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Search results for: 'cdk4 inhibitor'

Items 421-430 of 766

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  1. Belinostat (PXD101)
    A4096 Belinostat (PXD101)
     2 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: Hydroxamate-type HDAC inhibitor
      insoluble in H2O; ≥15.92 mg/mL
  2. S-Ruxolitinib (INCB018424)
    A4149 S-Ruxolitinib (INCB018424)
    Target: JAK
    Summary: JAK1/2 inhibitor,potent and selective
      Soluble in DMSO
  3. SAR405
    A8883 SAR405
     22 Citation
    Summary: Selective ATP-competitive inhibitor of Vps34
      ≥22.19 mg/mL
  4. TAK-632
    A8226 TAK-632
    Target: Raf
    Summary: Pan-RAF inhibitor,potent and selective
      ≥27.75 mg/mL
  5. PTC124 (Ataluren)
    A8553 PTC124 (Ataluren)
    Summary: CFTR-G542X nonsense allele inhibitor
      insoluble in H2O; ≥10.6 mg/mL
  6. PF-04217903
    A5096 PF-04217903
    Target: c-MET
    Summary: C-Met inhibitor,selective and ATP-competitive
      insoluble in EtOH; insoluble in H2O; ≥18.6 mg/mL
  7. MK-2461
    A8476 MK-2461
    Target: FLT3|PDGFR|MET|Ron
    Summary: C-Met (WT/mutants) inhibitor
      ≥24.8 mg/mL
  8. TAK-700 (Orteronel)
    A4326 TAK-700 (Orteronel)
     2 Citation
    Target: human lyase
    Summary: Human 17,20-lyase inhibitor
      insoluble in H2O; ≥11.2 mg/mL
  9. Tivantinib (ARQ 197)
    A8325 Tivantinib (ARQ 197)
     2 Citation
    Target: MET
    Summary: C-Met inhibitor,non-ATP-competitive
      ≥18.47 mg/mL
  10. Neratinib (HKI-272)
    A8322 Neratinib (HKI-272)
     1 Citation
    Target: EGFR
    Summary: HER2/EGFR inhibitor,potent and irreversible
      insoluble in H2O; ≥13.93 mg/mL

Items 421-430 of 766

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  1. Signaling Pathways 732item
  2. Natural Products 6item
  3. Lab Reagents 3item
Specificity
  1. Selective 470item
  2. Non-Selective 4item
Reversibility
  1. Reversible 34item
  2. Irreversible 25item
Target
  1. Caspases 6item
  2. Cyclin-Dependent Kinases 21item
  3. Proteasome 11item
  4. Cathepsins 5item
  5. Histone Deacetylases (HDACs) 26item
  6. Akt 11item
  7. Bcl-2 8item
  8. PI3K 27item
  9. CXCR 2item
  10. Raf 10item
  11. Aurora Kinases 18item
  12. Bcl-xl 3item
  13. CSF-1R 4item
  14. Glycoproteins 1 item
  15. p97 1 item
  16. Gap Junctions 1 item
  17. MDM2 1 item
  18. EZH2 3item
  19. mTOR 16item
  20. Bromodomains 5item
  21. AP-1 1 item
  22. MMP 6item
  23. Thymidine Phosphorylases 1 item
  24. Androgen Receptors 3item
  25. Peptidylprolyl isomerases 1 item
  26. Acyl coenzyme A: cholesterol acyltransferases 1 item
  27. Myosin II ATPases 1 item
  28. DT-diaphorases 1 item
  29. Voltage-gated Potassium (KV) Channels 1 item
  30. MER 1 item
  31. FLT3 16item
  32. GSK-3 6item
  33. Factor Xa 4item
  34. P-glycoprotein (P-gp) 3item
  35. PLK 9item
  36. Chk 4item
  37. Eph Receptors 2item
  38. VEGFR 28item
  39. PDGFR 19item
  40. c-Kit 9item
  41. RET 2item
  42. IRAK 2item
  43. Bromodomain-containing proteins(BRDs) 1 item
  44. Phosphodiesterases (PDEs) 12item
  45. Mcl-1 5item
  46. Hydrolase 1 item
  47. Thymidylate Synthase 3item
  48. p38 6item
  49. PKB 1 item
  50. JNK 1 item
  51. Bcr-Abl 10item
  52. MEK 8item
  53. PORCN 1 item
  54. DOT1L 1 item
  55. FGFR 10item
  56. Nrf2 1 item
  57. Pim 4item
  58. Sir2-like Family Deacetylases (Sirtuins) 1 item
  59. Voltage-gated Sodium (NaV) Channels 1 item
  60. Deubiquitinating enzymes (DUBs) 2item
  61. Smoothened 1 item
  62. Neuraminidases (NA) 1 item
  63. MET 5item
  64. Src 14item
  65. Trk Receptors 4item
  66. Aminopeptidases 1 item
  67. NMDA Receptors 1 item
  68. STAT 8item
  69. Microtubules/Tubulins 1 item
  70. EGFR 18item
  71. Reverse Transcriptases 6item
  72. ROCK 7item
  73. Hypoxia Inducible Factors (HIFs) 1 item
  74. FAK 4item
  75. JAK 17item
  76. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  77. Syk 4item
  78. EZH1 1 item
  79. DNA-PK 6item
  80. HSP90 8item
  81. AMPK 1 item
  82. CFTR 2item
  83. Topoisomerases 12item
  84. Cytochrome P450 (CYP450) 7item
  85. Ksp 1 item
  86. Renin 1 item
  87. ErbB 4item
  88. Toll-like receptors (TLRs) 2item
  89. Actin 2item
  90. Serine Proteases 1 item
  91. DNA Methyltransferases 1 item
  92. ERK 7item
  93. HMG-CoA Reductases 4item
  94. c-MET 6item
  95. PKC 11item
  96. Calpains 3item
  97. Ca2 /calmodulin-dependent protein kinases (CaMKs) 4item
  98. Protease-Activated Receptors 1 item
  99. Lyn 1 item
  100. RAD51 1 item
  101. HER2 1 item
  102. Pyk2 2item
  103. USP 1 item
  104. 5-HT2 Receptors 3item
  105. LRRK2 5item
  106. Voltage-gated Calcium Channels (CaV) 2item
  107. DGAT 1 item
  108. Insulin and Insulin-like Receptors 4item
  109. PARP 7item
  110. CB1 Receptors 1 item
  111. Pyruvate dehydrogenases (PDH) 1 item
  112. ALK 7item
  113. Sphingosine kinases (SphKs) 2item
  114. Monocarboxylate transporters (MCTs) 1 item
  115. CETP 1 item
  116. PKG 2item
  117. PKA 5item
  118. Myosin light chain kinases (MLCKs) 2item
  119. D1 and D5 Receptors 1 item
  120. D2 Receptors 3item
  121. D3 Receptors 2item
  122. 5-HT1 Receptors 2item
  123. 5-HT7 Receptors 1 item
  124. Lactate Dehydrogenases (LDH) 2item
  125. MK2 2item
  126. Angiotensin-Converting Enzymes (ACEs) 5item
  127. Tie-2 3item
  128. RSK 2item
  129. phosphatases 2item
  130. Autophagy 3item
  131. ATM/ATR 5item
  132. COX 11item
  133. CK1 1 item
  134. CK2 3item
  135. HIPK2 1 item
  136. HIPK3 1 item
  137. HIV Integrases 2item
  138. Squalene epoxidases 1 item
  139. PRAK 1 item
  140. MAPKAP-K2 1 item
  141. GpIIb/IIIa receptor 1 item
  142. Guanine nucleotide exchange factors (GEFs) 1 item
  143. 20S proteasomal chymotrypsin 1 item
  144. Geranylgeranyltransferase I 1 item
  145. Farnesyltransferase 1 item
  146. Nampt 3item
  147. eIF4F 1 item
  148. Cdc42 1 item
  149. SRPK1 1 item
  150. P2X Receptors 1 item
  151. Glutaminases 2item
  152. Carbonic Anhydrases 7item
  153. Ron 1 item
  154. G9a 1 item
  155. BLM 1 item
  156. HSV 1 item
  157. NADPH Oxidases 3item
  158. Calcium-activated chloride channels (CaCC) 1 item
  159. GPR35 1 item
  160. Aldehyde Dehydrogenases 1 item
  161. Synthases/Synthetases 2item
  162. MAGL 1 item
  163. Histamine H1 Receptors 2item
  164. Na /K ATPases 3item
  165. P110 1 item
  166. Hck 2item
  167. Inositol-requiring enzyme 1 (IRE1) 3item
  168. Na /K /Cl- Symporters (NKCCs) 2item
  169. GABAA Receptors 1 item
  170. Phospholipases 1 item
  171. Monoamine oxidases (MAOs) 1 item
  172. Organic anion transporters (OATs) 1 item
  173. TRP Channel 1 item
  174. RNA Polymerases 2item
  175. DYRK 1 item
  176. Norepinephrine transporter 1 item
  177. 5-HT Transporters 3item
  178. Xanthine oxidoreductases 1 item
  179. Dihydroorotate dehydrogenase 1 item
  180. Histone Demethylases 1 item
  181. MNK 2item
  182. 5-Lipoxygenases 1 item
  183. NO Donors / Precursors 2item
  184. CB2 Receptors 1 item
  185. HIV-1 reverse transcriptase 1 item
  186. IL Receptors 2item
  187. CCL2 1 item
  188. Noradrenaline reuptake 1 item
  189. Norepinephrine transporters 1 item
  190. Calcium-Activated Potassium (KCa) Channels 2item
  191. AChE 3item
  192. Insulin Receptors 1 item
  193. IRG-1R 1 item
  194. cAMP 1 item
  195. Sulfonylurea receptors 1 item
  196. Cdc2-like kinase (Clk) 1 item
  197. eEF-2 1 item
  198. Inward Rectifier Potassium (Kir) Channels 3item
  199. Cdc7 1 item
  200. CMV 1 item
  201. ZAP-70 1 item
  202. Catechol O-Methyltransferase (COMT) 2item
  203. fibrinolysis 1 item
  204. Angiotensin AT1 Receptors 1 item
  205. D4 Receptors 1 item
  206. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  207. NMDA receptor 1 item
  208. HBV Proteases 1 item
  209. Hydroxylases 2item
  210. Flk-1 1 item
  211. Papains 1 item
  212. Protein Arginine Methyltransferases 1 item
  213. IMPDH 1 item
  214. Na /Ca2 Exchangers (NCXs) 1 item
  215. NAE 2item
  216. Ubiquitin-activating Enzyme E1 2item
  217. SUMOylation 1 item
  218. ATGL 1 item
  219. BACE 2item
  220. Cytidine deaminases 1 item
  221. angiogenesis 1 item
  222. Glucagon Receptors 1 item
  223. 15-PGDH 1 item
  224. DPP-4 5item
  225. c-RET 3item
  226. Nonstructural protein 5B (NS5B) 1 item
  227. p70 rsk 3item
  228. voltage-gated chloride channels 1 item
  229. FPTase 1 item
  230. Microtubule/Tubulin 1 item
  231. VEGFR3/FLT4 1 item
  232. NTRK1/TRKA 1 item
  233. CSF-1R/c-Fms 1 item
  234. Menin-MLL 2item
  235. Tryptophan hydroxylases (TPH) 2item
  236. ADAMs 1 item
  237. NMPRTase 1 item
  238. Bfl-1 1 item
  239. TAM kinase 1 item
  240. p53-MDM2 interaction 2item
  241. nuclear export 1 item
  242. CRM1 1 item
  243. PTP 1 item
  244. KDR 2item
  245. Fyn kinase 1 item
  246. Abl kinases 1 item
  247. Trypsin-like protease 1 item
  248. AXL 1 item
  249. Glyoxalase I 1 item
  250. dCTP Pyrophosphatases 1 item
  251. Protein polybromo-1 1 item
  252. SMARCA4 1 item
  253. SMARCA2 1 item
  254. ERAD 1 item
  255. Dipeptidyl-peptidase II 1 item
  256. p53 4item
  257. metalloprotease 1 item
  258. HDAC 2item
  259. KDM 2item
  260. 5-HT receptors 1 item
  261. sodium channel 3item
  262. c-Fms tyrosine kinase 1 item
  263. human lyase 1 item
  264. insulin 1 item
  265. Ub-conjugating enzyme (E2) complex 1 item
  266. Smoothened receptor 1 item
  267. quinone oxidoreductase 1 item
  268. cysteine protease 2item
  269. STK 1 item
  270. USP1/USF1 complex 1 item
  271. IKK 1 item
  272. MSK 1 item
  273. gp120-CD4 interaction 1 item
  274. HCV polymerase 3item
  275. Ftase 1 item
  276. Subtilisin/Kex2p-like proprotein convertase 1 item
  277. PC-PLC 2item
  278. Elastases 1 item
  279. P97 ATPase 1 item
  280. NTPDases 1 item
  281. Mer tyrosine kinase 1 item
  282. Hec1 1 item
  283. neprilysin 1 item
  284. GLI 1 item
  285. decarboxylase 1 item
  286. HMGCR 1 item
  287. AAT 1 item
  288. ErbB-2 1 item
  289. adrenergic receptor 2item
  290. 5-HT4 Receptor 1 item
  291. sterol demethylase 1 item
  292. PDK-1 1 item
  293. GAPDH 1 item
  294. telomerase 1 item
  295. Histone Acetyltransferases (HATs) 3item
  296. complex I of the mitochondrial electron transport chain 1 item
  297. F1 Fo-ATPase 1 item
  298. Prk 1 item
  299. potassium channel 1 item
  300. calcium channel 1 item
  301. Ribonucleotide Reductases 1 item
  302. Trx 1 item
  303. Tyrosinases 1 item
  304. HSP70 1 item
  305. ICAM 1 item
  306. ITK 1 item
  307. HIF-PH 1 item
  308. NOD1 1 item
  309. NUAK 1 item
  310. Rho 1 item
  311. Ubiquitin E3 Ligases 1 item
  312. DCLK2 1 item
  313. FAAH 1 item
  314. PTK 1 item
  315. integrase 1 item
  316. L3MBTL 1 item
  317. NOS 2item
  318. MDMX 1 item
  319. TYK2 2item
  320. MUSK 1 item
  321. MAP3K 1 item
  322. GPR3 1 item
  323. Lck 1 item
  324. Adenosine Deaminases 2item
  325. mitochondrial pyruvate carrier (MPC) 1 item
  326. prolactin secretion 1 item
  327. gonadotropin release 1 item
  328. DprE 1 item
  329. carnitine reabsorption 1 item
  330. Histamine receptors 1 item
  331. GluR 1 item
  332. 5-HT receptor 1 item
  333. dopamine receptors 1 item
  334. AMPA receptor 1 item
  335. 5-alpha Reductases 1 item
  336. Flk1 2item
  337. p21 1 item
  338. DNA Ligases 1 item
  339. Prostaglandin synthesis 1 item
  340. Protein Tyrosine Phosphatases 1 item
  341. alkaline phosphatases 1 item
  342. ATPases 1 item
  343. glutamate release 1 item
  344. PAFR 1 item
  345. Aromatases 2item
  346. DHFR 1 item
  347. GARFT 1 item
  348. PHF 1 item
  349. FGR 1 item
  350. YES 2item
  351. Fyn 2item
  352. ARG 1 item
  353. Autotaxin 1 item
  354. UCH 1 item
  355. RHA 1 item
  356. HCV NS3-4A protease 1 item
  357. PKD 1 item
  358. Pyruvate kinases 1 item
  359. Thioredoxin Reductases 1 item
  360. enoyl-acyl-carrier protein reductase 1 item
  361. SHIP 1 item
  362. MCL1 1 item
  363. Bcl-w 1 item
  364. glutathione peroxidase 4 1 item
  365. NADH oxidase 1 item
  366. S-adenosylhomocysteine hydrolase 1 item
  367. Rho-kinase 1 item
  368. tropomyosin receptor kinase 1 item
  369. LSD 1 item
  370. DDX3 1 item
  371. PRMT 1 item
  372. ACE 1 item
  373. GLP 1 item
  374. SK 1 item
  375. MST 1 item
  376. PPK 1 item
  377. c-Syk 1 item
  378. CDK1/CyclinB 1 item
  379. NHE 1 item
  380. IDO 2item
  381. Tph 1 item
  382. PIM1 kinase 1 item
  383. phospholipase A2 1 item
  384. reverse transcriptase 1 item
  385. epoxide hydrolase 1 item
  386. Serotonin (5-HT) reuptake 1 item
  387. Cholesterol absorption 1 item
  388. Vascular Disrupting Agents (VDA) 1 item
  389. Androgen Receptor 1 item
  390. Substance P/NK1 Receptor 1 item
  391. gp120/CD4 1 item
  392. ATM 1 item
  393. Sirtuin 1 item
  394. NE 1 item
  395. PIKfyve 1 item
  396. Bax 1 item
  397. Glycogen Phosphorylases 1 item
  398. MTH1 1 item
  399. PTEN 1 item
  400. Insulin Receptor 1 item
  401. NS3/4a Proteases 1 item
  402. p90 S6K 1 item
Related Disease
  1. Acne 1 item
  2. Acute Kidney Injury 2item
  3. Acute Lung Injury 1 item
  4. Acute Myelogenous Leukemia 4item
  5. Acute Myeloid Leukemia 18item
  6. Acute Renal Failure 1 item
  7. Adrenocortical Carcinoma 3item
  8. Biliary Cancer 1 item
  9. Bladder Cancer 9item
  10. Bladder Carcinoma 3item
  11. Bladder Diseases 2item
  12. B-lymphoid Malignancies 1 item
  13. Brain Injuries Studies 3item
  14. Breast Cancer 71item
  15. Cancer 345item
  16. Castration-resistant Prostate Cancer 1 item
  17. Cervical Cancer 4item
  18. Cholangiocarcinoma 1 item
  19. Chronic Lymphocytic Leukemia 6item
  20. Chronic Myeloproliferative Disorders 1 item
  21. Clear Cell Renal Cell Carcinoma 1 item
  22. Cocaine-Related Disorders 2item
  23. Colon Cancer 23item
  24. Colon Carcinoma 3item
  25. Colorectal Cancer 28item
  26. Depression 2item
  27. Diabetes 7item
  28. Diffuse Large B-cell Lymphoma 1 item
  29. Dyskinesia 1 item
  30. Dyslipidemia 2item
  31. Epilepsy 3item
  32. Erectile Dysfunction 3item
  33. Friedreich's Ataxia 2item
  34. Fungi 1 item
  35. Glioblastoma 18item
  36. Glioma 10item
  37. HCV 3item
  38. Heart Failure 3item
  39. Hepatitis C 3item
  40. Hepatocellular Carcinoma 4item
  41. HIV 11item
  42. HIV Infections 9item
  43. Hypercholesterolemia 1 item
  44. Inflammation 1 item
  45. Inflammatory Diseases 4item
  46. Influenza 1 item
  47. Kidney Injury Studies 2item
  48. Leukemia 17item
  49. Liver Cancer 2item
  50. Lung Cancer 21item
  51. Lung Carcinoma 2item
  52. Lymphoma 24item
  53. Mantle Cell Lymphoma 2item
  54. Melanoma 18item
  55. Mixed Lineage Leukemia 1 item
  56. Multiple Myeloma 15item
  57. Myelofibrosis 2item
  58. Myeloma 2item
  59. Neuroblastoma 6item
  60. Neurocognitive Disorders 1 item
  61. Neuronal Protection 1 item
  62. Non-small Cell Lung Cancer 15item
  63. Non-small Cell Lung Carcinoma 1 item
  64. Obsessive-Compulsive Disorder 1 item
  65. Osteoporosis 2item
  66. Ovarian Cancer 22item
  67. Pancreatic Cancer 31item
  68. Pancreatic Carcinoma 1 item
  69. Prostate Cancer 36item
  70. Psoriasis 3item
  71. Psoriasis Vulgaris 1 item
  72. Pulmonary Fibrosis 2item
  73. Renal Cancer 3item
  74. Renal Cell Carcinoma 4item
  75. Rheumatoid Arthritis 11item
  76. Sarcoma 1 item
  77. Schizophrenia 5item
  78. Sleep Disorders 2item
  79. Soft Tissue Sarcoma 1 item
  80. Squamous Cell Carcinoma 2item
  81. Thyroid Cancer 4item
  82. Tuberculosis 1 item
  83. Type 2 Diabetes 8item