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  • Search results for: 'research area pi3k akt signaling pi3k inhibitors'

Search results for: 'research area pi3k akt signaling pi3k inhibitors'

Items 71-80 of 780

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  1. GDC-0879
    A5071 GDC-0879
     1 Citation
    Target: Raf
    Summary: B-Raf inhibitor,potent and selective
      insoluble in EtOH; insoluble in H2O; ≥16.7 mg/mL
  2. LY2228820
    A5566 LY2228820
     1 Citation
    Target: p38
    Summary: P38 MAP kinase inhibitor
      ≥30.65 mg/mL
  3. PD184352 (CI-1040)
    A1792 PD184352 (CI-1040)
    Target: MEK
    Summary: Selective MEK inhibitor
      ≥47.9 mg/mL
  4. DMAT
    A3368 DMAT
     2 Citation
    Target: Pim|CK2|HIPK2|HIPK3
    Summary: CK2 inhibitor,potent and selective
      ≥23.85 mg/mL
  5. CC-930
    A3288 CC-930
    Target: JNK
    Summary: JNK inhibitor,potent and selective
      Soluble in DMSO
  6. Trametinib (GSK1120212)
    A3018 Trametinib (GSK1120212)
     7 Citation
    Target: MEK
    Summary: MEK1 and MEK2 inhibitor, potent and selective
      insoluble in H2O; insoluble in EtOH; ≥15.38 mg/mL
  7. XAV-939
    A1877 XAV-939
     1 Citation
    Target: TNKS
    Summary: Tankyrase 1/2 inhibitor
      insoluble in H2O; insoluble in EtOH; ≥15.62 mg/mL
  8. PLX-4720
    A3016 PLX-4720
     1 Citation
    Target: Raf
    Summary: BRAF kinase inhibitor
      ≥20.69 mg/mL
  9. Stattic
    A2224 Stattic
     5 Citation
    Target: STAT
    Summary: STAT3 inhibitor,small-molecule and potent
      insoluble in H2O; insoluble in EtOH; ≥10.56 mg/mL
  10. BIX 02189
    A5801 BIX 02189
    Target: MEK|ERK
    Summary: Selective MEK5 inhibitor
      ≥22.05 mg/mL

Items 71-80 of 780

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Category
  1. Proteases 77item
  2. Apoptosis 41item
  3. Chromatin/Epigenetics 104item
  4. Metabolism 62item
  5. MAPK Signaling 46item
  6. Tyrosine Kinase 113item
  7. DNA Damage/DNA Repair 58item
  8. PI3K/Akt/mTOR Signaling 62item
  9. Microbiology & Virology 26item
  10. Cell Cycle/Checkpoint 74item
  11. Ubiquitination/ Proteasome 33item
  12. JAK/STAT Signaling 33item
  13. TGF-β / Smad Signaling 33item
  14. Angiogenesis 9item
  15. GPCR/G protein 18item
  16. Stem Cell 30item
  17. Membrane Transporter/Ion Channel 29item
  18. Endocrinology and Hormones 7item
  19. Neuroscience 25item
  20. Obesity, Appetite Control & Diabetes 2item
  21. Other Signal Transduction 3item
  22. Others 58item
  23. Immunology/Inflammation 13item
  24. Cardiovascular 1 item
Reversibility
  1. Reversible 54item
  2. Irreversible 25item
Target
  1. Caspases 10item
  2. Cyclin-Dependent Kinases 26item
  3. Proteasome 11item
  4. Cathepsins 11item
  5. Histone Deacetylases (HDACs) 27item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 6item
  8. Bcl-2 5item
  9. PI3K 27item
  10. CXCR 3item
  11. Raf 10item
  12. Aurora Kinases 14item
  13. Bcl-xl 3item
  14. CSF-1R 2item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. Gap Junctions 1 item
  18. MDM2 1 item
  19. EZH2 6item
  20. mTOR 15item
  21. Bromodomains 5item
  22. AP-1 1 item
  23. MMP 8item
  24. Thymidine Phosphorylases 1 item
  25. Androgen Receptors 3item
  26. Peptidylprolyl isomerases 1 item
  27. Acyl coenzyme A: cholesterol acyltransferases 1 item
  28. Myosin II ATPases 1 item
  29. DT-diaphorases 1 item
  30. MER 1 item
  31. FLT3 12item
  32. GSK-3 9item
  33. Factor Xa 3item
  34. P-glycoprotein (P-gp) 5item
  35. PLK 7item
  36. Chk 8item
  37. ULK1 1 item
  38. Eph Receptors 3item
  39. VEGFR 25item
  40. PDGFR 19item
  41. c-Kit 7item
  42. RET 3item
  43. IRAK 3item
  44. Bromodomain-containing proteins(BRDs) 1 item
  45. Phosphodiesterases (PDEs) 10item
  46. Mcl-1 5item
  47. Hydrolase 1 item
  48. Thymidylate Synthase 2item
  49. p38 9item
  50. PKB 1 item
  51. 3-phosphoglycerate dehydrogenase 1 item
  52. JNK 6item
  53. SGK 2item
  54. Bcr-Abl 10item
  55. Kynurenine-3-monooxygenase 1 item
  56. MEK 15item
  57. PORCN 1 item
  58. DOT1L 3item
  59. FGFR 9item
  60. Nrf2 1 item
  61. Insulin-like growth factor receptors(IGFRs) 1 item
  62. Pim 4item
  63. GABAB Receptors 1 item
  64. Sir2-like Family Deacetylases (Sirtuins) 2item
  65. Deubiquitinating enzymes (DUBs) 4item
  66. Smoothened 4item
  67. Ribosomal s6 kinases (RSK) 1 item
  68. Neuraminidases (NA) 1 item
  69. MET 7item
  70. Src 9item
  71. Trk Receptors 5item
  72. Integrins 1 item
  73. Aminopeptidases 2item
  74. STAT 5item
  75. ATP Citrate Lyases 1 item
  76. Microtubules/Tubulins 4item
  77. EGFR 15item
  78. Hedgehog 1 item
  79. Reverse Transcriptases 1 item
  80. ROCK 7item
  81. BTK 2item
  82. RIP kinases 1 item
  83. PAK 3item
  84. Hypoxia Inducible Factors (HIFs) 2item
  85. Tankyrases 1 item
  86. Inositol Phosphatases 1 item
  87. FAK 5item
  88. BMP and Other Activin Receptors 4item
  89. JAK 13item
  90. p300 1 item
  91. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  92. Syk 7item
  93. EZH1 2item
  94. DNA-PK 6item
  95. HSP90 10item
  96. AMPK 2item
  97. Gutathione S-transferase 1 item
  98. PDHK 1 item
  99. Angiotensin AT2 Receptors 1 item
  100. eIF4E/eIF3G interaction 1 item
  101. Notch 1 item
  102. S-nitrosoglutathione reductase 1 item
  103. CFTR 2item
  104. TNKS 1 item
  105. Topoisomerases 6item
  106. Cytochrome P450 (CYP450) 5item
  107. thrombin 1 item
  108. Ksp 1 item
  109. Ribosomes 1 item
  110. Renin 2item
  111. HIV proteases 1 item
  112. Pepsins 1 item
  113. Influenza viruses 1 item
  114. ErbB 2item
  115. Ferroptosis 1 item
  116. S6 kinases 1 item
  117. Toll-like receptors (TLRs) 2item
  118. Adenosine Kinases 2item
  119. Actin 1 item
  120. DNA Methyltransferases 3item
  121. Survivin 1 item
  122. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  123. ERK 5item
  124. HMG-CoA Reductases 5item
  125. Vacuolar-type ATPase 1 item
  126. c-MET 8item
  127. BMI-1 1 item
  128. PKC 6item
  129. Calpains 5item
  130. Ubiquitin-specific proteases 1 item
  131. HCV Proteases 3item
  132. Ca2 /calmodulin-dependent protein kinases (CaMKs) 7item
  133. MLK3 1 item
  134. SMYD2 1 item
  135. CREBBP 2item
  136. EP300 2item
  137. Lyn 1 item
  138. SGLT 1 item
  139. RAD51 1 item
  140. Trypsins 1 item
  141. HER2 2item
  142. Pyk2 3item
  143. USP 2item
  144. 5-HT2 Receptors 4item
  145. LRRK2 4item
  146. DGAT 2item
  147. Insulin and Insulin-like Receptors 3item
  148. PARP 4item
  149. Melanocortin (MC) Receptors 1 item
  150. Pyruvate dehydrogenases (PDH) 1 item
  151. ALK 5item
  152. ROS1 2item
  153. Sphingosine kinases (SphKs) 2item
  154. Trypsin 1 item
  155. Chymotrypsin 1 item
  156. Kallikrein 1 item
  157. Trypsinogen 1 item
  158. KRAS G12C 1 item
  159. GTPases 1 item
  160. Monocarboxylate transporters (MCTs) 1 item
  161. CETP 2item
  162. Dehydrogenase 1 item
  163. PKG 1 item
  164. PKA 1 item
  165. Myosin light chain kinases (MLCKs) 2item
  166. HIV-1 gp120 1 item
  167. D1 and D5 Receptors 1 item
  168. D2 Receptors 3item
  169. D3 Receptors 2item
  170. 5-HT1 Receptors 2item
  171. 5-HT7 Receptors 1 item
  172. CaM-KK 1 item
  173. Valosin-containing protein (VCP) 1 item
  174. MELK 1 item
  175. Serotonin reuptake 1 item
  176. Insulin-like growth factors (IGFs) 1 item
  177. Clk 1 item
  178. TBK1 1 item
  179. MARK1 1 item
  180. NUAK1 2item
  181. Integrin-ligand interactions 1 item
  182. CSF1R 1 item
  183. Bromodomain and Extra-Terminal motif (BET) 1 item
  184. NUAK2 1 item
  185. Na /H Exchangers (NHEs) 1 item
  186. Lactate Dehydrogenases (LDH) 2item
  187. MK2 3item
  188. Fatty-acid-binding proteins (FABPs) 1 item
  189. Angiotensin-Converting Enzymes (ACEs) 2item
  190. Tie-2 4item
  191. RSK 2item
  192. p70 S6K 1 item
  193. phosphatases 1 item
  194. Autophagy 2item
  195. ATM/ATR 7item
  196. Mixed lineage kinase domain-like protein (MLKL) 1 item
  197. COX 6item
  198. Heparanases 1 item
  199. CK1 1 item
  200. IDH2 1 item
  201. CK2 3item
  202. HIPK2 1 item
  203. HIPK3 1 item
  204. HIV Integrases 1 item
  205. Squalene epoxidases 2item
  206. PRAK 1 item
  207. MAPKAP-K2 1 item
  208. Delayed rectifier outward potassium current (IKr) 1 item
  209. 20S proteasomal chymotrypsin 1 item
  210. Geranylgeranyltransferase I 1 item
  211. Farnesyltransferase 1 item
  212. NAT10 1 item
  213. Nampt 2item
  214. eIF4F 1 item
  215. Cdc42 1 item
  216. SRPK1 1 item
  217. P2X Receptors 1 item
  218. Glutaminases 1 item
  219. Carbonic Anhydrases 5item
  220. Ron 1 item
  221. AP endonucleases 1 item
  222. G9a 2item
  223. BLM 1 item
  224. HSV 2item
  225. NADPH Oxidases 2item
  226. Calcium-activated chloride channels (CaCC) 1 item
  227. GPR35 1 item
  228. Aldehyde Dehydrogenases 1 item
  229. Synthases/Synthetases 3item
  230. c-Fyn 1 item
  231. TAK1 1 item
  232. Histamine H1 Receptors 1 item
  233. Na /K ATPases 2item
  234. P110 1 item
  235. Hck 1 item
  236. Inositol-requiring enzyme 1 (IRE1) 1 item
  237. SETD7 1 item
  238. Na /K /Cl- Symporters (NKCCs) 1 item
  239. GABAA Receptors 1 item
  240. Phospholipases 1 item
  241. RNA Polymerases 1 item
  242. Norepinephrine transporter 1 item
  243. 5-HT Transporters 3item
  244. Xanthine oxidoreductases 1 item
  245. Dihydroorotate dehydrogenase 1 item
  246. MNK 1 item
  247. NO Donors / Precursors 1 item
  248. HIV-1 reverse transcriptase 1 item
  249. IL Receptors 2item
  250. CCL2 1 item
  251. Norepinephrine transporters 1 item
  252. Calcium-Activated Potassium (KCa) Channels 1 item
  253. AChE 2item
  254. Insulin Receptors 1 item
  255. IRG-1R 1 item
  256. Proton Pump 1 item
  257. cAMP 1 item
  258. Sulfonylurea receptors 1 item
  259. eEF-2 1 item
  260. Inward Rectifier Potassium (Kir) Channels 2item
  261. Arp2/3 complex 1 item
  262. Cdc7 1 item
  263. CMV 1 item
  264. ZAP-70 1 item
  265. Catechol O-Methyltransferase (COMT) 2item
  266. fibrinolysis 1 item
  267. D4 Receptors 1 item
  268. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  269. HBV Proteases 1 item
  270. Flk-1 1 item
  271. Papains 1 item
  272. Protein Arginine Methyltransferases 1 item
  273. IMPDH 1 item
  274. Na /Ca2 Exchangers (NCXs) 1 item
  275. NAE 2item
  276. Ubiquitin-activating Enzyme E1 1 item
  277. SUMOylation 1 item
  278. ATGL 1 item
  279. BACE 1 item
  280. Cytidine deaminases 1 item
  281. angiogenesis 1 item
  282. Glucagon Receptors 1 item
  283. 15-PGDH 1 item
  284. DPP-4 4item
  285. c-RET 1 item
  286. Nonstructural protein 5B (NS5B) 1 item
  287. p70 rsk 1 item
  288. FPTase 1 item
  289. ADAMs 1 item
  290. TAM kinase 1 item
  291. p53-MDM2 interaction 1 item
  292. nuclear export 1 item
  293. CRM1 1 item
  294. AXL 1 item
  295. Protein polybromo-1 1 item
  296. SMARCA4 1 item
  297. SMARCA2 1 item
  298. Dipeptidyl-peptidase II 1 item
  299. HDAC 1 item
  300. c-Fms tyrosine kinase 1 item
  301. human lyase 1 item
  302. Ub-conjugating enzyme (E2) complex 1 item
  303. STK 1 item
  304. IKK 1 item
  305. MSK 1 item
  306. HCV polymerase 2item
  307. Ftase 1 item
  308. PC-PLC 1 item
  309. Elastases 1 item
  310. P97 ATPase 1 item
  311. NTPDases 1 item
  312. telomerase 1 item
  313. Histone Acetyltransferases (HATs) 1 item
  314. F1 Fo-ATPase 1 item
  315. ITK 1 item
  316. NOD1 1 item
  317. NUAK 1 item
  318. DCLK2 1 item
  319. FAAH 1 item
  320. TYK2 1 item
  321. Lck 1 item
  322. Aromatases 1 item
  323. PKD 1 item
  324. SHIP 1 item
  325. MCL1 1 item
  326. Bcl-w 1 item
  327. tropomyosin receptor kinase 1 item
  328. LSD 1 item
  329. PRMT 1 item
  330. GLP 1 item
  331. SK 1 item
  332. MST 1 item
  333. IDO 1 item
  334. Serotonin (5-HT) reuptake 1 item
  335. Androgen Receptor 1 item
  336. Substance P/NK1 Receptor 1 item
  337. gp120/CD4 1 item
  338. ATM 2item
  339. Sirtuin 1 item
  340. NE 1 item
  341. PIKfyve 1 item
  342. Glycogen Phosphorylases 1 item
  343. MTH1 1 item
  344. Insulin Receptor 1 item
Reported Experiments
  1. Animal Experiments 663item
  2. Cell Experiments 455item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 1 item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 6item
  7. Acute Myeloid Leukemia 26item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Biliary Cancer 1 item
  13. Bladder Cancer 10item
  14. Bladder Carcinoma 4item
  15. Bladder Diseases 2item
  16. B-lymphoid Malignancies 1 item
  17. Brain Injuries Studies 3item
  18. Breast Cancer 112item
  19. Cancer 422item
  20. Candida Peritonitis 1 item
  21. Candidemia 1 item
  22. Castration-resistant Prostate Cancer 1 item
  23. Cervical Cancer 5item
  24. Cholangiocarcinoma 2item
  25. Chronic Lymphocytic Leukemia 8item
  26. Chronic Myeloproliferative Disorders 1 item
  27. Clear Cell Renal Cell Carcinoma 2item
  28. Cocaine-Related Disorders 2item
  29. Colon Cancer 45item
  30. Colon Carcinoma 7item
  31. Colorectal Cancer 42item
  32. Depression 2item
  33. Diabetes 7item
  34. Diffuse Large B-cell Lymphoma 1 item
  35. Dyskinesia 1 item
  36. Dyslipidemia 2item
  37. Epilepsy 2item
  38. Erectile Dysfunction 3item
  39. Friedreich's Ataxia 1 item
  40. Fungal Infection 1 item
  41. Glioblastoma 32item
  42. Glioma 18item
  43. HCV 3item
  44. Heart Failure 1 item
  45. Hepatic Cancer 2item
  46. Hepatitis C 3item
  47. Hepatocellular Carcinoma 7item
  48. HIV 4item
  49. HIV Infections 9item
  50. Hypercholesterolemia 2item
  51. Immunological Diseases 1 item
  52. Inflammation 1 item
  53. Inflammatory Bowel Disease 1 item
  54. Inflammatory Diseases 13item
  55. Influenza 2item
  56. Kidney Injury Studies 1 item
  57. Leukemia 22item
  58. Liver Cancer 3item
  59. Lung Cancer 42item
  60. Lung Carcinoma 4item
  61. Lymphoma 29item
  62. Mantle Cell Lymphoma 2item
  63. Medulloblastoma 1 item
  64. Melanoma 34item
  65. Mixed Lineage Leukemia 3item
  66. Multiple Myeloma 23item
  67. Myelofibrosis 2item
  68. Myeloma 6item
  69. Neuroblastoma 13item
  70. Neurocognitive Disorders 1 item
  71. Neuronal Protection 1 item
  72. Non-small Cell Lung Cancer 26item
  73. Non-small Cell Lung Carcinoma 2item
  74. Obsessive-Compulsive Disorder 1 item
  75. Osteoporosis 2item
  76. Ovarian Cancer 34item
  77. Pancreatic Cancer 47item
  78. Pancreatic Carcinoma 3item
  79. Prostate Cancer 53item
  80. Psoriasis 4item
  81. Psoriasis Vulgaris 1 item
  82. Pulmonary Arterial Hypertension 2item
  83. Pulmonary Fibrosis 2item
  84. Renal Cancer 4item
  85. Renal Cell Carcinoma 8item
  86. Rheumatoid Arthritis 14item
  87. Sarcoma 1 item
  88. Schizophrenia 6item
  89. Sleep Disorders 1 item
  90. Soft Tissue Sarcoma 1 item
  91. Squamous Cell Carcinoma 2item
  92. Testicular Cancer 2item
  93. Thyroid Cancer 6item
  94. Type 2 Diabetes 11item