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  • Search results for: 'gsk 3 inhibitor 1'

Search results for: 'gsk 3 inhibitor 1'

Items 381-390 of 1060

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  1. Procainamide HCl
    B4798 Procainamide HCl
    Target: DNA Methyltransferases
    Summary: sodium channel blocker
      ≥13.65 mg/mL
  2. WAY-262611
    B4818 WAY-262611
    Summary: β-Catenin agonist
      insoluble in EtOH; insoluble in H2O; ≥8.95 mg/mL
  3. L-755,507
    B6970 L-755,507
    Summary: β3 adrenergic receptor agonist
      Soluble in DMSO
  4. IRL-2500
    B6872 IRL-2500
    Target: ETA Receptors|ETB Receptors
    Summary: endothelin receptor antagonist
  5. OSU-03012 (AR-12)
    A2846 OSU-03012 (AR-12)
     1 Citation
    Target: PDK-1
    Summary: Potent PDK1 inhibitor
      ≥23 mg/mL
  6. MK-4827
    A3617 MK-4827
    Target: PARP
    Summary: PARP-1/-2 inhibitor,potent and selective
      ≥32 mg/mL
  7. TG101348 (SAR302503)
    A4136 TG101348 (SAR302503)
     2 Citation
    Target: FLT3|JAK|c-RET
    Summary: JAK-2 inhibitor,potent and selective
      ≥26.23 mg/mL
  8. Z-FA-FMK
    A8170 Z-FA-FMK
    Target: cysteine protease
    Summary: Cysteine proteases inhibitor
      insoluble in H2O; ≥13.45 mg/mL
  9. SP 600125
    A4604 SP 600125
     7 Citation
    Target: JNK
    Summary: JNK1/2/3 inhibitor
      insoluble in H2O; ≥11 mg/mL
  10. Sunitinib malate
    A8255 Sunitinib malate
     2 Citation
    Target: VEGFR
    Summary: VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor
      ≥26.65 mg/mL

Items 381-390 of 1060

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Category
  1. Proteases 89item
  2. Apoptosis 60item
  3. Chromatin/Epigenetics 120item
  4. Metabolism 95item
  5. MAPK Signaling 47item
  6. Tyrosine Kinase 139item
  7. DNA Damage/DNA Repair 82item
  8. PI3K/Akt/mTOR Signaling 80item
  9. Microbiology & Virology 50item
  10. Cell Cycle/Checkpoint 84item
  11. Ubiquitination/ Proteasome 29item
  12. JAK/STAT Signaling 45item
  13. TGF-β / Smad Signaling 42item
  14. Angiogenesis 8item
  15. GPCR/G protein 54item
  16. Stem Cell 36item
  17. Membrane Transporter/Ion Channel 39item
  18. Endocrinology and Hormones 24item
  19. Neuroscience 52item
  20. Obesity, Appetite Control & Diabetes 2item
  21. Other Signal Transduction 3item
  22. Others 81item
  23. Immunology/Inflammation 19item
  24. Cardiovascular 3item
  25. Vitamin D Related 3item
  26. NF-κB 1 item
Specificity
  1. Selective 749item
  2. Non-Selective 5item
Reversibility
  1. Reversible 55item
  2. Irreversible 33item
Target
  1. Caspases 9item
  2. Cyclin-Dependent Kinases 25item
  3. Adenosine A2A Receptors 1 item
  4. Proteasome 12item
  5. Cathepsins 9item
  6. Histone Deacetylases (HDACs) 32item
  7. Inhibitor of apoptosis proteins (IAP) 3item
  8. Akt 13item
  9. Bcl-2 9item
  10. PI3K 36item
  11. CXCR 4item
  12. Raf 13item
  13. Aurora Kinases 20item
  14. Bcl-xl 2item
  15. CSF-1R 4item
  16. Glycoproteins 1 item
  17. p97 1 item
  18. Gap Junctions 1 item
  19. MDM2 3item
  20. EZH2 4item
  21. mTOR 20item
  22. Bromodomains 6item
  23. AP-1 3item
  24. MMP 8item
  25. Thymidine Phosphorylases 1 item
  26. Androgen Receptors 5item
  27. Peptidylprolyl isomerases 1 item
  28. Acyl coenzyme A: cholesterol acyltransferases 1 item
  29. Myosin II ATPases 1 item
  30. DT-diaphorases 1 item
  31. Voltage-gated Potassium (KV) Channels 1 item
  32. MER 1 item
  33. FLT3 19item
  34. GSK-3 10item
  35. Factor Xa 4item
  36. LPA Receptors 3item
  37. P-glycoprotein (P-gp) 5item
  38. PLK 10item
  39. Chk 7item
  40. Eph Receptors 2item
  41. VEGFR 40item
  42. PDGFR 25item
  43. c-Kit 13item
  44. RET 4item
  45. IRAK 1 item
  46. Bromodomain-containing proteins(BRDs) 1 item
  47. Phosphodiesterases (PDEs) 16item
  48. Mcl-1 6item
  49. Hydrolase 1 item
  50. Thymidylate Synthase 3item
  51. p38 10item
  52. PKB 1 item
  53. JNK 4item
  54. SGK 1 item
  55. Bcr-Abl 13item
  56. Kynurenine-3-monooxygenase 1 item
  57. MEK 13item
  58. PORCN 1 item
  59. DOT1L 3item
  60. FGFR 17item
  61. Nrf2 3item
  62. Insulin-like growth factor receptors(IGFRs) 1 item
  63. CGRP receptors 1 item
  64. Pim 3item
  65. Liver X receptors (LXRs) 2item
  66. Glucagon-like peptide 1 (GLP-1) receptors 2item
  67. Sir2-like Family Deacetylases (Sirtuins) 3item
  68. Voltage-gated Sodium (NaV) Channels 2item
  69. Deubiquitinating enzymes (DUBs) 3item
  70. PP1 1 item
  71. PP2A 1 item
  72. Smoothened 4item
  73. Eukaryotic elongation factors 1 item
  74. Neuraminidases (NA) 2item
  75. MET 7item
  76. Src 15item
  77. Trk Receptors 7item
  78. Integrins 1 item
  79. Aminopeptidases 4item
  80. NMDA Receptors 2item
  81. STAT 8item
  82. ATP Citrate Lyases 1 item
  83. Microtubules/Tubulins 5item
  84. Estrogen and Related Receptors 3item
  85. EGFR 23item
  86. Hedgehog 1 item
  87. Reverse Transcriptases 5item
  88. ROCK 9item
  89. BTK 1 item
  90. RIP kinases 1 item
  91. PAK 3item
  92. Hypoxia Inducible Factors (HIFs) 2item
  93. Tankyrases 1 item
  94. Inositol Phosphatases 1 item
  95. FAK 6item
  96. BMP and Other Activin Receptors 3item
  97. JAK 20item
  98. p300 1 item
  99. Stearoyl-CoA 9-desaturase (SCD-1) 2item
  100. Syk 7item
  101. Progesterone Receptors 2item
  102. EZH1 2item
  103. DNA-PK 7item
  104. HSP90 12item
  105. AMPK 3item
  106. Gutathione S-transferase 1 item
  107. CCR 2item
  108. PDHK 1 item
  109. Angiotensin AT2 Receptors 1 item
  110. Notch 1 item
  111. S-nitrosoglutathione reductase 1 item
  112. CFTR 3item
  113. TNKS 1 item
  114. Topoisomerases 13item
  115. Cytochrome P450 (CYP450) 10item
  116. thrombin 1 item
  117. Ksp 2item
  118. Renin 1 item
  119. Influenza viruses 1 item
  120. ErbB 5item
  121. S6 kinases 1 item
  122. Toll-like receptors (TLRs) 4item
  123. Adenosine Kinases 2item
  124. Serine Proteases 2item
  125. DNA Methyltransferases 4item
  126. Survivin 1 item
  127. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  128. ERK 7item
  129. HMG-CoA Reductases 6item
  130. c-MET 8item
  131. BMI-1 1 item
  132. PKC 14item
  133. Calpains 5item
  134. Ubiquitin-specific proteases 1 item
  135. M1 Receptors 1 item
  136. HCV Proteases 3item
  137. Ca2 /calmodulin-dependent protein kinases (CaMKs) 7item
  138. MLK3 1 item
  139. CREBBP 1 item
  140. EP300 1 item
  141. Protease-Activated Receptors 1 item
  142. Lyn 2item
  143. SGLT 1 item
  144. RAD51 2item
  145. Trypsins 1 item
  146. HER2 3item
  147. Pyk2 3item
  148. 5-HT2 Receptors 6item
  149. LRRK2 6item
  150. Voltage-gated Calcium Channels (CaV) 1 item
  151. Calcium chelator 1 item
  152. DGAT 2item
  153. Insulin and Insulin-like Receptors 4item
  154. PARP 6item
  155. CB1 Receptors 2item
  156. Pyruvate dehydrogenases (PDH) 2item
  157. ALK 9item
  158. ROS1 2item
  159. Sphingosine kinases (SphKs) 3item
  160. Trypsin 1 item
  161. Chymotrypsin 1 item
  162. Kallikrein 1 item
  163. Trypsinogen 1 item
  164. Monocarboxylate transporters (MCTs) 2item
  165. CETP 2item
  166. Dehydrogenase 1 item
  167. PKG 2item
  168. PKA 6item
  169. Myosin light chain kinases (MLCKs) 2item
  170. GPR30 1 item
  171. BCPCF efflux 1 item
  172. HIV-1 gp120 1 item
  173. D1 and D5 Receptors 1 item
  174. D2 Receptors 4item
  175. D3 Receptors 2item
  176. 5-HT1 Receptors 2item
  177. 5-HT7 Receptors 1 item
  178. AdipoR1 1 item
  179. AdipoR2 1 item
  180. MELK 1 item
  181. Serotonin reuptake 1 item
  182. Insulin-like growth factors (IGFs) 1 item
  183. CSF1R 1 item
  184. Bromodomain and Extra-Terminal motif (BET) 1 item
  185. Lactate Dehydrogenases (LDH) 2item
  186. MK2 2item
  187. Fatty-acid-binding proteins (FABPs) 1 item
  188. 5-HT3 Receptors 1 item
  189. Angiotensin-Converting Enzymes (ACEs) 4item
  190. Tie-2 5item
  191. RSK 3item
  192. p70 S6K 1 item
  193. Free Fatty Acid Receptors 2item
  194. phosphatases 1 item
  195. Autophagy 4item
  196. ATM/ATR 5item
  197. COX 11item
  198. YAP 1 item
  199. CK1 1 item
  200. Histamine H4 Receptors 2item
  201. CK2 3item
  202. HIPK2 1 item
  203. HIPK3 1 item
  204. HIV Integrases 1 item
  205. Squalene epoxidases 2item
  206. PRAK 1 item
  207. MAPKAP-K2 1 item
  208. Delayed rectifier outward potassium current (IKr) 1 item
  209. 20S proteasomal chymotrypsin 1 item
  210. Geranylgeranyltransferase I 1 item
  211. Farnesyltransferase 1 item
  212. Nampt 3item
  213. eIF4F 1 item
  214. Cdc42 1 item
  215. SRPK1 1 item
  216. P2X Receptors 2item
  217. Glutaminases 2item
  218. Carbonic Anhydrases 6item
  219. Ron 1 item
  220. G9a 1 item
  221. BLM 1 item
  222. HSV 2item
  223. NADPH Oxidases 3item
  224. Calcium-activated chloride channels (CaCC) 1 item
  225. GPR35 1 item
  226. Aldehyde Dehydrogenases 2item
  227. Synthases/Synthetases 2item
  228. MAGL 1 item
  229. NPY Receptors 1 item
  230. Leukotriene and Related Receptors 1 item
  231. Histamine H1 Receptors 5item
  232. Na /K ATPases 2item
  233. P110 1 item
  234. Hck 2item
  235. Inositol-requiring enzyme 1 (IRE1) 1 item
  236. Na /K /Cl- Symporters (NKCCs) 2item
  237. GABAA Receptors 1 item
  238. Histamine H2 Receptors 1 item
  239. Phospholipases 1 item
  240. TRP Channel 2item
  241. RNA Polymerases 2item
  242. Norepinephrine transporter 1 item
  243. 5-HT Transporters 3item
  244. Xanthine oxidoreductases 1 item
  245. Dihydroorotate dehydrogenase 1 item
  246. Guanylyl Cyclases 1 item
  247. Histone Demethylases 1 item
  248. MNK 2item
  249. 5-Lipoxygenases 1 item
  250. NO Donors / Precursors 1 item
  251. CB2 Receptors 1 item
  252. Glucocorticoid Receptors 3item
  253. HIV-1 reverse transcriptase 1 item
  254. IL Receptors 2item
  255. CCL2 1 item
  256. Norepinephrine transporters 1 item
  257. 15-lipoxygenases 1 item
  258. Calcium-Activated Potassium (KCa) Channels 2item
  259. AChE 3item
  260. Insulin Receptors 1 item
  261. IRG-1R 1 item
  262. cAMP 1 item
  263. Sulfonylurea receptors 1 item
  264. eEF-2 1 item
  265. Inward Rectifier Potassium (Kir) Channels 2item
  266. CRTH2 1 item
  267. Cdc7 1 item
  268. Nuclear Receptors 1 item
  269. CMV 1 item
  270. ZAP-70 1 item
  271. Catechol O-Methyltransferase (COMT) 2item
  272. fibrinolysis 1 item
  273. Angiotensin AT1 Receptors 3item
  274. D4 Receptors 1 item
  275. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  276. NMDA receptor 1 item
  277. HBV Proteases 1 item
  278. Hydroxylases 2item
  279. Flk-1 1 item
  280. Adenine receptors 1 item
  281. Papains 1 item
  282. Protein Arginine Methyltransferases 1 item
  283. IMPDH 1 item
  284. Na /Ca2 Exchangers (NCXs) 1 item
  285. NAE 2item
  286. Ubiquitin-activating Enzyme E1 2item
  287. SUMOylation 1 item
  288. ATGL 1 item
  289. BACE 1 item
  290. Cytidine deaminases 1 item
  291. angiogenesis 1 item
  292. Glucagon Receptors 1 item
  293. 15-PGDH 1 item
  294. DPP-4 5item
  295. PP4 1 item
  296. c-RET 3item
  297. Nonstructural protein 5B (NS5B) 1 item
  298. guanylyl cyclase 1 item
  299. ETA Receptors 2item
  300. ETB Receptors 1 item
  301. p70 rsk 3item
  302. voltage-gated chloride channels 1 item
  303. FPTase 1 item
  304. 5-HT1 Receptor 1 item
  305. Microtubule/Tubulin 1 item
  306. Myosin 1 item
  307. VEGFR3/FLT4 1 item
  308. NTRK1/TRKA 1 item
  309. CSF-1R/c-Fms 1 item
  310. interleukin receptor 1 item
  311. Tryptophan hydroxylases (TPH) 2item
  312. ADAMs 1 item
  313. NMPRTase 1 item
  314. Bfl-1 1 item
  315. TAM kinase 1 item
  316. p53-MDM2 interaction 1 item
  317. nuclear export 1 item
  318. CRM1 1 item
  319. PTP 1 item
  320. KDR 2item
  321. Fyn kinase 1 item
  322. AXL 1 item
  323. Glyoxalase I 1 item
  324. Dipeptidyl-peptidase II 1 item
  325. p53 5item
  326. metalloprotease 1 item
  327. HDAC 2item
  328. Antifungal 1 item
  329. 5-HT receptors 1 item
  330. sodium channel 2item
  331. c-Fms tyrosine kinase 1 item
  332. human lyase 1 item
  333. insulin 1 item
  334. Ub-conjugating enzyme (E2) complex 1 item
  335. Smoothened receptor 1 item
  336. cysteine protease 2item
  337. PPAR 1 item
  338. IKK 1 item
  339. MSK 1 item
  340. gp120-CD4 interaction 1 item
  341. HCV polymerase 2item
  342. Ftase 1 item
  343. PC-PLC 2item
  344. Elastases 1 item
  345. ATP synthase 1 item
  346. Vitamin D receptors (VDRs) 2item
  347. Antibiotic 3item
  348. Mer tyrosine kinase 1 item
  349. Hec1 1 item
  350. EAA receptor 1 item
  351. neprilysin 1 item
  352. GLI 1 item
  353. Stem Cell Differentiation 1 item
  354. PP2A/Nkd interaction 1 item
  355. Rev-Erb Receptors 1 item
  356. HMGCR 1 item
  357. ErbB-2 1 item
  358. adrenergic receptor 3item
  359. HIV 1 item
  360. 5-HT4 Receptor 1 item
  361. TRPA 1 item
  362. sterol demethylase 1 item
  363. PDK-1 1 item
  364. GAPDH 1 item
  365. Histone Acetyltransferases (HATs) 2item
  366. complex I of the mitochondrial electron transport chain 1 item
  367. F1 Fo-ATPase 1 item
  368. Prk 1 item
  369. potassium channel 1 item
  370. calcium channel 1 item
  371. Ribonucleotide Reductases 1 item
  372. Trx 1 item
  373. Tyrosinases 1 item
  374. Neurokinin receptor 1 item
  375. HSP70 1 item
  376. ICAM 1 item
  377. ITK 1 item
  378. HIF-PH 1 item
  379. NUAK 1 item
  380. Rho 1 item
  381. Aryl hydrocarbon receptors (AHRs) 1 item
  382. Ubiquitin E3 Ligases 1 item
  383. DCLK2 1 item
  384. FAAH 1 item
  385. PTK 1 item
  386. integrase 1 item
  387. phosphatidylinositol kinase 1 item
  388. NOS 2item
  389. TYK2 2item
  390. MUSK 1 item
  391. MAP3K 1 item
  392. GPR3 1 item
  393. AMPA Receptors 1 item
  394. Adenosine Deaminases 2item
  395. mitochondrial pyruvate carrier (MPC) 1 item
  396. DNA gyrase 1 item
  397. prolactin secretion 1 item
  398. gonadotropin release 1 item
  399. DprE 1 item
  400. Vitamin D 1 item
  401. carnitine reabsorption 1 item
  402. Histamine receptors 1 item
  403. GluR 1 item
  404. 5-HT receptor 1 item
  405. dopamine receptors 1 item
  406. AMPA receptor 1 item
  407. 5-alpha Reductases 1 item
  408. Flk1 2item
  409. SAPK 1 item
  410. p21 1 item
  411. NOP Receptors 1 item
  412. Prostaglandin synthesis 1 item
  413. Protein Tyrosine Phosphatases 1 item
  414. alkaline phosphatases 1 item
  415. ATPases 1 item
  416. glutamate release 1 item
  417. PAFR 1 item
  418. Aromatases 2item
  419. DHFR 1 item
  420. GARFT 1 item
  421. 5-HT 1 item
  422. FGR 1 item
  423. YES 2item
  424. Fyn 2item
  425. ARG 1 item
  426. Autotaxin 1 item
  427. UCH 1 item
  428. RHA 1 item
  429. HCV NS3-4A protease 1 item
  430. PKD 1 item
  431. Thioredoxin Reductases 1 item
  432. enoyl-acyl-carrier protein reductase 1 item
  433. SHIP 1 item
  434. MCL1 1 item
  435. Bcl-w 1 item
  436. glutathione peroxidase 4 1 item
  437. S-adenosylhomocysteine hydrolase 1 item
  438. Rho-kinase 1 item
  439. tropomyosin receptor kinase 1 item
  440. LSD 1 item
  441. DDX3 1 item
  442. PRMT 1 item
  443. ACE 1 item
  444. GLP 1 item
  445. SK 1 item
  446. MST 1 item
  447. PPK 1 item
  448. c-Syk 1 item
  449. CDK1/CyclinB 1 item
  450. NHE 1 item
  451. IDO 1 item
  452. Tph 1 item
  453. PIM1 kinase 1 item
  454. phospholipase A2 1 item
  455. reverse transcriptase 1 item
  456. epoxide hydrolase 1 item
  457. ghrelin receptor 1 item
  458. Serotonin (5-HT) reuptake 1 item
  459. Cholesterol absorption 1 item
  460. Vascular Disrupting Agents (VDA) 1 item
  461. Androgen Receptor 1 item
  462. Substance P/NK1 Receptor 1 item
  463. gp120/CD4 1 item
  464. ATM 1 item
  465. Sirtuin 1 item
  466. NE 1 item
  467. CRF1 Receptors 1 item
  468. PIKfyve 1 item
  469. Bax 1 item
  470. Glycogen Phosphorylases 1 item
  471. MTH1 1 item
  472. PTEN 1 item
  473. Insulin Receptor 1 item
  474. NS3/4a Proteases 1 item
  475. Ca2 -ATPases 1 item
  476. p90 S6K 1 item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 2item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 2item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 5item
  7. Acute Myeloid Leukemia 27item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Biliary Cancer 1 item
  13. Bladder Cancer 11item
  14. Bladder Carcinoma 4item
  15. Bladder Diseases 2item
  16. B-lymphoid Malignancies 1 item
  17. Brain Injuries Studies 3item
  18. Breast Cancer 119item
  19. Cancer 524item
  20. Candida Peritonitis 1 item
  21. Candidemia 1 item
  22. Castration-resistant Prostate Cancer 1 item
  23. Cervical Cancer 6item
  24. Cholangiocarcinoma 2item
  25. Chronic Lymphocytic Leukemia 8item
  26. Chronic Myeloproliferative Disorders 1 item
  27. Clear Cell Renal Cell Carcinoma 2item
  28. Cocaine-Related Disorders 2item
  29. Colon Cancer 41item
  30. Colon Carcinoma 7item
  31. Colorectal Cancer 40item
  32. Depression 2item
  33. Diabetes 8item
  34. Diffuse Large B-cell Lymphoma 1 item
  35. Dyskinesia 1 item
  36. Dyslipidemia 2item
  37. Epilepsy 4item
  38. Erectile Dysfunction 4item
  39. Friedreich's Ataxia 1 item
  40. Fungal Infection 1 item
  41. Fungi 1 item
  42. Glioblastoma 33item
  43. Glioma 18item
  44. HCV 4item
  45. Heart Failure 6item
  46. Hepatic Cancer 2item
  47. Hepatitis C 4item
  48. Hepatocellular Carcinoma 8item
  49. HIV 14item
  50. HIV Infections 12item
  51. Hypercholesterolemia 3item
  52. Immunological Diseases 1 item
  53. Inflammation 1 item
  54. Inflammatory Bowel Disease 1 item
  55. Inflammatory Diseases 18item
  56. Influenza 3item
  57. Kidney Injury Studies 2item
  58. Leukemia 26item
  59. Liver Cancer 3item
  60. Lung Cancer 39item
  61. Lung Carcinoma 4item
  62. Lymphoma 28item
  63. Mantle Cell Lymphoma 2item
  64. Medulloblastoma 1 item
  65. Melanoma 35item
  66. Mixed Lineage Leukemia 3item
  67. Multiple Myeloma 21item
  68. Myelofibrosis 2item
  69. Myeloma 8item
  70. Narcolepsy 1 item
  71. Neuroblastoma 14item
  72. Neurocognitive Disorders 1 item
  73. Neuronal Protection 1 item
  74. Non-small Cell Lung Cancer 27item
  75. Non-small Cell Lung Carcinoma 2item
  76. Obsessive-Compulsive Disorder 1 item
  77. Osteoporosis 2item
  78. Ovarian Cancer 34item
  79. Pancreatic Cancer 47item
  80. Pancreatic Carcinoma 3item
  81. Pentacyclic Triterpenoid 1 item
  82. Prostate Cancer 56item
  83. Psoriasis 4item
  84. Psoriasis Vulgaris 1 item
  85. Pulmonary Arterial Hypertension 2item
  86. Pulmonary Fibrosis 2item
  87. Renal Cancer 4item
  88. Renal Cell Carcinoma 9item
  89. Rheumatoid Arthritis 14item
  90. Sarcoma 1 item
  91. Schizophrenia 9item
  92. Sleep Disorders 1 item
  93. Soft Tissue Sarcoma 1 item
  94. Squamous Cell Carcinoma 2item
  95. Testicular Cancer 2item
  96. Thyroid Cancer 6item
  97. Tuberculosis 4item
  98. Type 2 Diabetes 16item