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Search results for: 'research area pi3k akt signaling pi3k inhibitors'

Items 381-390 of 928

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  1. U-104
    A4358 U-104
    Target: Carbonic Anhydrases
    Summary: CAIX inhibitor
      insoluble in H2O; ≥11.5 mg/mL
  2. PI-3065
    B4660 PI-3065
    Target: PI3K
    Summary: P110δkinase inhibitor
      ≥22.7 mg/mL
  3. GSK1904529A
    A1302 GSK1904529A
    Target: Insulin and Insulin-like Receptors
    Summary: Selective IGF-1R/IR inhibitor
      ≥42.6 mg/mL
  4. Dabrafenib (GSK2118436)
    B1407 Dabrafenib (GSK2118436)
     3 Citation
    Target: Raf
    Summary: Inhibitor of BRAF(V600) mutants
      ≥26 mg/mL
  5. SL-327
    A1894 SL-327
     1 Citation
    Target: MEK
    Summary: Selective MEK1/2 inhibitor
      insoluble in H2O; insoluble in EtOH; ≥16.75 mg/mL
  6. Fluvoxamine
    B1205 Fluvoxamine
    Target: Serotonin reuptake
    Summary: Selective serotonin reuptake inhibitor
      insoluble in H2O; ≥15.92 mg/mL
  7. NVP-BEP800
    A4064 NVP-BEP800
    Target: HSP90
    Summary: Oral Hsp90β inhibitor, novel, fully synthetic
  8. PF-03814735
    A4128 PF-03814735
    Target: Aurora Kinases
    Summary: Aurora A/B inhibitor
      Soluble in DMSO
  9. Raltitrexed
    B1476 Raltitrexed
    Target: Thymidylate Synthase
    Summary: Thymidylate synthase inhibitor
      insoluble in H2O; ≥154 mg/mL
  10. GNE0877
    B4633 GNE0877
    Target: LRRK2
    Summary: Potent and selective LRRK2 inhibitor
      ≥21 mg/mL

Items 381-390 of 928

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Category
  1. Proteases 88item
  2. Apoptosis 54item
  3. Chromatin/Epigenetics 116item
  4. Metabolism 90item
  5. MAPK Signaling 46item
  6. Tyrosine Kinase 137item
  7. DNA Damage/DNA Repair 69item
  8. PI3K/Akt/mTOR Signaling 79item
  9. Microbiology & Virology 36item
  10. Cell Cycle/Checkpoint 83item
  11. Ubiquitination/ Proteasome 29item
  12. JAK/STAT Signaling 45item
  13. TGF-β / Smad Signaling 42item
  14. Angiogenesis 8item
  15. GPCR/G protein 23item
  16. Stem Cell 34item
  17. Membrane Transporter/Ion Channel 30item
  18. Cancer Biology 1 item
  19. Endocrinology and Hormones 13item
  20. Neuroscience 38item
  21. Obesity, Appetite Control & Diabetes 2item
  22. Other Signal Transduction 6item
  23. Others 65item
  24. Immunology/Inflammation 15item
  25. Cardiovascular 5item
Specificity
  1. Selective 663item
  2. Non-Selective 4item
Reversibility
  1. Reversible 54item
  2. Irreversible 31item
Target
  1. Caspases 8item
  2. Cyclin-Dependent Kinases 25item
  3. Proteasome 12item
  4. Cathepsins 9item
  5. Histone Deacetylases (HDACs) 31item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 13item
  8. Bcl-2 8item
  9. PI3K 36item
  10. CXCR 3item
  11. Raf 13item
  12. Aurora Kinases 20item
  13. Bcl-xl 2item
  14. CSF-1R 4item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. Gap Junctions 1 item
  18. MDM2 1 item
  19. EZH2 4item
  20. mTOR 20item
  21. Bromodomains 6item
  22. AP-1 1 item
  23. MMP 7item
  24. Thymidine Phosphorylases 1 item
  25. Androgen Receptors 4item
  26. Peptidylprolyl isomerases 1 item
  27. Acyl coenzyme A: cholesterol acyltransferases 1 item
  28. Myosin II ATPases 1 item
  29. DT-diaphorases 1 item
  30. Voltage-gated Potassium (KV) Channels 1 item
  31. MER 1 item
  32. FLT3 19item
  33. GSK-3 10item
  34. Factor Xa 4item
  35. P-glycoprotein (P-gp) 5item
  36. PLK 10item
  37. Chk 7item
  38. Eph Receptors 2item
  39. VEGFR 40item
  40. PDGFR 25item
  41. c-Kit 13item
  42. RET 4item
  43. IRAK 1 item
  44. Bromodomain-containing proteins(BRDs) 1 item
  45. Phosphodiesterases (PDEs) 16item
  46. Mcl-1 6item
  47. Hydrolase 1 item
  48. Thymidylate Synthase 3item
  49. p38 9item
  50. PKB 1 item
  51. JNK 3item
  52. SGK 1 item
  53. Bcr-Abl 13item
  54. Kynurenine-3-monooxygenase 1 item
  55. MEK 13item
  56. PORCN 1 item
  57. DOT1L 3item
  58. FGFR 17item
  59. Nrf2 2item
  60. Insulin-like growth factor receptors(IGFRs) 1 item
  61. Pim 3item
  62. GABAB Receptors 1 item
  63. Sir2-like Family Deacetylases (Sirtuins) 3item
  64. Voltage-gated Sodium (NaV) Channels 1 item
  65. Deubiquitinating enzymes (DUBs) 3item
  66. Smoothened 4item
  67. Neuraminidases (NA) 2item
  68. MET 7item
  69. Src 14item
  70. Trk Receptors 6item
  71. Integrins 1 item
  72. Aminopeptidases 3item
  73. NMDA Receptors 1 item
  74. STAT 8item
  75. ATP Citrate Lyases 1 item
  76. Microtubules/Tubulins 4item
  77. EGFR 23item
  78. Hedgehog 1 item
  79. Reverse Transcriptases 5item
  80. ROCK 9item
  81. BTK 1 item
  82. RIP kinases 1 item
  83. PAK 3item
  84. Hypoxia Inducible Factors (HIFs) 2item
  85. Tankyrases 1 item
  86. Inositol Phosphatases 1 item
  87. FAK 6item
  88. BMP and Other Activin Receptors 3item
  89. JAK 20item
  90. p300 1 item
  91. Stearoyl-CoA 9-desaturase (SCD-1) 2item
  92. Syk 7item
  93. EZH1 2item
  94. DNA-PK 7item
  95. HSP90 12item
  96. AMPK 2item
  97. Gutathione S-transferase 1 item
  98. PDHK 1 item
  99. Angiotensin AT2 Receptors 1 item
  100. Notch 1 item
  101. S-nitrosoglutathione reductase 1 item
  102. CFTR 2item
  103. TNKS 1 item
  104. Topoisomerases 10item
  105. Cytochrome P450 (CYP450) 8item
  106. thrombin 1 item
  107. Ksp 2item
  108. Renin 1 item
  109. Influenza viruses 1 item
  110. ErbB 5item
  111. S6 kinases 1 item
  112. Toll-like receptors (TLRs) 3item
  113. Adenosine Kinases 2item
  114. Serine Proteases 2item
  115. DNA Methyltransferases 2item
  116. Survivin 1 item
  117. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  118. ERK 7item
  119. HMG-CoA Reductases 6item
  120. c-MET 8item
  121. BMI-1 1 item
  122. PKC 13item
  123. Calpains 5item
  124. Ubiquitin-specific proteases 1 item
  125. HCV Proteases 3item
  126. Ca2 /calmodulin-dependent protein kinases (CaMKs) 6item
  127. MLK3 1 item
  128. CREBBP 1 item
  129. EP300 1 item
  130. Lyn 2item
  131. SGLT 1 item
  132. RAD51 2item
  133. Trypsins 1 item
  134. HER2 3item
  135. Pyk2 3item
  136. 5-HT2 Receptors 4item
  137. LRRK2 6item
  138. Voltage-gated Calcium Channels (CaV) 1 item
  139. DGAT 2item
  140. Insulin and Insulin-like Receptors 4item
  141. PARP 6item
  142. Melanocortin (MC) Receptors 1 item
  143. Pyruvate dehydrogenases (PDH) 2item
  144. ALK 9item
  145. ROS1 2item
  146. Sphingosine kinases (SphKs) 3item
  147. Trypsin 1 item
  148. Chymotrypsin 1 item
  149. Kallikrein 1 item
  150. Trypsinogen 1 item
  151. Monocarboxylate transporters (MCTs) 2item
  152. CETP 2item
  153. Dehydrogenase 1 item
  154. PKG 2item
  155. PKA 6item
  156. Myosin light chain kinases (MLCKs) 2item
  157. HIV-1 gp120 1 item
  158. D1 and D5 Receptors 1 item
  159. D2 Receptors 3item
  160. D3 Receptors 2item
  161. 5-HT1 Receptors 2item
  162. 5-HT7 Receptors 1 item
  163. MELK 1 item
  164. Serotonin reuptake 1 item
  165. Insulin-like growth factors (IGFs) 1 item
  166. CSF1R 1 item
  167. Bromodomain and Extra-Terminal motif (BET) 1 item
  168. Lactate Dehydrogenases (LDH) 2item
  169. MK2 2item
  170. Fatty-acid-binding proteins (FABPs) 1 item
  171. Angiotensin-Converting Enzymes (ACEs) 4item
  172. Tie-2 5item
  173. RSK 3item
  174. p70 S6K 1 item
  175. phosphatases 1 item
  176. Autophagy 4item
  177. ATM/ATR 5item
  178. COX 11item
  179. CK1 1 item
  180. CK2 2item
  181. HIPK2 1 item
  182. HIPK3 1 item
  183. HIV Integrases 1 item
  184. Squalene epoxidases 2item
  185. PRAK 1 item
  186. MAPKAP-K2 1 item
  187. Delayed rectifier outward potassium current (IKr) 1 item
  188. 20S proteasomal chymotrypsin 1 item
  189. Geranylgeranyltransferase I 1 item
  190. Farnesyltransferase 1 item
  191. Nampt 3item
  192. eIF4F 1 item
  193. Cdc42 1 item
  194. SRPK1 1 item
  195. P2X Receptors 1 item
  196. Glutaminases 2item
  197. Carbonic Anhydrases 6item
  198. Ron 1 item
  199. G9a 1 item
  200. BLM 1 item
  201. HSV 1 item
  202. NADPH Oxidases 3item
  203. Calcium-activated chloride channels (CaCC) 1 item
  204. GPR35 1 item
  205. Aldehyde Dehydrogenases 1 item
  206. Synthases/Synthetases 2item
  207. Histamine H1 Receptors 3item
  208. Na /K ATPases 2item
  209. P110 1 item
  210. Hck 2item
  211. Inositol-requiring enzyme 1 (IRE1) 1 item
  212. Na /K /Cl- Symporters (NKCCs) 2item
  213. GABAA Receptors 1 item
  214. Phospholipases 1 item
  215. RNA Polymerases 1 item
  216. Norepinephrine transporter 1 item
  217. 5-HT Transporters 3item
  218. Xanthine oxidoreductases 1 item
  219. Dihydroorotate dehydrogenase 1 item
  220. MNK 2item
  221. 5-Lipoxygenases 1 item
  222. NO Donors / Precursors 1 item
  223. HIV-1 reverse transcriptase 1 item
  224. IL Receptors 2item
  225. CCL2 1 item
  226. Norepinephrine transporters 1 item
  227. Calcium-Activated Potassium (KCa) Channels 2item
  228. AChE 3item
  229. Insulin Receptors 1 item
  230. IRG-1R 1 item
  231. cAMP 1 item
  232. Sulfonylurea receptors 1 item
  233. eEF-2 1 item
  234. Inward Rectifier Potassium (Kir) Channels 2item
  235. Cdc7 1 item
  236. CMV 1 item
  237. ZAP-70 1 item
  238. Catechol O-Methyltransferase (COMT) 2item
  239. fibrinolysis 1 item
  240. Angiotensin AT1 Receptors 1 item
  241. D4 Receptors 1 item
  242. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  243. NMDA receptor 1 item
  244. HBV Proteases 1 item
  245. Hydroxylases 2item
  246. Flk-1 1 item
  247. Papains 1 item
  248. Protein Arginine Methyltransferases 1 item
  249. IMPDH 1 item
  250. Na /Ca2 Exchangers (NCXs) 1 item
  251. NAE 2item
  252. Ubiquitin-activating Enzyme E1 2item
  253. SUMOylation 1 item
  254. ATGL 1 item
  255. BACE 2item
  256. Cytidine deaminases 1 item
  257. angiogenesis 1 item
  258. Glucagon Receptors 1 item
  259. 15-PGDH 1 item
  260. DPP-4 5item
  261. c-RET 3item
  262. Nonstructural protein 5B (NS5B) 1 item
  263. p70 rsk 3item
  264. voltage-gated chloride channels 1 item
  265. FPTase 1 item
  266. Microtubule/Tubulin 1 item
  267. VEGFR3/FLT4 1 item
  268. NTRK1/TRKA 1 item
  269. CSF-1R/c-Fms 1 item
  270. Tryptophan hydroxylases (TPH) 2item
  271. ADAMs 1 item
  272. NMPRTase 1 item
  273. Bfl-1 1 item
  274. TAM kinase 1 item
  275. p53-MDM2 interaction 1 item
  276. nuclear export 1 item
  277. CRM1 1 item
  278. PTP 1 item
  279. KDR 2item
  280. Fyn kinase 1 item
  281. AXL 1 item
  282. Glyoxalase I 1 item
  283. Dipeptidyl-peptidase II 1 item
  284. p53 4item
  285. metalloprotease 1 item
  286. HDAC 2item
  287. 5-HT receptors 1 item
  288. sodium channel 2item
  289. c-Fms tyrosine kinase 1 item
  290. human lyase 1 item
  291. insulin 1 item
  292. Ub-conjugating enzyme (E2) complex 1 item
  293. Smoothened receptor 1 item
  294. cysteine protease 2item
  295. IKK 1 item
  296. MSK 1 item
  297. gp120-CD4 interaction 1 item
  298. HCV polymerase 2item
  299. Ftase 1 item
  300. PC-PLC 2item
  301. Elastases 1 item
  302. Antibiotic 1 item
  303. Mer tyrosine kinase 1 item
  304. Hec1 1 item
  305. neprilysin 1 item
  306. GLI 1 item
  307. HMGCR 1 item
  308. ErbB-2 1 item
  309. adrenergic receptor 2item
  310. 5-HT4 Receptor 1 item
  311. sterol demethylase 1 item
  312. PDK-1 1 item
  313. GAPDH 1 item
  314. Histone Acetyltransferases (HATs) 2item
  315. complex I of the mitochondrial electron transport chain 1 item
  316. F1 Fo-ATPase 1 item
  317. Prk 1 item
  318. potassium channel 1 item
  319. calcium channel 1 item
  320. Ribonucleotide Reductases 1 item
  321. Trx 1 item
  322. Tyrosinases 1 item
  323. HSP70 1 item
  324. ICAM 1 item
  325. ITK 1 item
  326. HIF-PH 1 item
  327. NUAK 1 item
  328. Rho 1 item
  329. Ubiquitin E3 Ligases 1 item
  330. DCLK2 1 item
  331. FAAH 1 item
  332. PTK 1 item
  333. integrase 1 item
  334. NOS 2item
  335. TYK2 2item
  336. MUSK 1 item
  337. MAP3K 1 item
  338. GPR3 1 item
  339. Adenosine Deaminases 2item
  340. mitochondrial pyruvate carrier (MPC) 1 item
  341. Thrombin Receptor 1 item
  342. prolactin secretion 1 item
  343. gonadotropin release 1 item
  344. DprE 1 item
  345. carnitine reabsorption 1 item
  346. Histamine receptors 1 item
  347. GluR 1 item
  348. 5-HT receptor 1 item
  349. dopamine receptors 1 item
  350. AMPA receptor 1 item
  351. 5-alpha Reductases 1 item
  352. Flk1 2item
  353. p21 1 item
  354. Prostaglandin synthesis 1 item
  355. Protein Tyrosine Phosphatases 1 item
  356. alkaline phosphatases 1 item
  357. ATPases 1 item
  358. glutamate release 1 item
  359. PAFR 1 item
  360. Aromatases 2item
  361. DHFR 1 item
  362. GARFT 1 item
  363. FGR 1 item
  364. YES 2item
  365. Fyn 2item
  366. ARG 1 item
  367. Autotaxin 1 item
  368. UCH 1 item
  369. RHA 1 item
  370. HCV NS3-4A protease 1 item
  371. TRPC channel 1 item
  372. PKD 1 item
  373. Thioredoxin Reductases 1 item
  374. enoyl-acyl-carrier protein reductase 1 item
  375. SHIP 1 item
  376. FKBP 1 item
  377. MCL1 1 item
  378. Bcl-w 1 item
  379. glutathione peroxidase 4 1 item
  380. S-adenosylhomocysteine hydrolase 1 item
  381. Rho-kinase 1 item
  382. tropomyosin receptor kinase 1 item
  383. LSD 1 item
  384. DDX3 1 item
  385. PRMT 1 item
  386. ACE 1 item
  387. GLP 1 item
  388. SK 1 item
  389. MST 1 item
  390. PPK 1 item
  391. c-Syk 1 item
  392. CDK1/CyclinB 1 item
  393. NHE 1 item
  394. IDO 1 item
  395. Tph 1 item
  396. PIM1 kinase 1 item
  397. phospholipase A2 1 item
  398. reverse transcriptase 1 item
  399. epoxide hydrolase 1 item
  400. Serotonin (5-HT) reuptake 1 item
  401. Cholesterol absorption 1 item
  402. Vascular Disrupting Agents (VDA) 1 item
  403. Androgen Receptor 1 item
  404. Substance P/NK1 Receptor 1 item
  405. gp120/CD4 1 item
  406. ATM 1 item
  407. Sirtuin 1 item
  408. NE 1 item
  409. PIKfyve 1 item
  410. Bax 1 item
  411. Glycogen Phosphorylases 1 item
  412. MTH1 1 item
  413. PTEN 1 item
  414. Insulin Receptor 1 item
  415. NS3/4a Proteases 1 item
  416. Ca2 -ATPases 1 item
  417. p90 S6K 1 item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 2item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 5item
  7. Acute Myeloid Leukemia 25item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Biliary Cancer 1 item
  13. Bladder Cancer 11item
  14. Bladder Carcinoma 4item
  15. Bladder Diseases 2item
  16. B-lymphoid Malignancies 1 item
  17. Brain Injuries Studies 3item
  18. Breast Cancer 110item
  19. Cancer 492item
  20. Candida Peritonitis 1 item
  21. Candidemia 1 item
  22. Castration-resistant Prostate Cancer 1 item
  23. Cervical Cancer 6item
  24. Cholangiocarcinoma 2item
  25. Chronic Lymphocytic Leukemia 8item
  26. Chronic Myeloproliferative Disorders 1 item
  27. Clear Cell Renal Cell Carcinoma 2item
  28. Cocaine-Related Disorders 2item
  29. Colon Cancer 41item
  30. Colon Carcinoma 7item
  31. Colorectal Cancer 40item
  32. Depression 2item
  33. Diabetes 7item
  34. Diffuse Large B-cell Lymphoma 1 item
  35. Dyskinesia 1 item
  36. Dyslipidemia 2item
  37. Epilepsy 4item
  38. Erectile Dysfunction 4item
  39. Friedreich's Ataxia 1 item
  40. Fungal Infection 1 item
  41. Fungi 1 item
  42. Glioblastoma 30item
  43. Glioma 17item
  44. HCV 4item
  45. Heart Failure 4item
  46. Hepatic Cancer 2item
  47. Hepatitis C 4item
  48. Hepatocellular Carcinoma 7item
  49. HIV 13item
  50. HIV Infections 9item
  51. Hypercholesterolemia 3item
  52. Immunological Diseases 1 item
  53. Inflammation 1 item
  54. Inflammatory Bowel Disease 1 item
  55. Inflammatory Diseases 14item
  56. Influenza 3item
  57. Kidney Injury Studies 2item
  58. Leukemia 23item
  59. Liver Cancer 3item
  60. Lung Cancer 38item
  61. Lung Carcinoma 4item
  62. Lymphoma 26item
  63. Mantle Cell Lymphoma 2item
  64. Medulloblastoma 1 item
  65. Melanoma 31item
  66. Mixed Lineage Leukemia 3item
  67. Multiple Myeloma 21item
  68. Myelofibrosis 2item
  69. Myeloma 6item
  70. Neuroblastoma 13item
  71. Neurocognitive Disorders 1 item
  72. Neuronal Protection 1 item
  73. Non-small Cell Lung Cancer 26item
  74. Non-small Cell Lung Carcinoma 2item
  75. Obsessive-Compulsive Disorder 1 item
  76. Osteoporosis 2item
  77. Ovarian Cancer 33item
  78. Pancreatic Cancer 46item
  79. Pancreatic Carcinoma 3item
  80. Prostate Cancer 49item
  81. Psoriasis 4item
  82. Psoriasis Vulgaris 1 item
  83. Pulmonary Arterial Hypertension 2item
  84. Pulmonary Fibrosis 2item
  85. Renal Cancer 4item
  86. Renal Cell Carcinoma 8item
  87. Rheumatoid Arthritis 14item
  88. Sarcoma 1 item
  89. Schizophrenia 7item
  90. Sleep Disorders 1 item
  91. Soft Tissue Sarcoma 1 item
  92. Squamous Cell Carcinoma 2item
  93. Testicular Cancer 2item
  94. Thyroid Cancer 6item
  95. Tuberculosis 1 item
  96. Type 2 Diabetes 11item