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  • Search results for: 'research area apoptosis bcl 2 family'

Search results for: 'research area apoptosis bcl 2 family'

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  1. ABT-263 (Navitoclax)
    A3007 ABT-263 (Navitoclax)
     15 Citation
    Target: Bcl-2|Bcl-w
    Summary: Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w
      ≥48.73 mg/mL
  2. Obatoclax mesylate (GX15-070)
    A4194 Obatoclax mesylate (GX15-070)
     1 Citation
    Target: Bcl-2
    Summary: Potent Bcl-2 inhibitor
      insoluble in H2O; ≥20.7 mg/mL
  3. ABT-199
    A8194 ABT-199
     14 Citation
    Target: Bcl-2
    Summary: Bcl-2 inhibitor,potent and selective
      ≥43.42 mg/mL
  4. Sabutoclax
    A4199 Sabutoclax
     2 Citation
    Target: Bcl-2|Mcl-1|Bfl-1
    Summary: pan-Bcl-2 inhibitor
      insoluble in H2O; ≥205.6 mg/mL
  5. TW-37
    A4234 TW-37
     1 Citation
    Target: Bcl-2|Bcl-xl|Mcl-1
    Summary: Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1
      insoluble in H2O; ≥19.75 mg/mL
  6. HA14-1
    A8168 HA14-1
    Target: Bcl-2
    Summary: Bcl-2 inhibitor,potent and cell-permeable
      insoluble in H2O; ≥20.45 mg/mL
  7. AT-101
    A3196 AT-101
    Target: NS3/4a Proteases
    Summary: BH3-mimetic,gossypol enantiomer
      ≥20.7 mg/mL
  8. WEHI-539
    A3935 WEHI-539
     15 Citation
    Target: Bcl-xl
    Summary: Bcl-xL inhibitor,potent and selective
      insoluble in DMSO; insoluble in H2O; insoluble in EtOH
  9. Apogossypolone (ApoG2)
    A4200 Apogossypolone (ApoG2)
     2 Citation
    Target: Bcl-2|Bcl-xl|Mcl-1
    Summary: Bcl-2 inhibitor,nonpeptidic small molecule
      ≥24.55 mg/mL
  10. Bax inhibitor peptide V5
    A4461 Bax inhibitor peptide V5
    Target: Bax
    Summary: Bax inhibitor
      ≥29.35 mg/mL

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  1. Signaling Pathways 316item
  2. Natural Products 12item
  3. Protein 2item
  4. Probes & Dyes 2item
  5. Peptides & Proteins 3item
  6. Lab Reagents 6item
Specificity
  1. Selective 186item
Reversibility
  1. Reversible 18item
  2. Irreversible 12item
Target
  1. Caspases 7item
  2. Cyclin-Dependent Kinases 9item
  3. Adenosine A2A Receptors 1 item
  4. Proteasome 4item
  5. Cathepsins 2item
  6. Histone Deacetylases (HDACs) 6item
  7. Inhibitor of apoptosis proteins (IAP) 1 item
  8. Akt 4item
  9. Bcl-2 8item
  10. PI3K 3item
  11. CXCR 2item
  12. Raf 4item
  13. Aurora Kinases 7item
  14. Bcl-xl 3item
  15. CSF-1R 1 item
  16. MDM2 1 item
  17. EZH2 1 item
  18. mTOR 4item
  19. Bromodomains 3item
  20. AP-1 2item
  21. MMP 3item
  22. Myosin II ATPases 1 item
  23. DT-diaphorases 1 item
  24. Voltage-gated Potassium (KV) Channels 1 item
  25. FLT3 5item
  26. GSK-3 2item
  27. Factor Xa 1 item
  28. Farnesoid X receptors (FXRs) 1 item
  29. PLK 4item
  30. Chk 1 item
  31. Eph Receptors 2item
  32. VEGFR 20item
  33. PDGFR 8item
  34. c-Kit 5item
  35. RET 1 item
  36. Phosphodiesterases (PDEs) 3item
  37. Mcl-1 4item
  38. Thymidylate Synthase 1 item
  39. p38 1 item
  40. PKB 1 item
  41. Bcr-Abl 3item
  42. MEK 7item
  43. DOT1L 1 item
  44. FGFR 6item
  45. Nrf2 1 item
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  47. Sir2-like Family Deacetylases (Sirtuins) 1 item
  48. Voltage-gated Sodium (NaV) Channels 2item
  49. MET 3item
  50. Src 4item
  51. RARs 1 item
  52. Trk Receptors 2item
  53. Aminopeptidases 1 item
  54. STAT 2item
  55. Estrogen and Related Receptors 2item
  56. EGFR 8item
  57. Reverse Transcriptases 1 item
  58. ROCK 1 item
  59. Hypoxia Inducible Factors (HIFs) 1 item
  60. FAK 2item
  61. JAK 10item
  62. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  63. EZH1 1 item
  64. DNA-PK 2item
  65. HSP90 2item
  66. AMPK 1 item
  67. Topoisomerases 1 item
  68. Cytochrome P450 (CYP450) 5item
  69. Ksp 1 item
  70. Renin 1 item
  71. ErbB 1 item
  72. Toll-like receptors (TLRs) 1 item
  73. DNA Methyltransferases 1 item
  74. ERK 1 item
  75. c-MET 2item
  76. PKC 3item
  77. Pyk2 2item
  78. 5-HT2 Receptors 1 item
  79. LRRK2 4item
  80. Voltage-gated Calcium Channels (CaV) 1 item
  81. Insulin and Insulin-like Receptors 3item
  82. PARP 4item
  83. Pyruvate dehydrogenases (PDH) 1 item
  84. ALK 2item
  85. Sphingosine kinases (SphKs) 1 item
  86. PKG 1 item
  87. PKA 4item
  88. D1 and D5 Receptors 1 item
  89. D2 Receptors 1 item
  90. 5-HT1 Receptors 1 item
  91. AdipoR2 1 item
  92. MK2 1 item
  93. Tie-2 3item
  94. RSK 1 item
  95. phosphatases 2item
  96. Autophagy 1 item
  97. ATM/ATR 1 item
  98. COX 10item
  99. CK2 2item
  100. Guanine nucleotide exchange factors (GEFs) 1 item
  101. 20S proteasomal chymotrypsin 1 item
  102. Geranylgeranyltransferase I 1 item
  103. Farnesyltransferase 1 item
  104. Nampt 1 item
  105. eIF4F 1 item
  106. Glutaminases 1 item
  107. HSV 1 item
  108. NADPH Oxidases 2item
  109. Calcium-activated chloride channels (CaCC) 1 item
  110. GPR35 1 item
  111. MAGL 1 item
  112. Histamine H1 Receptors 3item
  113. Na /K ATPases 1 item
  114. P110 1 item
  115. Hck 1 item
  116. GABAA Receptors 1 item
  117. Opioid receptors 1 item
  118. Phospholipases 1 item
  119. TRP Channel 3item
  120. FoxM1 1 item
  121. M2 Receptors 1 item
  122. MNK 1 item
  123. Glucocorticoid Receptors 2item
  124. Adenosine A1 Receptors 1 item
  125. 15-lipoxygenases 1 item
  126. eEF-2 1 item
  127. Inward Rectifier Potassium (Kir) Channels 1 item
  128. Cdc7 1 item
  129. CMV 1 item
  130. ZAP-70 1 item
  131. Hexokinases 1 item
  132. Flk-1 1 item
  133. Antioxidants 2item
  134. Cytidine deaminases 1 item
  135. angiogenesis 1 item
  136. Glucagon Receptors 1 item
  137. DPP-4 3item
  138. c-RET 2item
  139. p70 rsk 1 item
  140. FPTase 2item
  141. AChR 1 item
  142. Microtubule/Tubulin 2item
  143. interleukin receptor 1 item
  144. Menin-MLL 2item
  145. Bfl-1 1 item
  146. sodium channels 1 item
  147. p53-MDM2 interaction 1 item
  148. KDR 2item
  149. Fyn kinase 1 item
  150. PARs 1 item
  151. p53 5item
  152. HDAC 1 item
  153. KDM 1 item
  154. c-Fms tyrosine kinase 1 item
  155. PAR 1 item
  156. cysteine protease 1 item
  157. STK 1 item
  158. HDM2 ubiquitin ligase 1 item
  159. USP1/USF1 complex 1 item
  160. IKK 1 item
  161. gp120-CD4 interaction 1 item
  162. HCV polymerase 3item
  163. Lyn kinase 1 item
  164. Ftase 1 item
  165. PC-PLC 1 item
  166. GK 1 item
  167. Glucosidases 1 item
  168. Antibiotic 1 item
  169. cannabinoid receptor 1 item
  170. DNA Alkylating 1 item
  171. Rev-Erb Receptors 1 item
  172. ErbB-2 1 item
  173. HIV 1 item
  174. sterol demethylase 1 item
  175. PDK-1 1 item
  176. GAPDH 1 item
  177. Histone Acetyltransferases (HATs) 2item
  178. Telomerases 1 item
  179. Prk 1 item
  180. Tyrosinases 1 item
  181. HSP70 1 item
  182. Aryl hydrocarbon receptors (AHRs) 1 item
  183. DCLK2 1 item
  184. phosphatidylinositol kinase 1 item
  185. Lck 1 item
  186. Adenosine Deaminases 1 item
  187. Thrombin Receptor 1 item
  188. UCP 1 item
  189. DprE 1 item
  190. Flk1 2item
  191. p21 1 item
  192. Prostaglandin synthesis 1 item
  193. glutamate release 1 item
  194. PAFR 1 item
  195. Aromatases 1 item
  196. DHFR 1 item
  197. GARFT 1 item
  198. PHF 1 item
  199. UCH 1 item
  200. RHA 1 item
  201. HCV NS3-4A protease 1 item
  202. TRPC channel 1 item
  203. PKD 1 item
  204. Pyruvate kinases 1 item
  205. Bcl-w 1 item
  206. NADH oxidase 1 item
  207. GLP-2 receptor 1 item
  208. SK 1 item
  209. MST 1 item
  210. PPK 1 item
  211. c-Syk 1 item
  212. CDK1/CyclinB 1 item
  213. Tph 1 item
  214. glucose uptake 1 item
  215. reverse transcriptase 1 item
  216. GLP-1 receptor 1 item
  217. Vascular Disrupting Agents (VDA) 1 item
  218. Substance P/NK1 Receptor 1 item
  219. gp120/CD4 1 item
  220. Bax 1 item
  221. MTH1 1 item
  222. PTEN 1 item
  223. NS3/4a Proteases 1 item
  224. p90 S6K 1 item
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  10. Breast Cancer 41item
  11. Cancer 133item
  12. Castration-resistant Prostate Cancer 1 item
  13. Cervical Cancer 4item
  14. Cholangiocarcinoma 1 item
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  21. Diabetes 3item
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  23. Epilepsy 1 item
  24. Fungi 1 item
  25. Glioblastoma 10item
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  27. HCV 3item
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  30. HIV 5item
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  32. Inflammatory Diseases 6item
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  35. Lung Cancer 10item
  36. Lymphoma 8item
  37. Mantle Cell Lymphoma 1 item
  38. Melanoma 7item
  39. Mixed Lineage Leukemia 1 item
  40. Multiple Myeloma 8item
  41. Myelofibrosis 2item
  42. Neuroblastoma 1 item
  43. Non-small Cell Lung Cancer 7item
  44. Ovarian Cancer 5item
  45. Pain Relief 1 item
  46. Pancreatic Cancer 12item
  47. Pancreatic Carcinoma 1 item
  48. Pentacyclic Triterpenoid 1 item
  49. Prostate Cancer 16item
  50. Psoriasis 1 item
  51. Pulmonary Fibrosis 2item
  52. Renal Cancer 1 item
  53. Rheumatoid Arthritis 4item
  54. Sarcoma 1 item
  55. Soft Tissue Sarcoma 1 item
  56. Squamous Cell Carcinoma 1 item
  57. Thyroid Cancer 2item
  58. Tuberculosis 1 item
  59. Type 2 Diabetes 3item