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  • Search results for: 'p53 and mdm2 proteins interaction inhibitor chiral'

Search results for: 'p53 and mdm2 proteins interaction inhibitor chiral'

Items 1-10 of 981

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  1. Nutlin-3
    A4228 Nutlin-3
    Target: MDM2
    Summary: MDM2 antagonist,inhibits MDM2-p53 interaction
      ≥58.2 mg/mL
  2. JNJ-26854165 (Serdemetan)
    A4204 JNJ-26854165 (Serdemetan)
     1 Citation
    Target: p53|HDM2 ubiquitin ligase
    Summary: P53 activator, blocking Mdm2-p53 interaction
      insoluble in EtOH; insoluble in H2O; ≥14.8 mg/mL
  3. RG7112
    A3762 RG7112
     5 Citation
    Target: MDM2
    Summary: MDM2 inhibitor, first clinical
      ≥36.4 mg/mL
  4. IKK-2 inhibitor VIII
    A3485 IKK-2 inhibitor VIII
    Summary: IKK-2 inhibitor,potent and selective
      Soluble in DMSO
  5. AMG232
    A8804 AMG232
     2 Citation
    Target: p53-MDM2 interaction
    Summary: p53-MDM2 inhibitor, novel
      Soluble in DMSO
  6. Tenovin-1
    A4203 Tenovin-1
    Target: Sir2-like Family Deacetylases (Sirtuins)|p53|p21
    Summary: SIRT2 inhibitor, activates p53
      insoluble in H2O; insoluble in EtOH; ≥15 mg/mL
  7. Pifithrin-α (PFTα)
    A4206 Pifithrin-α (PFTα)
     2 Citation
    Target: p53
    Summary: p53 inhibitor
      insoluble in H2O; ≥17.45 mg/mL
  8. Pifithrin-μ
    A4482 Pifithrin-μ
     1 Citation
    Target: Autophagy|p53|HSP70
    Summary: Inhibitor of p53 binding and anti-apoptotic
      insoluble in H2O; ≥18.1 mg/mL
  9. Calpain Inhibitor I, ALLN
    A2602 Calpain Inhibitor I, ALLN
     2 Citation
    Target: Cathepsins|Calpains
    Summary: Calpain I/II/ B/L inhibitor
  10. NSC 319726
    A4208 NSC 319726
    Target: p53
    Summary: Reactivator of mutant p53

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  4. Probes & Dyes 1 item
  5. Peptides & Proteins 2item
  6. Lab Reagents 4item
Specificity
  1. Selective 695item
  2. Non-Selective 5item
Reversibility
  1. Reversible 54item
  2. Irreversible 31item
Target
  1. Caspases 8item
  2. Cyclin-Dependent Kinases 25item
  3. Proteasome 12item
  4. Cathepsins 9item
  5. Histone Deacetylases (HDACs) 32item
  6. Inhibitor of apoptosis proteins (IAP) 2item
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  60. Insulin-like growth factor receptors(IGFRs) 1 item
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  64. Voltage-gated Sodium (NaV) Channels 1 item
  65. Deubiquitinating enzymes (DUBs) 3item
  66. PP1 1 item
  67. PP2A 1 item
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  70. MET 7item
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  88. Hypoxia Inducible Factors (HIFs) 2item
  89. Tankyrases 1 item
  90. Inositol Phosphatases 1 item
  91. FAK 7item
  92. BMP and Other Activin Receptors 3item
  93. JAK 20item
  94. p300 1 item
  95. Stearoyl-CoA 9-desaturase (SCD-1) 2item
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  106. CFTR 4item
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  115. S6 kinases 1 item
  116. Toll-like receptors (TLRs) 3item
  117. Adenosine Kinases 2item
  118. Serine Proteases 2item
  119. DNA Methyltransferases 2item
  120. Survivin 1 item
  121. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  122. ERK 8item
  123. HMG-CoA Reductases 6item
  124. c-MET 8item
  125. BMI-1 1 item
  126. PKC 14item
  127. Calpains 5item
  128. Ubiquitin-specific proteases 1 item
  129. HCV Proteases 3item
  130. Ca2 /calmodulin-dependent protein kinases (CaMKs) 6item
  131. MLK3 1 item
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  133. CREBBP 1 item
  134. EP300 1 item
  135. Lyn 2item
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  141. USP 1 item
  142. 5-HT2 Receptors 4item
  143. LRRK2 6item
  144. Voltage-gated Calcium Channels (CaV) 2item
  145. DGAT 2item
  146. Insulin and Insulin-like Receptors 4item
  147. PARP 7item
  148. CB1 Receptors 1 item
  149. Melanocortin (MC) Receptors 1 item
  150. Pyruvate dehydrogenases (PDH) 2item
  151. ALK 10item
  152. ROS1 2item
  153. Sphingosine kinases (SphKs) 3item
  154. Trypsin 1 item
  155. Chymotrypsin 1 item
  156. Kallikrein 1 item
  157. Trypsinogen 1 item
  158. Monocarboxylate transporters (MCTs) 2item
  159. CETP 2item
  160. Dehydrogenase 1 item
  161. PKG 2item
  162. PKA 6item
  163. Myosin light chain kinases (MLCKs) 2item
  164. HIV-1 gp120 1 item
  165. D1 and D5 Receptors 1 item
  166. D2 Receptors 3item
  167. D3 Receptors 2item
  168. 5-HT1 Receptors 2item
  169. 5-HT7 Receptors 1 item
  170. MELK 1 item
  171. Serotonin reuptake 1 item
  172. Insulin-like growth factors (IGFs) 1 item
  173. CSF1R 1 item
  174. Bromodomain and Extra-Terminal motif (BET) 1 item
  175. Lactate Dehydrogenases (LDH) 2item
  176. MK2 2item
  177. Fatty-acid-binding proteins (FABPs) 1 item
  178. Angiotensin-Converting Enzymes (ACEs) 6item
  179. Tie-2 5item
  180. RSK 3item
  181. p70 S6K 1 item
  182. Free Fatty Acid Receptors 1 item
  183. phosphatases 2item
  184. Autophagy 4item
  185. ATM/ATR 5item
  186. COX 12item
  187. CK1 1 item
  188. Farnesyl Diphosphate Synthases 1 item
  189. CK2 2item
  190. HIPK2 1 item
  191. HIPK3 1 item
  192. HIV Integrases 2item
  193. Squalene epoxidases 2item
  194. PRAK 1 item
  195. MAPKAP-K2 1 item
  196. Delayed rectifier outward potassium current (IKr) 1 item
  197. GpIIb/IIIa receptor 1 item
  198. Guanine nucleotide exchange factors (GEFs) 1 item
  199. 20S proteasomal chymotrypsin 1 item
  200. Geranylgeranyltransferase I 1 item
  201. Farnesyltransferase 1 item
  202. Nampt 3item
  203. eIF4F 1 item
  204. Cdc42 1 item
  205. SRPK1 1 item
  206. P2X Receptors 1 item
  207. Glutaminases 2item
  208. Carbonic Anhydrases 7item
  209. Ron 1 item
  210. G9a 1 item
  211. BLM 1 item
  212. HSV 1 item
  213. NADPH Oxidases 3item
  214. Calcium-activated chloride channels (CaCC) 1 item
  215. GPR35 1 item
  216. Aldehyde Dehydrogenases 1 item
  217. Synthases/Synthetases 2item
  218. MAGL 1 item
  219. Histamine H1 Receptors 2item
  220. Na /K ATPases 3item
  221. P110 1 item
  222. Hck 2item
  223. Inositol-requiring enzyme 1 (IRE1) 2item
  224. Na /K /Cl- Symporters (NKCCs) 2item
  225. GABAA Receptors 2item
  226. Phospholipases 1 item
  227. Monoamine oxidases (MAOs) 1 item
  228. Organic anion transporters (OATs) 1 item
  229. TRP Channel 1 item
  230. RNA Polymerases 2item
  231. Norepinephrine transporter 1 item
  232. 5-HT Transporters 3item
  233. Xanthine oxidoreductases 1 item
  234. Dihydroorotate dehydrogenase 1 item
  235. FoxM1 1 item
  236. Histone Demethylases 1 item
  237. MNK 2item
  238. 5-Lipoxygenases 1 item
  239. NO Donors / Precursors 2item
  240. CB2 Receptors 1 item
  241. HIV-1 reverse transcriptase 1 item
  242. IL Receptors 2item
  243. CCL2 1 item
  244. Noradrenaline reuptake 1 item
  245. Norepinephrine transporters 1 item
  246. Calcium-Activated Potassium (KCa) Channels 2item
  247. AChE 3item
  248. Insulin Receptors 1 item
  249. IRG-1R 1 item
  250. cAMP 1 item
  251. Sulfonylurea receptors 1 item
  252. Cdc2-like kinase (Clk) 1 item
  253. eEF-2 1 item
  254. Inward Rectifier Potassium (Kir) Channels 3item
  255. Cdc7 1 item
  256. CMV 1 item
  257. ZAP-70 1 item
  258. Catechol O-Methyltransferase (COMT) 2item
  259. fibrinolysis 1 item
  260. Angiotensin AT1 Receptors 1 item
  261. D4 Receptors 1 item
  262. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  263. NMDA receptor 1 item
  264. HBV Proteases 1 item
  265. Hydroxylases 2item
  266. Flk-1 1 item
  267. Papains 1 item
  268. Protein Arginine Methyltransferases 1 item
  269. IMPDH 1 item
  270. Na /Ca2 Exchangers (NCXs) 1 item
  271. NAE 2item
  272. Ubiquitin-activating Enzyme E1 2item
  273. SUMOylation 1 item
  274. ATGL 1 item
  275. BACE 1 item
  276. Cytidine deaminases 1 item
  277. GPR40 1 item
  278. angiogenesis 1 item
  279. Glucagon Receptors 1 item
  280. 15-PGDH 1 item
  281. DPP-4 5item
  282. PP4 1 item
  283. c-RET 3item
  284. Nonstructural protein 5B (NS5B) 1 item
  285. p70 rsk 3item
  286. voltage-gated chloride channels 1 item
  287. FPTase 1 item
  288. Microtubule/Tubulin 1 item
  289. VEGFR3/FLT4 1 item
  290. NTRK1/TRKA 1 item
  291. CSF-1R/c-Fms 1 item
  292. Tryptophan hydroxylases (TPH) 2item
  293. ADAMs 1 item
  294. NMPRTase 1 item
  295. Bfl-1 1 item
  296. TAM kinase 1 item
  297. p53-MDM2 interaction 1 item
  298. nuclear export 1 item
  299. CRM1 1 item
  300. PTP 1 item
  301. KDR 2item
  302. Fyn kinase 1 item
  303. Trypsin-like protease 1 item
  304. AXL 1 item
  305. Glyoxalase I 1 item
  306. ERAD 1 item
  307. Dipeptidyl-peptidase II 1 item
  308. p53 6item
  309. metalloprotease 1 item
  310. HDAC 2item
  311. 5-HT receptors 1 item
  312. sodium channel 3item
  313. c-Fms tyrosine kinase 1 item
  314. human lyase 1 item
  315. insulin 1 item
  316. Ub-conjugating enzyme (E2) complex 1 item
  317. Smoothened receptor 1 item
  318. cysteine protease 2item
  319. HDM2 ubiquitin ligase 1 item
  320. IKK 1 item
  321. MSK 1 item
  322. gp120-CD4 interaction 1 item
  323. HCV polymerase 2item
  324. Ftase 1 item
  325. PC-PLC 2item
  326. Elastases 1 item
  327. Glucosidases 1 item
  328. Mer tyrosine kinase 1 item
  329. Hec1 1 item
  330. neprilysin 1 item
  331. GLI 1 item
  332. decarboxylase 1 item
  333. HMGCR 1 item
  334. ErbB-2 1 item
  335. adrenergic receptor 2item
  336. 5-HT4 Receptor 1 item
  337. sterol demethylase 1 item
  338. PDK-1 1 item
  339. GAPDH 1 item
  340. Histone Acetyltransferases (HATs) 2item
  341. complex I of the mitochondrial electron transport chain 1 item
  342. F1 Fo-ATPase 1 item
  343. Prk 1 item
  344. potassium channel 1 item
  345. calcium channel 1 item
  346. Ribonucleotide Reductases 1 item
  347. Trx 1 item
  348. Tyrosinases 1 item
  349. HSP70 1 item
  350. ICAM 1 item
  351. ITK 1 item
  352. HIF-PH 1 item
  353. NUAK 1 item
  354. Rho 1 item
  355. Ubiquitin E3 Ligases 1 item
  356. DCLK2 1 item
  357. FAAH 1 item
  358. PTK 1 item
  359. integrase 1 item
  360. NOS 2item
  361. TYK2 2item
  362. MUSK 1 item
  363. MAP3K 1 item
  364. GPR3 1 item
  365. Adenosine Deaminases 2item
  366. mitochondrial pyruvate carrier (MPC) 1 item
  367. prolactin secretion 1 item
  368. gonadotropin release 1 item
  369. DprE 1 item
  370. carnitine reabsorption 1 item
  371. Histamine receptors 1 item
  372. GluR 1 item
  373. 5-HT receptor 1 item
  374. dopamine receptors 1 item
  375. AMPA receptor 1 item
  376. 5-alpha Reductases 1 item
  377. Flk1 2item
  378. p21 1 item
  379. Prostaglandin synthesis 1 item
  380. Protein Tyrosine Phosphatases 1 item
  381. alkaline phosphatases 1 item
  382. ATPases 1 item
  383. glutamate release 1 item
  384. PAFR 1 item
  385. Aromatases 2item
  386. DHFR 1 item
  387. GARFT 1 item
  388. FGR 1 item
  389. YES 2item
  390. Fyn 2item
  391. ARG 1 item
  392. Autotaxin 1 item
  393. UCH 1 item
  394. RHA 1 item
  395. HCV NS3-4A protease 1 item
  396. PKD 1 item
  397. Pyruvate kinases 1 item
  398. Thioredoxin Reductases 1 item
  399. enoyl-acyl-carrier protein reductase 1 item
  400. SHIP 1 item
  401. FKBP 1 item
  402. MCL1 1 item
  403. Bcl-w 1 item
  404. glutathione peroxidase 4 1 item
  405. S-adenosylhomocysteine hydrolase 1 item
  406. Rho-kinase 1 item
  407. tropomyosin receptor kinase 1 item
  408. LSD 1 item
  409. DDX3 1 item
  410. PRMT 1 item
  411. ACE 1 item
  412. GLP 1 item
  413. SK 1 item
  414. MST 1 item
  415. PPK 1 item
  416. c-Syk 1 item
  417. CDK1/CyclinB 1 item
  418. NHE 1 item
  419. IDO 2item
  420. Tph 1 item
  421. PIM1 kinase 1 item
  422. phospholipase A2 1 item
  423. reverse transcriptase 1 item
  424. epoxide hydrolase 1 item
  425. Serotonin (5-HT) reuptake 1 item
  426. Cholesterol absorption 1 item
  427. Vascular Disrupting Agents (VDA) 1 item
  428. Androgen Receptor 1 item
  429. Substance P/NK1 Receptor 1 item
  430. gp120/CD4 1 item
  431. ATM 1 item
  432. Sirtuin 1 item
  433. NE 1 item
  434. PIKfyve 1 item
  435. Bax 1 item
  436. Glycogen Phosphorylases 1 item
  437. MTH1 1 item
  438. PTEN 1 item
  439. Insulin Receptor 1 item
  440. NS3/4a Proteases 1 item
  441. Ca2 -ATPases 1 item
  442. p90 S6K 1 item
  443. Dynamins 1 item
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  7. Acute Myeloid Leukemia 25item
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  48. Hepatitis C 4item
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  50. HIV 13item
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