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Search results for: 'cdk4 inhibitor'

Items 41-50 of 914

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  1. CHIR-99021 (CT99021)
    A3011 CHIR-99021 (CT99021)
     2 Citation
    Target: GSK-3
    Summary: GSK-3 inhibitor, Cell-permeable, ATP-competitive
      ≥23.27 mg/mL
  2. Pyridone 6
    A3741 Pyridone 6
    Target: JAK
    Summary: Pan-JAK inhibitor
      insoluble in H2O; ≥15.45 mg/mL
  3. YO-01027 (Dibenzazepine, DBZ)
    A4018 YO-01027 (Dibenzazepine, DBZ)
     1 Citation
    Summary: γ-secretase inhibitor
      ≥23.17 mg/mL
  4. EX 527 (SEN0014196)
    A4181 EX 527 (SEN0014196)
     1 Citation
    Target: Sirtuin
    Summary: SIRT1 inhibitor
      insoluble in H2O; ≥12.43 mg/mL
  5. SLx-2119
    A3825 SLx-2119
     1 Citation
    Target: ROCK
    Summary: Selective ROCK2 inhibitor
      ≥22.65 mg/mL
  6. DAPT (GSI-IX)
    A8200 DAPT (GSI-IX)
     6 Citation
    Summary: γ-secretase inhibitor,potent and specific
      ≥21.62 mg/mL
  7. Purvalanol B
    A8565 Purvalanol B
     1 Citation
    Target: Cyclin-Dependent Kinases
    Summary: CDK1/CDK2/CDK4 inhibitor
      ≥21.65 mg/mL
  8. Boc-D-FMK
    A1904 Boc-D-FMK
     1 Citation
    Target: Caspases
    Summary: Pan-caspase inhibitor
      insoluble in H2O; ≥11.65 mg/mL
  9. TBB
    A3861 TBB
     1 Citation
    Target: CK2
    Summary: Casein kinase-2 (CK2) inhibitor
      insoluble in H2O; ≥159.2 mg/mL
  10. AR-A014418
    A3184 AR-A014418
     2 Citation
    Target: GSK-3
    Summary: GSK3β inhibitor, ATP-competitive and selective
      insoluble in EtOH; insoluble in H2O; ≥15.4 mg/mL

Items 41-50 of 914

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Category
  1. Proteases 88item
  2. Apoptosis 52item
  3. Chromatin/Epigenetics 116item
  4. Metabolism 90item
  5. MAPK Signaling 46item
  6. Tyrosine Kinase 137item
  7. DNA Damage/DNA Repair 69item
  8. PI3K/Akt/mTOR Signaling 79item
  9. Microbiology & Virology 36item
  10. Cell Cycle/Checkpoint 83item
  11. Ubiquitination/ Proteasome 29item
  12. JAK/STAT Signaling 45item
  13. TGF-β / Smad Signaling 41item
  14. Angiogenesis 8item
  15. GPCR/G protein 23item
  16. Stem Cell 33item
  17. Membrane Transporter/Ion Channel 28item
  18. Endocrinology and Hormones 13item
  19. Neuroscience 32item
  20. Others 64item
  21. Immunology/Inflammation 15item
Specificity
  1. Selective 660item
  2. Non-Selective 4item
Reversibility
  1. Reversible 54item
  2. Irreversible 31item
Target
  1. Caspases 8item
  2. Cyclin-Dependent Kinases 25item
  3. Proteasome 12item
  4. Cathepsins 9item
  5. Histone Deacetylases (HDACs) 31item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 13item
  8. Bcl-2 8item
  9. PI3K 36item
  10. CXCR 3item
  11. Raf 13item
  12. Aurora Kinases 20item
  13. Bcl-xl 2item
  14. CSF-1R 4item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. Gap Junctions 1 item
  18. MDM2 1 item
  19. EZH2 4item
  20. mTOR 20item
  21. Bromodomains 6item
  22. AP-1 1 item
  23. MMP 7item
  24. Thymidine Phosphorylases 1 item
  25. Androgen Receptors 4item
  26. Peptidylprolyl isomerases 1 item
  27. Acyl coenzyme A: cholesterol acyltransferases 1 item
  28. Myosin II ATPases 1 item
  29. DT-diaphorases 1 item
  30. Voltage-gated Potassium (KV) Channels 1 item
  31. MER 1 item
  32. FLT3 19item
  33. GSK-3 10item
  34. Factor Xa 4item
  35. P-glycoprotein (P-gp) 5item
  36. PLK 10item
  37. Chk 7item
  38. Eph Receptors 2item
  39. VEGFR 40item
  40. PDGFR 25item
  41. c-Kit 13item
  42. RET 4item
  43. IRAK 1 item
  44. Bromodomain-containing proteins(BRDs) 1 item
  45. Phosphodiesterases (PDEs) 16item
  46. Mcl-1 6item
  47. Hydrolase 1 item
  48. Thymidylate Synthase 3item
  49. p38 9item
  50. PKB 1 item
  51. JNK 3item
  52. SGK 1 item
  53. Bcr-Abl 13item
  54. Kynurenine-3-monooxygenase 1 item
  55. MEK 13item
  56. PORCN 1 item
  57. DOT1L 3item
  58. FGFR 17item
  59. Nrf2 2item
  60. Insulin-like growth factor receptors(IGFRs) 1 item
  61. Pim 3item
  62. Sir2-like Family Deacetylases (Sirtuins) 3item
  63. Voltage-gated Sodium (NaV) Channels 1 item
  64. Deubiquitinating enzymes (DUBs) 3item
  65. Smoothened 4item
  66. Neuraminidases (NA) 2item
  67. MET 7item
  68. Src 14item
  69. Trk Receptors 6item
  70. Integrins 1 item
  71. Aminopeptidases 3item
  72. NMDA Receptors 1 item
  73. STAT 8item
  74. ATP Citrate Lyases 1 item
  75. Microtubules/Tubulins 4item
  76. EGFR 23item
  77. Hedgehog 1 item
  78. Reverse Transcriptases 5item
  79. ROCK 9item
  80. BTK 1 item
  81. RIP kinases 1 item
  82. PAK 3item
  83. Hypoxia Inducible Factors (HIFs) 2item
  84. Tankyrases 1 item
  85. Inositol Phosphatases 1 item
  86. FAK 6item
  87. BMP and Other Activin Receptors 3item
  88. JAK 20item
  89. p300 1 item
  90. Stearoyl-CoA 9-desaturase (SCD-1) 2item
  91. Syk 7item
  92. EZH1 2item
  93. DNA-PK 7item
  94. HSP90 12item
  95. AMPK 2item
  96. Gutathione S-transferase 1 item
  97. PDHK 1 item
  98. Angiotensin AT2 Receptors 1 item
  99. Notch 1 item
  100. S-nitrosoglutathione reductase 1 item
  101. CFTR 2item
  102. TNKS 1 item
  103. Topoisomerases 10item
  104. Cytochrome P450 (CYP450) 8item
  105. thrombin 1 item
  106. Ksp 2item
  107. Renin 1 item
  108. Influenza viruses 1 item
  109. ErbB 5item
  110. S6 kinases 1 item
  111. Toll-like receptors (TLRs) 3item
  112. Adenosine Kinases 2item
  113. Serine Proteases 2item
  114. DNA Methyltransferases 2item
  115. Survivin 1 item
  116. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  117. ERK 7item
  118. HMG-CoA Reductases 6item
  119. c-MET 8item
  120. BMI-1 1 item
  121. PKC 13item
  122. Calpains 5item
  123. Ubiquitin-specific proteases 1 item
  124. HCV Proteases 3item
  125. Ca2 /calmodulin-dependent protein kinases (CaMKs) 6item
  126. MLK3 1 item
  127. CREBBP 1 item
  128. EP300 1 item
  129. Lyn 2item
  130. SGLT 1 item
  131. RAD51 2item
  132. Trypsins 1 item
  133. HER2 3item
  134. Pyk2 3item
  135. 5-HT2 Receptors 4item
  136. LRRK2 6item
  137. Voltage-gated Calcium Channels (CaV) 1 item
  138. DGAT 2item
  139. Insulin and Insulin-like Receptors 4item
  140. PARP 6item
  141. Pyruvate dehydrogenases (PDH) 2item
  142. ALK 9item
  143. ROS1 2item
  144. Sphingosine kinases (SphKs) 3item
  145. Trypsin 1 item
  146. Chymotrypsin 1 item
  147. Kallikrein 1 item
  148. Trypsinogen 1 item
  149. Monocarboxylate transporters (MCTs) 2item
  150. CETP 2item
  151. Dehydrogenase 1 item
  152. PKG 2item
  153. PKA 6item
  154. Myosin light chain kinases (MLCKs) 2item
  155. HIV-1 gp120 1 item
  156. D1 and D5 Receptors 1 item
  157. D2 Receptors 3item
  158. D3 Receptors 2item
  159. 5-HT1 Receptors 2item
  160. 5-HT7 Receptors 1 item
  161. MELK 1 item
  162. Serotonin reuptake 1 item
  163. Insulin-like growth factors (IGFs) 1 item
  164. CSF1R 1 item
  165. Bromodomain and Extra-Terminal motif (BET) 1 item
  166. Lactate Dehydrogenases (LDH) 2item
  167. MK2 2item
  168. Fatty-acid-binding proteins (FABPs) 1 item
  169. Angiotensin-Converting Enzymes (ACEs) 4item
  170. Tie-2 5item
  171. RSK 3item
  172. p70 S6K 1 item
  173. phosphatases 1 item
  174. Autophagy 4item
  175. ATM/ATR 5item
  176. COX 11item
  177. CK1 1 item
  178. CK2 2item
  179. HIPK2 1 item
  180. HIPK3 1 item
  181. HIV Integrases 1 item
  182. Squalene epoxidases 2item
  183. PRAK 1 item
  184. MAPKAP-K2 1 item
  185. Delayed rectifier outward potassium current (IKr) 1 item
  186. 20S proteasomal chymotrypsin 1 item
  187. Geranylgeranyltransferase I 1 item
  188. Farnesyltransferase 1 item
  189. Nampt 3item
  190. eIF4F 1 item
  191. Cdc42 1 item
  192. SRPK1 1 item
  193. P2X Receptors 1 item
  194. Glutaminases 2item
  195. Carbonic Anhydrases 6item
  196. Ron 1 item
  197. G9a 1 item
  198. BLM 1 item
  199. HSV 1 item
  200. NADPH Oxidases 3item
  201. Calcium-activated chloride channels (CaCC) 1 item
  202. GPR35 1 item
  203. Aldehyde Dehydrogenases 1 item
  204. Synthases/Synthetases 2item
  205. Histamine H1 Receptors 2item
  206. Na /K ATPases 2item
  207. P110 1 item
  208. Hck 2item
  209. Inositol-requiring enzyme 1 (IRE1) 1 item
  210. Na /K /Cl- Symporters (NKCCs) 2item
  211. GABAA Receptors 1 item
  212. Phospholipases 1 item
  213. RNA Polymerases 1 item
  214. Norepinephrine transporter 1 item
  215. 5-HT Transporters 3item
  216. Xanthine oxidoreductases 1 item
  217. Dihydroorotate dehydrogenase 1 item
  218. MNK 2item
  219. 5-Lipoxygenases 1 item
  220. NO Donors / Precursors 1 item
  221. HIV-1 reverse transcriptase 1 item
  222. IL Receptors 2item
  223. CCL2 1 item
  224. Norepinephrine transporters 1 item
  225. Calcium-Activated Potassium (KCa) Channels 2item
  226. AChE 3item
  227. Insulin Receptors 1 item
  228. IRG-1R 1 item
  229. cAMP 1 item
  230. Sulfonylurea receptors 1 item
  231. eEF-2 1 item
  232. Inward Rectifier Potassium (Kir) Channels 2item
  233. Cdc7 1 item
  234. CMV 1 item
  235. ZAP-70 1 item
  236. Catechol O-Methyltransferase (COMT) 2item
  237. fibrinolysis 1 item
  238. Angiotensin AT1 Receptors 1 item
  239. D4 Receptors 1 item
  240. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  241. NMDA receptor 1 item
  242. HBV Proteases 1 item
  243. Hydroxylases 2item
  244. Flk-1 1 item
  245. Papains 1 item
  246. Protein Arginine Methyltransferases 1 item
  247. IMPDH 1 item
  248. Na /Ca2 Exchangers (NCXs) 1 item
  249. NAE 2item
  250. Ubiquitin-activating Enzyme E1 2item
  251. SUMOylation 1 item
  252. ATGL 1 item
  253. BACE 1 item
  254. Cytidine deaminases 1 item
  255. angiogenesis 1 item
  256. Glucagon Receptors 1 item
  257. 15-PGDH 1 item
  258. DPP-4 5item
  259. c-RET 3item
  260. Nonstructural protein 5B (NS5B) 1 item
  261. p70 rsk 3item
  262. voltage-gated chloride channels 1 item
  263. FPTase 1 item
  264. Microtubule/Tubulin 1 item
  265. VEGFR3/FLT4 1 item
  266. NTRK1/TRKA 1 item
  267. CSF-1R/c-Fms 1 item
  268. Tryptophan hydroxylases (TPH) 2item
  269. ADAMs 1 item
  270. NMPRTase 1 item
  271. Bfl-1 1 item
  272. TAM kinase 1 item
  273. p53-MDM2 interaction 1 item
  274. nuclear export 1 item
  275. CRM1 1 item
  276. PTP 1 item
  277. KDR 2item
  278. Fyn kinase 1 item
  279. AXL 1 item
  280. Glyoxalase I 1 item
  281. Dipeptidyl-peptidase II 1 item
  282. p53 4item
  283. metalloprotease 1 item
  284. HDAC 2item
  285. 5-HT receptors 1 item
  286. sodium channel 2item
  287. c-Fms tyrosine kinase 1 item
  288. human lyase 1 item
  289. insulin 1 item
  290. Ub-conjugating enzyme (E2) complex 1 item
  291. Smoothened receptor 1 item
  292. cysteine protease 2item
  293. IKK 1 item
  294. MSK 1 item
  295. gp120-CD4 interaction 1 item
  296. HCV polymerase 2item
  297. Ftase 1 item
  298. PC-PLC 2item
  299. Elastases 1 item
  300. Mer tyrosine kinase 1 item
  301. Hec1 1 item
  302. neprilysin 1 item
  303. GLI 1 item
  304. HMGCR 1 item
  305. ErbB-2 1 item
  306. adrenergic receptor 2item
  307. 5-HT4 Receptor 1 item
  308. sterol demethylase 1 item
  309. PDK-1 1 item
  310. GAPDH 1 item
  311. Histone Acetyltransferases (HATs) 2item
  312. complex I of the mitochondrial electron transport chain 1 item
  313. F1 Fo-ATPase 1 item
  314. Prk 1 item
  315. potassium channel 1 item
  316. calcium channel 1 item
  317. Ribonucleotide Reductases 1 item
  318. Trx 1 item
  319. Tyrosinases 1 item
  320. HSP70 1 item
  321. ICAM 1 item
  322. ITK 1 item
  323. HIF-PH 1 item
  324. NUAK 1 item
  325. Rho 1 item
  326. Ubiquitin E3 Ligases 1 item
  327. DCLK2 1 item
  328. FAAH 1 item
  329. PTK 1 item
  330. integrase 1 item
  331. NOS 2item
  332. TYK2 2item
  333. MUSK 1 item
  334. MAP3K 1 item
  335. GPR3 1 item
  336. Adenosine Deaminases 2item
  337. mitochondrial pyruvate carrier (MPC) 1 item
  338. prolactin secretion 1 item
  339. gonadotropin release 1 item
  340. DprE 1 item
  341. carnitine reabsorption 1 item
  342. Histamine receptors 1 item
  343. GluR 1 item
  344. 5-HT receptor 1 item
  345. dopamine receptors 1 item
  346. AMPA receptor 1 item
  347. 5-alpha Reductases 1 item
  348. Flk1 2item
  349. p21 1 item
  350. Prostaglandin synthesis 1 item
  351. Protein Tyrosine Phosphatases 1 item
  352. alkaline phosphatases 1 item
  353. ATPases 1 item
  354. glutamate release 1 item
  355. PAFR 1 item
  356. Aromatases 2item
  357. DHFR 1 item
  358. GARFT 1 item
  359. FGR 1 item
  360. YES 2item
  361. Fyn 2item
  362. ARG 1 item
  363. Autotaxin 1 item
  364. UCH 1 item
  365. RHA 1 item
  366. HCV NS3-4A protease 1 item
  367. PKD 1 item
  368. Thioredoxin Reductases 1 item
  369. enoyl-acyl-carrier protein reductase 1 item
  370. SHIP 1 item
  371. MCL1 1 item
  372. Bcl-w 1 item
  373. glutathione peroxidase 4 1 item
  374. S-adenosylhomocysteine hydrolase 1 item
  375. Rho-kinase 1 item
  376. tropomyosin receptor kinase 1 item
  377. LSD 1 item
  378. DDX3 1 item
  379. PRMT 1 item
  380. ACE 1 item
  381. GLP 1 item
  382. SK 1 item
  383. MST 1 item
  384. PPK 1 item
  385. c-Syk 1 item
  386. CDK1/CyclinB 1 item
  387. NHE 1 item
  388. IDO 1 item
  389. Tph 1 item
  390. PIM1 kinase 1 item
  391. phospholipase A2 1 item
  392. reverse transcriptase 1 item
  393. epoxide hydrolase 1 item
  394. Serotonin (5-HT) reuptake 1 item
  395. Cholesterol absorption 1 item
  396. Vascular Disrupting Agents (VDA) 1 item
  397. Androgen Receptor 1 item
  398. Substance P/NK1 Receptor 1 item
  399. gp120/CD4 1 item
  400. ATM 1 item
  401. Sirtuin 1 item
  402. NE 1 item
  403. PIKfyve 1 item
  404. Bax 1 item
  405. Glycogen Phosphorylases 1 item
  406. MTH1 1 item
  407. PTEN 1 item
  408. Insulin Receptor 1 item
  409. NS3/4a Proteases 1 item
  410. Ca2 -ATPases 1 item
  411. p90 S6K 1 item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 2item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 5item
  7. Acute Myeloid Leukemia 25item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Biliary Cancer 1 item
  13. Bladder Cancer 11item
  14. Bladder Carcinoma 4item
  15. Bladder Diseases 2item
  16. B-lymphoid Malignancies 1 item
  17. Brain Injuries Studies 3item
  18. Breast Cancer 110item
  19. Cancer 489item
  20. Candida Peritonitis 1 item
  21. Candidemia 1 item
  22. Castration-resistant Prostate Cancer 1 item
  23. Cervical Cancer 6item
  24. Cholangiocarcinoma 2item
  25. Chronic Lymphocytic Leukemia 8item
  26. Chronic Myeloproliferative Disorders 1 item
  27. Clear Cell Renal Cell Carcinoma 2item
  28. Cocaine-Related Disorders 2item
  29. Colon Cancer 41item
  30. Colon Carcinoma 7item
  31. Colorectal Cancer 40item
  32. Depression 2item
  33. Diabetes 7item
  34. Diffuse Large B-cell Lymphoma 1 item
  35. Dyskinesia 1 item
  36. Dyslipidemia 2item
  37. Epilepsy 4item
  38. Erectile Dysfunction 4item
  39. Friedreich's Ataxia 1 item
  40. Fungal Infection 1 item
  41. Fungi 1 item
  42. Glioblastoma 30item
  43. Glioma 17item
  44. HCV 4item
  45. Heart Failure 3item
  46. Hepatic Cancer 2item
  47. Hepatitis C 4item
  48. Hepatocellular Carcinoma 7item
  49. HIV 13item
  50. HIV Infections 9item
  51. Hypercholesterolemia 3item
  52. Immunological Diseases 1 item
  53. Inflammation 1 item
  54. Inflammatory Bowel Disease 1 item
  55. Inflammatory Diseases 14item
  56. Influenza 3item
  57. Kidney Injury Studies 2item
  58. Leukemia 23item
  59. Liver Cancer 3item
  60. Lung Cancer 38item
  61. Lung Carcinoma 4item
  62. Lymphoma 26item
  63. Mantle Cell Lymphoma 2item
  64. Medulloblastoma 1 item
  65. Melanoma 31item
  66. Mixed Lineage Leukemia 3item
  67. Multiple Myeloma 21item
  68. Myelofibrosis 2item
  69. Myeloma 6item
  70. Neuroblastoma 13item
  71. Neurocognitive Disorders 1 item
  72. Neuronal Protection 1 item
  73. Non-small Cell Lung Cancer 26item
  74. Non-small Cell Lung Carcinoma 2item
  75. Obsessive-Compulsive Disorder 1 item
  76. Osteoporosis 2item
  77. Ovarian Cancer 33item
  78. Pancreatic Cancer 46item
  79. Pancreatic Carcinoma 3item
  80. Prostate Cancer 49item
  81. Psoriasis 4item
  82. Psoriasis Vulgaris 1 item
  83. Pulmonary Arterial Hypertension 2item
  84. Pulmonary Fibrosis 2item
  85. Renal Cancer 4item
  86. Renal Cell Carcinoma 8item
  87. Rheumatoid Arthritis 14item
  88. Sarcoma 1 item
  89. Schizophrenia 7item
  90. Sleep Disorders 1 item
  91. Soft Tissue Sarcoma 1 item
  92. Squamous Cell Carcinoma 2item
  93. Testicular Cancer 2item
  94. Thyroid Cancer 6item
  95. Tuberculosis 1 item
  96. Type 2 Diabetes 11item