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  • Search results for: 'mutant idh1 inhibitor'

Search results for: 'mutant idh1 inhibitor'

Items 361-370 of 2975

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  1. SRPIN340
    B2032 SRPIN340
    Target: SRPK1
    Summary: Selective SRPK1 inhibitor
      insoluble in H2O; ≥10.9 mg/mL
  2. AZD6244 (Selumetinib)
    A8207 AZD6244 (Selumetinib)
     3 Citation
    Summary: MEK inhibitor
      ≥22.88 mg/mL
  3. MLN0905
    A8680 MLN0905
    Target: PLK
    Summary: Potent PLK1 inhibitor
      ≥24.35 mg/mL
  4. GLPG0634
    B1130 GLPG0634
     1 Citation
    Target: JAK
    Summary: JAK1 inhibitor
      ≥21.3 mg/mL
  5. Aminoglutethimide
    B1380 Aminoglutethimide
    Summary: Aromatase inhibitor
      insoluble in H2O; ≥13.8 mg/mL
  6. Irsogladine
    B1593 Irsogladine
    Summary: PDE4 inhibitor
      insoluble in H2O; insoluble in EtOH; ≥12.80 mg/mL
  7. Tacrolimus (FK506)
    B2143 Tacrolimus (FK506)
     2 Citation
    Target: Peptidylprolyl isomerases
    Summary: Macrolide calcineurin inhibitor,immunosuppressant
      ≥26.6 mg/mL
  8. CI994 (Tacedinaline)
    A4102 CI994 (Tacedinaline)
     1 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: HDAC inhibitor
      insoluble in H2O; insoluble in EtOH; ≥50 mg/mL
  9. Ponatinib (AP24534)
    A5467 Ponatinib (AP24534)
     1 Citation
    Target: VEGFR|PDGFR|Bcr-Abl|FGFR|Src
    Summary: pan-BCR-ABL inhibitor,multi-kinase inhibitor
      ≥53.3 mg/mL
  10. Lomeguatrib
    A1912 Lomeguatrib
    Target: O6-methylguanine-DNA-methyl-transferase (MGMT)
    Summary: MGMT inhibitor
      ≥50 mg/mL

Items 361-370 of 2975

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  1. Proteases 218item
  2. Apoptosis 139item
  3. Chromatin/Epigenetics 345item
  4. Metabolism 328item
  5. MAPK Signaling 139item
  6. Tyrosine Kinase 325item
  7. DNA Damage/DNA Repair 168item
  8. PI3K/Akt/mTOR Signaling 172item
  9. Microbiology & Virology 94item
  10. Cell Cycle/Checkpoint 218item
  11. Ubiquitination/ Proteasome 75item
  12. JAK/STAT Signaling 101item
  13. TGF-β / Smad Signaling 87item
  14. Angiogenesis 38item
  15. GPCR/G protein 78item
  16. Stem Cell 87item
  17. Membrane Transporter/Ion Channel 172item
  18. Cancer Biology 6item
  19. Endocrinology and Hormones 25item
  20. Neuroscience 176item
  21. Obesity, Appetite Control & Diabetes 1 item
  22. Peptide Inhibitors and Substrate 1 item
  23. Other Signal Transduction 4item
  24. Others 328item
  25. Immunology/Inflammation 65item
  26. Cardiovascular 3item
  27. Vitamin D Related 1 item
Specificity
  1. Selective 777item
  2. Non-Selective 4item
Reversibility
  1. Reversible 65item
  2. Irreversible 38item
Target
  1. Caspases 13item
  2. Cyclin-Dependent Kinases 33item
  3. Proteasome 14item
  4. Cathepsins 11item
  5. Histone Deacetylases (HDACs) 36item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 13item
  8. Bcl-2 8item
  9. PI3K 37item
  10. CXCR 3item
  11. Raf 13item
  12. Aurora Kinases 23item
  13. Bcl-xl 3item
  14. CSF-1R 4item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. Gap Junctions 2item
  18. MDM2 1 item
  19. EZH2 6item
  20. mTOR 22item
  21. Bromodomains 8item
  22. AP-1 1 item
  23. MMP 8item
  24. Thymidine Phosphorylases 1 item
  25. Androgen Receptors 4item
  26. Peptidylprolyl isomerases 1 item
  27. Acyl coenzyme A: cholesterol acyltransferases 1 item
  28. Myosin II ATPases 1 item
  29. DT-diaphorases 1 item
  30. Voltage-gated Potassium (KV) Channels 1 item
  31. MER 1 item
  32. FLT3 19item
  33. GSK-3 11item
  34. Factor Xa 4item
  35. P-glycoprotein (P-gp) 5item
  36. PLK 11item
  37. Chk 8item
  38. ULK1 1 item
  39. Eph Receptors 3item
  40. VEGFR 40item
  41. PDGFR 27item
  42. c-Kit 13item
  43. RET 4item
  44. IRAK 5item
  45. Bromodomain-containing proteins(BRDs) 1 item
  46. Phosphodiesterases (PDEs) 16item
  47. Mcl-1 7item
  48. Hydrolase 1 item
  49. Thymidylate Synthase 3item
  50. p38 9item
  51. PKB 1 item
  52. 3-phosphoglycerate dehydrogenase 1 item
  53. JNK 7item
  54. SGK 2item
  55. Bcr-Abl 15item
  56. Kynurenine-3-monooxygenase 1 item
  57. MEK 16item
  58. PORCN 1 item
  59. DOT1L 3item
  60. FGFR 17item
  61. Nrf2 2item
  62. Insulin-like growth factor receptors(IGFRs) 1 item
  63. Pim 4item
  64. Sir2-like Family Deacetylases (Sirtuins) 3item
  65. Voltage-gated Sodium (NaV) Channels 1 item
  66. Deubiquitinating enzymes (DUBs) 5item
  67. Smoothened 4item
  68. Ribosomal s6 kinases (RSK) 1 item
  69. Neuraminidases (NA) 3item
  70. MET 7item
  71. Src 18item
  72. Trk Receptors 6item
  73. Integrins 1 item
  74. Aminopeptidases 3item
  75. NMDA Receptors 1 item
  76. STAT 8item
  77. ATP Citrate Lyases 1 item
  78. Microtubules/Tubulins 5item
  79. EGFR 25item
  80. Hedgehog 1 item
  81. Reverse Transcriptases 6item
  82. ROCK 12item
  83. BTK 2item
  84. RIP kinases 1 item
  85. PAK 3item
  86. PD-1/PD-L1 interaction 1 item
  87. Hypoxia Inducible Factors (HIFs) 2item
  88. Tankyrases 1 item
  89. Inositol Phosphatases 1 item
  90. FAK 6item
  91. BMP and Other Activin Receptors 4item
  92. JAK 22item
  93. p300 1 item
  94. Stearoyl-CoA 9-desaturase (SCD-1) 2item
  95. Syk 7item
  96. EZH1 2item
  97. DNA-PK 8item
  98. HSP90 12item
  99. AMPK 2item
  100. Gutathione S-transferase 2item
  101. PDHK 1 item
  102. Angiotensin AT2 Receptors 1 item
  103. eIF4E/eIF3G interaction 1 item
  104. Notch 1 item
  105. S-nitrosoglutathione reductase 1 item
  106. CFTR 3item
  107. TNKS 1 item
  108. Topoisomerases 12item
  109. Cytochrome P450 (CYP450) 8item
  110. M3 Receptors 1 item
  111. thrombin 1 item
  112. Ksp 2item
  113. Ribosomes 1 item
  114. Renin 2item
  115. HIV proteases 1 item
  116. Pepsins 1 item
  117. Influenza viruses 1 item
  118. ErbB 5item
  119. Ferroptosis 1 item
  120. S6 kinases 1 item
  121. Toll-like receptors (TLRs) 3item
  122. Adenosine Kinases 2item
  123. Actin 2item
  124. Serine Proteases 2item
  125. DNA Methyltransferases 3item
  126. Survivin 1 item
  127. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  128. ERK 7item
  129. HMG-CoA Reductases 6item
  130. Vacuolar-type ATPase 1 item
  131. Kinases 1 item
  132. c-MET 8item
  133. BMI-1 1 item
  134. PKC 14item
  135. Calpains 5item
  136. Ubiquitin-specific proteases 1 item
  137. HCV Proteases 3item
  138. Ca2 /calmodulin-dependent protein kinases (CaMKs) 7item
  139. MLK3 1 item
  140. SMYD2 1 item
  141. CREBBP 2item
  142. EP300 2item
  143. Protease-Activated Receptors 1 item
  144. Lyn 2item
  145. SGLT 1 item
  146. RAD51 2item
  147. Trypsins 1 item
  148. HER2 3item
  149. Pyk2 3item
  150. USP 2item
  151. 5-HT2 Receptors 4item
  152. LRRK2 6item
  153. Voltage-gated Calcium Channels (CaV) 1 item
  154. DGAT 2item
  155. Insulin and Insulin-like Receptors 4item
  156. PARP 8item
  157. Pyruvate dehydrogenases (PDH) 2item
  158. ALK 9item
  159. ROS1 2item
  160. Sphingosine kinases (SphKs) 3item
  161. Trypsin 1 item
  162. Chymotrypsin 1 item
  163. Kallikrein 1 item
  164. Trypsinogen 1 item
  165. KRAS G12C 1 item
  166. GTPases 1 item
  167. Monocarboxylate transporters (MCTs) 2item
  168. CETP 2item
  169. Dehydrogenase 1 item
  170. PKG 3item
  171. PKA 7item
  172. Myosin light chain kinases (MLCKs) 3item
  173. HIV-1 gp120 1 item
  174. D1 and D5 Receptors 1 item
  175. D2 Receptors 3item
  176. D3 Receptors 2item
  177. 5-HT1 Receptors 2item
  178. 5-HT7 Receptors 1 item
  179. CaM-KK 1 item
  180. Valosin-containing protein (VCP) 1 item
  181. MELK 1 item
  182. Serotonin reuptake 1 item
  183. Insulin-like growth factors (IGFs) 1 item
  184. Clk 1 item
  185. TBK1 1 item
  186. MARK1 1 item
  187. NUAK1 2item
  188. Integrin-ligand interactions 1 item
  189. CSF1R 1 item
  190. Bromodomain and Extra-Terminal motif (BET) 1 item
  191. NUAK2 1 item
  192. Na /H Exchangers (NHEs) 1 item
  193. Lactate Dehydrogenases (LDH) 3item
  194. MK2 4item
  195. Fatty-acid-binding proteins (FABPs) 1 item
  196. Angiotensin-Converting Enzymes (ACEs) 4item
  197. Tie-2 5item
  198. RSK 3item
  199. p70 S6K 1 item
  200. phosphatases 1 item
  201. Autophagy 4item
  202. ATM/ATR 8item
  203. Mixed lineage kinase domain-like protein (MLKL) 1 item
  204. COX 11item
  205. Heparanases 1 item
  206. CK1 2item
  207. IDH2 1 item
  208. CK2 3item
  209. HIPK2 1 item
  210. HIPK3 1 item
  211. HIV Integrases 2item
  212. Squalene epoxidases 2item
  213. PRAK 1 item
  214. MAPKAP-K2 1 item
  215. Delayed rectifier outward potassium current (IKr) 1 item
  216. 20S proteasomal chymotrypsin 1 item
  217. Geranylgeranyltransferase I 1 item
  218. Farnesyltransferase 1 item
  219. NAT10 1 item
  220. Nampt 3item
  221. eIF4F 1 item
  222. Cdc42 1 item
  223. SRPK1 1 item
  224. P2X Receptors 1 item
  225. Glutaminases 2item
  226. Carbonic Anhydrases 6item
  227. Ron 1 item
  228. AP endonucleases 1 item
  229. G9a 2item
  230. BLM 1 item
  231. HSV 2item
  232. NADPH Oxidases 3item
  233. Calcium-activated chloride channels (CaCC) 1 item
  234. GPR35 1 item
  235. Urokinases 1 item
  236. Aldehyde Dehydrogenases 1 item
  237. Synthases/Synthetases 3item
  238. c-Fyn 1 item
  239. TAK1 1 item
  240. Histamine H1 Receptors 2item
  241. Na /K ATPases 2item
  242. P110 1 item
  243. Hck 2item
  244. Inositol-requiring enzyme 1 (IRE1) 1 item
  245. SETD7 1 item
  246. Na /K /Cl- Symporters (NKCCs) 2item
  247. GABAA Receptors 1 item
  248. Phospholipases 1 item
  249. RNA Polymerases 1 item
  250. DYRK 1 item
  251. Norepinephrine transporter 1 item
  252. 5-HT Transporters 3item
  253. Xanthine oxidoreductases 1 item
  254. Dihydroorotate dehydrogenase 1 item
  255. MNK 2item
  256. 5-Lipoxygenases 1 item
  257. NO Donors / Precursors 1 item
  258. HIV-1 reverse transcriptase 1 item
  259. IL Receptors 2item
  260. CCL2 1 item
  261. Norepinephrine transporters 1 item
  262. Calcium-Activated Potassium (KCa) Channels 2item
  263. AChE 3item
  264. Insulin Receptors 1 item
  265. IRG-1R 1 item
  266. Proton Pump 1 item
  267. cAMP 1 item
  268. Sulfonylurea receptors 1 item
  269. eEF-2 1 item
  270. Inward Rectifier Potassium (Kir) Channels 2item
  271. Arp2/3 complex 1 item
  272. Cdc7 1 item
  273. CMV 1 item
  274. ZAP-70 1 item
  275. Catechol O-Methyltransferase (COMT) 2item
  276. fibrinolysis 1 item
  277. Angiotensin AT1 Receptors 1 item
  278. D4 Receptors 1 item
  279. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  280. NMDA receptor 1 item
  281. HBV Proteases 1 item
  282. Hydroxylases 2item
  283. Flk-1 1 item
  284. Papains 2item
  285. Protein Arginine Methyltransferases 1 item
  286. IMPDH 1 item
  287. Na /Ca2 Exchangers (NCXs) 1 item
  288. NAE 2item
  289. Ubiquitin-activating Enzyme E1 2item
  290. SUMOylation 1 item
  291. ATGL 1 item
  292. BACE 2item
  293. Cytidine deaminases 1 item
  294. angiogenesis 1 item
  295. Glucagon Receptors 1 item
  296. 15-PGDH 1 item
  297. DPP-4 5item
  298. c-RET 3item
  299. Nonstructural protein 5B (NS5B) 1 item
  300. p70 rsk 3item
  301. voltage-gated chloride channels 1 item
  302. FPTase 1 item
  303. Microtubule/Tubulin 1 item
  304. VEGFR3/FLT4 1 item
  305. NTRK1/TRKA 1 item
  306. CSF-1R/c-Fms 1 item
  307. Menin-MLL 2item
  308. Tryptophan hydroxylases (TPH) 2item
  309. ADAMs 1 item
  310. NMPRTase 1 item
  311. Bfl-1 1 item
  312. TAM kinase 1 item
  313. p53-MDM2 interaction 2item
  314. nuclear export 1 item
  315. CRM1 1 item
  316. PTP 1 item
  317. KDR 2item
  318. Fyn kinase 1 item
  319. Abl kinases 1 item
  320. AXL 1 item
  321. Glyoxalase I 1 item
  322. dCTP Pyrophosphatases 1 item
  323. Protein polybromo-1 1 item
  324. SMARCA4 1 item
  325. SMARCA2 1 item
  326. Dipeptidyl-peptidase II 1 item
  327. p53 5item
  328. metalloprotease 1 item
  329. HDAC 2item
  330. KDM 2item
  331. 5-HT receptors 1 item
  332. sodium channel 2item
  333. c-Fms tyrosine kinase 1 item
  334. human lyase 1 item
  335. insulin 1 item
  336. Ub-conjugating enzyme (E2) complex 1 item
  337. Smoothened receptor 1 item
  338. quinone oxidoreductase 1 item
  339. cysteine protease 2item
  340. haspin kinase 1 item
  341. STK 1 item
  342. USP1/USF1 complex 1 item
  343. IKK 1 item
  344. MSK 1 item
  345. gp120-CD4 interaction 1 item
  346. HCV polymerase 3item
  347. Ftase 1 item
  348. Subtilisin/Kex2p-like proprotein convertase 1 item
  349. PC-PLC 2item
  350. Elastases 1 item
  351. P97 ATPase 1 item
  352. NTPDases 1 item
  353. Mer tyrosine kinase 1 item
  354. Hec1 1 item
  355. neprilysin 1 item
  356. GLI 1 item
  357. HMGCR 1 item
  358. AAT 1 item
  359. ErbB-2 1 item
  360. adrenergic receptor 2item
  361. 5-HT4 Receptor 1 item
  362. sterol demethylase 1 item
  363. PDK-1 1 item
  364. GAPDH 1 item
  365. telomerase 1 item
  366. Histone Acetyltransferases (HATs) 3item
  367. complex I of the mitochondrial electron transport chain 1 item
  368. F1 Fo-ATPase 1 item
  369. Prk 1 item
  370. potassium channel 1 item
  371. calcium channel 1 item
  372. Ribonucleotide Reductases 1 item
  373. Trx 1 item
  374. Tyrosinases 1 item
  375. HSP70 1 item
  376. ICAM 1 item
  377. ITK 1 item
  378. HIF-PH 1 item
  379. NOD1 1 item
  380. NUAK 1 item
  381. Rho 1 item
  382. Ubiquitin E3 Ligases 1 item
  383. DCLK2 1 item
  384. FAAH 1 item
  385. PTK 1 item
  386. integrase 1 item
  387. L3MBTL 1 item
  388. NOS 2item
  389. MDMX 1 item
  390. TYK2 2item
  391. MUSK 1 item
  392. MAP3K 1 item
  393. GPR3 1 item
  394. Lck 1 item
  395. Adenosine Deaminases 2item
  396. mitochondrial pyruvate carrier (MPC) 1 item
  397. prolactin secretion 1 item
  398. gonadotropin release 1 item
  399. DprE 1 item
  400. carnitine reabsorption 1 item
  401. Histamine receptors 1 item
  402. GluR 1 item
  403. 5-HT receptor 1 item
  404. dopamine receptors 1 item
  405. AMPA receptor 1 item
  406. 5-alpha Reductases 1 item
  407. Flk1 2item
  408. p21 1 item
  409. DNA Ligases 1 item
  410. Prostaglandin synthesis 1 item
  411. Protein Tyrosine Phosphatases 1 item
  412. alkaline phosphatases 1 item
  413. ATPases 1 item
  414. glutamate release 1 item
  415. PAFR 1 item
  416. Aromatases 2item
  417. DHFR 1 item
  418. GARFT 1 item
  419. PHF 1 item
  420. FGR 1 item
  421. YES 2item
  422. Fyn 2item
  423. ARG 1 item
  424. Autotaxin 1 item
  425. UCH 1 item
  426. RHA 1 item
  427. HCV NS3-4A protease 1 item
  428. PKD 1 item
  429. Thioredoxin Reductases 1 item
  430. enoyl-acyl-carrier protein reductase 1 item
  431. SHIP 1 item
  432. MCL1 1 item
  433. Bcl-w 1 item
  434. glutathione peroxidase 4 1 item
  435. NADH oxidase 1 item
  436. S-adenosylhomocysteine hydrolase 1 item
  437. Rho-kinase 1 item
  438. tropomyosin receptor kinase 1 item
  439. LSD 1 item
  440. DDX3 1 item
  441. PRMT 1 item
  442. ACE 1 item
  443. GLP 1 item
  444. SK 1 item
  445. MST 1 item
  446. PPK 1 item
  447. c-Syk 1 item
  448. CDK1/CyclinB 1 item
  449. NHE 1 item
  450. IDO 1 item
  451. Tph 1 item
  452. PIM1 kinase 1 item
  453. phospholipase A2 1 item
  454. reverse transcriptase 1 item
  455. epoxide hydrolase 1 item
  456. Serotonin (5-HT) reuptake 1 item
  457. Cholesterol absorption 1 item
  458. Vascular Disrupting Agents (VDA) 1 item
  459. Androgen Receptor 1 item
  460. Substance P/NK1 Receptor 1 item
  461. gp120/CD4 1 item
  462. Histone Methyltransferase 1 item
  463. ATM 2item
  464. Sirtuin 1 item
  465. NE 1 item
  466. PIKfyve 1 item
  467. Bax 1 item
  468. Glycogen Phosphorylases 1 item
  469. MTH1 1 item
  470. PTEN 1 item
  471. Insulin Receptor 1 item
  472. NS3/4a Proteases 1 item
  473. Ca2 -ATPases 1 item
  474. p90 S6K 1 item
Reported Experiments
  1. Animal Experiments 917item
  2. Cell Experiments 733item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 2item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 6item
  7. Acute Myeloid Leukemia 26item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Biliary Cancer 1 item
  13. Bladder Cancer 11item
  14. Bladder Carcinoma 4item
  15. Bladder Diseases 2item
  16. B-lymphoid Malignancies 1 item
  17. Brain Injuries Studies 3item
  18. Breast Cancer 117item
  19. Cancer 531item
  20. Candida Peritonitis 1 item
  21. Candidemia 1 item
  22. Castration-resistant Prostate Cancer 1 item
  23. Cervical Cancer 6item
  24. Cholangiocarcinoma 2item
  25. Chronic Lymphocytic Leukemia 8item
  26. Chronic Myeloproliferative Disorders 1 item
  27. Clear Cell Renal Cell Carcinoma 2item
  28. Cocaine-Related Disorders 2item
  29. Colon Cancer 47item
  30. Colon Carcinoma 7item
  31. Colorectal Cancer 43item
  32. Depression 2item
  33. Diabetes 8item
  34. Diffuse Large B-cell Lymphoma 1 item
  35. Dyskinesia 1 item
  36. Dyslipidemia 2item
  37. Epilepsy 4item
  38. Erectile Dysfunction 4item
  39. Friedreich's Ataxia 1 item
  40. Fungal Infection 1 item
  41. Fungi 1 item
  42. Glioblastoma 32item
  43. Glioma 18item
  44. HCV 5item
  45. Heart Failure 3item
  46. Hepatic Cancer 2item
  47. Hepatitis C 4item
  48. Hepatocellular Carcinoma 7item
  49. HIV 14item
  50. HIV Infections 10item
  51. Hypercholesterolemia 3item
  52. Immunological Diseases 1 item
  53. Inflammation 1 item
  54. Inflammatory Bowel Disease 1 item
  55. Inflammatory Diseases 15item
  56. Influenza 3item
  57. Kidney Injury Studies 2item
  58. Leukemia 26item
  59. Liver Cancer 3item
  60. Lung Cancer 42item
  61. Lung Carcinoma 4item
  62. Lymphoma 29item
  63. Mantle Cell Lymphoma 2item
  64. Medulloblastoma 1 item
  65. Melanoma 35item
  66. Mixed Lineage Leukemia 3item
  67. Multiple Myeloma 23item
  68. Myelofibrosis 2item
  69. Myeloma 6item
  70. Neuroblastoma 13item
  71. Neurocognitive Disorders 1 item
  72. Neuronal Protection 1 item
  73. Non-small Cell Lung Cancer 27item
  74. Non-small Cell Lung Carcinoma 2item
  75. Obsessive-Compulsive Disorder 1 item
  76. Osteoporosis 3item
  77. Ovarian Cancer 35item
  78. Pancreatic Cancer 47item
  79. Pancreatic Carcinoma 3item
  80. Prostate Cancer 54item
  81. Psoriasis 4item
  82. Psoriasis Vulgaris 1 item
  83. Pulmonary Arterial Hypertension 2item
  84. Pulmonary Fibrosis 2item
  85. Renal Cancer 4item
  86. Renal Cell Carcinoma 8item
  87. Rheumatoid Arthritis 14item
  88. Sarcoma 1 item
  89. Schizophrenia 7item
  90. Sleep Disorders 1 item
  91. Soft Tissue Sarcoma 1 item
  92. Squamous Cell Carcinoma 2item
  93. Testicular Cancer 2item
  94. Thyroid Cancer 6item
  95. Tuberculosis 1 item
  96. Type 2 Diabetes 11item