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  • Search results for: 'p53 and mdm2 proteins interaction inhibitor chiral'

Search results for: 'p53 and mdm2 proteins interaction inhibitor chiral'

Items 351-360 of 793

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  1. MLN4924
    B1036 MLN4924
     5 Citation
    Target: NAE|Ubiquitin-activating Enzyme E1|SUMOylation
    Summary: NAE inhibitor
      ≥22.18 mg/mL
  2. PF-2545920
    A4325 PF-2545920
    Target: Phosphodiesterases (PDEs)
    Summary: PDE10A inhibitor,potent and selective
      insoluble in H2O; ≥19.35 mg/mL
  3. VX-745
    A8686 VX-745
    Target: p38
    Summary: P38α inhibitor,highly potent and selective
      ≥21.8 mg/mL
  4. Nexturastat A
    B3704 Nexturastat A
    Target: Histone Deacetylases (HDACs)
    Summary: HDAC6 inhibitor,highly potent and selective
      insoluble in H2O; ≥16.3 mg/mL
  5. WWL 70
    A8891 WWL 70
    Summary: α/β-hydrolase domain 6 inhibitor
      insoluble in EtOH; insoluble in H2O; ≥14.45 mg/mL
  6. R428
    A8329 R428
     10 Citation
    Summary: Selective Axl inhibitor
      ≥25 mg/mL
  7. GDC-0879
    A5071 GDC-0879
     1 Citation
    Target: Raf
    Summary: B-Raf inhibitor,potent and selective
      insoluble in EtOH; insoluble in H2O; ≥16.7 mg/mL
  8. MRT67307 HCl
    A3635 MRT67307 HCl
    Target: TBK1|MARK1|NUAK1
    Summary: SIK/TBK-1/IKKe inhibitor
      ≥23.25 mg/mL
  9. Lonafarnib
    A4379 Lonafarnib
    Target: FPTase
    Summary: Ftase inhibitor,potent and selective
      ≥31.95 mg/mL
  10. CP-673451
    B2173 CP-673451
    Target: PDGFR
    Summary: PDGFRα/β inhibitor,potent and selective

Items 351-360 of 793

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Category
  1. Proteases 77item
  2. Apoptosis 43item
  3. Chromatin/Epigenetics 105item
  4. Metabolism 62item
  5. MAPK Signaling 46item
  6. Tyrosine Kinase 114item
  7. DNA Damage/DNA Repair 59item
  8. PI3K/Akt/mTOR Signaling 61item
  9. Microbiology & Virology 27item
  10. Cell Cycle/Checkpoint 75item
  11. Ubiquitination/ Proteasome 33item
  12. JAK/STAT Signaling 33item
  13. TGF-β / Smad Signaling 34item
  14. Angiogenesis 9item
  15. GPCR/G protein 22item
  16. Stem Cell 29item
  17. Membrane Transporter/Ion Channel 30item
  18. Endocrinology and Hormones 7item
  19. Neuroscience 23item
  20. Obesity, Appetite Control & Diabetes 1 item
  21. Other Signal Transduction 2item
  22. Others 62item
  23. Immunology/Inflammation 13item
Reversibility
  1. Reversible 54item
  2. Irreversible 25item
Target
  1. Caspases 10item
  2. Cyclin-Dependent Kinases 26item
  3. Proteasome 11item
  4. Cathepsins 11item
  5. Histone Deacetylases (HDACs) 27item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 6item
  8. Bcl-2 5item
  9. PI3K 26item
  10. CXCR 4item
  11. Raf 10item
  12. Aurora Kinases 14item
  13. Bcl-xl 3item
  14. CSF-1R 2item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. Gap Junctions 1 item
  18. MDM2 2item
  19. EZH2 6item
  20. mTOR 15item
  21. Bromodomains 5item
  22. AP-1 1 item
  23. MMP 8item
  24. Thymidine Phosphorylases 1 item
  25. Androgen Receptors 3item
  26. Peptidylprolyl isomerases 1 item
  27. Acyl coenzyme A: cholesterol acyltransferases 1 item
  28. Myosin II ATPases 1 item
  29. DT-diaphorases 1 item
  30. MER 1 item
  31. FLT3 12item
  32. GSK-3 9item
  33. Factor Xa 3item
  34. P-glycoprotein (P-gp) 5item
  35. PLK 7item
  36. Chk 8item
  37. ULK1 1 item
  38. Eph Receptors 3item
  39. VEGFR 25item
  40. PDGFR 19item
  41. c-Kit 7item
  42. RET 3item
  43. IRAK 3item
  44. Bromodomain-containing proteins(BRDs) 1 item
  45. Phosphodiesterases (PDEs) 10item
  46. Mcl-1 5item
  47. Hydrolase 1 item
  48. Thymidylate Synthase 2item
  49. p38 9item
  50. PKB 1 item
  51. 3-phosphoglycerate dehydrogenase 1 item
  52. JNK 6item
  53. SGK 2item
  54. Bcr-Abl 10item
  55. Kynurenine-3-monooxygenase 1 item
  56. MEK 15item
  57. PORCN 1 item
  58. DOT1L 3item
  59. FGFR 9item
  60. Nrf2 1 item
  61. Insulin-like growth factor receptors(IGFRs) 1 item
  62. Pim 4item
  63. Sir2-like Family Deacetylases (Sirtuins) 2item
  64. Deubiquitinating enzymes (DUBs) 4item
  65. PP1 1 item
  66. PP2A 1 item
  67. Smoothened 4item
  68. Ribosomal s6 kinases (RSK) 1 item
  69. Neuraminidases (NA) 1 item
  70. MET 7item
  71. Src 9item
  72. Trk Receptors 5item
  73. Integrins 1 item
  74. Aminopeptidases 2item
  75. STAT 5item
  76. ATP Citrate Lyases 1 item
  77. Microtubules/Tubulins 4item
  78. EGFR 15item
  79. Hedgehog 1 item
  80. Reverse Transcriptases 1 item
  81. ROCK 7item
  82. BTK 2item
  83. RIP kinases 1 item
  84. PAK 3item
  85. Hypoxia Inducible Factors (HIFs) 2item
  86. Tankyrases 1 item
  87. Inositol Phosphatases 1 item
  88. FAK 5item
  89. BMP and Other Activin Receptors 4item
  90. JAK 13item
  91. p300 1 item
  92. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  93. Syk 7item
  94. EZH1 2item
  95. DNA-PK 6item
  96. HSP90 10item
  97. AMPK 2item
  98. Gutathione S-transferase 1 item
  99. PDHK 1 item
  100. Angiotensin AT2 Receptors 1 item
  101. eIF4E/eIF3G interaction 1 item
  102. Notch 1 item
  103. S-nitrosoglutathione reductase 1 item
  104. CFTR 4item
  105. TNKS 1 item
  106. Topoisomerases 7item
  107. Cytochrome P450 (CYP450) 5item
  108. thrombin 1 item
  109. Ksp 1 item
  110. Ribosomes 1 item
  111. Renin 2item
  112. HIV proteases 1 item
  113. Pepsins 1 item
  114. Influenza viruses 1 item
  115. ErbB 2item
  116. Ferroptosis 1 item
  117. S6 kinases 1 item
  118. Toll-like receptors (TLRs) 2item
  119. Adenosine Kinases 2item
  120. Actin 1 item
  121. DNA Methyltransferases 3item
  122. Survivin 1 item
  123. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  124. ERK 5item
  125. HMG-CoA Reductases 5item
  126. Vacuolar-type ATPase 1 item
  127. c-MET 8item
  128. BMI-1 1 item
  129. PKC 6item
  130. Calpains 5item
  131. Ubiquitin-specific proteases 1 item
  132. HCV Proteases 3item
  133. Ca2 /calmodulin-dependent protein kinases (CaMKs) 7item
  134. MLK3 1 item
  135. SMYD2 1 item
  136. CREBBP 2item
  137. EP300 2item
  138. Lyn 1 item
  139. SGLT 1 item
  140. RAD51 1 item
  141. Trypsins 1 item
  142. HER2 2item
  143. Pyk2 3item
  144. USP 2item
  145. 5-HT2 Receptors 4item
  146. LRRK2 4item
  147. DGAT 2item
  148. Insulin and Insulin-like Receptors 3item
  149. PARP 4item
  150. Melanocortin (MC) Receptors 1 item
  151. Pyruvate dehydrogenases (PDH) 1 item
  152. ALK 5item
  153. ROS1 2item
  154. Sphingosine kinases (SphKs) 2item
  155. Trypsin 1 item
  156. Chymotrypsin 1 item
  157. Kallikrein 1 item
  158. Trypsinogen 1 item
  159. KRAS G12C 1 item
  160. GTPases 1 item
  161. Monocarboxylate transporters (MCTs) 1 item
  162. CETP 2item
  163. Dehydrogenase 1 item
  164. PKG 1 item
  165. PKA 1 item
  166. Myosin light chain kinases (MLCKs) 2item
  167. HIV-1 gp120 1 item
  168. D1 and D5 Receptors 1 item
  169. D2 Receptors 3item
  170. D3 Receptors 2item
  171. 5-HT1 Receptors 2item
  172. 5-HT7 Receptors 1 item
  173. CaM-KK 1 item
  174. Valosin-containing protein (VCP) 1 item
  175. MELK 1 item
  176. Serotonin reuptake 1 item
  177. Insulin-like growth factors (IGFs) 1 item
  178. Clk 1 item
  179. TBK1 1 item
  180. MARK1 1 item
  181. NUAK1 2item
  182. Integrin-ligand interactions 1 item
  183. CSF1R 1 item
  184. Bromodomain and Extra-Terminal motif (BET) 1 item
  185. NUAK2 1 item
  186. Na /H Exchangers (NHEs) 1 item
  187. Lactate Dehydrogenases (LDH) 2item
  188. MK2 3item
  189. Fatty-acid-binding proteins (FABPs) 1 item
  190. Angiotensin-Converting Enzymes (ACEs) 2item
  191. Tie-2 4item
  192. RSK 2item
  193. p70 S6K 1 item
  194. Free Fatty Acid Receptors 2item
  195. phosphatases 1 item
  196. Autophagy 2item
  197. ATM/ATR 7item
  198. Mixed lineage kinase domain-like protein (MLKL) 1 item
  199. COX 6item
  200. Heparanases 1 item
  201. CK1 1 item
  202. IDH2 1 item
  203. Farnesyl Diphosphate Synthases 1 item
  204. CK2 3item
  205. HIPK2 1 item
  206. HIPK3 1 item
  207. HIV Integrases 1 item
  208. Cryptochromes 1 item
  209. Squalene epoxidases 2item
  210. PRAK 1 item
  211. MAPKAP-K2 1 item
  212. Delayed rectifier outward potassium current (IKr) 1 item
  213. 20S proteasomal chymotrypsin 1 item
  214. Geranylgeranyltransferase I 1 item
  215. Farnesyltransferase 1 item
  216. NAT10 1 item
  217. Nampt 2item
  218. eIF4F 1 item
  219. Cdc42 1 item
  220. SRPK1 1 item
  221. P2X Receptors 1 item
  222. Glutaminases 1 item
  223. Carbonic Anhydrases 5item
  224. Ron 1 item
  225. AP endonucleases 1 item
  226. G9a 2item
  227. BLM 1 item
  228. HSV 2item
  229. NADPH Oxidases 2item
  230. Calcium-activated chloride channels (CaCC) 1 item
  231. GPR35 1 item
  232. Aldehyde Dehydrogenases 1 item
  233. Synthases/Synthetases 3item
  234. c-Fyn 1 item
  235. TAK1 1 item
  236. Histamine H1 Receptors 1 item
  237. Na /K ATPases 2item
  238. P110 1 item
  239. Hck 1 item
  240. Inositol-requiring enzyme 1 (IRE1) 1 item
  241. SETD7 1 item
  242. Na /K /Cl- Symporters (NKCCs) 1 item
  243. GABAA Receptors 1 item
  244. Phospholipases 1 item
  245. RNA Polymerases 1 item
  246. Norepinephrine transporter 1 item
  247. 5-HT Transporters 3item
  248. Xanthine oxidoreductases 1 item
  249. Dihydroorotate dehydrogenase 1 item
  250. FoxM1 1 item
  251. Apoptosis Inducers 1 item
  252. MNK 1 item
  253. NO Donors / Precursors 1 item
  254. HIV-1 reverse transcriptase 1 item
  255. IL Receptors 2item
  256. CCL2 1 item
  257. Norepinephrine transporters 1 item
  258. Calcium-Activated Potassium (KCa) Channels 1 item
  259. AChE 2item
  260. Insulin Receptors 1 item
  261. IRG-1R 1 item
  262. Proton Pump 1 item
  263. cAMP 1 item
  264. Sulfonylurea receptors 1 item
  265. eEF-2 1 item
  266. Inward Rectifier Potassium (Kir) Channels 2item
  267. Arp2/3 complex 1 item
  268. Cdc7 1 item
  269. CMV 1 item
  270. ZAP-70 1 item
  271. Catechol O-Methyltransferase (COMT) 2item
  272. fibrinolysis 1 item
  273. D4 Receptors 1 item
  274. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  275. HBV Proteases 1 item
  276. Flk-1 1 item
  277. Papains 1 item
  278. Protein Arginine Methyltransferases 1 item
  279. IMPDH 1 item
  280. Na /Ca2 Exchangers (NCXs) 1 item
  281. NAE 2item
  282. Ubiquitin-activating Enzyme E1 1 item
  283. SUMOylation 1 item
  284. ATGL 1 item
  285. BACE 1 item
  286. Cytidine deaminases 1 item
  287. GPR40 1 item
  288. angiogenesis 1 item
  289. Glucagon Receptors 1 item
  290. 15-PGDH 1 item
  291. DPP-4 4item
  292. PP4 1 item
  293. c-RET 1 item
  294. Nonstructural protein 5B (NS5B) 1 item
  295. p70 rsk 1 item
  296. FPTase 1 item
  297. ADAMs 1 item
  298. TAM kinase 1 item
  299. p53-MDM2 interaction 1 item
  300. nuclear export 1 item
  301. CRM1 1 item
  302. AXL 1 item
  303. Protein polybromo-1 1 item
  304. SMARCA4 1 item
  305. SMARCA2 1 item
  306. Dipeptidyl-peptidase II 1 item
  307. HDAC 1 item
  308. c-Fms tyrosine kinase 1 item
  309. human lyase 1 item
  310. Ub-conjugating enzyme (E2) complex 1 item
  311. STK 1 item
  312. IKK 1 item
  313. MSK 1 item
  314. HCV polymerase 2item
  315. Ftase 1 item
  316. PC-PLC 1 item
  317. Elastases 1 item
  318. P97 ATPase 1 item
  319. NTPDases 1 item
  320. telomerase 1 item
  321. Histone Acetyltransferases (HATs) 1 item
  322. F1 Fo-ATPase 1 item
  323. ITK 1 item
  324. NOD1 1 item
  325. NUAK 1 item
  326. DCLK2 1 item
  327. FAAH 1 item
  328. TYK2 1 item
  329. Lck 1 item
  330. Aromatases 1 item
  331. PKD 1 item
  332. SHIP 1 item
  333. MCL1 1 item
  334. Bcl-w 1 item
  335. tropomyosin receptor kinase 1 item
  336. LSD 1 item
  337. PRMT 1 item
  338. GLP 1 item
  339. SK 1 item
  340. MST 1 item
  341. IDO 1 item
  342. Serotonin (5-HT) reuptake 1 item
  343. Androgen Receptor 1 item
  344. Substance P/NK1 Receptor 1 item
  345. gp120/CD4 1 item
  346. ATM 2item
  347. Sirtuin 1 item
  348. NE 1 item
  349. PIKfyve 1 item
  350. Glycogen Phosphorylases 1 item
  351. MTH1 1 item
  352. Insulin Receptor 1 item
Reported Experiments
  1. Animal Experiments 675item
  2. Cell Experiments 460item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 1 item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 6item
  7. Acute Myeloid Leukemia 26item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Biliary Cancer 1 item
  13. Bladder Cancer 10item
  14. Bladder Carcinoma 4item
  15. Bladder Diseases 2item
  16. B-lymphoid Malignancies 1 item
  17. Brain Injuries Studies 3item
  18. Breast Cancer 115item
  19. Cancer 429item
  20. Candida Peritonitis 1 item
  21. Candidemia 1 item
  22. Castration-resistant Prostate Cancer 1 item
  23. Cervical Cancer 5item
  24. Cholangiocarcinoma 2item
  25. Chronic Lymphocytic Leukemia 8item
  26. Chronic Myeloproliferative Disorders 1 item
  27. Clear Cell Renal Cell Carcinoma 2item
  28. Cocaine-Related Disorders 2item
  29. Colon Cancer 46item
  30. Colon Carcinoma 7item
  31. Colorectal Cancer 42item
  32. Depression 2item
  33. Diabetes 8item
  34. Diffuse Large B-cell Lymphoma 1 item
  35. Dyskinesia 1 item
  36. Dyslipidemia 2item
  37. Epilepsy 2item
  38. Erectile Dysfunction 3item
  39. Friedreich's Ataxia 1 item
  40. Fungal Infection 1 item
  41. Glioblastoma 32item
  42. Glioma 18item
  43. HCV 3item
  44. Heart Failure 1 item
  45. Hepatic Cancer 2item
  46. Hepatitis C 3item
  47. Hepatocellular Carcinoma 7item
  48. HIV 4item
  49. HIV Infections 9item
  50. Hypercholesterolemia 2item
  51. Immunological Diseases 1 item
  52. Inflammation 1 item
  53. Inflammatory Bowel Disease 1 item
  54. Inflammatory Diseases 13item
  55. Influenza 2item
  56. Kidney Injury Studies 1 item
  57. Leukemia 22item
  58. Liver Cancer 4item
  59. Lung Cancer 43item
  60. Lung Carcinoma 4item
  61. Lymphoma 29item
  62. Mantle Cell Lymphoma 2item
  63. Medulloblastoma 1 item
  64. Melanoma 34item
  65. Mixed Lineage Leukemia 3item
  66. Multiple Myeloma 23item
  67. Myelofibrosis 2item
  68. Myeloma 6item
  69. Neuroblastoma 13item
  70. Neurocognitive Disorders 1 item
  71. Neuronal Protection 1 item
  72. Non-small Cell Lung Cancer 26item
  73. Non-small Cell Lung Carcinoma 2item
  74. Obsessive-Compulsive Disorder 1 item
  75. Osteoporosis 2item
  76. Ovarian Cancer 34item
  77. Pancreatic Cancer 48item
  78. Pancreatic Carcinoma 3item
  79. Prostate Cancer 54item
  80. Psoriasis 4item
  81. Psoriasis Vulgaris 1 item
  82. Pulmonary Arterial Hypertension 2item
  83. Pulmonary Fibrosis 2item
  84. Renal Cancer 4item
  85. Renal Cell Carcinoma 8item
  86. Rheumatoid Arthritis 14item
  87. Sarcoma 1 item
  88. Schizophrenia 6item
  89. Sleep Disorders 1 item
  90. Soft Tissue Sarcoma 1 item
  91. Squamous Cell Carcinoma 2item
  92. Testicular Cancer 2item
  93. Thyroid Cancer 6item
  94. Type 2 Diabetes 12item