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  • Search results for: 'p53 and mdm2 proteins interaction inhibitor racemic'

Search results for: 'p53 and mdm2 proteins interaction inhibitor racemic'

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  1. Nutlin-3
    A4228 Nutlin-3
    Target: MDM2
    Summary: MDM2 antagonist,inhibits MDM2-p53 interaction
      ≥58.2 mg/mL
  2. JNJ-26854165 (Serdemetan)
    A4204 JNJ-26854165 (Serdemetan)
     1 Citation
    Target: p53|HDM2 ubiquitin ligase
    Summary: P53 activator, blocking Mdm2-p53 interaction
      insoluble in EtOH; insoluble in H2O; ≥14.8 mg/mL
  3. RG7112
    A3762 RG7112
     5 Citation
    Target: MDM2
    Summary: MDM2 inhibitor, first clinical
      ≥36.4 mg/mL
  4. AMG232
    A8804 AMG232
     2 Citation
    Target: p53-MDM2 interaction
    Summary: p53-MDM2 inhibitor, novel
      Soluble in DMSO
  5. Pifithrin-μ
    A4482 Pifithrin-μ
     1 Citation
    Target: Autophagy|p53|HSP70
    Summary: Inhibitor of p53 binding and anti-apoptotic
      insoluble in H2O; ≥18.1 mg/mL
  6. NSC 319726
    A4208 NSC 319726
    Target: p53
    Summary: Reactivator of mutant p53
  7. Bax inhibitor peptide V5
    A4461 Bax inhibitor peptide V5
    Target: Bax
    Summary: Bax inhibitor
      ≥29.35 mg/mL
  8. AKT inhibitor VIII
    A3149 AKT inhibitor VIII
     2 Citation
    Target: Akt
    Summary: Allosteric Akt kinase inhibitor
      insoluble in H2O; insoluble in EtOH; ≥9.2 mg/mL
  9. Glyoxalase I inhibitor
    A3440 Glyoxalase I inhibitor
    Target: Glyoxalase I
    Summary: Glyoxalase I inhibitor
      Soluble in DMSO
  10. GSK126
    A3446 GSK126
     5 Citation
    Target: EZH2
    Summary: EZH2 inhibitor
      insoluble in H2O; insoluble in EtOH; ≥4.38 mg/mL

Items 1-10 of 509

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  1. Signaling Pathways 499item
  2. Natural Products 1 item
  3. Lab Reagents 1 item
Specificity
  1. Selective 394item
  2. Non-Selective 2item
Reversibility
  1. Reversible 24item
  2. Irreversible 19item
Target
  1. Caspases 2item
  2. Cyclin-Dependent Kinases 22item
  3. Proteasome 9item
  4. Cathepsins 2item
  5. Histone Deacetylases (HDACs) 22item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 11item
  8. Bcl-2 7item
  9. PI3K 26item
  10. CXCR 2item
  11. Raf 11item
  12. Aurora Kinases 16item
  13. Bcl-xl 2item
  14. CSF-1R 4item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. MDM2 2item
  18. EZH2 3item
  19. mTOR 15item
  20. Bromodomains 4item
  21. MMP 2item
  22. Thymidine Phosphorylases 1 item
  23. Androgen Receptors 3item
  24. DT-diaphorases 1 item
  25. FLT3 12item
  26. GSK-3 5item
  27. P-glycoprotein (P-gp) 5item
  28. PLK 9item
  29. Chk 5item
  30. Eph Receptors 2item
  31. VEGFR 36item
  32. PDGFR 20item
  33. c-Kit 10item
  34. RET 4item
  35. Bromodomain-containing proteins(BRDs) 1 item
  36. Phosphodiesterases (PDEs) 3item
  37. Mcl-1 5item
  38. Thymidylate Synthase 3item
  39. p38 3item
  40. JNK 1 item
  41. SGK 1 item
  42. Bcr-Abl 8item
  43. MEK 11item
  44. PORCN 1 item
  45. DOT1L 3item
  46. FGFR 13item
  47. Insulin-like growth factor receptors(IGFRs) 1 item
  48. Pim 3item
  49. Liver X receptors (LXRs) 1 item
  50. Sir2-like Family Deacetylases (Sirtuins) 2item
  51. Deubiquitinating enzymes (DUBs) 2item
  52. PP1 1 item
  53. PP2A 1 item
  54. Smoothened 4item
  55. MET 7item
  56. Src 8item
  57. Trk Receptors 5item
  58. Integrins 1 item
  59. Aminopeptidases 2item
  60. STAT 8item
  61. Microtubules/Tubulins 3item
  62. EGFR 19item
  63. Hedgehog 1 item
  64. ROCK 1 item
  65. PAK 3item
  66. Hypoxia Inducible Factors (HIFs) 2item
  67. FAK 7item
  68. BMP and Other Activin Receptors 2item
  69. JAK 12item
  70. p300 1 item
  71. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  72. Syk 4item
  73. EZH1 1 item
  74. DNA-PK 5item
  75. HSP90 12item
  76. Gutathione S-transferase 1 item
  77. Notch 1 item
  78. TNKS 1 item
  79. Topoisomerases 11item
  80. Cytochrome P450 (CYP450) 4item
  81. Ksp 1 item
  82. ErbB 5item
  83. DNA Methyltransferases 2item
  84. Survivin 1 item
  85. ERK 4item
  86. HMG-CoA Reductases 2item
  87. c-MET 7item
  88. BMI-1 1 item
  89. PKC 9item
  90. Calpains 2item
  91. Ubiquitin-specific proteases 1 item
  92. Ca2 /calmodulin-dependent protein kinases (CaMKs) 2item
  93. CREBBP 1 item
  94. EP300 1 item
  95. Lyn 1 item
  96. RAD51 2item
  97. HER2 2item
  98. Pyk2 3item
  99. USP 1 item
  100. 5-HT2 Receptors 1 item
  101. Insulin and Insulin-like Receptors 2item
  102. PARP 3item
  103. Pyruvate dehydrogenases (PDH) 1 item
  104. ALK 8item
  105. ROS1 2item
  106. Sphingosine kinases (SphKs) 2item
  107. Monocarboxylate transporters (MCTs) 1 item
  108. Dehydrogenase 1 item
  109. PKG 1 item
  110. PKA 4item
  111. D1 and D5 Receptors 1 item
  112. D2 Receptors 1 item
  113. D3 Receptors 1 item
  114. MELK 1 item
  115. Insulin-like growth factors (IGFs) 1 item
  116. CSF1R 1 item
  117. Bromodomain and Extra-Terminal motif (BET) 1 item
  118. MK2 1 item
  119. Angiotensin-Converting Enzymes (ACEs) 1 item
  120. Tie-2 4item
  121. RSK 2item
  122. p70 S6K 1 item
  123. Autophagy 3item
  124. ATM/ATR 4item
  125. COX 2item
  126. Farnesyl Diphosphate Synthases 1 item
  127. CK2 1 item
  128. HIPK2 1 item
  129. HIPK3 1 item
  130. HIV Integrases 1 item
  131. PRAK 1 item
  132. MAPKAP-K2 1 item
  133. Guanine nucleotide exchange factors (GEFs) 1 item
  134. 20S proteasomal chymotrypsin 1 item
  135. Geranylgeranyltransferase I 1 item
  136. Farnesyltransferase 1 item
  137. Nampt 3item
  138. eIF4F 1 item
  139. Cdc42 1 item
  140. Glutaminases 2item
  141. Carbonic Anhydrases 1 item
  142. Ron 1 item
  143. BLM 1 item
  144. Aldehyde Dehydrogenases 1 item
  145. Synthases/Synthetases 1 item
  146. P110 1 item
  147. Hck 1 item
  148. Inositol-requiring enzyme 1 (IRE1) 1 item
  149. Norepinephrine transporter 1 item
  150. 5-HT Transporters 1 item
  151. FoxM1 1 item
  152. Histone Demethylases 1 item
  153. MNK 1 item
  154. HIV-1 reverse transcriptase 1 item
  155. Calcium-Activated Potassium (KCa) Channels 1 item
  156. Insulin Receptors 1 item
  157. IRG-1R 1 item
  158. cAMP 1 item
  159. Sulfonylurea receptors 1 item
  160. eEF-2 1 item
  161. Cdc7 1 item
  162. CMV 1 item
  163. ZAP-70 1 item
  164. Catechol O-Methyltransferase (COMT) 1 item
  165. fibrinolysis 1 item
  166. D4 Receptors 1 item
  167. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  168. Flk-1 1 item
  169. Papains 1 item
  170. Protein Arginine Methyltransferases 1 item
  171. NAE 2item
  172. Ubiquitin-activating Enzyme E1 1 item
  173. SUMOylation 1 item
  174. Cytidine deaminases 1 item
  175. angiogenesis 1 item
  176. DPP-4 1 item
  177. PP4 1 item
  178. c-RET 2item
  179. p70 rsk 2item
  180. VEGFR3/FLT4 1 item
  181. NTRK1/TRKA 1 item
  182. CSF-1R/c-Fms 1 item
  183. NMPRTase 1 item
  184. Bfl-1 1 item
  185. TAM kinase 1 item
  186. p53-MDM2 interaction 1 item
  187. nuclear export 1 item
  188. CRM1 1 item
  189. KDR 2item
  190. AXL 1 item
  191. Glyoxalase I 1 item
  192. ERAD 1 item
  193. p53 4item
  194. HDAC 1 item
  195. human lyase 1 item
  196. insulin 1 item
  197. Ub-conjugating enzyme (E2) complex 1 item
  198. Smoothened receptor 1 item
  199. HDM2 ubiquitin ligase 1 item
  200. Hec1 1 item
  201. GLI 1 item
  202. ErbB-2 1 item
  203. PDK-1 1 item
  204. Prk 1 item
  205. Ribonucleotide Reductases 1 item
  206. Trx 1 item
  207. HSP70 1 item
  208. TYK2 1 item
  209. MUSK 1 item
  210. MAP3K 1 item
  211. Adenosine Deaminases 1 item
  212. Flk1 2item
  213. DHFR 1 item
  214. GARFT 1 item
  215. RHA 1 item
  216. MCL1 1 item
  217. Bcl-w 1 item
  218. tropomyosin receptor kinase 1 item
  219. LSD 1 item
  220. DDX3 1 item
  221. SK 1 item
  222. PPK 1 item
  223. c-Syk 1 item
  224. CDK1/CyclinB 1 item
  225. IDO 1 item
  226. PIM1 kinase 1 item
  227. phospholipase A2 1 item
  228. Substance P/NK1 Receptor 1 item
  229. Bax 1 item