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  • Search results for: 'gsk 3 inhibitor 1'

Search results for: 'gsk 3 inhibitor 1'

Items 211-220 of 1116

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  1. DMOG
    A4506 DMOG
    Target: Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs)
    Summary: Competitive HIF-PH inhibitor, cell-permeable
  2. K-252c
    A8344 K-252c
    Target: PKC|PKA
    Summary: Protein kinase inhibitor
      insoluble in EtOH; insoluble in H2O; ≥15.55 mg/mL
  3. Donepezil HCl
    B1602 Donepezil HCl
    Target: AChE
    Summary: AChE inhibitor
      insoluble in EtOH; insoluble in DMSO; ≥10.4 mg/mL
  4. U-104
    A4358 U-104
    Target: Carbonic Anhydrases
    Summary: CAIX inhibitor
      insoluble in H2O; ≥11.5 mg/mL
  5. PI-3065
    B4660 PI-3065
    Target: PI3K
    Summary: P110δkinase inhibitor
      ≥22.7 mg/mL
  6. U0126-EtOH
    A1337 U0126-EtOH
     10 Citation
    Target: MEK
    Summary: MEK1/2 inhibitor
      ≥21.33 mg/mL
  7. Z-LEHD-FMK
    B3233 Z-LEHD-FMK
     8 Citation
    Target: Caspases
    Summary: Irreversible Caspase-9 inhibitor.
      insoluble in H2O; ≥107.4 mg/mL
  8. UNC2025
    B8016 UNC2025
     1 Citation
    Target: MER|FLT3
    Summary: orally bioavailable dual MER/FLT3 inhibitor
      ≥23.85 mg/mL
  9. TG100713
    B2177 TG100713
    Target: PI3K
    Summary: pan-PI3K inhibitor
      soluble in DMSO
  10. PP242
    A8318 PP242
    Target: mTOR
    Summary: MTOR inhibitor, selective and ATP-competitive

Items 211-220 of 1116

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  1. Signaling Pathways 1060item
  2. Natural Products 17item
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  4. Peptides 1 item
  5. Probes & Dyes 2item
  6. Cell Biology 1 item
  7. Peptides & Proteins 1 item
  8. Lab Reagents 16item
Specificity
  1. Selective 777item
  2. Non-Selective 6item
Reversibility
  1. Reversible 55item
  2. Irreversible 33item
Target
  1. Caspases 9item
  2. Cyclin-Dependent Kinases 25item
  3. Adenosine A2A Receptors 1 item
  4. Proteasome 12item
  5. Cathepsins 9item
  6. Histone Deacetylases (HDACs) 33item
  7. Inhibitor of apoptosis proteins (IAP) 3item
  8. Akt 13item
  9. Bcl-2 9item
  10. PI3K 36item
  11. CXCR 5item
  12. Raf 13item
  13. Aurora Kinases 20item
  14. Bcl-xl 2item
  15. CSF-1R 4item
  16. Glycoproteins 1 item
  17. p97 1 item
  18. Gap Junctions 1 item
  19. MDM2 3item
  20. EZH2 4item
  21. mTOR 20item
  22. Bromodomains 6item
  23. AP-1 3item
  24. MMP 8item
  25. Thymidine Phosphorylases 1 item
  26. Androgen Receptors 5item
  27. Peptidylprolyl isomerases 1 item
  28. Acyl coenzyme A: cholesterol acyltransferases 1 item
  29. Myosin II ATPases 1 item
  30. DT-diaphorases 1 item
  31. Voltage-gated Potassium (KV) Channels 1 item
  32. MER 1 item
  33. FLT3 19item
  34. GSK-3 10item
  35. Factor Xa 4item
  36. LPA Receptors 3item
  37. P-glycoprotein (P-gp) 5item
  38. PLK 10item
  39. Chk 7item
  40. Eph Receptors 2item
  41. VEGFR 40item
  42. PDGFR 25item
  43. c-Kit 13item
  44. RET 4item
  45. IRAK 1 item
  46. Bromodomain-containing proteins(BRDs) 1 item
  47. Phosphodiesterases (PDEs) 16item
  48. Mcl-1 6item
  49. Hydrolase 1 item
  50. Thymidylate Synthase 3item
  51. p38 10item
  52. PKB 1 item
  53. JNK 4item
  54. SGK 1 item
  55. Bcr-Abl 13item
  56. Kynurenine-3-monooxygenase 1 item
  57. MEK 13item
  58. PORCN 1 item
  59. DOT1L 3item
  60. FGFR 17item
  61. Nrf2 3item
  62. Insulin-like growth factor receptors(IGFRs) 1 item
  63. CGRP receptors 1 item
  64. Pim 4item
  65. Liver X receptors (LXRs) 2item
  66. Glucagon-like peptide 1 (GLP-1) receptors 2item
  67. Sir2-like Family Deacetylases (Sirtuins) 3item
  68. Voltage-gated Sodium (NaV) Channels 2item
  69. Deubiquitinating enzymes (DUBs) 3item
  70. PP1 1 item
  71. PP2A 1 item
  72. Smoothened 4item
  73. Eukaryotic elongation factors 1 item
  74. Neuraminidases (NA) 2item
  75. MET 7item
  76. Src 15item
  77. Trk Receptors 7item
  78. Integrins 1 item
  79. Aminopeptidases 4item
  80. NMDA Receptors 2item
  81. STAT 10item
  82. ATP Citrate Lyases 1 item
  83. Microtubules/Tubulins 6item
  84. Estrogen and Related Receptors 3item
  85. EGFR 23item
  86. Hedgehog 1 item
  87. Reverse Transcriptases 6item
  88. ROCK 9item
  89. BTK 1 item
  90. RIP kinases 1 item
  91. Monocyte chemotactic proteins 1 item
  92. PAK 3item
  93. Hypoxia Inducible Factors (HIFs) 2item
  94. Tankyrases 1 item
  95. Inositol Phosphatases 1 item
  96. FAK 7item
  97. BMP and Other Activin Receptors 3item
  98. JAK 20item
  99. p300 1 item
  100. Stearoyl-CoA 9-desaturase (SCD-1) 2item
  101. Syk 7item
  102. Progesterone Receptors 2item
  103. EZH1 2item
  104. DNA-PK 7item
  105. HSP90 12item
  106. AMPK 3item
  107. Gutathione S-transferase 1 item
  108. CCR 2item
  109. PDHK 1 item
  110. Angiotensin AT2 Receptors 2item
  111. Notch 1 item
  112. S-nitrosoglutathione reductase 1 item
  113. CFTR 3item
  114. TNKS 1 item
  115. Topoisomerases 16item
  116. Cytochrome P450 (CYP450) 10item
  117. thrombin 1 item
  118. Ksp 2item
  119. Renin 1 item
  120. Influenza viruses 1 item
  121. ErbB 5item
  122. S6 kinases 1 item
  123. Toll-like receptors (TLRs) 4item
  124. Adenosine Kinases 2item
  125. Actin 1 item
  126. Serine Proteases 2item
  127. DNA Methyltransferases 4item
  128. Survivin 1 item
  129. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  130. ERK 8item
  131. HMG-CoA Reductases 6item
  132. c-MET 8item
  133. BMI-1 1 item
  134. PKC 14item
  135. Calpains 5item
  136. Ubiquitin-specific proteases 1 item
  137. M1 Receptors 1 item
  138. HCV Proteases 3item
  139. Ca2 /calmodulin-dependent protein kinases (CaMKs) 7item
  140. MLK3 1 item
  141. O-GlcNAcase 1 item
  142. CREBBP 1 item
  143. EP300 1 item
  144. Protease-Activated Receptors 1 item
  145. Lyn 2item
  146. SGLT 1 item
  147. RAD51 2item
  148. Trypsins 1 item
  149. HER2 3item
  150. Pyk2 3item
  151. USP 1 item
  152. 5-HT2 Receptors 6item
  153. LRRK2 6item
  154. Voltage-gated Calcium Channels (CaV) 2item
  155. Calcium chelator 1 item
  156. DGAT 2item
  157. Insulin and Insulin-like Receptors 4item
  158. PARP 7item
  159. CB1 Receptors 3item
  160. Pyruvate dehydrogenases (PDH) 2item
  161. ALK 10item
  162. ROS1 2item
  163. Sphingosine kinases (SphKs) 3item
  164. Trypsin 1 item
  165. Chymotrypsin 1 item
  166. Kallikrein 1 item
  167. Trypsinogen 1 item
  168. Monocarboxylate transporters (MCTs) 2item
  169. CETP 2item
  170. Dehydrogenase 1 item
  171. PKG 2item
  172. PKA 6item
  173. Myosin light chain kinases (MLCKs) 2item
  174. GPR30 1 item
  175. BCPCF efflux 1 item
  176. HIV-1 gp120 1 item
  177. D1 and D5 Receptors 1 item
  178. D2 Receptors 4item
  179. D3 Receptors 2item
  180. 5-HT1 Receptors 2item
  181. 5-HT7 Receptors 1 item
  182. AdipoR1 1 item
  183. AdipoR2 1 item
  184. MELK 1 item
  185. Serotonin reuptake 1 item
  186. Insulin-like growth factors (IGFs) 1 item
  187. CSF1R 1 item
  188. Bromodomain and Extra-Terminal motif (BET) 1 item
  189. Lactate Dehydrogenases (LDH) 2item
  190. MK2 2item
  191. Fatty-acid-binding proteins (FABPs) 1 item
  192. 5-HT3 Receptors 1 item
  193. Angiotensin-Converting Enzymes (ACEs) 6item
  194. Tie-2 5item
  195. RSK 3item
  196. p70 S6K 1 item
  197. Free Fatty Acid Receptors 2item
  198. phosphatases 2item
  199. Autophagy 4item
  200. ATM/ATR 5item
  201. COX 12item
  202. YAP 1 item
  203. CK1 1 item
  204. Histamine H4 Receptors 2item
  205. CK2 3item
  206. HIPK2 1 item
  207. HIPK3 1 item
  208. HIV Integrases 2item
  209. Pregnane X Receptors 1 item
  210. Squalene epoxidases 2item
  211. PRAK 1 item
  212. MAPKAP-K2 1 item
  213. Delayed rectifier outward potassium current (IKr) 1 item
  214. GpIIb/IIIa receptor 1 item
  215. Guanine nucleotide exchange factors (GEFs) 1 item
  216. 20S proteasomal chymotrypsin 1 item
  217. Geranylgeranyltransferase I 1 item
  218. Farnesyltransferase 1 item
  219. Nampt 3item
  220. eIF4F 1 item
  221. Cdc42 1 item
  222. SRPK1 1 item
  223. P2X Receptors 2item
  224. Glutaminases 2item
  225. Carbonic Anhydrases 7item
  226. Ron 1 item
  227. G9a 1 item
  228. BLM 1 item
  229. HSV 2item
  230. NADPH Oxidases 3item
  231. Calcium-activated chloride channels (CaCC) 1 item
  232. GPR35 1 item
  233. Aldehyde Dehydrogenases 2item
  234. Synthases/Synthetases 2item
  235. MAGL 2item
  236. NPY Receptors 1 item
  237. Leukotriene and Related Receptors 1 item
  238. Histamine H1 Receptors 6item
  239. Na /K ATPases 3item
  240. P110 1 item
  241. Hck 2item
  242. Inositol-requiring enzyme 1 (IRE1) 2item
  243. Na /K /Cl- Symporters (NKCCs) 2item
  244. GABAA Receptors 1 item
  245. Histamine H2 Receptors 1 item
  246. Phospholipases 1 item
  247. Monoamine oxidases (MAOs) 2item
  248. Organic anion transporters (OATs) 1 item
  249. TRP Channel 3item
  250. RNA Polymerases 3item
  251. Norepinephrine transporter 1 item
  252. 5-HT Transporters 3item
  253. Xanthine oxidoreductases 1 item
  254. Dihydroorotate dehydrogenase 1 item
  255. Guanylyl Cyclases 1 item
  256. Histone Demethylases 2item
  257. MNK 2item
  258. 5-Lipoxygenases 1 item
  259. NO Donors / Precursors 2item
  260. CB2 Receptors 2item
  261. Glucocorticoid Receptors 4item
  262. HIV-1 reverse transcriptase 1 item
  263. IL Receptors 2item
  264. CCL2 1 item
  265. Noradrenaline reuptake 1 item
  266. Norepinephrine transporters 1 item
  267. 15-lipoxygenases 1 item
  268. Calcium-Activated Potassium (KCa) Channels 2item
  269. AChE 3item
  270. Insulin Receptors 1 item
  271. IRG-1R 1 item
  272. cAMP 1 item
  273. Sulfonylurea receptors 1 item
  274. Cdc2-like kinase (Clk) 1 item
  275. eEF-2 1 item
  276. Inward Rectifier Potassium (Kir) Channels 3item
  277. CRTH2 1 item
  278. Cdc7 1 item
  279. Nuclear Receptors 1 item
  280. CMV 1 item
  281. ZAP-70 1 item
  282. Catechol O-Methyltransferase (COMT) 2item
  283. fibrinolysis 1 item
  284. Angiotensin AT1 Receptors 3item
  285. D4 Receptors 1 item
  286. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  287. NMDA receptor 1 item
  288. HBV Proteases 1 item
  289. Hydroxylases 2item
  290. Flk-1 1 item
  291. Adenine receptors 1 item
  292. Antioxidants 1 item
  293. Papains 1 item
  294. Protein Arginine Methyltransferases 1 item
  295. IMPDH 1 item
  296. Na /Ca2 Exchangers (NCXs) 1 item
  297. NAE 2item
  298. Ubiquitin-activating Enzyme E1 2item
  299. SUMOylation 1 item
  300. ATGL 1 item
  301. BACE 1 item
  302. Cytidine deaminases 1 item
  303. angiogenesis 1 item
  304. Glucagon Receptors 1 item
  305. 15-PGDH 1 item
  306. DPP-4 5item
  307. PP4 1 item
  308. c-RET 3item
  309. Nonstructural protein 5B (NS5B) 1 item
  310. guanylyl cyclase 1 item
  311. ETA Receptors 2item
  312. ETB Receptors 1 item
  313. p70 rsk 3item
  314. voltage-gated chloride channels 1 item
  315. FPTase 1 item
  316. 5-HT1 Receptor 1 item
  317. Microtubule/Tubulin 1 item
  318. Myosin 1 item
  319. VEGFR3/FLT4 1 item
  320. NTRK1/TRKA 1 item
  321. CSF-1R/c-Fms 1 item
  322. interleukin receptor 1 item
  323. Tryptophan hydroxylases (TPH) 2item
  324. ADAMs 1 item
  325. NMPRTase 1 item
  326. Bfl-1 1 item
  327. TAM kinase 1 item
  328. p53-MDM2 interaction 1 item
  329. nuclear export 1 item
  330. CRM1 1 item
  331. PTP 1 item
  332. KDR 2item
  333. Fyn kinase 1 item
  334. Trypsin-like protease 1 item
  335. AXL 1 item
  336. Glyoxalase I 1 item
  337. ERAD 1 item
  338. Dipeptidyl-peptidase II 1 item
  339. p53 5item
  340. metalloprotease 1 item
  341. HDAC 2item
  342. Antifungal 1 item
  343. 5-HT receptors 1 item
  344. sodium channel 3item
  345. c-Fms tyrosine kinase 1 item
  346. human lyase 1 item
  347. insulin 1 item
  348. Ub-conjugating enzyme (E2) complex 1 item
  349. Smoothened receptor 1 item
  350. lipase 1 item
  351. cysteine protease 2item
  352. PPAR 1 item
  353. IKK 1 item
  354. MSK 1 item
  355. gp120-CD4 interaction 1 item
  356. HCV polymerase 2item
  357. Ftase 1 item
  358. PC-PLC 2item
  359. Elastases 1 item
  360. ATP synthase 1 item
  361. Glucosidases 1 item
  362. Vitamin D receptors (VDRs) 2item
  363. Antibiotic 5item
  364. Mer tyrosine kinase 1 item
  365. Hec1 1 item
  366. EAA receptor 1 item
  367. neprilysin 1 item
  368. GLI 1 item
  369. decarboxylase 1 item
  370. Stem Cell Differentiation 1 item
  371. PP2A/Nkd interaction 1 item
  372. Rev-Erb Receptors 1 item
  373. HMGCR 1 item
  374. ErbB-2 1 item
  375. adrenergic receptor 3item
  376. HIV 1 item
  377. 5-HT4 Receptor 1 item
  378. TRPA 1 item
  379. sterol demethylase 1 item
  380. PDK-1 1 item
  381. GAPDH 1 item
  382. Histone Acetyltransferases (HATs) 2item
  383. complex I of the mitochondrial electron transport chain 1 item
  384. F1 Fo-ATPase 1 item
  385. Prk 1 item
  386. potassium channel 1 item
  387. calcium channel 1 item
  388. Ribonucleotide Reductases 1 item
  389. Trx 1 item
  390. Tyrosinases 1 item
  391. Neurokinin receptor 1 item
  392. HSP70 1 item
  393. ICAM 1 item
  394. ITK 1 item
  395. HIF-PH 1 item
  396. troponin 1 item
  397. NUAK 1 item
  398. Rho 1 item
  399. Aryl hydrocarbon receptors (AHRs) 1 item
  400. Ubiquitin E3 Ligases 1 item
  401. DCLK2 1 item
  402. FAAH 1 item
  403. PTK 1 item
  404. integrase 1 item
  405. phosphatidylinositol kinase 1 item
  406. NOS 2item
  407. TYK2 2item
  408. MUSK 1 item
  409. MAP3K 1 item
  410. GPR3 1 item
  411. AMPA Receptors 1 item
  412. Adenosine Deaminases 2item
  413. mitochondrial pyruvate carrier (MPC) 1 item
  414. DNA gyrase 1 item
  415. prolactin secretion 1 item
  416. gonadotropin release 1 item
  417. DprE 1 item
  418. Vitamin D 1 item
  419. carnitine reabsorption 1 item
  420. Histamine receptors 1 item
  421. GluR 1 item
  422. 5-HT receptor 1 item
  423. dopamine receptors 1 item
  424. AMPA receptor 1 item
  425. 5-alpha Reductases 1 item
  426. Flk1 2item
  427. SAPK 1 item
  428. p21 1 item
  429. NOP Receptors 1 item
  430. Prostaglandin synthesis 1 item
  431. Protein Tyrosine Phosphatases 1 item
  432. alkaline phosphatases 1 item
  433. ATPases 1 item
  434. glutamate release 1 item
  435. PAFR 1 item
  436. Aromatases 2item
  437. DHFR 1 item
  438. GARFT 1 item
  439. 5-HT 1 item
  440. FGR 1 item
  441. YES 2item
  442. Fyn 2item
  443. ARG 1 item
  444. Autotaxin 1 item
  445. UCH 1 item
  446. RHA 1 item
  447. HCV NS3-4A protease 1 item
  448. PKD 1 item
  449. Pyruvate kinases 1 item
  450. Thioredoxin Reductases 1 item
  451. enoyl-acyl-carrier protein reductase 1 item
  452. SHIP 1 item
  453. HMG 1 item
  454. HSD 1 item
  455. MCL1 1 item
  456. Bcl-w 1 item
  457. glutathione peroxidase 4 1 item
  458. S-adenosylhomocysteine hydrolase 1 item
  459. Rho-kinase 1 item
  460. tropomyosin receptor kinase 1 item
  461. LSD 1 item
  462. DDX3 1 item
  463. PRMT 1 item
  464. ACE 1 item
  465. GLP 1 item
  466. SK 1 item
  467. MST 1 item
  468. PPK 1 item
  469. c-Syk 1 item
  470. CDK1/CyclinB 1 item
  471. NHE 1 item
  472. IDO 2item
  473. Tph 1 item
  474. PIM1 kinase 1 item
  475. phospholipase A2 1 item
  476. reverse transcriptase 1 item
  477. epoxide hydrolase 1 item
  478. ghrelin receptor 1 item
  479. Serotonin (5-HT) reuptake 1 item
  480. Cholesterol absorption 1 item
  481. Vascular Disrupting Agents (VDA) 1 item
  482. Androgen Receptor 1 item
  483. Substance P/NK1 Receptor 1 item
  484. gp120/CD4 1 item
  485. ATM 1 item
  486. Sirtuin 1 item
  487. NE 1 item
  488. CRF1 Receptors 1 item
  489. PIKfyve 1 item
  490. Bax 1 item
  491. Glycogen Phosphorylases 1 item
  492. MTH1 1 item
  493. PTEN 1 item
  494. Insulin Receptor 1 item
  495. NS3/4a Proteases 1 item
  496. Ca2 -ATPases 1 item
  497. p90 S6K 1 item
  498. Dynamins 1 item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 2item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 3item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 5item
  7. Acute Myeloid Leukemia 27item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Biliary Cancer 1 item
  13. Bladder Cancer 11item
  14. Bladder Carcinoma 4item
  15. Bladder Diseases 2item
  16. B-lymphoid Malignancies 1 item
  17. Brain Injuries Studies 3item
  18. Breast Cancer 123item
  19. Cancer 537item
  20. Candida Peritonitis 1 item
  21. Candidemia 1 item
  22. Castration-resistant Prostate Cancer 1 item
  23. Cervical Cancer 6item
  24. Cholangiocarcinoma 2item
  25. Chronic Lymphocytic Leukemia 8item
  26. Chronic Myeloproliferative Disorders 1 item
  27. Clear Cell Renal Cell Carcinoma 2item
  28. Cocaine-Related Disorders 2item
  29. Colon Cancer 43item
  30. Colon Carcinoma 7item
  31. Colorectal Cancer 40item
  32. Depression 2item
  33. Diabetes 8item
  34. Diffuse Large B-cell Lymphoma 1 item
  35. Dyskinesia 1 item
  36. Dyslipidemia 2item
  37. Epilepsy 4item
  38. Erectile Dysfunction 4item
  39. Friedreich's Ataxia 2item
  40. Fungal Infection 1 item
  41. Fungi 1 item
  42. Glioblastoma 33item
  43. Glioma 18item
  44. HCV 4item
  45. Heart Failure 7item
  46. Hepatic Cancer 2item
  47. Hepatitis C 4item
  48. Hepatocellular Carcinoma 8item
  49. HIV 14item
  50. HIV Infections 12item
  51. Hypercholesterolemia 3item
  52. Immunological Diseases 1 item
  53. Inflammation 1 item
  54. Inflammatory Bowel Disease 1 item
  55. Inflammatory Diseases 20item
  56. Influenza 3item
  57. Kidney Injury Studies 3item
  58. Leukemia 27item
  59. Liver Cancer 3item
  60. Lung Cancer 42item
  61. Lung Carcinoma 4item
  62. Lymphoma 31item
  63. Mantle Cell Lymphoma 2item
  64. Medulloblastoma 1 item
  65. Melanoma 35item
  66. Mixed Lineage Leukemia 3item
  67. Multiple Myeloma 21item
  68. Myelofibrosis 2item
  69. Myeloma 8item
  70. Narcolepsy 1 item
  71. Neuroblastoma 14item
  72. Neurocognitive Disorders 1 item
  73. Neuronal Protection 1 item
  74. Non-small Cell Lung Cancer 27item
  75. Non-small Cell Lung Carcinoma 2item
  76. Obsessive-Compulsive Disorder 1 item
  77. Osteoporosis 2item
  78. Ovarian Cancer 35item
  79. Pancreatic Cancer 49item
  80. Pancreatic Carcinoma 3item
  81. Pentacyclic Triterpenoid 1 item
  82. Prostate Cancer 59item
  83. Psoriasis 4item
  84. Psoriasis Vulgaris 1 item
  85. Pulmonary Arterial Hypertension 2item
  86. Pulmonary Fibrosis 2item
  87. Renal Cancer 4item
  88. Renal Cell Carcinoma 10item
  89. Rheumatoid Arthritis 14item
  90. Sarcoma 1 item
  91. Schizophrenia 10item
  92. Sleep Disorders 2item
  93. Soft Tissue Sarcoma 1 item
  94. Squamous Cell Carcinoma 2item
  95. Testicular Cancer 2item
  96. Thyroid Cancer 6item
  97. Tuberculosis 4item
  98. Type 2 Diabetes 17item