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  • Search results for: 'p53 and mdm2 proteins interaction inhibitor chiral'

Search results for: 'p53 and mdm2 proteins interaction inhibitor chiral'

Items 341-350 of 826

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  1. Dabrafenib (GSK2118436)
    B1407 Dabrafenib (GSK2118436)
     3 Citation
    Target: Raf
    Summary: Inhibitor of BRAF(V600) mutants
      ≥26 mg/mL
  2. SL-327
    A1894 SL-327
     1 Citation
    Target: MEK
    Summary: Selective MEK1/2 inhibitor
      insoluble in H2O; insoluble in EtOH; ≥16.75 mg/mL
  3. Fluvoxamine
    B1205 Fluvoxamine
    Target: Serotonin reuptake
    Summary: Selective serotonin reuptake inhibitor
      insoluble in H2O; ≥15.92 mg/mL
  4. PF-03814735
    A4128 PF-03814735
    Target: Aurora Kinases
    Summary: Aurora A/B inhibitor
      Soluble in DMSO
  5. Otamixaban
    A3690 Otamixaban
    Target: Factor Xa
    Summary: Direct factor Xa inhibitors,potent and selective
      ≥22.35 mg/mL
  6. Everolimus (RAD001)
    A8169 Everolimus (RAD001)
     8 Citation
    Target: mTOR
    Summary: MTOR inhibitor
      ≥47.91 mg/mL
  7. Raltitrexed
    B1476 Raltitrexed
    Target: Thymidylate Synthase
    Summary: Thymidylate synthase inhibitor
      insoluble in H2O; ≥154 mg/mL
  8. AZ 10417808
    A4416 AZ 10417808
    Target: Caspases
    Summary: Caspase-3 inhibitor,selective non-peptide
      <10.86 mg/mL
  9. BMS-626529
    A3253 BMS-626529
     2 Citation
    Target: HIV-1 gp120
    Summary: HIV-1 attachment inhibitor
      insoluble in H2O; insoluble in EtOH; ≥1.48 mg/mL
  10. GNE0877
    B4633 GNE0877
    Target: LRRK2
    Summary: Potent and selective LRRK2 inhibitor
      ≥21 mg/mL

Items 341-350 of 826

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Category
  1. Signaling Pathways 793item
  2. Natural Products 2item
  3. Kits 1 item
  4. Peptides 4item
  5. Peptides & Proteins 1 item
  6. Lab Reagents 3item
Reversibility
  1. Reversible 54item
  2. Irreversible 26item
Target
  1. Caspases 11item
  2. Cyclin-Dependent Kinases 26item
  3. Proteasome 11item
  4. Cathepsins 11item
  5. Histone Deacetylases (HDACs) 28item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 6item
  8. Bcl-2 5item
  9. PI3K 26item
  10. CXCR 4item
  11. Raf 10item
  12. Aurora Kinases 14item
  13. Bcl-xl 3item
  14. CSF-1R 2item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. Gap Junctions 1 item
  18. MDM2 2item
  19. EZH2 6item
  20. mTOR 15item
  21. Bromodomains 5item
  22. AP-1 1 item
  23. MMP 8item
  24. Thymidine Phosphorylases 1 item
  25. Androgen Receptors 3item
  26. Peptidylprolyl isomerases 1 item
  27. Acyl coenzyme A: cholesterol acyltransferases 1 item
  28. Myosin II ATPases 1 item
  29. DT-diaphorases 1 item
  30. Voltage-gated Potassium (KV) Channels 1 item
  31. MER 1 item
  32. FLT3 12item
  33. GSK-3 9item
  34. Factor Xa 3item
  35. P-glycoprotein (P-gp) 5item
  36. PLK 7item
  37. Chk 8item
  38. ULK1 1 item
  39. Eph Receptors 3item
  40. VEGFR 25item
  41. PDGFR 19item
  42. c-Kit 7item
  43. RET 3item
  44. IRAK 3item
  45. Bromodomain-containing proteins(BRDs) 1 item
  46. Phosphodiesterases (PDEs) 10item
  47. Mcl-1 5item
  48. Hydrolase 1 item
  49. Thymidylate Synthase 2item
  50. p38 9item
  51. PKB 1 item
  52. 3-phosphoglycerate dehydrogenase 1 item
  53. JNK 6item
  54. SGK 2item
  55. Bcr-Abl 10item
  56. Kynurenine-3-monooxygenase 1 item
  57. MEK 15item
  58. PORCN 1 item
  59. DOT1L 3item
  60. FGFR 9item
  61. Nrf2 1 item
  62. Insulin-like growth factor receptors(IGFRs) 1 item
  63. Pim 5item
  64. Sir2-like Family Deacetylases (Sirtuins) 2item
  65. Deubiquitinating enzymes (DUBs) 4item
  66. PP1 1 item
  67. PP2A 1 item
  68. Smoothened 4item
  69. Ribosomal s6 kinases (RSK) 1 item
  70. Neuraminidases (NA) 1 item
  71. MET 7item
  72. Src 9item
  73. Trk Receptors 6item
  74. Integrins 1 item
  75. Aminopeptidases 2item
  76. STAT 7item
  77. ATP Citrate Lyases 1 item
  78. Microtubules/Tubulins 4item
  79. EGFR 15item
  80. Hedgehog 1 item
  81. Reverse Transcriptases 1 item
  82. ROCK 7item
  83. BTK 2item
  84. RIP kinases 1 item
  85. Monocyte chemotactic proteins 1 item
  86. PAK 3item
  87. Hypoxia Inducible Factors (HIFs) 2item
  88. Tankyrases 1 item
  89. Inositol Phosphatases 1 item
  90. FAK 5item
  91. BMP and Other Activin Receptors 4item
  92. JAK 13item
  93. p300 1 item
  94. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  95. Syk 7item
  96. EZH1 2item
  97. DNA-PK 6item
  98. HSP90 10item
  99. AMPK 2item
  100. Gutathione S-transferase 1 item
  101. PDHK 1 item
  102. Angiotensin AT2 Receptors 1 item
  103. eIF4E/eIF3G interaction 1 item
  104. Notch 1 item
  105. S-nitrosoglutathione reductase 1 item
  106. CFTR 4item
  107. TNKS 1 item
  108. Topoisomerases 8item
  109. Cytochrome P450 (CYP450) 5item
  110. thrombin 1 item
  111. Ksp 1 item
  112. Ribosomes 1 item
  113. Renin 2item
  114. HIV proteases 1 item
  115. Pepsins 1 item
  116. Influenza viruses 1 item
  117. ErbB 2item
  118. Ferroptosis 1 item
  119. S6 kinases 1 item
  120. Toll-like receptors (TLRs) 2item
  121. Adenosine Kinases 2item
  122. Actin 1 item
  123. DNA Methyltransferases 3item
  124. Survivin 1 item
  125. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  126. ERK 5item
  127. HMG-CoA Reductases 5item
  128. Vacuolar-type ATPase 1 item
  129. c-MET 8item
  130. BMI-1 1 item
  131. PKC 7item
  132. Calpains 6item
  133. Ubiquitin-specific proteases 1 item
  134. HCV Proteases 3item
  135. Ca2 /calmodulin-dependent protein kinases (CaMKs) 7item
  136. MLK3 1 item
  137. SMYD2 1 item
  138. O-GlcNAcase 1 item
  139. CREBBP 2item
  140. EP300 2item
  141. Lyn 1 item
  142. SGLT 1 item
  143. RAD51 1 item
  144. Trypsins 1 item
  145. HER2 2item
  146. Pyk2 3item
  147. USP 3item
  148. 5-HT2 Receptors 4item
  149. LRRK2 4item
  150. Voltage-gated Calcium Channels (CaV) 1 item
  151. DGAT 2item
  152. Insulin and Insulin-like Receptors 3item
  153. PARP 5item
  154. CB1 Receptors 1 item
  155. Melanocortin (MC) Receptors 1 item
  156. Pyruvate dehydrogenases (PDH) 1 item
  157. ALK 5item
  158. ROS1 2item
  159. Sphingosine kinases (SphKs) 2item
  160. Trypsin 1 item
  161. Chymotrypsin 1 item
  162. Kallikrein 1 item
  163. Trypsinogen 1 item
  164. KRAS G12C 1 item
  165. GTPases 1 item
  166. Monocarboxylate transporters (MCTs) 1 item
  167. CETP 2item
  168. Dehydrogenase 1 item
  169. PKG 1 item
  170. PKA 1 item
  171. Myosin light chain kinases (MLCKs) 2item
  172. HIV-1 gp120 1 item
  173. D1 and D5 Receptors 1 item
  174. D2 Receptors 3item
  175. D3 Receptors 2item
  176. 5-HT1 Receptors 2item
  177. 5-HT7 Receptors 1 item
  178. CaM-KK 1 item
  179. Valosin-containing protein (VCP) 1 item
  180. MELK 1 item
  181. Serotonin reuptake 1 item
  182. Insulin-like growth factors (IGFs) 1 item
  183. Clk 1 item
  184. TBK1 1 item
  185. MARK1 1 item
  186. NUAK1 2item
  187. Integrin-ligand interactions 1 item
  188. CSF1R 1 item
  189. Bromodomain and Extra-Terminal motif (BET) 1 item
  190. NUAK2 1 item
  191. Na /H Exchangers (NHEs) 1 item
  192. Lactate Dehydrogenases (LDH) 2item
  193. MK2 3item
  194. Fatty-acid-binding proteins (FABPs) 1 item
  195. Angiotensin-Converting Enzymes (ACEs) 4item
  196. Tie-2 4item
  197. RSK 2item
  198. p70 S6K 1 item
  199. Granzyme B 1 item
  200. Free Fatty Acid Receptors 2item
  201. phosphatases 1 item
  202. Autophagy 2item
  203. ATM/ATR 7item
  204. Mixed lineage kinase domain-like protein (MLKL) 1 item
  205. COX 6item
  206. Heparanases 1 item
  207. CK1 1 item
  208. IDH2 1 item
  209. Farnesyl Diphosphate Synthases 1 item
  210. CK2 3item
  211. HIPK2 1 item
  212. HIPK3 1 item
  213. HIV Integrases 2item
  214. Cryptochromes 1 item
  215. Squalene epoxidases 2item
  216. PRAK 1 item
  217. MAPKAP-K2 1 item
  218. Delayed rectifier outward potassium current (IKr) 1 item
  219. GpIIb/IIIa receptor 1 item
  220. Guanine nucleotide exchange factors (GEFs) 1 item
  221. 20S proteasomal chymotrypsin 1 item
  222. Geranylgeranyltransferase I 1 item
  223. Farnesyltransferase 1 item
  224. NAT10 1 item
  225. Nampt 2item
  226. eIF4F 1 item
  227. Cdc42 1 item
  228. SRPK1 1 item
  229. P2X Receptors 1 item
  230. Glutaminases 1 item
  231. Carbonic Anhydrases 6item
  232. Ron 1 item
  233. AP endonucleases 1 item
  234. G9a 2item
  235. BLM 1 item
  236. HSV 2item
  237. NADPH Oxidases 2item
  238. Calcium-activated chloride channels (CaCC) 1 item
  239. GPR35 1 item
  240. Aldehyde Dehydrogenases 1 item
  241. Synthases/Synthetases 3item
  242. MAGL 1 item
  243. c-Fyn 1 item
  244. TAK1 1 item
  245. Histamine H1 Receptors 1 item
  246. Na /K ATPases 2item
  247. P110 1 item
  248. Hck 1 item
  249. Inositol-requiring enzyme 1 (IRE1) 2item
  250. SETD7 1 item
  251. Na /K /Cl- Symporters (NKCCs) 1 item
  252. GABAA Receptors 1 item
  253. Phospholipases 1 item
  254. Organic anion transporters (OATs) 1 item
  255. TRP Channel 1 item
  256. RNA Polymerases 1 item
  257. DYRK 1 item
  258. Norepinephrine transporter 1 item
  259. 5-HT Transporters 3item
  260. Xanthine oxidoreductases 1 item
  261. Dihydroorotate dehydrogenase 1 item
  262. FoxM1 1 item
  263. Histone Demethylases 1 item
  264. Apoptosis Inducers 1 item
  265. MNK 1 item
  266. NO Donors / Precursors 2item
  267. CB2 Receptors 1 item
  268. HIV-1 reverse transcriptase 1 item
  269. IL Receptors 2item
  270. CCL2 1 item
  271. Noradrenaline reuptake 1 item
  272. Norepinephrine transporters 1 item
  273. Calcium-Activated Potassium (KCa) Channels 1 item
  274. AChE 2item
  275. Insulin Receptors 1 item
  276. IRG-1R 1 item
  277. Proton Pump 1 item
  278. cAMP 1 item
  279. Sulfonylurea receptors 1 item
  280. Cdc2-like kinase (Clk) 1 item
  281. eEF-2 1 item
  282. Inward Rectifier Potassium (Kir) Channels 2item
  283. Arp2/3 complex 1 item
  284. Cdc7 1 item
  285. CMV 1 item
  286. ZAP-70 1 item
  287. Catechol O-Methyltransferase (COMT) 2item
  288. fibrinolysis 1 item
  289. D4 Receptors 1 item
  290. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  291. HBV Proteases 1 item
  292. Flk-1 1 item
  293. Papains 1 item
  294. Protein Arginine Methyltransferases 1 item
  295. IMPDH 1 item
  296. Na /Ca2 Exchangers (NCXs) 1 item
  297. NAE 2item
  298. Ubiquitin-activating Enzyme E1 1 item
  299. SUMOylation 1 item
  300. ATGL 1 item
  301. BACE 1 item
  302. Cytidine deaminases 1 item
  303. GPR40 1 item
  304. angiogenesis 1 item
  305. Glucagon Receptors 1 item
  306. 15-PGDH 1 item
  307. DPP-4 4item
  308. PP4 1 item
  309. c-RET 1 item
  310. Nonstructural protein 5B (NS5B) 1 item
  311. p70 rsk 1 item
  312. FPTase 1 item
  313. ADAMs 1 item
  314. TAM kinase 1 item
  315. p53-MDM2 interaction 1 item
  316. nuclear export 1 item
  317. CRM1 1 item
  318. AXL 1 item
  319. Protein polybromo-1 1 item
  320. SMARCA4 1 item
  321. SMARCA2 1 item
  322. Dipeptidyl-peptidase II 1 item
  323. HDAC 1 item
  324. c-Fms tyrosine kinase 1 item
  325. human lyase 1 item
  326. Ub-conjugating enzyme (E2) complex 1 item
  327. STK 1 item
  328. IKK 1 item
  329. MSK 1 item
  330. HCV polymerase 2item
  331. Ftase 1 item
  332. PC-PLC 1 item
  333. Elastases 1 item
  334. P97 ATPase 1 item
  335. NTPDases 1 item
  336. telomerase 1 item
  337. Histone Acetyltransferases (HATs) 1 item
  338. F1 Fo-ATPase 1 item
  339. ITK 1 item
  340. NOD1 1 item
  341. NUAK 1 item
  342. DCLK2 1 item
  343. FAAH 1 item
  344. TYK2 1 item
  345. Lck 1 item
  346. Aromatases 1 item
  347. PKD 1 item
  348. SHIP 1 item
  349. MCL1 1 item
  350. Bcl-w 1 item
  351. tropomyosin receptor kinase 1 item
  352. LSD 1 item
  353. PRMT 1 item
  354. GLP 1 item
  355. SK 1 item
  356. MST 1 item
  357. IDO 1 item
  358. Serotonin (5-HT) reuptake 1 item
  359. Androgen Receptor 1 item
  360. Substance P/NK1 Receptor 1 item
  361. gp120/CD4 1 item
  362. ATM 2item
  363. Sirtuin 1 item
  364. NE 1 item
  365. PIKfyve 1 item
  366. Glycogen Phosphorylases 1 item
  367. RGS 1 item
  368. MTH1 1 item
  369. Insulin Receptor 1 item
Reported Experiments
  1. Animal Experiments 695item
  2. Cell Experiments 478item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 1 item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 6item
  7. Acute Myeloid Leukemia 26item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Biliary Cancer 1 item
  13. Bladder Cancer 10item
  14. Bladder Carcinoma 4item
  15. Bladder Diseases 2item
  16. B-lymphoid Malignancies 1 item
  17. Brain Injuries Studies 3item
  18. Breast Cancer 118item
  19. Cancer 437item
  20. Candida Peritonitis 1 item
  21. Candidemia 1 item
  22. Castration-resistant Prostate Cancer 1 item
  23. Cervical Cancer 5item
  24. Cholangiocarcinoma 2item
  25. Chronic Lymphocytic Leukemia 8item
  26. Chronic Myeloproliferative Disorders 1 item
  27. Clear Cell Renal Cell Carcinoma 2item
  28. Cocaine-Related Disorders 2item
  29. Colon Cancer 47item
  30. Colon Carcinoma 7item
  31. Colorectal Cancer 42item
  32. Depression 2item
  33. Diabetes 8item
  34. Diffuse Large B-cell Lymphoma 1 item
  35. Dyskinesia 1 item
  36. Dyslipidemia 2item
  37. Epilepsy 2item
  38. Erectile Dysfunction 3item
  39. Friedreich's Ataxia 2item
  40. Fungal Infection 1 item
  41. Glioblastoma 32item
  42. Glioma 18item
  43. HCV 3item
  44. Heart Failure 1 item
  45. Hepatic Cancer 2item
  46. Hepatitis C 3item
  47. Hepatocellular Carcinoma 7item
  48. HIV 4item
  49. HIV Infections 9item
  50. Hypercholesterolemia 2item
  51. Immunological Diseases 1 item
  52. Inflammation 1 item
  53. Inflammatory Bowel Disease 1 item
  54. Inflammatory Diseases 14item
  55. Influenza 2item
  56. Kidney Injury Studies 1 item
  57. Leukemia 23item
  58. Liver Cancer 4item
  59. Lung Cancer 45item
  60. Lung Carcinoma 4item
  61. Lymphoma 31item
  62. Mantle Cell Lymphoma 2item
  63. Medulloblastoma 1 item
  64. Melanoma 34item
  65. Mixed Lineage Leukemia 3item
  66. Multiple Myeloma 24item
  67. Myelofibrosis 2item
  68. Myeloma 6item
  69. Neuroblastoma 13item
  70. Neurocognitive Disorders 1 item
  71. Neuronal Protection 1 item
  72. Non-small Cell Lung Cancer 26item
  73. Non-small Cell Lung Carcinoma 2item
  74. Obsessive-Compulsive Disorder 1 item
  75. Osteoporosis 2item
  76. Ovarian Cancer 35item
  77. Pancreatic Cancer 50item
  78. Pancreatic Carcinoma 3item
  79. Prostate Cancer 55item
  80. Psoriasis 4item
  81. Psoriasis Vulgaris 1 item
  82. Pulmonary Arterial Hypertension 2item
  83. Pulmonary Fibrosis 2item
  84. Renal Cancer 4item
  85. Renal Cell Carcinoma 8item
  86. Rheumatoid Arthritis 14item
  87. Sarcoma 1 item
  88. Schizophrenia 7item
  89. Sleep Disorders 2item
  90. Soft Tissue Sarcoma 1 item
  91. Squamous Cell Carcinoma 2item
  92. Testicular Cancer 2item
  93. Thyroid Cancer 6item
  94. Type 2 Diabetes 13item