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  • Search results for: 'p53 and mdm2 proteins interaction inhibitor chiral'

Search results for: 'p53 and mdm2 proteins interaction inhibitor chiral'

Items 121-130 of 942

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  1. Dorsomorphin (Compound C)
    B3252 Dorsomorphin (Compound C)
     5 Citation
    Target: AMPK
    Summary: AMPK inhibitor
      insoluble in H2O; insoluble in EtOH; ≥8.49 mg/mL
  2. Enzastaurin (LY317615)
    A1670 Enzastaurin (LY317615)
     2 Citation
    Target: PKC
    Summary: PKC beta inhibitor,potent and selective
      insoluble in EtOH; insoluble in H2O; ≥8.59 mg/mL
  3. EPZ004777 HCl
    B1581 EPZ004777 HCl
    Target: DOT1L
    Summary: DOT1L inhibitor,potent and selective
      insoluble in H2O; ≥16.5 mg/mL
  4. AUY922 (NVP-AUY922)
    A4057 AUY922 (NVP-AUY922)
     1 Citation
    Target: HSP90
    Summary: Potent Hsp90 inhibitor
      ≥23.27 mg/mL
  5. LY2090314
    A3570 LY2090314
    Target: GSK-3
    Summary: Potent GSK-3 inhibitor
      insoluble in H2O; ≥91 mg/mL
  6. SNX-2112
    A4068 SNX-2112
     1 Citation
    Summary: Hsp90 inhibitor,ATP-competitve,potent and selective
      ≥23.05 mg/mL
  7. Go 6976
    A8341 Go 6976
    Target: PKC
    Summary: PKCα/PKCβ1 inhibitor
      ≥15.77 mg/mL
  8. Ro 31-8220
    B1287 Ro 31-8220
    Target: PKC
    Summary: pan-PKC inhibitor
      Soluble in DMSO
  9. LDN-193189
    A8324 LDN-193189
    Target: BMP and Other Activin Receptors
    Summary: ALK inhibitor,potent and selective
      insoluble in DMSO; insoluble in EtOH; insoluble in H2O
  10. CID 755673
    A8678 CID 755673
    Target: PKD
    Summary: PKD inhibitor

Items 121-130 of 942

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Category
  1. Proteases 88item
  2. Apoptosis 57item
  3. Chromatin/Epigenetics 117item
  4. Metabolism 90item
  5. MAPK Signaling 46item
  6. Tyrosine Kinase 138item
  7. DNA Damage/DNA Repair 70item
  8. PI3K/Akt/mTOR Signaling 79item
  9. Microbiology & Virology 38item
  10. Cell Cycle/Checkpoint 84item
  11. Ubiquitination/ Proteasome 29item
  12. JAK/STAT Signaling 45item
  13. TGF-β / Smad Signaling 43item
  14. Angiogenesis 8item
  15. GPCR/G protein 26item
  16. Stem Cell 33item
  17. Membrane Transporter/Ion Channel 31item
  18. Cancer Biology 1 item
  19. Endocrinology and Hormones 14item
  20. Neuroscience 36item
  21. Obesity, Appetite Control & Diabetes 1 item
  22. Other Signal Transduction 2item
  23. Others 69item
  24. Immunology/Inflammation 15item
  25. Cardiovascular 1 item
  26. Vitamin D Related 1 item
Specificity
  1. Selective 675item
  2. Non-Selective 4item
Reversibility
  1. Reversible 54item
  2. Irreversible 31item
Target
  1. Caspases 8item
  2. Cyclin-Dependent Kinases 25item
  3. Proteasome 12item
  4. Cathepsins 9item
  5. Histone Deacetylases (HDACs) 31item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 13item
  8. Bcl-2 8item
  9. PI3K 36item
  10. CXCR 4item
  11. Raf 13item
  12. Aurora Kinases 20item
  13. Bcl-xl 2item
  14. CSF-1R 4item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. Gap Junctions 1 item
  18. MDM2 2item
  19. EZH2 4item
  20. mTOR 20item
  21. Bromodomains 6item
  22. AP-1 1 item
  23. MMP 7item
  24. Thymidine Phosphorylases 1 item
  25. Androgen Receptors 4item
  26. Peptidylprolyl isomerases 1 item
  27. Acyl coenzyme A: cholesterol acyltransferases 1 item
  28. Myosin II ATPases 1 item
  29. DT-diaphorases 1 item
  30. Voltage-gated Potassium (KV) Channels 1 item
  31. MER 1 item
  32. FLT3 19item
  33. GSK-3 10item
  34. Factor Xa 4item
  35. P-glycoprotein (P-gp) 5item
  36. PLK 10item
  37. Chk 7item
  38. Eph Receptors 2item
  39. VEGFR 40item
  40. PDGFR 25item
  41. c-Kit 13item
  42. RET 4item
  43. IRAK 1 item
  44. Bromodomain-containing proteins(BRDs) 1 item
  45. Phosphodiesterases (PDEs) 16item
  46. Mcl-1 6item
  47. Hydrolase 1 item
  48. Thymidylate Synthase 3item
  49. p38 9item
  50. PKB 1 item
  51. JNK 3item
  52. SGK 1 item
  53. Bcr-Abl 13item
  54. Kynurenine-3-monooxygenase 1 item
  55. MEK 13item
  56. PORCN 1 item
  57. DOT1L 3item
  58. FGFR 17item
  59. Nrf2 2item
  60. Insulin-like growth factor receptors(IGFRs) 1 item
  61. Pim 3item
  62. Liver X receptors (LXRs) 1 item
  63. Sir2-like Family Deacetylases (Sirtuins) 3item
  64. Voltage-gated Sodium (NaV) Channels 1 item
  65. Deubiquitinating enzymes (DUBs) 3item
  66. PP1 1 item
  67. PP2A 1 item
  68. Smoothened 4item
  69. Neuraminidases (NA) 2item
  70. MET 7item
  71. Src 14item
  72. Trk Receptors 6item
  73. Integrins 1 item
  74. Aminopeptidases 3item
  75. NMDA Receptors 1 item
  76. STAT 8item
  77. ATP Citrate Lyases 1 item
  78. Microtubules/Tubulins 4item
  79. Estrogen and Related Receptors 1 item
  80. EGFR 23item
  81. Hedgehog 1 item
  82. Reverse Transcriptases 5item
  83. ROCK 9item
  84. BTK 1 item
  85. RIP kinases 1 item
  86. PAK 3item
  87. Hypoxia Inducible Factors (HIFs) 2item
  88. Tankyrases 1 item
  89. Inositol Phosphatases 1 item
  90. FAK 6item
  91. BMP and Other Activin Receptors 3item
  92. JAK 20item
  93. p300 1 item
  94. Stearoyl-CoA 9-desaturase (SCD-1) 2item
  95. Syk 7item
  96. EZH1 2item
  97. DNA-PK 7item
  98. HSP90 12item
  99. AMPK 2item
  100. Gutathione S-transferase 1 item
  101. PDHK 1 item
  102. Angiotensin AT2 Receptors 1 item
  103. Notch 1 item
  104. S-nitrosoglutathione reductase 1 item
  105. CFTR 4item
  106. TNKS 1 item
  107. Topoisomerases 11item
  108. Cytochrome P450 (CYP450) 8item
  109. thrombin 1 item
  110. Ksp 2item
  111. Renin 1 item
  112. Influenza viruses 1 item
  113. ErbB 5item
  114. S6 kinases 1 item
  115. Toll-like receptors (TLRs) 3item
  116. Adenosine Kinases 2item
  117. Serine Proteases 2item
  118. DNA Methyltransferases 2item
  119. Survivin 1 item
  120. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  121. ERK 7item
  122. HMG-CoA Reductases 6item
  123. c-MET 8item
  124. BMI-1 1 item
  125. PKC 14item
  126. Calpains 5item
  127. Ubiquitin-specific proteases 1 item
  128. HCV Proteases 3item
  129. Ca2 /calmodulin-dependent protein kinases (CaMKs) 6item
  130. MLK3 1 item
  131. CREBBP 1 item
  132. EP300 1 item
  133. Lyn 2item
  134. SGLT 1 item
  135. RAD51 2item
  136. Trypsins 1 item
  137. HER2 3item
  138. Pyk2 3item
  139. 5-HT2 Receptors 4item
  140. LRRK2 6item
  141. Voltage-gated Calcium Channels (CaV) 1 item
  142. DGAT 2item
  143. Insulin and Insulin-like Receptors 4item
  144. PARP 6item
  145. Melanocortin (MC) Receptors 1 item
  146. Pyruvate dehydrogenases (PDH) 2item
  147. ALK 9item
  148. ROS1 2item
  149. Sphingosine kinases (SphKs) 3item
  150. Trypsin 1 item
  151. Chymotrypsin 1 item
  152. Kallikrein 1 item
  153. Trypsinogen 1 item
  154. Monocarboxylate transporters (MCTs) 2item
  155. CETP 2item
  156. Dehydrogenase 1 item
  157. PKG 2item
  158. PKA 6item
  159. Myosin light chain kinases (MLCKs) 2item
  160. HIV-1 gp120 1 item
  161. D1 and D5 Receptors 1 item
  162. D2 Receptors 3item
  163. D3 Receptors 2item
  164. 5-HT1 Receptors 2item
  165. 5-HT7 Receptors 1 item
  166. MELK 1 item
  167. Serotonin reuptake 1 item
  168. Insulin-like growth factors (IGFs) 1 item
  169. CSF1R 1 item
  170. Bromodomain and Extra-Terminal motif (BET) 1 item
  171. Lactate Dehydrogenases (LDH) 2item
  172. MK2 2item
  173. Fatty-acid-binding proteins (FABPs) 1 item
  174. Angiotensin-Converting Enzymes (ACEs) 4item
  175. Tie-2 5item
  176. RSK 3item
  177. p70 S6K 1 item
  178. Free Fatty Acid Receptors 1 item
  179. phosphatases 1 item
  180. Autophagy 4item
  181. ATM/ATR 5item
  182. COX 11item
  183. CK1 1 item
  184. Farnesyl Diphosphate Synthases 1 item
  185. CK2 2item
  186. HIPK2 1 item
  187. HIPK3 1 item
  188. HIV Integrases 1 item
  189. Squalene epoxidases 2item
  190. PRAK 1 item
  191. MAPKAP-K2 1 item
  192. Delayed rectifier outward potassium current (IKr) 1 item
  193. 20S proteasomal chymotrypsin 1 item
  194. Geranylgeranyltransferase I 1 item
  195. Farnesyltransferase 1 item
  196. Nampt 3item
  197. eIF4F 1 item
  198. Cdc42 1 item
  199. SRPK1 1 item
  200. P2X Receptors 1 item
  201. Glutaminases 2item
  202. Carbonic Anhydrases 6item
  203. Ron 1 item
  204. G9a 1 item
  205. BLM 1 item
  206. HSV 1 item
  207. NADPH Oxidases 3item
  208. Calcium-activated chloride channels (CaCC) 1 item
  209. GPR35 1 item
  210. Aldehyde Dehydrogenases 1 item
  211. Synthases/Synthetases 2item
  212. Histamine H1 Receptors 2item
  213. Na /K ATPases 2item
  214. P110 1 item
  215. Hck 2item
  216. Inositol-requiring enzyme 1 (IRE1) 1 item
  217. Na /K /Cl- Symporters (NKCCs) 2item
  218. GABAA Receptors 2item
  219. Phospholipases 1 item
  220. RNA Polymerases 1 item
  221. Norepinephrine transporter 1 item
  222. 5-HT Transporters 3item
  223. Xanthine oxidoreductases 1 item
  224. Dihydroorotate dehydrogenase 1 item
  225. FoxM1 1 item
  226. MNK 2item
  227. 5-Lipoxygenases 1 item
  228. NO Donors / Precursors 1 item
  229. HIV-1 reverse transcriptase 1 item
  230. IL Receptors 2item
  231. CCL2 1 item
  232. Norepinephrine transporters 1 item
  233. Calcium-Activated Potassium (KCa) Channels 2item
  234. AChE 3item
  235. Insulin Receptors 1 item
  236. IRG-1R 1 item
  237. cAMP 1 item
  238. Sulfonylurea receptors 1 item
  239. eEF-2 1 item
  240. Inward Rectifier Potassium (Kir) Channels 2item
  241. Cdc7 1 item
  242. CMV 1 item
  243. ZAP-70 1 item
  244. Catechol O-Methyltransferase (COMT) 2item
  245. fibrinolysis 1 item
  246. Angiotensin AT1 Receptors 1 item
  247. D4 Receptors 1 item
  248. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  249. NMDA receptor 1 item
  250. HBV Proteases 1 item
  251. Hydroxylases 2item
  252. Flk-1 1 item
  253. Papains 1 item
  254. Protein Arginine Methyltransferases 1 item
  255. IMPDH 1 item
  256. Na /Ca2 Exchangers (NCXs) 1 item
  257. NAE 2item
  258. Ubiquitin-activating Enzyme E1 2item
  259. SUMOylation 1 item
  260. ATGL 1 item
  261. BACE 1 item
  262. Cytidine deaminases 1 item
  263. GPR40 1 item
  264. angiogenesis 1 item
  265. Glucagon Receptors 1 item
  266. 15-PGDH 1 item
  267. DPP-4 5item
  268. PP4 1 item
  269. c-RET 3item
  270. Nonstructural protein 5B (NS5B) 1 item
  271. p70 rsk 3item
  272. voltage-gated chloride channels 1 item
  273. FPTase 1 item
  274. Microtubule/Tubulin 1 item
  275. VEGFR3/FLT4 1 item
  276. NTRK1/TRKA 1 item
  277. CSF-1R/c-Fms 1 item
  278. Tryptophan hydroxylases (TPH) 2item
  279. ADAMs 1 item
  280. NMPRTase 1 item
  281. Bfl-1 1 item
  282. TAM kinase 1 item
  283. p53-MDM2 interaction 1 item
  284. nuclear export 1 item
  285. CRM1 1 item
  286. PTP 1 item
  287. KDR 2item
  288. Fyn kinase 1 item
  289. AXL 1 item
  290. Glyoxalase I 1 item
  291. Dipeptidyl-peptidase II 1 item
  292. p53 6item
  293. metalloprotease 1 item
  294. HDAC 2item
  295. 5-HT receptors 1 item
  296. sodium channel 2item
  297. c-Fms tyrosine kinase 1 item
  298. human lyase 1 item
  299. insulin 1 item
  300. Ub-conjugating enzyme (E2) complex 1 item
  301. Smoothened receptor 1 item
  302. cysteine protease 2item
  303. HDM2 ubiquitin ligase 1 item
  304. IKK 1 item
  305. MSK 1 item
  306. gp120-CD4 interaction 1 item
  307. HCV polymerase 2item
  308. Ftase 1 item
  309. PC-PLC 2item
  310. Elastases 1 item
  311. Mer tyrosine kinase 1 item
  312. Hec1 1 item
  313. neprilysin 1 item
  314. GLI 1 item
  315. HMGCR 1 item
  316. ErbB-2 1 item
  317. adrenergic receptor 2item
  318. 5-HT4 Receptor 1 item
  319. sterol demethylase 1 item
  320. PDK-1 1 item
  321. GAPDH 1 item
  322. Histone Acetyltransferases (HATs) 2item
  323. complex I of the mitochondrial electron transport chain 1 item
  324. F1 Fo-ATPase 1 item
  325. Prk 1 item
  326. potassium channel 1 item
  327. calcium channel 1 item
  328. Ribonucleotide Reductases 1 item
  329. Trx 1 item
  330. Tyrosinases 1 item
  331. HSP70 1 item
  332. ICAM 1 item
  333. ITK 1 item
  334. HIF-PH 1 item
  335. NUAK 1 item
  336. Rho 1 item
  337. Ubiquitin E3 Ligases 1 item
  338. DCLK2 1 item
  339. FAAH 1 item
  340. PTK 1 item
  341. integrase 1 item
  342. NOS 2item
  343. TYK2 2item
  344. MUSK 1 item
  345. MAP3K 1 item
  346. GPR3 1 item
  347. Adenosine Deaminases 2item
  348. mitochondrial pyruvate carrier (MPC) 1 item
  349. prolactin secretion 1 item
  350. gonadotropin release 1 item
  351. DprE 1 item
  352. carnitine reabsorption 1 item
  353. Histamine receptors 1 item
  354. GluR 1 item
  355. 5-HT receptor 1 item
  356. dopamine receptors 1 item
  357. AMPA receptor 1 item
  358. 5-alpha Reductases 1 item
  359. Flk1 2item
  360. p21 1 item
  361. Prostaglandin synthesis 1 item
  362. Protein Tyrosine Phosphatases 1 item
  363. alkaline phosphatases 1 item
  364. ATPases 1 item
  365. glutamate release 1 item
  366. PAFR 1 item
  367. Aromatases 2item
  368. DHFR 1 item
  369. GARFT 1 item
  370. FGR 1 item
  371. YES 2item
  372. Fyn 2item
  373. ARG 1 item
  374. Autotaxin 1 item
  375. UCH 1 item
  376. RHA 1 item
  377. HCV NS3-4A protease 1 item
  378. PKD 1 item
  379. Thioredoxin Reductases 1 item
  380. enoyl-acyl-carrier protein reductase 1 item
  381. SHIP 1 item
  382. FKBP 1 item
  383. MCL1 1 item
  384. Bcl-w 1 item
  385. glutathione peroxidase 4 1 item
  386. S-adenosylhomocysteine hydrolase 1 item
  387. Rho-kinase 1 item
  388. tropomyosin receptor kinase 1 item
  389. LSD 1 item
  390. DDX3 1 item
  391. PRMT 1 item
  392. ACE 1 item
  393. GLP 1 item
  394. SK 1 item
  395. MST 1 item
  396. PPK 1 item
  397. c-Syk 1 item
  398. CDK1/CyclinB 1 item
  399. NHE 1 item
  400. IDO 1 item
  401. Tph 1 item
  402. PIM1 kinase 1 item
  403. phospholipase A2 1 item
  404. reverse transcriptase 1 item
  405. epoxide hydrolase 1 item
  406. Serotonin (5-HT) reuptake 1 item
  407. Cholesterol absorption 1 item
  408. Vascular Disrupting Agents (VDA) 1 item
  409. Androgen Receptor 1 item
  410. Substance P/NK1 Receptor 1 item
  411. gp120/CD4 1 item
  412. ATM 1 item
  413. Sirtuin 1 item
  414. NE 1 item
  415. PIKfyve 1 item
  416. Bax 1 item
  417. Glycogen Phosphorylases 1 item
  418. MTH1 1 item
  419. PTEN 1 item
  420. Insulin Receptor 1 item
  421. NS3/4a Proteases 1 item
  422. Ca2 -ATPases 1 item
  423. p90 S6K 1 item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 2item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 5item
  7. Acute Myeloid Leukemia 25item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Anesthesia 1 item
  12. Autoimmune Diseases 1 item
  13. Biliary Cancer 1 item
  14. Bladder Cancer 11item
  15. Bladder Carcinoma 4item
  16. Bladder Diseases 2item
  17. B-lymphoid Malignancies 1 item
  18. Brain Injuries Studies 3item
  19. Breast Cancer 113item
  20. Cancer 499item
  21. Candida Peritonitis 1 item
  22. Candidemia 1 item
  23. Castration-resistant Prostate Cancer 1 item
  24. Cervical Cancer 6item
  25. Cholangiocarcinoma 2item
  26. Chronic Lymphocytic Leukemia 8item
  27. Chronic Myeloproliferative Disorders 1 item
  28. Clear Cell Renal Cell Carcinoma 2item
  29. Cocaine-Related Disorders 2item
  30. Colon Cancer 41item
  31. Colon Carcinoma 7item
  32. Colorectal Cancer 40item
  33. Depression 2item
  34. Diabetes 7item
  35. Diffuse Large B-cell Lymphoma 1 item
  36. Dyskinesia 1 item
  37. Dyslipidemia 2item
  38. Epilepsy 4item
  39. Erectile Dysfunction 4item
  40. Friedreich's Ataxia 1 item
  41. Fungal Infection 1 item
  42. Fungi 1 item
  43. Glioblastoma 30item
  44. Glioma 17item
  45. HCV 4item
  46. Heart Failure 3item
  47. Hepatic Cancer 2item
  48. Hepatitis C 4item
  49. Hepatocellular Carcinoma 7item
  50. HIV 13item
  51. HIV Infections 9item
  52. Hypercholesterolemia 3item
  53. Immunological Diseases 1 item
  54. Inflammation 1 item
  55. Inflammatory Bowel Disease 1 item
  56. Inflammatory Diseases 14item
  57. Influenza 3item
  58. Kidney Injury Studies 2item
  59. Leukemia 23item
  60. Liver Cancer 4item
  61. Lung Cancer 38item
  62. Lung Carcinoma 4item
  63. Lymphoma 26item
  64. Mantle Cell Lymphoma 2item
  65. Medulloblastoma 1 item
  66. Melanoma 31item
  67. Mixed Lineage Leukemia 3item
  68. Multiple Myeloma 21item
  69. Myelofibrosis 2item
  70. Myeloma 6item
  71. Neuroblastoma 13item
  72. Neurocognitive Disorders 1 item
  73. Neuronal Protection 1 item
  74. Non-small Cell Lung Cancer 26item
  75. Non-small Cell Lung Carcinoma 2item
  76. Obsessive-Compulsive Disorder 1 item
  77. Osteoporosis 2item
  78. Ovarian Cancer 33item
  79. Pancreatic Cancer 47item
  80. Pancreatic Carcinoma 3item
  81. Prostate Cancer 50item
  82. Psoriasis 4item
  83. Psoriasis Vulgaris 1 item
  84. Pulmonary Arterial Hypertension 2item
  85. Pulmonary Fibrosis 2item
  86. Renal Cancer 4item
  87. Renal Cell Carcinoma 8item
  88. Rheumatoid Arthritis 14item
  89. Sarcoma 1 item
  90. Schizophrenia 7item
  91. Sleep Disorders 1 item
  92. Soft Tissue Sarcoma 1 item
  93. Squamous Cell Carcinoma 2item
  94. Testicular Cancer 2item
  95. Thyroid Cancer 6item
  96. Tuberculosis 1 item
  97. Type 2 Diabetes 12item