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Search results for: 'cdk4 inhibitor'

Items 171-180 of 732

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  1. THZ1
    A8882 THZ1
     12 Citation
    Target: Cyclin-Dependent Kinases
    Summary: Covalent CDK7 inhibitor,potent and selective
      ≥28.3 mg/mL
  2. BMS-509744
    A3250 BMS-509744
    Target: ITK
    Summary: Itk inhibitor,potent and selective
      Soluble in DMSO
  3. Valdecoxib
    B1459 Valdecoxib
    Target: COX
    Summary: COX-2 inhibitor
      insoluble in H2O; ≥15.72 mg/mL
  4. Rofecoxib
    B1454 Rofecoxib
    Target: COX
    Summary: COX-2 inhibitor
      insoluble in H2O; insoluble in EtOH; ≥15.72 mg/mL
  5. Golvatinib (E7050)
    B1439 Golvatinib (E7050)
    Target: VEGFR
    Summary: C-Met/VEGFR-2 inhibitor
  6. Z-IETD-FMK
    B3232 Z-IETD-FMK
     12 Citation
    Target: Caspases
    Summary: Caspase-8 inhibitor
      ≥32.73 mg/mL
  7. Vorinostat (SAHA, MK0683)
    A4084 Vorinostat (SAHA, MK0683)
     9 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: HDAC inhibitor
      insoluble in EtOH; insoluble in H2O; ≥4.41 mg/mL
  8. XL019
    A3937 XL019
    Target: JAK
    Summary: JAK2 inhibitor,potent and selective
      insoluble in EtOH; insoluble in H2O; ≥11.125 mg/mL
  9. SB202190 (FHPI)
    A1632 SB202190 (FHPI)
     5 Citation
    Target: p38
    Summary: P38 MAPK inhibitor
  10. RO4929097
    A4005 RO4929097
     1 Citation
    Summary: γ secretase inhibitor
      ≥23.47 mg/mL

Items 171-180 of 732

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Category
  1. Proteases 68item
  2. Apoptosis 44item
  3. Chromatin/Epigenetics 96item
  4. Metabolism 74item
  5. MAPK Signaling 31item
  6. Tyrosine Kinase 97item
  7. DNA Damage/DNA Repair 60item
  8. PI3K/Akt/mTOR Signaling 60item
  9. Microbiology & Virology 30item
  10. Cell Cycle/Checkpoint 68item
  11. Ubiquitination/ Proteasome 27item
  12. JAK/STAT Signaling 36item
  13. TGF-β / Smad Signaling 29item
  14. Angiogenesis 5item
  15. GPCR/G protein 16item
  16. Stem Cell 23item
  17. Membrane Transporter/Ion Channel 24item
  18. Endocrinology and Hormones 12item
  19. Neuroscience 29item
  20. Others 57item
  21. Immunology/Inflammation 14item
Specificity
  1. Selective 452item
  2. Non-Selective 3item
Reversibility
  1. Reversible 34item
  2. Irreversible 25item
Target
  1. Caspases 6item
  2. Cyclin-Dependent Kinases 21item
  3. Proteasome 11item
  4. Cathepsins 5item
  5. Histone Deacetylases (HDACs) 25item
  6. Akt 11item
  7. Bcl-2 8item
  8. PI3K 27item
  9. CXCR 2item
  10. Raf 10item
  11. Aurora Kinases 18item
  12. Bcl-xl 3item
  13. CSF-1R 4item
  14. Glycoproteins 1 item
  15. p97 1 item
  16. Gap Junctions 1 item
  17. MDM2 1 item
  18. EZH2 3item
  19. mTOR 16item
  20. Bromodomains 5item
  21. AP-1 1 item
  22. MMP 6item
  23. Thymidine Phosphorylases 1 item
  24. Androgen Receptors 3item
  25. Peptidylprolyl isomerases 1 item
  26. Acyl coenzyme A: cholesterol acyltransferases 1 item
  27. Myosin II ATPases 1 item
  28. DT-diaphorases 1 item
  29. Voltage-gated Potassium (KV) Channels 1 item
  30. MER 1 item
  31. FLT3 16item
  32. GSK-3 6item
  33. Factor Xa 4item
  34. P-glycoprotein (P-gp) 3item
  35. PLK 9item
  36. Chk 4item
  37. Eph Receptors 2item
  38. VEGFR 28item
  39. PDGFR 19item
  40. c-Kit 9item
  41. RET 2item
  42. IRAK 2item
  43. Bromodomain-containing proteins(BRDs) 1 item
  44. Phosphodiesterases (PDEs) 12item
  45. Mcl-1 5item
  46. Hydrolase 1 item
  47. Thymidylate Synthase 3item
  48. p38 6item
  49. PKB 1 item
  50. JNK 1 item
  51. Bcr-Abl 10item
  52. MEK 8item
  53. PORCN 1 item
  54. DOT1L 1 item
  55. FGFR 10item
  56. Nrf2 1 item
  57. Pim 3item
  58. Sir2-like Family Deacetylases (Sirtuins) 1 item
  59. Voltage-gated Sodium (NaV) Channels 1 item
  60. Deubiquitinating enzymes (DUBs) 2item
  61. Smoothened 1 item
  62. Neuraminidases (NA) 1 item
  63. MET 5item
  64. Src 14item
  65. Trk Receptors 4item
  66. Aminopeptidases 1 item
  67. NMDA Receptors 1 item
  68. STAT 6item
  69. Microtubules/Tubulins 1 item
  70. EGFR 18item
  71. Reverse Transcriptases 5item
  72. ROCK 7item
  73. Hypoxia Inducible Factors (HIFs) 1 item
  74. FAK 3item
  75. JAK 17item
  76. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  77. Syk 4item
  78. EZH1 1 item
  79. DNA-PK 6item
  80. HSP90 8item
  81. AMPK 1 item
  82. CFTR 2item
  83. Topoisomerases 10item
  84. Cytochrome P450 (CYP450) 7item
  85. Ksp 1 item
  86. Renin 1 item
  87. ErbB 4item
  88. Toll-like receptors (TLRs) 2item
  89. Actin 2item
  90. Serine Proteases 1 item
  91. DNA Methyltransferases 1 item
  92. ERK 6item
  93. HMG-CoA Reductases 4item
  94. c-MET 6item
  95. PKC 11item
  96. Calpains 3item
  97. Ca2 /calmodulin-dependent protein kinases (CaMKs) 4item
  98. Protease-Activated Receptors 1 item
  99. Lyn 1 item
  100. RAD51 1 item
  101. HER2 1 item
  102. Pyk2 2item
  103. 5-HT2 Receptors 3item
  104. LRRK2 5item
  105. Voltage-gated Calcium Channels (CaV) 1 item
  106. DGAT 1 item
  107. Insulin and Insulin-like Receptors 4item
  108. PARP 6item
  109. Pyruvate dehydrogenases (PDH) 1 item
  110. ALK 6item
  111. Sphingosine kinases (SphKs) 2item
  112. Monocarboxylate transporters (MCTs) 1 item
  113. CETP 1 item
  114. PKG 2item
  115. PKA 5item
  116. Myosin light chain kinases (MLCKs) 2item
  117. D1 and D5 Receptors 1 item
  118. D2 Receptors 3item
  119. D3 Receptors 2item
  120. 5-HT1 Receptors 2item
  121. 5-HT7 Receptors 1 item
  122. Lactate Dehydrogenases (LDH) 2item
  123. MK2 2item
  124. Angiotensin-Converting Enzymes (ACEs) 3item
  125. Tie-2 3item
  126. RSK 2item
  127. phosphatases 1 item
  128. Autophagy 3item
  129. ATM/ATR 5item
  130. COX 10item
  131. CK1 1 item
  132. CK2 3item
  133. HIPK2 1 item
  134. HIPK3 1 item
  135. HIV Integrases 1 item
  136. Squalene epoxidases 1 item
  137. PRAK 1 item
  138. MAPKAP-K2 1 item
  139. 20S proteasomal chymotrypsin 1 item
  140. Geranylgeranyltransferase I 1 item
  141. Farnesyltransferase 1 item
  142. Nampt 3item
  143. eIF4F 1 item
  144. Cdc42 1 item
  145. SRPK1 1 item
  146. P2X Receptors 1 item
  147. Glutaminases 2item
  148. Carbonic Anhydrases 6item
  149. Ron 1 item
  150. G9a 1 item
  151. BLM 1 item
  152. HSV 1 item
  153. NADPH Oxidases 3item
  154. Calcium-activated chloride channels (CaCC) 1 item
  155. GPR35 1 item
  156. Aldehyde Dehydrogenases 1 item
  157. Synthases/Synthetases 2item
  158. Histamine H1 Receptors 2item
  159. Na /K ATPases 2item
  160. P110 1 item
  161. Hck 2item
  162. Inositol-requiring enzyme 1 (IRE1) 1 item
  163. Na /K /Cl- Symporters (NKCCs) 2item
  164. GABAA Receptors 1 item
  165. Phospholipases 1 item
  166. RNA Polymerases 1 item
  167. DYRK 1 item
  168. Norepinephrine transporter 1 item
  169. 5-HT Transporters 3item
  170. Xanthine oxidoreductases 1 item
  171. Dihydroorotate dehydrogenase 1 item
  172. MNK 2item
  173. 5-Lipoxygenases 1 item
  174. NO Donors / Precursors 1 item
  175. HIV-1 reverse transcriptase 1 item
  176. IL Receptors 2item
  177. CCL2 1 item
  178. Norepinephrine transporters 1 item
  179. Calcium-Activated Potassium (KCa) Channels 2item
  180. AChE 3item
  181. Insulin Receptors 1 item
  182. IRG-1R 1 item
  183. cAMP 1 item
  184. Sulfonylurea receptors 1 item
  185. eEF-2 1 item
  186. Inward Rectifier Potassium (Kir) Channels 2item
  187. Cdc7 1 item
  188. CMV 1 item
  189. ZAP-70 1 item
  190. Catechol O-Methyltransferase (COMT) 2item
  191. fibrinolysis 1 item
  192. Angiotensin AT1 Receptors 1 item
  193. D4 Receptors 1 item
  194. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  195. NMDA receptor 1 item
  196. HBV Proteases 1 item
  197. Hydroxylases 2item
  198. Flk-1 1 item
  199. Papains 1 item
  200. Protein Arginine Methyltransferases 1 item
  201. IMPDH 1 item
  202. Na /Ca2 Exchangers (NCXs) 1 item
  203. NAE 2item
  204. Ubiquitin-activating Enzyme E1 2item
  205. SUMOylation 1 item
  206. ATGL 1 item
  207. BACE 2item
  208. Cytidine deaminases 1 item
  209. angiogenesis 1 item
  210. Glucagon Receptors 1 item
  211. 15-PGDH 1 item
  212. DPP-4 5item
  213. c-RET 3item
  214. Nonstructural protein 5B (NS5B) 1 item
  215. p70 rsk 3item
  216. voltage-gated chloride channels 1 item
  217. FPTase 1 item
  218. Microtubule/Tubulin 1 item
  219. VEGFR3/FLT4 1 item
  220. NTRK1/TRKA 1 item
  221. CSF-1R/c-Fms 1 item
  222. Menin-MLL 2item
  223. Tryptophan hydroxylases (TPH) 2item
  224. ADAMs 1 item
  225. NMPRTase 1 item
  226. Bfl-1 1 item
  227. TAM kinase 1 item
  228. p53-MDM2 interaction 2item
  229. nuclear export 1 item
  230. CRM1 1 item
  231. PTP 1 item
  232. KDR 2item
  233. Fyn kinase 1 item
  234. Abl kinases 1 item
  235. AXL 1 item
  236. Glyoxalase I 1 item
  237. dCTP Pyrophosphatases 1 item
  238. Protein polybromo-1 1 item
  239. SMARCA4 1 item
  240. SMARCA2 1 item
  241. Dipeptidyl-peptidase II 1 item
  242. p53 4item
  243. metalloprotease 1 item
  244. HDAC 2item
  245. KDM 2item
  246. 5-HT receptors 1 item
  247. sodium channel 2item
  248. c-Fms tyrosine kinase 1 item
  249. human lyase 1 item
  250. insulin 1 item
  251. Ub-conjugating enzyme (E2) complex 1 item
  252. Smoothened receptor 1 item
  253. quinone oxidoreductase 1 item
  254. cysteine protease 2item
  255. STK 1 item
  256. USP1/USF1 complex 1 item
  257. IKK 1 item
  258. MSK 1 item
  259. gp120-CD4 interaction 1 item
  260. HCV polymerase 3item
  261. Ftase 1 item
  262. Subtilisin/Kex2p-like proprotein convertase 1 item
  263. PC-PLC 2item
  264. Elastases 1 item
  265. P97 ATPase 1 item
  266. NTPDases 1 item
  267. Mer tyrosine kinase 1 item
  268. Hec1 1 item
  269. neprilysin 1 item
  270. GLI 1 item
  271. HMGCR 1 item
  272. AAT 1 item
  273. ErbB-2 1 item
  274. adrenergic receptor 2item
  275. 5-HT4 Receptor 1 item
  276. sterol demethylase 1 item
  277. PDK-1 1 item
  278. GAPDH 1 item
  279. telomerase 1 item
  280. Histone Acetyltransferases (HATs) 3item
  281. complex I of the mitochondrial electron transport chain 1 item
  282. F1 Fo-ATPase 1 item
  283. Prk 1 item
  284. potassium channel 1 item
  285. calcium channel 1 item
  286. Ribonucleotide Reductases 1 item
  287. Trx 1 item
  288. Tyrosinases 1 item
  289. HSP70 1 item
  290. ICAM 1 item
  291. ITK 1 item
  292. HIF-PH 1 item
  293. NOD1 1 item
  294. NUAK 1 item
  295. Rho 1 item
  296. Ubiquitin E3 Ligases 1 item
  297. DCLK2 1 item
  298. FAAH 1 item
  299. PTK 1 item
  300. integrase 1 item
  301. L3MBTL 1 item
  302. NOS 2item
  303. MDMX 1 item
  304. TYK2 2item
  305. MUSK 1 item
  306. MAP3K 1 item
  307. GPR3 1 item
  308. Lck 1 item
  309. Adenosine Deaminases 2item
  310. mitochondrial pyruvate carrier (MPC) 1 item
  311. prolactin secretion 1 item
  312. gonadotropin release 1 item
  313. DprE 1 item
  314. carnitine reabsorption 1 item
  315. Histamine receptors 1 item
  316. GluR 1 item
  317. 5-HT receptor 1 item
  318. dopamine receptors 1 item
  319. AMPA receptor 1 item
  320. 5-alpha Reductases 1 item
  321. Flk1 2item
  322. p21 1 item
  323. DNA Ligases 1 item
  324. Prostaglandin synthesis 1 item
  325. Protein Tyrosine Phosphatases 1 item
  326. alkaline phosphatases 1 item
  327. ATPases 1 item
  328. glutamate release 1 item
  329. PAFR 1 item
  330. Aromatases 2item
  331. DHFR 1 item
  332. GARFT 1 item
  333. PHF 1 item
  334. FGR 1 item
  335. YES 2item
  336. Fyn 2item
  337. ARG 1 item
  338. Autotaxin 1 item
  339. UCH 1 item
  340. RHA 1 item
  341. HCV NS3-4A protease 1 item
  342. PKD 1 item
  343. Thioredoxin Reductases 1 item
  344. enoyl-acyl-carrier protein reductase 1 item
  345. SHIP 1 item
  346. MCL1 1 item
  347. Bcl-w 1 item
  348. glutathione peroxidase 4 1 item
  349. NADH oxidase 1 item
  350. S-adenosylhomocysteine hydrolase 1 item
  351. Rho-kinase 1 item
  352. tropomyosin receptor kinase 1 item
  353. LSD 1 item
  354. DDX3 1 item
  355. PRMT 1 item
  356. ACE 1 item
  357. GLP 1 item
  358. SK 1 item
  359. MST 1 item
  360. PPK 1 item
  361. c-Syk 1 item
  362. CDK1/CyclinB 1 item
  363. NHE 1 item
  364. IDO 1 item
  365. Tph 1 item
  366. PIM1 kinase 1 item
  367. phospholipase A2 1 item
  368. reverse transcriptase 1 item
  369. epoxide hydrolase 1 item
  370. Serotonin (5-HT) reuptake 1 item
  371. Cholesterol absorption 1 item
  372. Vascular Disrupting Agents (VDA) 1 item
  373. Androgen Receptor 1 item
  374. Substance P/NK1 Receptor 1 item
  375. gp120/CD4 1 item
  376. ATM 1 item
  377. Sirtuin 1 item
  378. NE 1 item
  379. PIKfyve 1 item
  380. Bax 1 item
  381. Glycogen Phosphorylases 1 item
  382. MTH1 1 item
  383. PTEN 1 item
  384. Insulin Receptor 1 item
  385. NS3/4a Proteases 1 item
  386. p90 S6K 1 item
Related Disease
  1. Acne 1 item
  2. Acute Kidney Injury 2item
  3. Acute Lung Injury 1 item
  4. Acute Myelogenous Leukemia 4item
  5. Acute Myeloid Leukemia 18item
  6. Acute Renal Failure 1 item
  7. Adrenocortical Carcinoma 3item
  8. Biliary Cancer 1 item
  9. Bladder Cancer 9item
  10. Bladder Carcinoma 3item
  11. Bladder Diseases 2item
  12. B-lymphoid Malignancies 1 item
  13. Brain Injuries Studies 3item
  14. Breast Cancer 68item
  15. Cancer 335item
  16. Castration-resistant Prostate Cancer 1 item
  17. Cervical Cancer 4item
  18. Cholangiocarcinoma 1 item
  19. Chronic Lymphocytic Leukemia 6item
  20. Chronic Myeloproliferative Disorders 1 item
  21. Clear Cell Renal Cell Carcinoma 1 item
  22. Cocaine-Related Disorders 2item
  23. Colon Cancer 22item
  24. Colon Carcinoma 3item
  25. Colorectal Cancer 28item
  26. Depression 2item
  27. Diabetes 7item
  28. Diffuse Large B-cell Lymphoma 1 item
  29. Dyskinesia 1 item
  30. Dyslipidemia 2item
  31. Epilepsy 3item
  32. Erectile Dysfunction 3item
  33. Friedreich's Ataxia 1 item
  34. Fungi 1 item
  35. Glioblastoma 18item
  36. Glioma 10item
  37. HCV 3item
  38. Heart Failure 3item
  39. Hepatitis C 3item
  40. Hepatocellular Carcinoma 4item
  41. HIV 11item
  42. HIV Infections 9item
  43. Hypercholesterolemia 1 item
  44. Inflammation 1 item
  45. Inflammatory Diseases 4item
  46. Influenza 1 item
  47. Kidney Injury Studies 2item
  48. Leukemia 16item
  49. Liver Cancer 2item
  50. Lung Cancer 19item
  51. Lung Carcinoma 2item
  52. Lymphoma 22item
  53. Mantle Cell Lymphoma 2item
  54. Melanoma 18item
  55. Mixed Lineage Leukemia 1 item
  56. Multiple Myeloma 15item
  57. Myelofibrosis 2item
  58. Myeloma 2item
  59. Neuroblastoma 6item
  60. Neurocognitive Disorders 1 item
  61. Neuronal Protection 1 item
  62. Non-small Cell Lung Cancer 15item
  63. Non-small Cell Lung Carcinoma 1 item
  64. Obsessive-Compulsive Disorder 1 item
  65. Osteoporosis 2item
  66. Ovarian Cancer 21item
  67. Pancreatic Cancer 30item
  68. Pancreatic Carcinoma 1 item
  69. Prostate Cancer 35item
  70. Psoriasis 3item
  71. Psoriasis Vulgaris 1 item
  72. Pulmonary Fibrosis 2item
  73. Renal Cancer 3item
  74. Renal Cell Carcinoma 4item
  75. Rheumatoid Arthritis 11item
  76. Sarcoma 1 item
  77. Schizophrenia 4item
  78. Sleep Disorders 1 item
  79. Soft Tissue Sarcoma 1 item
  80. Squamous Cell Carcinoma 2item
  81. Thyroid Cancer 4item
  82. Tuberculosis 1 item
  83. Type 2 Diabetes 7item