    Summary: Potent Wnt signaling inhibitor
      insoluble in EtOH; insoluble in H2O; ≥20.45 mg/mL
  10. AEG 3482
    B9010 AEG 3482
    Target: JNK
    Summary: inhibitor of Jun kinase (JNK)-dependent apoptosis
      insoluble in EtOH; insoluble in H2O; ≥14 mg/mL

Items 111-120 of 775

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Category
  1. Proteases 77item
  2. Apoptosis 41item
  3. Chromatin/Epigenetics 104item
  4. Metabolism 62item
  5. MAPK Signaling 46item
  6. Tyrosine Kinase 113item
  7. DNA Damage/DNA Repair 58item
  8. PI3K/Akt/mTOR Signaling 61item
  9. Microbiology & Virology 26item
  10. Cell Cycle/Checkpoint 74item
  11. Ubiquitination/ Proteasome 33item
  12. JAK/STAT Signaling 33item
  13. TGF-β / Smad Signaling 33item
  14. Angiogenesis 9item
  15. GPCR/G protein 18item
  16. Stem Cell 29item
  17. Membrane Transporter/Ion Channel 28item
  18. Endocrinology and Hormones 7item
  19. Neuroscience 22item
  20. Other Signal Transduction 1 item
  21. Others 58item
  22. Immunology/Inflammation 13item
Reversibility
  1. Reversible 54item
  2. Irreversible 25item
Target
  1. Caspases 10item
  2. Cyclin-Dependent Kinases 26item
  3. Proteasome 11item
  4. Cathepsins 11item
  5. Histone Deacetylases (HDACs) 27item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 6item
  8. Bcl-2 5item
  9. PI3K 26item
  10. CXCR 3item
  11. Raf 10item
  12. Aurora Kinases 14item
  13. Bcl-xl 3item
  14. CSF-1R 2item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. Gap Junctions 1 item
  18. MDM2 1 item
  19. EZH2 6item
  20. mTOR 15item
  21. Bromodomains 5item
  22. AP-1 1 item
  23. MMP 8item
  24. Thymidine Phosphorylases 1 item
  25. Androgen Receptors 3item
  26. Peptidylprolyl isomerases 1 item
  27. Acyl coenzyme A: cholesterol acyltransferases 1 item
  28. Myosin II ATPases 1 item
  29. DT-diaphorases 1 item
  30. MER 1 item
  31. FLT3 12item
  32. GSK-3 9item
  33. Factor Xa 3item
  34. P-glycoprotein (P-gp) 5item
  35. PLK 7item
  36. Chk 8item
  37. ULK1 1 item
  38. Eph Receptors 3item
  39. VEGFR 25item
  40. PDGFR 19item
  41. c-Kit 7item
  42. RET 3item
  43. IRAK 3item
  44. Bromodomain-containing proteins(BRDs) 1 item
  45. Phosphodiesterases (PDEs) 10item
  46. Mcl-1 5item
  47. Hydrolase 1 item
  48. Thymidylate Synthase 2item
  49. p38 9item
  50. PKB 1 item
  51. 3-phosphoglycerate dehydrogenase 1 item
  52. JNK 6item
  53. SGK 2item
  54. Bcr-Abl 10item
  55. Kynurenine-3-monooxygenase 1 item
  56. MEK 15item
  57. PORCN 1 item
  58. DOT1L 3item
  59. FGFR 9item
  60. Nrf2 1 item
  61. Insulin-like growth factor receptors(IGFRs) 1 item
  62. Pim 4item
  63. Sir2-like Family Deacetylases (Sirtuins) 2item
  64. Deubiquitinating enzymes (DUBs) 4item
  65. Smoothened 4item
  66. Ribosomal s6 kinases (RSK) 1 item
  67. Neuraminidases (NA) 1 item
  68. MET 7item
  69. Src 9item
  70. Trk Receptors 5item
  71. Integrins 1 item
  72. Aminopeptidases 2item
  73. STAT 5item
  74. ATP Citrate Lyases 1 item
  75. Microtubules/Tubulins 4item
  76. EGFR 15item
  77. Hedgehog 1 item
  78. Reverse Transcriptases 1 item
  79. ROCK 7item
  80. BTK 2item
  81. RIP kinases 1 item
  82. PAK 3item
  83. Hypoxia Inducible Factors (HIFs) 2item
  84. Tankyrases 1 item
  85. Inositol Phosphatases 1 item
  86. FAK 5item
  87. BMP and Other Activin Receptors 4item
  88. JAK 13item
  89. p300 1 item
  90. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  91. Syk 7item
  92. EZH1 2item
  93. DNA-PK 6item
  94. HSP90 10item
  95. AMPK 2item
  96. Gutathione S-transferase 1 item
  97. PDHK 1 item
  98. Angiotensin AT2 Receptors 1 item
  99. eIF4E/eIF3G interaction 1 item
  100. Notch 1 item
  101. S-nitrosoglutathione reductase 1 item
  102. CFTR 2item
  103. TNKS 1 item
  104. Topoisomerases 6item
  105. Cytochrome P450 (CYP450) 5item
  106. thrombin 1 item
  107. Ksp 1 item
  108. Ribosomes 1 item
  109. Renin 2item
  110. HIV proteases 1 item
  111. Pepsins 1 item
  112. Influenza viruses 1 item
  113. ErbB 2item
  114. Ferroptosis 1 item
  115. S6 kinases 1 item
  116. Toll-like receptors (TLRs) 2item
  117. Adenosine Kinases 2item
  118. Actin 1 item
  119. DNA Methyltransferases 3item
  120. Survivin 1 item
  121. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  122. ERK 5item
  123. HMG-CoA Reductases 5item
  124. Vacuolar-type ATPase 1 item
  125. c-MET 8item
  126. BMI-1 1 item
  127. PKC 6item
  128. Calpains 5item
  129. Ubiquitin-specific proteases 1 item
  130. HCV Proteases 3item
  131. Ca2 /calmodulin-dependent protein kinases (CaMKs) 7item
  132. MLK3 1 item
  133. SMYD2 1 item
  134. CREBBP 2item
  135. EP300 2item
  136. Lyn 1 item
  137. SGLT 1 item
  138. RAD51 1 item
  139. Trypsins 1 item
  140. HER2 2item
  141. Pyk2 3item
  142. USP 2item
  143. 5-HT2 Receptors 4item
  144. LRRK2 4item
  145. DGAT 2item
  146. Insulin and Insulin-like Receptors 3item
  147. PARP 4item
  148. Pyruvate dehydrogenases (PDH) 1 item
  149. ALK 5item
  150. ROS1 2item
  151. Sphingosine kinases (SphKs) 2item
  152. Trypsin 1 item
  153. Chymotrypsin 1 item
  154. Kallikrein 1 item
  155. Trypsinogen 1 item
  156. KRAS G12C 1 item
  157. GTPases 1 item
  158. Monocarboxylate transporters (MCTs) 1 item
  159. CETP 2item
  160. Dehydrogenase 1 item
  161. PKG 1 item
  162. PKA 1 item
  163. Myosin light chain kinases (MLCKs) 2item
  164. HIV-1 gp120 1 item
  165. D1 and D5 Receptors 1 item
  166. D2 Receptors 3item
  167. D3 Receptors 2item
  168. 5-HT1 Receptors 2item
  169. 5-HT7 Receptors 1 item
  170. CaM-KK 1 item
  171. Valosin-containing protein (VCP) 1 item
  172. MELK 1 item
  173. Serotonin reuptake 1 item
  174. Insulin-like growth factors (IGFs) 1 item
  175. Clk 1 item
  176. TBK1 1 item
  177. MARK1 1 item
  178. NUAK1 2item
  179. Integrin-ligand interactions 1 item
  180. CSF1R 1 item
  181. Bromodomain and Extra-Terminal motif (BET) 1 item
  182. NUAK2 1 item
  183. Na /H Exchangers (NHEs) 1 item
  184. Lactate Dehydrogenases (LDH) 2item
  185. MK2 3item
  186. Fatty-acid-binding proteins (FABPs) 1 item
  187. Angiotensin-Converting Enzymes (ACEs) 2item
  188. Tie-2 4item
  189. RSK 2item
  190. p70 S6K 1 item
  191. phosphatases 1 item
  192. Autophagy 2item
  193. ATM/ATR 7item
  194. Mixed lineage kinase domain-like protein (MLKL) 1 item
  195. COX 6item
  196. Heparanases 1 item
  197. CK1 1 item
  198. IDH2 1 item
  199. CK2 3item
  200. HIPK2 1 item
  201. HIPK3 1 item
  202. HIV Integrases 1 item
  203. Squalene epoxidases 2item
  204. PRAK 1 item
  205. MAPKAP-K2 1 item
  206. Delayed rectifier outward potassium current (IKr) 1 item
  207. 20S proteasomal chymotrypsin 1 item
  208. Geranylgeranyltransferase I 1 item
  209. Farnesyltransferase 1 item
  210. NAT10 1 item
  211. Nampt 2item
  212. eIF4F 1 item
  213. Cdc42 1 item
  214. SRPK1 1 item
  215. P2X Receptors 1 item
  216. Glutaminases 1 item
  217. Carbonic Anhydrases 5item
  218. Ron 1 item
  219. AP endonucleases 1 item
  220. G9a 2item
  221. BLM 1 item
  222. HSV 2item
  223. NADPH Oxidases 2item
  224. Calcium-activated chloride channels (CaCC) 1 item
  225. GPR35 1 item
  226. Aldehyde Dehydrogenases 1 item
  227. Synthases/Synthetases 3item
  228. c-Fyn 1 item
  229. TAK1 1 item
  230. Histamine H1 Receptors 1 item
  231. Na /K ATPases 2item
  232. P110 1 item
  233. Hck 1 item
  234. Inositol-requiring enzyme 1 (IRE1) 1 item
  235. SETD7 1 item
  236. Na /K /Cl- Symporters (NKCCs) 1 item
  237. GABAA Receptors 1 item
  238. Phospholipases 1 item
  239. RNA Polymerases 1 item
  240. Norepinephrine transporter 1 item
  241. 5-HT Transporters 3item
  242. Xanthine oxidoreductases 1 item
  243. Dihydroorotate dehydrogenase 1 item
  244. MNK 1 item
  245. NO Donors / Precursors 1 item
  246. HIV-1 reverse transcriptase 1 item
  247. IL Receptors 2item
  248. CCL2 1 item
  249. Norepinephrine transporters 1 item
  250. Calcium-Activated Potassium (KCa) Channels 1 item
  251. AChE 2item
  252. Insulin Receptors 1 item
  253. IRG-1R 1 item
  254. Proton Pump 1 item
  255. cAMP 1 item
  256. Sulfonylurea receptors 1 item
  257. eEF-2 1 item
  258. Inward Rectifier Potassium (Kir) Channels 2item
  259. Arp2/3 complex 1 item
  260. Cdc7 1 item
  261. CMV 1 item
  262. ZAP-70 1 item
  263. Catechol O-Methyltransferase (COMT) 2item
  264. fibrinolysis 1 item
  265. D4 Receptors 1 item
  266. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  267. HBV Proteases 1 item
  268. Flk-1 1 item
  269. Papains 1 item
  270. Protein Arginine Methyltransferases 1 item
  271. IMPDH 1 item
  272. Na /Ca2 Exchangers (NCXs) 1 item
  273. NAE 2item
  274. Ubiquitin-activating Enzyme E1 1 item
  275. SUMOylation 1 item
  276. ATGL 1 item
  277. BACE 1 item
  278. Cytidine deaminases 1 item
  279. angiogenesis 1 item
  280. Glucagon Receptors 1 item
  281. 15-PGDH 1 item
  282. DPP-4 4item
  283. c-RET 1 item
  284. Nonstructural protein 5B (NS5B) 1 item
  285. p70 rsk 1 item
  286. FPTase 1 item
  287. ADAMs 1 item
  288. TAM kinase 1 item
  289. p53-MDM2 interaction 1 item
  290. nuclear export 1 item
  291. CRM1 1 item
  292. AXL 1 item
  293. Protein polybromo-1 1 item
  294. SMARCA4 1 item
  295. SMARCA2 1 item
  296. Dipeptidyl-peptidase II 1 item
  297. HDAC 1 item
  298. c-Fms tyrosine kinase 1 item
  299. human lyase 1 item
  300. Ub-conjugating enzyme (E2) complex 1 item
  301. STK 1 item
  302. IKK 1 item
  303. MSK 1 item
  304. HCV polymerase 2item
  305. Ftase 1 item
  306. PC-PLC 1 item
  307. Elastases 1 item
  308. P97 ATPase 1 item
  309. NTPDases 1 item
  310. telomerase 1 item
  311. Histone Acetyltransferases (HATs) 1 item
  312. F1 Fo-ATPase 1 item
  313. ITK 1 item
  314. NOD1 1 item
  315. NUAK 1 item
  316. DCLK2 1 item
  317. FAAH 1 item
  318. TYK2 1 item
  319. Lck 1 item
  320. Aromatases 1 item
  321. PKD 1 item
  322. SHIP 1 item
  323. MCL1 1 item
  324. Bcl-w 1 item
  325. tropomyosin receptor kinase 1 item
  326. LSD 1 item
  327. PRMT 1 item
  328. GLP 1 item
  329. SK 1 item
  330. MST 1 item
  331. IDO 1 item
  332. Serotonin (5-HT) reuptake 1 item
  333. Androgen Receptor 1 item
  334. Substance P/NK1 Receptor 1 item
  335. gp120/CD4 1 item
  336. ATM 2item
  337. Sirtuin 1 item
  338. NE 1 item
  339. PIKfyve 1 item
  340. Glycogen Phosphorylases 1 item
  341. MTH1 1 item
  342. Insulin Receptor 1 item
Reported Experiments
  1. Animal Experiments 660item
  2. Cell Experiments 452item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 1 item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 6item
  7. Acute Myeloid Leukemia 26item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Biliary Cancer 1 item
  13. Bladder Cancer 10item
  14. Bladder Carcinoma 4item
  15. Bladder Diseases 2item
  16. B-lymphoid Malignancies 1 item
  17. Brain Injuries Studies 3item
  18. Breast Cancer 112item
  19. Cancer 422item
  20. Candida Peritonitis 1 item
  21. Candidemia 1 item
  22. Castration-resistant Prostate Cancer 1 item
  23. Cervical Cancer 5item
  24. Cholangiocarcinoma 2item
  25. Chronic Lymphocytic Leukemia 8item
  26. Chronic Myeloproliferative Disorders 1 item
  27. Clear Cell Renal Cell Carcinoma 2item
  28. Cocaine-Related Disorders 2item
  29. Colon Cancer 45item
  30. Colon Carcinoma 7item
  31. Colorectal Cancer 42item
  32. Depression 2item
  33. Diabetes 7item
  34. Diffuse Large B-cell Lymphoma 1 item
  35. Dyskinesia 1 item
  36. Dyslipidemia 2item
  37. Epilepsy 2item
  38. Erectile Dysfunction 3item
  39. Friedreich's Ataxia 1 item
  40. Fungal Infection 1 item
  41. Glioblastoma 32item
  42. Glioma 18item
  43. HCV 3item
  44. Heart Failure 1 item
  45. Hepatic Cancer 2item
  46. Hepatitis C 3item
  47. Hepatocellular Carcinoma 7item
  48. HIV 4item
  49. HIV Infections 9item
  50. Hypercholesterolemia 2item
  51. Immunological Diseases 1 item
  52. Inflammation 1 item
  53. Inflammatory Bowel Disease 1 item
  54. Inflammatory Diseases 13item
  55. Influenza 2item
  56. Kidney Injury Studies 1 item
  57. Leukemia 22item
  58. Liver Cancer 3item
  59. Lung Cancer 42item
  60. Lung Carcinoma 4item
  61. Lymphoma 29item
  62. Mantle Cell Lymphoma 2item
  63. Medulloblastoma 1 item
  64. Melanoma 34item
  65. Mixed Lineage Leukemia 3item
  66. Multiple Myeloma 23item
  67. Myelofibrosis 2item
  68. Myeloma 6item
  69. Neuroblastoma 13item
  70. Neurocognitive Disorders 1 item
  71. Neuronal Protection 1 item
  72. Non-small Cell Lung Cancer 26item
  73. Non-small Cell Lung Carcinoma 2item
  74. Obsessive-Compulsive Disorder 1 item
  75. Osteoporosis 2item
  76. Ovarian Cancer 34item
  77. Pancreatic Cancer 47item
  78. Pancreatic Carcinoma 3item
  79. Prostate Cancer 53item
  80. Psoriasis 4item
  81. Psoriasis Vulgaris 1 item
  82. Pulmonary Arterial Hypertension 2item
  83. Pulmonary Fibrosis 2item
  84. Renal Cancer 4item
  85. Renal Cell Carcinoma 8item
  86. Rheumatoid Arthritis 14item
  87. Sarcoma 1 item
  88. Schizophrenia 6item
  89. Sleep Disorders 1 item
  90. Soft Tissue Sarcoma 1 item
  91. Squamous Cell Carcinoma 2item
  92. Testicular Cancer 2item
  93. Thyroid Cancer 6item
  94. Type 2 Diabetes 11item