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  • Search results for: 'research area pi3k akt signaling pi3k inhibitors'

Search results for: 'research area pi3k akt signaling pi3k inhibitors'

Items 281-290 of 3046

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  1. M344
    A4105 M344
     1 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: HDAC inhibitor,potent and cell-permeable
  2. Go 6976
    A8341 Go 6976
    Target: PKC
    Summary: PKCα/PKCβ1 inhibitor
      ≥15.77 mg/mL
  3. SB 431542
    A8249 SB 431542
     2 Citation
    Summary: ALK inhibitor
  4. (-)-Epigallocatechin gallate (EGCG)
    A2600 (-)-Epigallocatechin gallate (EGCG)
    Target: BACE
    Summary: Antioxidant, antiangiogenic and antitumor agent
      ≥22.9 mg/mL
  5. NS3694
    C4468 NS3694
    Summary: inhibits apoptosome formation and caspase activation
      ≥46 mg/mL
  6. Sorafenib
    A3009 Sorafenib
     2 Citation
    Target: Raf|VEGFR
    Summary: Raf kinases and tyrosine kinases inhibitor
      ≥23.25 mg/mL
  7. HNHA
    C4305 HNHA
    Summary: HDAC inhibitor
      ≤20 mg/mL
  8. Hexa-D-arginine TFA
    B5692 Hexa-D-arginine TFA
    Summary: furin inhibitor
      Soluble to 1 mg/mL
  9. YO-01027 (Dibenzazepine, DBZ)
    A4018 YO-01027 (Dibenzazepine, DBZ)
     1 Citation
    Summary: γ-secretase inhibitor
      ≥23.17 mg/mL
  10. 10-DEBC hydrochloride
    B7105 10-DEBC hydrochloride
    Target: Akt
    Summary: Akt inhibitor
      Soluble in DMSO

Items 281-290 of 3046

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Category
  1. Proteases 218item
  2. Apoptosis 139item
  3. Chromatin/Epigenetics 345item
  4. Metabolism 329item
  5. MAPK Signaling 140item
  6. Tyrosine Kinase 325item
  7. DNA Damage/DNA Repair 168item
  8. PI3K/Akt/mTOR Signaling 177item
  9. Microbiology & Virology 95item
  10. Cell Cycle/Checkpoint 220item
  11. Ubiquitination/ Proteasome 75item
  12. JAK/STAT Signaling 102item
  13. TGF-β / Smad Signaling 89item
  14. Angiogenesis 38item
  15. GPCR/G protein 80item
  16. Stem Cell 94item
  17. Membrane Transporter/Ion Channel 173item
  18. Cancer Biology 16item
  19. Endocrinology and Hormones 38item
  20. Neuroscience 190item
  21. Obesity, Appetite Control & Diabetes 4item
  22. Peptide Inhibitors and Substrate 1 item
  23. Other Signal Transduction 43item
  24. Others 339item
  25. Immunology/Inflammation 71item
  26. Cardiovascular 26item
  27. Vitamin D Related 1 item
Specificity
  1. Selective 780item
  2. Non-Selective 4item
Reversibility
  1. Reversible 65item
  2. Irreversible 38item
Target
  1. Caspases 13item
  2. Cyclin-Dependent Kinases 33item
  3. Proteasome 14item
  4. Cathepsins 11item
  5. Histone Deacetylases (HDACs) 36item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 13item
  8. Bcl-2 8item
  9. PI3K 38item
  10. CXCR 3item
  11. Raf 13item
  12. Aurora Kinases 23item
  13. Bcl-xl 3item
  14. CSF-1R 4item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. Gap Junctions 2item
  18. MDM2 1 item
  19. EZH2 6item
  20. mTOR 22item
  21. Bromodomains 8item
  22. AP-1 1 item
  23. MMP 8item
  24. Thymidine Phosphorylases 1 item
  25. Androgen Receptors 4item
  26. Peptidylprolyl isomerases 1 item
  27. Acyl coenzyme A: cholesterol acyltransferases 1 item
  28. Myosin II ATPases 1 item
  29. DT-diaphorases 1 item
  30. Voltage-gated Potassium (KV) Channels 1 item
  31. MER 1 item
  32. FLT3 19item
  33. GSK-3 11item
  34. Factor Xa 4item
  35. P-glycoprotein (P-gp) 5item
  36. PLK 11item
  37. Chk 8item
  38. ULK1 1 item
  39. Eph Receptors 3item
  40. VEGFR 40item
  41. PDGFR 27item
  42. c-Kit 13item
  43. RET 4item
  44. IRAK 5item
  45. Bromodomain-containing proteins(BRDs) 1 item
  46. Phosphodiesterases (PDEs) 16item
  47. Mcl-1 7item
  48. Hydrolase 1 item
  49. Thymidylate Synthase 3item
  50. p38 9item
  51. PKB 1 item
  52. 3-phosphoglycerate dehydrogenase 1 item
  53. JNK 7item
  54. SGK 2item
  55. Bcr-Abl 15item
  56. Kynurenine-3-monooxygenase 1 item
  57. MEK 16item
  58. PORCN 1 item
  59. DOT1L 3item
  60. FGFR 17item
  61. Nrf2 2item
  62. Insulin-like growth factor receptors(IGFRs) 1 item
  63. Pim 4item
  64. GABAB Receptors 1 item
  65. Sir2-like Family Deacetylases (Sirtuins) 3item
  66. Voltage-gated Sodium (NaV) Channels 1 item
  67. Deubiquitinating enzymes (DUBs) 5item
  68. Smoothened 4item
  69. Ribosomal s6 kinases (RSK) 1 item
  70. Neuraminidases (NA) 2item
  71. MET 7item
  72. Src 18item
  73. Trk Receptors 6item
  74. Integrins 1 item
  75. Aminopeptidases 3item
  76. NMDA Receptors 1 item
  77. STAT 8item
  78. ATP Citrate Lyases 1 item
  79. Microtubules/Tubulins 5item
  80. EGFR 25item
  81. Hedgehog 1 item
  82. Reverse Transcriptases 6item
  83. ROCK 12item
  84. BTK 2item
  85. RIP kinases 1 item
  86. PAK 3item
  87. PD-1/PD-L1 interaction 1 item
  88. Hypoxia Inducible Factors (HIFs) 2item
  89. Tankyrases 1 item
  90. Inositol Phosphatases 1 item
  91. FAK 6item
  92. BMP and Other Activin Receptors 4item
  93. JAK 22item
  94. p300 1 item
  95. Stearoyl-CoA 9-desaturase (SCD-1) 2item
  96. Syk 7item
  97. EZH1 2item
  98. DNA-PK 8item
  99. HSP90 12item
  100. AMPK 2item
  101. Gutathione S-transferase 2item
  102. PDHK 1 item
  103. Angiotensin AT2 Receptors 1 item
  104. eIF4E/eIF3G interaction 1 item
  105. Notch 1 item
  106. S-nitrosoglutathione reductase 1 item
  107. CFTR 2item
  108. TNKS 1 item
  109. Topoisomerases 12item
  110. Cytochrome P450 (CYP450) 8item
  111. M3 Receptors 1 item
  112. thrombin 1 item
  113. Ksp 2item
  114. Ribosomes 1 item
  115. Renin 2item
  116. HIV proteases 1 item
  117. Pepsins 1 item
  118. Influenza viruses 1 item
  119. ErbB 5item
  120. Ferroptosis 1 item
  121. S6 kinases 1 item
  122. Toll-like receptors (TLRs) 3item
  123. Adenosine Kinases 2item
  124. Actin 2item
  125. Serine Proteases 2item
  126. DNA Methyltransferases 3item
  127. Survivin 1 item
  128. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  129. ERK 7item
  130. HMG-CoA Reductases 6item
  131. Vacuolar-type ATPase 1 item
  132. Kinases 1 item
  133. c-MET 8item
  134. BMI-1 1 item
  135. PKC 14item
  136. Calpains 5item
  137. Ubiquitin-specific proteases 1 item
  138. HCV Proteases 3item
  139. Ca2 /calmodulin-dependent protein kinases (CaMKs) 7item
  140. MLK3 1 item
  141. SMYD2 1 item
  142. CREBBP 2item
  143. EP300 2item
  144. Protease-Activated Receptors 1 item
  145. Lyn 2item
  146. SGLT 1 item
  147. RAD51 2item
  148. Trypsins 1 item
  149. HER2 3item
  150. Pyk2 3item
  151. USP 2item
  152. 5-HT2 Receptors 4item
  153. LRRK2 6item
  154. Voltage-gated Calcium Channels (CaV) 1 item
  155. DGAT 2item
  156. Insulin and Insulin-like Receptors 4item
  157. PARP 8item
  158. Melanocortin (MC) Receptors 1 item
  159. Pyruvate dehydrogenases (PDH) 2item
  160. ALK 9item
  161. ROS1 2item
  162. Sphingosine kinases (SphKs) 3item
  163. Trypsin 1 item
  164. Chymotrypsin 1 item
  165. Kallikrein 1 item
  166. Trypsinogen 1 item
  167. KRAS G12C 1 item
  168. GTPases 1 item
  169. Monocarboxylate transporters (MCTs) 2item
  170. CETP 2item
  171. Dehydrogenase 1 item
  172. PKG 3item
  173. PKA 7item
  174. Myosin light chain kinases (MLCKs) 3item
  175. HIV-1 gp120 1 item
  176. D1 and D5 Receptors 1 item
  177. D2 Receptors 3item
  178. D3 Receptors 2item
  179. 5-HT1 Receptors 2item
  180. 5-HT7 Receptors 1 item
  181. CaM-KK 1 item
  182. Valosin-containing protein (VCP) 1 item
  183. MELK 1 item
  184. Serotonin reuptake 1 item
  185. Insulin-like growth factors (IGFs) 1 item
  186. Clk 1 item
  187. TBK1 1 item
  188. MARK1 1 item
  189. NUAK1 2item
  190. Integrin-ligand interactions 1 item
  191. CSF1R 1 item
  192. Bromodomain and Extra-Terminal motif (BET) 1 item
  193. NUAK2 1 item
  194. Na /H Exchangers (NHEs) 1 item
  195. Lactate Dehydrogenases (LDH) 3item
  196. MK2 4item
  197. Fatty-acid-binding proteins (FABPs) 1 item
  198. Angiotensin-Converting Enzymes (ACEs) 4item
  199. Tie-2 5item
  200. RSK 3item
  201. p70 S6K 1 item
  202. phosphatases 1 item
  203. Autophagy 4item
  204. ATM/ATR 8item
  205. Mixed lineage kinase domain-like protein (MLKL) 1 item
  206. COX 11item
  207. Heparanases 1 item
  208. CK1 2item
  209. IDH2 1 item
  210. CK2 3item
  211. HIPK2 1 item
  212. HIPK3 1 item
  213. HIV Integrases 2item
  214. Squalene epoxidases 2item
  215. PRAK 1 item
  216. MAPKAP-K2 1 item
  217. Delayed rectifier outward potassium current (IKr) 1 item
  218. 20S proteasomal chymotrypsin 1 item
  219. Geranylgeranyltransferase I 1 item
  220. Farnesyltransferase 1 item
  221. NAT10 1 item
  222. Nampt 3item
  223. eIF4F 1 item
  224. Cdc42 1 item
  225. SRPK1 1 item
  226. P2X Receptors 1 item
  227. Glutaminases 2item
  228. Carbonic Anhydrases 6item
  229. Ron 1 item
  230. AP endonucleases 1 item
  231. G9a 2item
  232. BLM 1 item
  233. HSV 2item
  234. NADPH Oxidases 3item
  235. Calcium-activated chloride channels (CaCC) 1 item
  236. GPR35 1 item
  237. Urokinases 1 item
  238. Aldehyde Dehydrogenases 1 item
  239. Synthases/Synthetases 3item
  240. c-Fyn 1 item
  241. TAK1 1 item
  242. Histamine H1 Receptors 3item
  243. Na /K ATPases 2item
  244. P110 1 item
  245. Hck 2item
  246. Inositol-requiring enzyme 1 (IRE1) 1 item
  247. SETD7 1 item
  248. Na /K /Cl- Symporters (NKCCs) 2item
  249. GABAA Receptors 1 item
  250. Phospholipases 1 item
  251. RNA Polymerases 1 item
  252. DYRK 1 item
  253. Norepinephrine transporter 1 item
  254. 5-HT Transporters 3item
  255. Xanthine oxidoreductases 1 item
  256. Dihydroorotate dehydrogenase 1 item
  257. MNK 2item
  258. 5-Lipoxygenases 1 item
  259. NO Donors / Precursors 1 item
  260. HIV-1 reverse transcriptase 1 item
  261. IL Receptors 2item
  262. CCL2 1 item
  263. Norepinephrine transporters 1 item
  264. Calcium-Activated Potassium (KCa) Channels 2item
  265. AChE 3item
  266. Insulin Receptors 1 item
  267. IRG-1R 1 item
  268. Proton Pump 1 item
  269. cAMP 1 item
  270. Sulfonylurea receptors 1 item
  271. eEF-2 1 item
  272. Inward Rectifier Potassium (Kir) Channels 2item
  273. Arp2/3 complex 1 item
  274. Cdc7 1 item
  275. CMV 1 item
  276. ZAP-70 1 item
  277. Catechol O-Methyltransferase (COMT) 2item
  278. fibrinolysis 1 item
  279. Angiotensin AT1 Receptors 1 item
  280. D4 Receptors 1 item
  281. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  282. NMDA receptor 1 item
  283. HBV Proteases 1 item
  284. Hydroxylases 2item
  285. Flk-1 1 item
  286. Papains 2item
  287. Protein Arginine Methyltransferases 1 item
  288. IMPDH 1 item
  289. Na /Ca2 Exchangers (NCXs) 1 item
  290. NAE 2item
  291. Ubiquitin-activating Enzyme E1 2item
  292. SUMOylation 1 item
  293. ATGL 1 item
  294. BACE 3item
  295. Cytidine deaminases 1 item
  296. angiogenesis 1 item
  297. Glucagon Receptors 1 item
  298. 15-PGDH 1 item
  299. DPP-4 5item
  300. c-RET 3item
  301. Nonstructural protein 5B (NS5B) 1 item
  302. p70 rsk 3item
  303. voltage-gated chloride channels 1 item
  304. FPTase 1 item
  305. Microtubule/Tubulin 1 item
  306. VEGFR3/FLT4 1 item
  307. NTRK1/TRKA 1 item
  308. CSF-1R/c-Fms 1 item
  309. Menin-MLL 2item
  310. Tryptophan hydroxylases (TPH) 2item
  311. ADAMs 1 item
  312. NMPRTase 1 item
  313. Bfl-1 1 item
  314. TAM kinase 1 item
  315. sodium channels 1 item
  316. p53-MDM2 interaction 2item
  317. nuclear export 1 item
  318. CRM1 1 item
  319. PTP 1 item
  320. KDR 2item
  321. Fyn kinase 1 item
  322. Abl kinases 1 item
  323. AXL 1 item
  324. Glyoxalase I 1 item
  325. dCTP Pyrophosphatases 1 item
  326. Protein polybromo-1 1 item
  327. SMARCA4 1 item
  328. SMARCA2 1 item
  329. Dipeptidyl-peptidase II 1 item
  330. p53 4item
  331. metalloprotease 1 item
  332. HDAC 2item
  333. KDM 2item
  334. 5-HT receptors 1 item
  335. sodium channel 2item
  336. c-Fms tyrosine kinase 1 item
  337. human lyase 1 item
  338. insulin 1 item
  339. Ub-conjugating enzyme (E2) complex 1 item
  340. Smoothened receptor 1 item
  341. quinone oxidoreductase 1 item
  342. cysteine protease 2item
  343. Nrf2/ARE signal 1 item
  344. PPAR 1 item
  345. haspin kinase 1 item
  346. STK 1 item
  347. USP1/USF1 complex 1 item
  348. IKK 1 item
  349. MSK 1 item
  350. gp120-CD4 interaction 1 item
  351. HCV polymerase 3item
  352. Ftase 1 item
  353. Subtilisin/Kex2p-like proprotein convertase 1 item
  354. PC-PLC 2item
  355. Elastases 1 item
  356. P97 ATPase 1 item
  357. NTPDases 1 item
  358. Antibiotic 1 item
  359. Mer tyrosine kinase 1 item
  360. Hec1 1 item
  361. neprilysin 1 item
  362. GLI 1 item
  363. HMGCR 1 item
  364. AAT 1 item
  365. ErbB-2 1 item
  366. adrenergic receptor 2item
  367. 5-HT4 Receptor 1 item
  368. sterol demethylase 1 item
  369. PDK-1 1 item
  370. GAPDH 1 item
  371. telomerase 1 item
  372. Histone Acetyltransferases (HATs) 3item
  373. complex I of the mitochondrial electron transport chain 1 item
  374. F1 Fo-ATPase 1 item
  375. Prk 1 item
  376. potassium channel 1 item
  377. calcium channel 1 item
  378. Ribonucleotide Reductases 1 item
  379. Trx 1 item
  380. Tyrosinases 1 item
  381. HSP70 1 item
  382. ICAM 1 item
  383. ITK 1 item
  384. HIF-PH 1 item
  385. NOD1 1 item
  386. NUAK 1 item
  387. Rho 1 item
  388. Ubiquitin E3 Ligases 1 item
  389. DCLK2 1 item
  390. FAAH 1 item
  391. PTK 1 item
  392. integrase 1 item
  393. L3MBTL 1 item
  394. NOS 2item
  395. MDMX 1 item
  396. TYK2 2item
  397. MUSK 1 item
  398. MAP3K 1 item
  399. GPR3 1 item
  400. Lck 1 item
  401. Adenosine Deaminases 2item
  402. mitochondrial pyruvate carrier (MPC) 1 item
  403. Thrombin Receptor 1 item
  404. prolactin secretion 1 item
  405. gonadotropin release 1 item
  406. DprE 1 item
  407. carnitine reabsorption 1 item
  408. Histamine receptors 1 item
  409. GluR 1 item
  410. 5-HT receptor 1 item
  411. dopamine receptors 1 item
  412. AMPA receptor 1 item
  413. 5-alpha Reductases 1 item
  414. Flk1 2item
  415. p21 1 item
  416. DNA Ligases 1 item
  417. Prostaglandin synthesis 1 item
  418. Protein Tyrosine Phosphatases 1 item
  419. alkaline phosphatases 1 item
  420. ATPases 1 item
  421. glutamate release 1 item
  422. PAFR 1 item
  423. Aromatases 2item
  424. DHFR 1 item
  425. GARFT 1 item
  426. PHF 1 item
  427. FGR 1 item
  428. YES 2item
  429. Fyn 2item
  430. ARG 1 item
  431. Autotaxin 1 item
  432. UCH 1 item
  433. RHA 1 item
  434. HCV NS3-4A protease 1 item
  435. TRPC channel 1 item
  436. PKD 1 item
  437. Thioredoxin Reductases 1 item
  438. enoyl-acyl-carrier protein reductase 1 item
  439. SHIP 1 item
  440. FKBP 1 item
  441. MCL1 1 item
  442. Bcl-w 1 item
  443. glutathione peroxidase 4 1 item
  444. NADH oxidase 1 item
  445. S-adenosylhomocysteine hydrolase 1 item
  446. Rho-kinase 1 item
  447. tropomyosin receptor kinase 1 item
  448. LSD 1 item
  449. DDX3 1 item
  450. PRMT 1 item
  451. ACE 1 item
  452. GLP 1 item
  453. SK 1 item
  454. MST 1 item
  455. PPK 1 item
  456. c-Syk 1 item
  457. CDK1/CyclinB 1 item
  458. NHE 1 item
  459. IDO 1 item
  460. Tph 1 item
  461. PIM1 kinase 1 item
  462. phospholipase A2 1 item
  463. reverse transcriptase 1 item
  464. epoxide hydrolase 1 item
  465. Serotonin (5-HT) reuptake 1 item
  466. Cholesterol absorption 1 item
  467. Vascular Disrupting Agents (VDA) 1 item
  468. Androgen Receptor 1 item
  469. Substance P/NK1 Receptor 1 item
  470. gp120/CD4 1 item
  471. Histone Methyltransferase 1 item
  472. ATM 2item
  473. Sirtuin 1 item
  474. NE 1 item
  475. PIKfyve 1 item
  476. Bax 1 item
  477. Glycogen Phosphorylases 1 item
  478. MTH1 1 item
  479. PTEN 1 item
  480. Insulin Receptor 1 item
  481. NS3/4a Proteases 1 item
  482. Ca2 -ATPases 1 item
  483. p90 S6K 1 item
Reported Experiments
  1. Animal Experiments 928item
  2. Cell Experiments 750item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 2item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 6item
  7. Acute Myeloid Leukemia 26item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Biliary Cancer 1 item
  13. Bladder Cancer 11item
  14. Bladder Carcinoma 4item
  15. Bladder Diseases 2item
  16. B-lymphoid Malignancies 1 item
  17. Brain Injuries Studies 3item
  18. Breast Cancer 117item
  19. Cancer 533item
  20. Candida Peritonitis 1 item
  21. Candidemia 1 item
  22. Castration-resistant Prostate Cancer 1 item
  23. Cervical Cancer 6item
  24. Cholangiocarcinoma 2item
  25. Chronic Lymphocytic Leukemia 8item
  26. Chronic Myeloproliferative Disorders 1 item
  27. Clear Cell Renal Cell Carcinoma 2item
  28. Cocaine-Related Disorders 2item
  29. Colon Cancer 47item
  30. Colon Carcinoma 7item
  31. Colorectal Cancer 43item
  32. Depression 2item
  33. Diabetes 8item
  34. Diffuse Large B-cell Lymphoma 1 item
  35. Dyskinesia 1 item
  36. Dyslipidemia 2item
  37. Epilepsy 4item
  38. Erectile Dysfunction 4item
  39. Friedreich's Ataxia 1 item
  40. Fungal Infection 1 item
  41. Fungi 1 item
  42. Glioblastoma 32item
  43. Glioma 18item
  44. HCV 5item
  45. Heart Failure 4item
  46. Hepatic Cancer 2item
  47. Hepatitis C 4item
  48. Hepatocellular Carcinoma 7item
  49. HIV 14item
  50. HIV Infections 10item
  51. Hypercholesterolemia 3item
  52. Immunological Diseases 1 item
  53. Inflammation 1 item
  54. Inflammatory Bowel Disease 1 item
  55. Inflammatory Diseases 15item
  56. Influenza 3item
  57. Kidney Injury Studies 2item
  58. Leukemia 26item
  59. Liver Cancer 3item
  60. Lung Cancer 42item
  61. Lung Carcinoma 4item
  62. Lymphoma 29item
  63. Mantle Cell Lymphoma 2item
  64. Medulloblastoma 1 item
  65. Melanoma 35item
  66. Mixed Lineage Leukemia 3item
  67. Multiple Myeloma 23item
  68. Myelofibrosis 2item
  69. Myeloma 6item
  70. Neuroblastoma 13item
  71. Neurocognitive Disorders 1 item
  72. Neuronal Protection 1 item
  73. Non-small Cell Lung Cancer 27item
  74. Non-small Cell Lung Carcinoma 2item
  75. Obsessive-Compulsive Disorder 1 item
  76. Osteoporosis 3item
  77. Ovarian Cancer 35item
  78. Pancreatic Cancer 47item
  79. Pancreatic Carcinoma 3item
  80. Prostate Cancer 54item
  81. Psoriasis 4item
  82. Psoriasis Vulgaris 1 item
  83. Pulmonary Arterial Hypertension 2item
  84. Pulmonary Fibrosis 2item
  85. Renal Cancer 4item
  86. Renal Cell Carcinoma 8item
  87. Rheumatoid Arthritis 14item
  88. Sarcoma 1 item
  89. Schizophrenia 7item
  90. Sleep Disorders 1 item
  91. Soft Tissue Sarcoma 1 item
  92. Squamous Cell Carcinoma 2item
  93. Testicular Cancer 2item
  94. Thyroid Cancer 6item
  95. Tuberculosis 1 item
  96. Type 2 Diabetes 11item