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  • Search results for: 'research area pi3k akt signaling pi3k inhibitors'

Search results for: 'research area pi3k akt signaling pi3k inhibitors'

Items 231-240 of 533

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  1. BIIB021
    A4058 BIIB021
    Target: HSP90
    Summary: Hsp90 inhibitor,selective and competitive
      insoluble in EtOH; insoluble in H2O; ≥14.95 mg/mL
  2. HO-3867
    B4970 HO-3867
     1 Citation
    Target: STAT
    Summary: STAT3 inhibitor, selective
      insoluble in EtOH; insoluble in H2O; ≥18.15 mg/mL
  3. LY2784544
    A4147 LY2784544
    Target: Aurora Kinases|FLT3|VEGFR|FGFR|Trk Receptors|JAK|ALK|TYK2|MUSK|MAP3K
    Summary: JAK2 inhibitor,highly potent and selective
      ≥23.5 mg/mL
  4. Tivozanib (AV-951)
    A2251 Tivozanib (AV-951)
    Target: VEGFR
    Summary: VEGFR inhibitor,potent and selective
      ≥22.75 mg/mL
  5. MLN4924
    B1036 MLN4924
     5 Citation
    Target: NAE|Ubiquitin-activating Enzyme E1|SUMOylation
    Summary: NAE inhibitor
      ≥22.18 mg/mL
  6. Imatinib (STI571)
    B2171 Imatinib (STI571)
    Target: PDGFR|c-Kit|Bcr-Abl
    Summary: Protein-tyrosine kinase inhibitor
      ≥24.68 mg/mL
  7. R428
    A8329 R428
     10 Citation
    Summary: Selective Axl inhibitor
      ≥25 mg/mL
  8. CP-673451
    B2173 CP-673451
    Target: PDGFR
    Summary: PDGFRα/β inhibitor,potent and selective
  9. RG7112
    A3762 RG7112
     5 Citation
    Target: MDM2
    Summary: MDM2 inhibitor, first clinical
      ≥36.4 mg/mL
  10. AUY922 (NVP-AUY922)
    A4057 AUY922 (NVP-AUY922)
     1 Citation
    Target: HSP90
    Summary: Potent Hsp90 inhibitor
      ≥23.27 mg/mL

Items 231-240 of 533

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  1. Category Signaling Pathways Remove This Item
  2. Related Disease Cancer Remove This Item
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Category
  1. Proteases 33item
  2. Apoptosis 35item
  3. Chromatin/Epigenetics 82item
  4. Metabolism 32item
  5. MAPK Signaling 27item
  6. Tyrosine Kinase 108item
  7. DNA Damage/DNA Repair 53item
  8. PI3K/Akt/mTOR Signaling 50item
  9. Microbiology & Virology 4item
  10. Cell Cycle/Checkpoint 70item
  11. Ubiquitination/ Proteasome 29item
  12. JAK/STAT Signaling 35item
  13. TGF-β / Smad Signaling 22item
  14. Angiogenesis 6item
  15. GPCR/G protein 8item
  16. Stem Cell 25item
  17. Membrane Transporter/Ion Channel 6item
  18. Endocrinology and Hormones 4item
  19. Neuroscience 5item
  20. Others 27item
  21. Immunology/Inflammation 4item
Specificity
  1. Selective 422item
  2. Non-Selective 2item
Reversibility
  1. Reversible 28item
  2. Irreversible 22item
Target
  1. Caspases 3item
  2. Cyclin-Dependent Kinases 25item
  3. Proteasome 9item
  4. Cathepsins 2item
  5. Histone Deacetylases (HDACs) 24item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 11item
  8. Bcl-2 7item
  9. PI3K 26item
  10. CXCR 1 item
  11. Raf 11item
  12. Aurora Kinases 18item
  13. Bcl-xl 2item
  14. CSF-1R 4item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. MDM2 1 item
  18. EZH2 5item
  19. mTOR 15item
  20. Bromodomains 5item
  21. MMP 3item
  22. Thymidine Phosphorylases 1 item
  23. Androgen Receptors 3item
  24. DT-diaphorases 1 item
  25. FLT3 12item
  26. GSK-3 5item
  27. P-glycoprotein (P-gp) 5item
  28. PLK 9item
  29. Chk 5item
  30. ULK1 1 item
  31. Eph Receptors 3item
  32. VEGFR 36item
  33. PDGFR 21item
  34. c-Kit 10item
  35. RET 4item
  36. Bromodomain-containing proteins(BRDs) 1 item
  37. Phosphodiesterases (PDEs) 3item
  38. Mcl-1 5item
  39. Thymidylate Synthase 3item
  40. p38 3item
  41. 3-phosphoglycerate dehydrogenase 1 item
  42. JNK 1 item
  43. SGK 2item
  44. Bcr-Abl 8item
  45. MEK 11item
  46. PORCN 1 item
  47. DOT1L 3item
  48. FGFR 13item
  49. Insulin-like growth factor receptors(IGFRs) 1 item
  50. Pim 3item
  51. Sir2-like Family Deacetylases (Sirtuins) 2item
  52. Deubiquitinating enzymes (DUBs) 4item
  53. Smoothened 4item
  54. Ribosomal s6 kinases (RSK) 1 item
  55. MET 7item
  56. Src 8item
  57. Trk Receptors 5item
  58. Integrins 1 item
  59. Aminopeptidases 2item
  60. STAT 6item
  61. Microtubules/Tubulins 4item
  62. EGFR 20item
  63. Hedgehog 1 item
  64. ROCK 1 item
  65. PAK 3item
  66. Hypoxia Inducible Factors (HIFs) 2item
  67. FAK 6item
  68. BMP and Other Activin Receptors 2item
  69. JAK 12item
  70. p300 1 item
  71. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  72. Syk 4item
  73. EZH1 1 item
  74. DNA-PK 5item
  75. HSP90 12item
  76. Gutathione S-transferase 1 item
  77. eIF4E/eIF3G interaction 1 item
  78. Notch 1 item
  79. TNKS 1 item
  80. Topoisomerases 8item
  81. Cytochrome P450 (CYP450) 4item
  82. Ksp 1 item
  83. ErbB 5item
  84. DNA Methyltransferases 3item
  85. Survivin 1 item
  86. ERK 4item
  87. HMG-CoA Reductases 2item
  88. Vacuolar-type ATPase 1 item
  89. c-MET 7item
  90. BMI-1 1 item
  91. PKC 10item
  92. Calpains 2item
  93. Ubiquitin-specific proteases 1 item
  94. Ca2 /calmodulin-dependent protein kinases (CaMKs) 2item
  95. SMYD2 1 item
  96. CREBBP 1 item
  97. EP300 1 item
  98. Lyn 1 item
  99. RAD51 2item
  100. HER2 2item
  101. Pyk2 3item
  102. 5-HT2 Receptors 1 item
  103. Insulin and Insulin-like Receptors 2item
  104. PARP 3item
  105. Pyruvate dehydrogenases (PDH) 1 item
  106. ALK 7item
  107. ROS1 2item
  108. Sphingosine kinases (SphKs) 2item
  109. KRAS G12C 1 item
  110. Monocarboxylate transporters (MCTs) 1 item
  111. Dehydrogenase 1 item
  112. PKG 2item
  113. PKA 5item
  114. Myosin light chain kinases (MLCKs) 1 item
  115. D1 and D5 Receptors 1 item
  116. D2 Receptors 1 item
  117. D3 Receptors 1 item
  118. Valosin-containing protein (VCP) 1 item
  119. MELK 1 item
  120. Insulin-like growth factors (IGFs) 1 item
  121. Integrin-ligand interactions 1 item
  122. CSF1R 1 item
  123. Bromodomain and Extra-Terminal motif (BET) 1 item
  124. MK2 2item
  125. Angiotensin-Converting Enzymes (ACEs) 1 item
  126. Tie-2 4item
  127. RSK 2item
  128. p70 S6K 1 item
  129. Autophagy 3item
  130. ATM/ATR 6item
  131. COX 2item
  132. Heparanases 1 item
  133. CK1 1 item
  134. IDH2 1 item
  135. CK2 1 item
  136. HIPK2 1 item
  137. HIPK3 1 item
  138. PRAK 1 item
  139. MAPKAP-K2 1 item
  140. 20S proteasomal chymotrypsin 1 item
  141. Geranylgeranyltransferase I 1 item
  142. Farnesyltransferase 1 item
  143. Nampt 3item
  144. eIF4F 1 item
  145. Cdc42 1 item
  146. Glutaminases 2item
  147. Carbonic Anhydrases 1 item
  148. Ron 1 item
  149. BLM 1 item
  150. Aldehyde Dehydrogenases 1 item
  151. Synthases/Synthetases 2item
  152. P110 1 item
  153. Hck 1 item
  154. Inositol-requiring enzyme 1 (IRE1) 1 item
  155. Norepinephrine transporter 1 item
  156. 5-HT Transporters 1 item
  157. MNK 1 item
  158. HIV-1 reverse transcriptase 1 item
  159. Calcium-Activated Potassium (KCa) Channels 1 item
  160. Insulin Receptors 1 item
  161. IRG-1R 1 item
  162. cAMP 1 item
  163. Sulfonylurea receptors 1 item
  164. eEF-2 1 item
  165. Cdc7 1 item
  166. CMV 1 item
  167. ZAP-70 1 item
  168. Catechol O-Methyltransferase (COMT) 1 item
  169. fibrinolysis 1 item
  170. D4 Receptors 1 item
  171. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  172. Flk-1 1 item
  173. Papains 1 item
  174. Protein Arginine Methyltransferases 1 item
  175. NAE 2item
  176. Ubiquitin-activating Enzyme E1 1 item
  177. SUMOylation 1 item
  178. BACE 1 item
  179. Cytidine deaminases 1 item
  180. angiogenesis 1 item
  181. DPP-4 1 item
  182. c-RET 2item
  183. p70 rsk 2item
  184. VEGFR3/FLT4 1 item
  185. NTRK1/TRKA 1 item
  186. CSF-1R/c-Fms 1 item
  187. NMPRTase 1 item
  188. Bfl-1 1 item
  189. TAM kinase 1 item
  190. p53-MDM2 interaction 1 item
  191. nuclear export 1 item
  192. CRM1 1 item
  193. KDR 2item
  194. AXL 1 item
  195. Glyoxalase I 1 item
  196. p53 2item
  197. HDAC 1 item
  198. human lyase 1 item
  199. insulin 1 item
  200. Ub-conjugating enzyme (E2) complex 1 item
  201. Smoothened receptor 1 item
  202. Antibiotic 1 item
  203. Hec1 1 item
  204. GLI 1 item
  205. ErbB-2 1 item
  206. PDK-1 1 item
  207. Prk 1 item
  208. Ribonucleotide Reductases 1 item
  209. Trx 1 item
  210. HSP70 1 item
  211. TYK2 1 item
  212. MUSK 1 item
  213. MAP3K 1 item
  214. Adenosine Deaminases 1 item
  215. Flk1 2item
  216. DHFR 1 item
  217. GARFT 1 item
  218. RHA 1 item
  219. MCL1 1 item
  220. Bcl-w 1 item
  221. tropomyosin receptor kinase 1 item
  222. LSD 1 item
  223. DDX3 1 item
  224. SK 1 item
  225. PPK 1 item
  226. c-Syk 1 item
  227. CDK1/CyclinB 1 item
  228. IDO 1 item
  229. PIM1 kinase 1 item
  230. phospholipase A2 1 item
  231. Substance P/NK1 Receptor 1 item
  232. Bax 1 item
Reported Experiments
  1. Animal Experiments 492item
  2. Cell Experiments 338item