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  • Search results for: 'p53 and mdm2 proteins interaction inhibitor chiral'

Search results for: 'p53 and mdm2 proteins interaction inhibitor chiral'

Items 541-550 of 553

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  1. Amitriptyline HCl
    B2231 Amitriptyline HCl
    Target: Trk Receptors|5-HT2 Receptors|Norepinephrine transporter|5-HT Transporters
    Summary: Serotonin /norepinephrine receptor/5-HT4/5-HT2 inhibitor
      ≥15.69 mg/mL
  2. TP-0903
    B5940 TP-0903
    Target: AXL
    Summary: AXL receptor tyrosine kinase inhibitor, anti-cancer agent
      ≥25.8 mg/mL
  3. AZD8186
    B5950 AZD8186
    Target: PI3K
    Summary: Potent and selective inhibitor of PI3Kβ and PI3Kδ
      insoluble in H2O; insoluble in EtOH; ≥45.7 mg/mL
  4. Reversine
    A3760 Reversine
    Target: Aurora Kinases
    Summary: A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor
      insoluble in H2O; ≥19.65 mg/mL
  5. Ketoconazole
    A4316 Ketoconazole
    Target: Cytochrome P450 (CYP450)
    Summary: Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase
      ≥23.4 mg/mL
  6. LY3023414
    B6099 LY3023414
    Target: Akt|PI3K|mTOR|DNA-PK
    Summary: class I PI3K isoforms, mTOR and DNA-PK inhibitor
      ≥40.6 mg/mL
  7. Fruquintinib(HMPL-013)
    B5864 Fruquintinib(HMPL-013)
    Target: VEGFR
    Summary: Potent and selective inhibitor of VEGFR 1, 2, 3
      insoluble in H2O; insoluble in EtOH; ≥6.35 mg/mL
  8. EW-7197
    B5946 EW-7197
     1 Citation
    Target: BMP and Other Activin Receptors
    Summary: Selective inhibitor of TGF-β type I receptor kinase
      ≥39.9 mg/mL
  9. Pexmetinib (ARRY-614)
    B6012 Pexmetinib (ARRY-614)
    Target: p38|Tie-2
    Summary: dual inhibitor of p38 MAPK and Tie2/Tek receptor tyrosine kinase
      insoluble in H2O; ≥107.6 mg/mL
  10. Dovitinib (TKI258) Lactate
    B5953 Dovitinib (TKI258) Lactate
    Target: CSF-1R|FLT3|VEGFR|PDGFR|c-Kit|FGFR
    Summary: Oral tyrosine kinase inhibitor (TKI) against FGFR1–3, VEGFR1–3, and platelet-derived growth factor receptor (PDGFR).
      insoluble in EtOH; ≥10.62 mg/mL

Items 541-550 of 553

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Category
  1. Signaling Pathways 541item
  2. Natural Products 1 item
  3. Lab Reagents 1 item
Specificity
  1. Selective 437item
  2. Non-Selective 2item
Reversibility
  1. Reversible 28item
  2. Irreversible 22item
Target
  1. Caspases 3item
  2. Cyclin-Dependent Kinases 25item
  3. Proteasome 9item
  4. Cathepsins 2item
  5. Histone Deacetylases (HDACs) 25item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 11item
  8. Bcl-2 7item
  9. PI3K 26item
  10. CXCR 2item
  11. Raf 11item
  12. Aurora Kinases 18item
  13. Bcl-xl 2item
  14. CSF-1R 4item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. MDM2 2item
  18. EZH2 5item
  19. mTOR 15item
  20. Bromodomains 5item
  21. MMP 3item
  22. Thymidine Phosphorylases 1 item
  23. Androgen Receptors 3item
  24. DT-diaphorases 1 item
  25. FLT3 12item
  26. GSK-3 5item
  27. P-glycoprotein (P-gp) 5item
  28. PLK 9item
  29. Chk 5item
  30. ULK1 1 item
  31. Eph Receptors 3item
  32. VEGFR 36item
  33. PDGFR 21item
  34. c-Kit 10item
  35. RET 4item
  36. Bromodomain-containing proteins(BRDs) 1 item
  37. Phosphodiesterases (PDEs) 3item
  38. Mcl-1 5item
  39. Thymidylate Synthase 3item
  40. p38 3item
  41. 3-phosphoglycerate dehydrogenase 1 item
  42. JNK 1 item
  43. SGK 2item
  44. Bcr-Abl 8item
  45. MEK 11item
  46. PORCN 1 item
  47. DOT1L 3item
  48. FGFR 13item
  49. Insulin-like growth factor receptors(IGFRs) 1 item
  50. Pim 4item
  51. Liver X receptors (LXRs) 1 item
  52. Sir2-like Family Deacetylases (Sirtuins) 2item
  53. Deubiquitinating enzymes (DUBs) 4item
  54. PP1 1 item
  55. PP2A 1 item
  56. Smoothened 4item
  57. Ribosomal s6 kinases (RSK) 1 item
  58. MET 7item
  59. Src 8item
  60. Trk Receptors 5item
  61. Integrins 1 item
  62. Aminopeptidases 2item
  63. STAT 9item
  64. Microtubules/Tubulins 4item
  65. EGFR 20item
  66. Hedgehog 1 item
  67. ROCK 1 item
  68. PAK 3item
  69. Hypoxia Inducible Factors (HIFs) 2item
  70. FAK 7item
  71. BMP and Other Activin Receptors 2item
  72. JAK 12item
  73. p300 1 item
  74. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  75. Syk 4item
  76. EZH1 1 item
  77. DNA-PK 5item
  78. HSP90 12item
  79. Gutathione S-transferase 1 item
  80. eIF4E/eIF3G interaction 1 item
  81. Notch 1 item
  82. TNKS 1 item
  83. Topoisomerases 11item
  84. Cytochrome P450 (CYP450) 4item
  85. Ksp 1 item
  86. ErbB 5item
  87. DNA Methyltransferases 3item
  88. Survivin 1 item
  89. ERK 4item
  90. HMG-CoA Reductases 2item
  91. Vacuolar-type ATPase 1 item
  92. c-MET 7item
  93. BMI-1 1 item
  94. PKC 10item
  95. Calpains 2item
  96. Ubiquitin-specific proteases 1 item
  97. Ca2 /calmodulin-dependent protein kinases (CaMKs) 2item
  98. SMYD2 1 item
  99. CREBBP 1 item
  100. EP300 1 item
  101. Lyn 1 item
  102. RAD51 2item
  103. HER2 2item
  104. Pyk2 3item
  105. USP 1 item
  106. 5-HT2 Receptors 1 item
  107. Insulin and Insulin-like Receptors 2item
  108. PARP 3item
  109. Pyruvate dehydrogenases (PDH) 1 item
  110. ALK 8item
  111. ROS1 2item
  112. Sphingosine kinases (SphKs) 2item
  113. KRAS G12C 1 item
  114. Monocarboxylate transporters (MCTs) 1 item
  115. Dehydrogenase 1 item
  116. PKG 2item
  117. PKA 5item
  118. Myosin light chain kinases (MLCKs) 1 item
  119. D1 and D5 Receptors 1 item
  120. D2 Receptors 1 item
  121. D3 Receptors 1 item
  122. Valosin-containing protein (VCP) 1 item
  123. MELK 1 item
  124. Insulin-like growth factors (IGFs) 1 item
  125. Integrin-ligand interactions 1 item
  126. CSF1R 1 item
  127. Bromodomain and Extra-Terminal motif (BET) 1 item
  128. MK2 2item
  129. Angiotensin-Converting Enzymes (ACEs) 1 item
  130. Tie-2 4item
  131. RSK 2item
  132. p70 S6K 1 item
  133. Autophagy 3item
  134. ATM/ATR 6item
  135. COX 2item
  136. Heparanases 1 item
  137. CK1 1 item
  138. IDH2 1 item
  139. Farnesyl Diphosphate Synthases 1 item
  140. CK2 1 item
  141. HIPK2 1 item
  142. HIPK3 1 item
  143. HIV Integrases 1 item
  144. PRAK 1 item
  145. MAPKAP-K2 1 item
  146. Guanine nucleotide exchange factors (GEFs) 1 item
  147. 20S proteasomal chymotrypsin 1 item
  148. Geranylgeranyltransferase I 1 item
  149. Farnesyltransferase 1 item
  150. Nampt 3item
  151. eIF4F 1 item
  152. Cdc42 1 item
  153. Glutaminases 2item
  154. Carbonic Anhydrases 1 item
  155. Ron 1 item
  156. BLM 1 item
  157. Aldehyde Dehydrogenases 1 item
  158. Synthases/Synthetases 2item
  159. P110 1 item
  160. Hck 1 item
  161. Inositol-requiring enzyme 1 (IRE1) 1 item
  162. DYRK 1 item
  163. Norepinephrine transporter 1 item
  164. 5-HT Transporters 1 item
  165. FoxM1 1 item
  166. Histone Demethylases 1 item
  167. Apoptosis Inducers 1 item
  168. MNK 1 item
  169. HIV-1 reverse transcriptase 1 item
  170. Calcium-Activated Potassium (KCa) Channels 1 item
  171. Insulin Receptors 1 item
  172. IRG-1R 1 item
  173. cAMP 1 item
  174. Sulfonylurea receptors 1 item
  175. eEF-2 1 item
  176. Cdc7 1 item
  177. CMV 1 item
  178. ZAP-70 1 item
  179. Catechol O-Methyltransferase (COMT) 1 item
  180. fibrinolysis 1 item
  181. D4 Receptors 1 item
  182. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  183. Flk-1 1 item
  184. Papains 1 item
  185. Protein Arginine Methyltransferases 1 item
  186. NAE 2item
  187. Ubiquitin-activating Enzyme E1 1 item
  188. SUMOylation 1 item
  189. Cytidine deaminases 1 item
  190. angiogenesis 1 item
  191. DPP-4 1 item
  192. PP4 1 item
  193. c-RET 2item
  194. p70 rsk 2item
  195. VEGFR3/FLT4 1 item
  196. NTRK1/TRKA 1 item
  197. CSF-1R/c-Fms 1 item
  198. NMPRTase 1 item
  199. Bfl-1 1 item
  200. TAM kinase 1 item
  201. p53-MDM2 interaction 1 item
  202. nuclear export 1 item
  203. CRM1 1 item
  204. KDR 2item
  205. AXL 1 item
  206. Glyoxalase I 1 item
  207. ERAD 1 item
  208. p53 4item
  209. HDAC 1 item
  210. human lyase 1 item
  211. insulin 1 item
  212. Ub-conjugating enzyme (E2) complex 1 item
  213. Smoothened receptor 1 item
  214. HDM2 ubiquitin ligase 1 item
  215. Hec1 1 item
  216. GLI 1 item
  217. ErbB-2 1 item
  218. PDK-1 1 item
  219. Prk 1 item
  220. Ribonucleotide Reductases 1 item
  221. Trx 1 item
  222. HSP70 1 item
  223. TYK2 1 item
  224. MUSK 1 item
  225. MAP3K 1 item
  226. Adenosine Deaminases 1 item
  227. Flk1 2item
  228. DHFR 1 item
  229. GARFT 1 item
  230. RHA 1 item
  231. MCL1 1 item
  232. Bcl-w 1 item
  233. tropomyosin receptor kinase 1 item
  234. LSD 1 item
  235. DDX3 1 item
  236. SK 1 item
  237. PPK 1 item
  238. c-Syk 1 item
  239. CDK1/CyclinB 1 item
  240. IDO 1 item
  241. PIM1 kinase 1 item
  242. phospholipase A2 1 item
  243. Substance P/NK1 Receptor 1 item
  244. Bax 1 item
Reported Experiments
  1. Animal Experiments 509item
  2. Cell Experiments 353item