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  • Search results for: 'mutant idh1 inhibitor'

Search results for: 'mutant idh1 inhibitor'

Items 721-730 of 805

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  1. GDC-0449 (Vismodegib)
    A3021 GDC-0449 (Vismodegib)
     1 Citation
    Target: P-glycoprotein (P-gp)|Hedgehog
    Summary: Hedgehog antagonist,potent and selective
      ≥21.08 mg/mL
  2. GDC-0152
    A4224 GDC-0152
     2 Citation
    Target: Inhibitor of apoptosis proteins (IAP)
    Summary: IAP antagonist,potent amd samll-molecule
      ≥24.95 mg/mL
  3. TOK-001
    A8623 TOK-001
    Target: Androgen Receptors|Cytochrome P450 (CYP450)
    Summary: CYP17 inhibitor and androgen receptor (AR) antagonist
      insoluble in H2O; ≥12.4 mg/mL
  4. ARRY-380
    A8366 ARRY-380
    Target: HER2
    Summary: Tyrosine kinase HER2 and p95-HER2 inhibitor
      ≥28.5 mg/mL
  5. KU-0060648
    A1769 KU-0060648
     1 Citation
    Target: PI3K|DNA-PK
    Summary: Dual DNA-PK/PI3-K inhibitor, ATP-competitive
  6. Aprepitant
    A1684 Aprepitant
    Target: Substance P/NK1 Receptor
    Summary: Substance P (SP) inhibitor
      ≥26.72 mg/mL
  7. BS-181
    A3266 BS-181
    Target: Cyclin-Dependent Kinases
    Summary: CDK7 inhibitor,highly selective
      Soluble in DMSO
  8. Istaroxime
    A3507 Istaroxime
     1 Citation
    Target: Na /K ATPases
    Summary: Na+/K+ ATPase inhibitor
      Soluble in H2O
  9. TAK-242
    A3850 TAK-242
     7 Citation
    Target: Toll-like receptors (TLRs)|NO Donors / Precursors|IL Receptors
    Summary: TLR 4 signaling inhibitor
  10. Teriflunomide
    B1850 Teriflunomide
    Target: Dihydroorotate dehydrogenase
    Summary: Inhibitor of dihydroorotate dehydrogenase
      insoluble in H2O; ≥13.5 mg/mL

Items 721-730 of 805

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Category
  1. Signaling Pathways 777item
  2. Natural Products 2item
  3. Kits 1 item
  4. Lab Reagents 3item
Reversibility
  1. Reversible 54item
  2. Irreversible 26item
Target
  1. Caspases 11item
  2. Cyclin-Dependent Kinases 26item
  3. Proteasome 11item
  4. Cathepsins 11item
  5. Histone Deacetylases (HDACs) 28item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 6item
  8. Bcl-2 5item
  9. PI3K 26item
  10. CXCR 3item
  11. Raf 10item
  12. Aurora Kinases 14item
  13. Bcl-xl 3item
  14. CSF-1R 2item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. Gap Junctions 1 item
  18. MDM2 1 item
  19. EZH2 6item
  20. mTOR 15item
  21. Bromodomains 5item
  22. AP-1 1 item
  23. MMP 8item
  24. Thymidine Phosphorylases 1 item
  25. Androgen Receptors 3item
  26. Peptidylprolyl isomerases 1 item
  27. Acyl coenzyme A: cholesterol acyltransferases 1 item
  28. Myosin II ATPases 1 item
  29. DT-diaphorases 1 item
  30. Voltage-gated Potassium (KV) Channels 1 item
  31. MER 1 item
  32. FLT3 12item
  33. GSK-3 9item
  34. Factor Xa 3item
  35. P-glycoprotein (P-gp) 5item
  36. PLK 7item
  37. Chk 8item
  38. ULK1 1 item
  39. Eph Receptors 3item
  40. VEGFR 25item
  41. PDGFR 19item
  42. c-Kit 7item
  43. RET 3item
  44. IRAK 3item
  45. Bromodomain-containing proteins(BRDs) 1 item
  46. Phosphodiesterases (PDEs) 10item
  47. Mcl-1 5item
  48. Hydrolase 1 item
  49. Thymidylate Synthase 2item
  50. p38 9item
  51. PKB 1 item
  52. 3-phosphoglycerate dehydrogenase 1 item
  53. JNK 6item
  54. SGK 2item
  55. Bcr-Abl 10item
  56. Kynurenine-3-monooxygenase 1 item
  57. MEK 15item
  58. PORCN 1 item
  59. DOT1L 3item
  60. FGFR 9item
  61. Nrf2 1 item
  62. Insulin-like growth factor receptors(IGFRs) 1 item
  63. Pim 5item
  64. Sir2-like Family Deacetylases (Sirtuins) 2item
  65. Deubiquitinating enzymes (DUBs) 4item
  66. Smoothened 4item
  67. Ribosomal s6 kinases (RSK) 1 item
  68. Neuraminidases (NA) 2item
  69. MET 7item
  70. Src 9item
  71. Trk Receptors 5item
  72. Integrins 1 item
  73. Aminopeptidases 2item
  74. STAT 7item
  75. ATP Citrate Lyases 1 item
  76. Microtubules/Tubulins 4item
  77. EGFR 15item
  78. Hedgehog 1 item
  79. Reverse Transcriptases 1 item
  80. ROCK 7item
  81. BTK 2item
  82. RIP kinases 1 item
  83. Monocyte chemotactic proteins 1 item
  84. PAK 3item
  85. Hypoxia Inducible Factors (HIFs) 2item
  86. Tankyrases 1 item
  87. Inositol Phosphatases 1 item
  88. FAK 5item
  89. BMP and Other Activin Receptors 4item
  90. JAK 13item
  91. p300 1 item
  92. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  93. Syk 7item
  94. EZH1 2item
  95. DNA-PK 6item
  96. HSP90 10item
  97. AMPK 2item
  98. Gutathione S-transferase 1 item
  99. PDHK 1 item
  100. Angiotensin AT2 Receptors 1 item
  101. eIF4E/eIF3G interaction 1 item
  102. Notch 1 item
  103. S-nitrosoglutathione reductase 1 item
  104. CFTR 3item
  105. TNKS 1 item
  106. Topoisomerases 7item
  107. Cytochrome P450 (CYP450) 5item
  108. thrombin 1 item
  109. Ksp 1 item
  110. Ribosomes 1 item
  111. Renin 2item
  112. HIV proteases 1 item
  113. Pepsins 1 item
  114. Influenza viruses 1 item
  115. ErbB 2item
  116. Ferroptosis 1 item
  117. S6 kinases 1 item
  118. Toll-like receptors (TLRs) 2item
  119. Adenosine Kinases 2item
  120. Actin 1 item
  121. DNA Methyltransferases 3item
  122. Survivin 1 item
  123. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  124. ERK 5item
  125. HMG-CoA Reductases 5item
  126. Vacuolar-type ATPase 1 item
  127. c-MET 8item
  128. BMI-1 1 item
  129. PKC 7item
  130. Calpains 6item
  131. Ubiquitin-specific proteases 1 item
  132. HCV Proteases 3item
  133. Ca2 /calmodulin-dependent protein kinases (CaMKs) 7item
  134. MLK3 1 item
  135. SMYD2 1 item
  136. O-GlcNAcase 1 item
  137. CREBBP 2item
  138. EP300 2item
  139. Lyn 1 item
  140. SGLT 1 item
  141. RAD51 1 item
  142. Trypsins 1 item
  143. HER2 2item
  144. Pyk2 3item
  145. USP 3item
  146. 5-HT2 Receptors 4item
  147. LRRK2 4item
  148. Voltage-gated Calcium Channels (CaV) 1 item
  149. DGAT 2item
  150. Insulin and Insulin-like Receptors 3item
  151. PARP 5item
  152. CB1 Receptors 1 item
  153. Pyruvate dehydrogenases (PDH) 1 item
  154. ALK 5item
  155. ROS1 2item
  156. Sphingosine kinases (SphKs) 2item
  157. Trypsin 1 item
  158. Chymotrypsin 1 item
  159. Kallikrein 1 item
  160. Trypsinogen 1 item
  161. KRAS G12C 1 item
  162. GTPases 1 item
  163. Monocarboxylate transporters (MCTs) 1 item
  164. CETP 2item
  165. Dehydrogenase 1 item
  166. PKG 1 item
  167. PKA 1 item
  168. Myosin light chain kinases (MLCKs) 2item
  169. HIV-1 gp120 1 item
  170. D1 and D5 Receptors 1 item
  171. D2 Receptors 3item
  172. D3 Receptors 2item
  173. 5-HT1 Receptors 2item
  174. 5-HT7 Receptors 1 item
  175. CaM-KK 1 item
  176. Valosin-containing protein (VCP) 1 item
  177. MELK 1 item
  178. Serotonin reuptake 1 item
  179. Insulin-like growth factors (IGFs) 1 item
  180. Clk 1 item
  181. TBK1 1 item
  182. MARK1 1 item
  183. NUAK1 2item
  184. Integrin-ligand interactions 1 item
  185. CSF1R 1 item
  186. Bromodomain and Extra-Terminal motif (BET) 1 item
  187. NUAK2 1 item
  188. Na /H Exchangers (NHEs) 1 item
  189. Lactate Dehydrogenases (LDH) 2item
  190. MK2 3item
  191. Fatty-acid-binding proteins (FABPs) 1 item
  192. Angiotensin-Converting Enzymes (ACEs) 4item
  193. Tie-2 4item
  194. RSK 2item
  195. p70 S6K 1 item
  196. Granzyme B 1 item
  197. phosphatases 1 item
  198. Autophagy 2item
  199. ATM/ATR 7item
  200. Mixed lineage kinase domain-like protein (MLKL) 1 item
  201. COX 6item
  202. Heparanases 1 item
  203. CK1 1 item
  204. IDH2 1 item
  205. CK2 3item
  206. HIPK2 1 item
  207. HIPK3 1 item
  208. HIV Integrases 2item
  209. Squalene epoxidases 2item
  210. PRAK 1 item
  211. MAPKAP-K2 1 item
  212. Delayed rectifier outward potassium current (IKr) 1 item
  213. GpIIb/IIIa receptor 1 item
  214. Guanine nucleotide exchange factors (GEFs) 1 item
  215. 20S proteasomal chymotrypsin 1 item
  216. Geranylgeranyltransferase I 1 item
  217. Farnesyltransferase 1 item
  218. NAT10 1 item
  219. Nampt 2item
  220. eIF4F 1 item
  221. Cdc42 1 item
  222. SRPK1 1 item
  223. P2X Receptors 1 item
  224. Glutaminases 1 item
  225. Carbonic Anhydrases 6item
  226. Ron 1 item
  227. AP endonucleases 1 item
  228. G9a 2item
  229. BLM 1 item
  230. HSV 2item
  231. NADPH Oxidases 2item
  232. Calcium-activated chloride channels (CaCC) 1 item
  233. GPR35 1 item
  234. Aldehyde Dehydrogenases 1 item
  235. Synthases/Synthetases 3item
  236. MAGL 1 item
  237. c-Fyn 1 item
  238. TAK1 1 item
  239. Histamine H1 Receptors 1 item
  240. Na /K ATPases 2item
  241. P110 1 item
  242. Hck 1 item
  243. Inositol-requiring enzyme 1 (IRE1) 2item
  244. SETD7 1 item
  245. Na /K /Cl- Symporters (NKCCs) 1 item
  246. GABAA Receptors 1 item
  247. Phospholipases 1 item
  248. Organic anion transporters (OATs) 1 item
  249. TRP Channel 1 item
  250. RNA Polymerases 1 item
  251. DYRK 1 item
  252. Norepinephrine transporter 1 item
  253. 5-HT Transporters 3item
  254. Xanthine oxidoreductases 1 item
  255. Dihydroorotate dehydrogenase 1 item
  256. Histone Demethylases 1 item
  257. MNK 1 item
  258. NO Donors / Precursors 2item
  259. CB2 Receptors 1 item
  260. HIV-1 reverse transcriptase 1 item
  261. IL Receptors 2item
  262. CCL2 1 item
  263. Noradrenaline reuptake 1 item
  264. Norepinephrine transporters 1 item
  265. Calcium-Activated Potassium (KCa) Channels 1 item
  266. AChE 2item
  267. Insulin Receptors 1 item
  268. IRG-1R 1 item
  269. Proton Pump 1 item
  270. cAMP 1 item
  271. Sulfonylurea receptors 1 item
  272. Cdc2-like kinase (Clk) 1 item
  273. eEF-2 1 item
  274. Inward Rectifier Potassium (Kir) Channels 2item
  275. Arp2/3 complex 1 item
  276. Cdc7 1 item
  277. CMV 1 item
  278. ZAP-70 1 item
  279. Catechol O-Methyltransferase (COMT) 2item
  280. fibrinolysis 1 item
  281. D4 Receptors 1 item
  282. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  283. HBV Proteases 1 item
  284. Flk-1 1 item
  285. Papains 1 item
  286. Protein Arginine Methyltransferases 1 item
  287. IMPDH 1 item
  288. Na /Ca2 Exchangers (NCXs) 1 item
  289. NAE 2item
  290. Ubiquitin-activating Enzyme E1 1 item
  291. SUMOylation 1 item
  292. ATGL 1 item
  293. BACE 1 item
  294. Cytidine deaminases 1 item
  295. angiogenesis 1 item
  296. Glucagon Receptors 1 item
  297. 15-PGDH 1 item
  298. DPP-4 4item
  299. c-RET 1 item
  300. Nonstructural protein 5B (NS5B) 1 item
  301. p70 rsk 1 item
  302. FPTase 1 item
  303. ADAMs 1 item
  304. TAM kinase 1 item
  305. p53-MDM2 interaction 1 item
  306. nuclear export 1 item
  307. CRM1 1 item
  308. AXL 1 item
  309. Protein polybromo-1 1 item
  310. SMARCA4 1 item
  311. SMARCA2 1 item
  312. Dipeptidyl-peptidase II 1 item
  313. HDAC 1 item
  314. c-Fms tyrosine kinase 1 item
  315. human lyase 1 item
  316. Ub-conjugating enzyme (E2) complex 1 item
  317. STK 1 item
  318. IKK 1 item
  319. MSK 1 item
  320. HCV polymerase 2item
  321. Ftase 1 item
  322. PC-PLC 1 item
  323. Elastases 1 item
  324. P97 ATPase 1 item
  325. NTPDases 1 item
  326. telomerase 1 item
  327. Histone Acetyltransferases (HATs) 1 item
  328. F1 Fo-ATPase 1 item
  329. ITK 1 item
  330. NOD1 1 item
  331. NUAK 1 item
  332. DCLK2 1 item
  333. FAAH 1 item
  334. TYK2 1 item
  335. Lck 1 item
  336. Aromatases 1 item
  337. PKD 1 item
  338. SHIP 1 item
  339. MCL1 1 item
  340. Bcl-w 1 item
  341. tropomyosin receptor kinase 1 item
  342. LSD 1 item
  343. PRMT 1 item
  344. GLP 1 item
  345. SK 1 item
  346. MST 1 item
  347. IDO 1 item
  348. Serotonin (5-HT) reuptake 1 item
  349. Androgen Receptor 1 item
  350. Substance P/NK1 Receptor 1 item
  351. gp120/CD4 1 item
  352. ATM 2item
  353. Sirtuin 1 item
  354. NE 1 item
  355. PIKfyve 1 item
  356. Glycogen Phosphorylases 1 item
  357. RGS 1 item
  358. MTH1 1 item
  359. Insulin Receptor 1 item
Reported Experiments
  1. Animal Experiments 682item
  2. Cell Experiments 470item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 1 item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 6item
  7. Acute Myeloid Leukemia 26item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Biliary Cancer 1 item
  13. Bladder Cancer 10item
  14. Bladder Carcinoma 4item
  15. Bladder Diseases 2item
  16. B-lymphoid Malignancies 1 item
  17. Brain Injuries Studies 3item
  18. Breast Cancer 115item
  19. Cancer 430item
  20. Candida Peritonitis 1 item
  21. Candidemia 1 item
  22. Castration-resistant Prostate Cancer 1 item
  23. Cervical Cancer 5item
  24. Cholangiocarcinoma 2item
  25. Chronic Lymphocytic Leukemia 8item
  26. Chronic Myeloproliferative Disorders 1 item
  27. Clear Cell Renal Cell Carcinoma 2item
  28. Cocaine-Related Disorders 2item
  29. Colon Cancer 46item
  30. Colon Carcinoma 7item
  31. Colorectal Cancer 42item
  32. Depression 2item
  33. Diabetes 7item
  34. Diffuse Large B-cell Lymphoma 1 item
  35. Dyskinesia 1 item
  36. Dyslipidemia 2item
  37. Epilepsy 2item
  38. Erectile Dysfunction 3item
  39. Friedreich's Ataxia 2item
  40. Fungal Infection 1 item
  41. Glioblastoma 32item
  42. Glioma 18item
  43. HCV 3item
  44. Heart Failure 1 item
  45. Hepatic Cancer 2item
  46. Hepatitis C 3item
  47. Hepatocellular Carcinoma 7item
  48. HIV 4item
  49. HIV Infections 9item
  50. Hypercholesterolemia 2item
  51. Immunological Diseases 1 item
  52. Inflammation 1 item
  53. Inflammatory Bowel Disease 1 item
  54. Inflammatory Diseases 14item
  55. Influenza 2item
  56. Kidney Injury Studies 1 item
  57. Leukemia 23item
  58. Liver Cancer 3item
  59. Lung Cancer 44item
  60. Lung Carcinoma 4item
  61. Lymphoma 31item
  62. Mantle Cell Lymphoma 2item
  63. Medulloblastoma 1 item
  64. Melanoma 34item
  65. Mixed Lineage Leukemia 3item
  66. Multiple Myeloma 24item
  67. Myelofibrosis 2item
  68. Myeloma 6item
  69. Neuroblastoma 13item
  70. Neurocognitive Disorders 1 item
  71. Neuronal Protection 1 item
  72. Non-small Cell Lung Cancer 26item
  73. Non-small Cell Lung Carcinoma 2item
  74. Obsessive-Compulsive Disorder 1 item
  75. Osteoporosis 2item
  76. Ovarian Cancer 35item
  77. Pancreatic Cancer 49item
  78. Pancreatic Carcinoma 3item
  79. Prostate Cancer 54item
  80. Psoriasis 4item
  81. Psoriasis Vulgaris 1 item
  82. Pulmonary Arterial Hypertension 2item
  83. Pulmonary Fibrosis 2item
  84. Renal Cancer 4item
  85. Renal Cell Carcinoma 8item
  86. Rheumatoid Arthritis 14item
  87. Sarcoma 1 item
  88. Schizophrenia 7item
  89. Sleep Disorders 2item
  90. Soft Tissue Sarcoma 1 item
  91. Squamous Cell Carcinoma 2item
  92. Testicular Cancer 2item
  93. Thyroid Cancer 6item
  94. Type 2 Diabetes 12item