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  • Search results for: 'research area pi3k akt signaling pi3k inhibitors'

Search results for: 'research area pi3k akt signaling pi3k inhibitors'

Items 241-250 of 545

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  1. RG7112
    A3762 RG7112
     5 Citation
    Target: MDM2
    Summary: MDM2 inhibitor, first clinical
      ≥36.4 mg/mL
  2. AUY922 (NVP-AUY922)
    A4057 AUY922 (NVP-AUY922)
     1 Citation
    Target: HSP90
    Summary: Potent Hsp90 inhibitor
      ≥23.27 mg/mL
  3. YM155
    A4221 YM155
     2 Citation
    Target: Survivin
    Summary: Survivin suppressant,apoptosis inhibitor
      ≥22.15 mg/mL
  4. Nu 6027
    A1986 Nu 6027
    Target: Cyclin-Dependent Kinases|ATM/ATR
    Summary: ATR/CDK inhibitor, potent and selective
      insoluble in H2O; ≥12.55 mg/mL
  5. Brivanib (BMS-540215)
    A2597 Brivanib (BMS-540215)
    Target: VEGFR|FGFR|Flk1
    Summary: VEGFR-2 inhibitor,ATP-competitive
      insoluble in H2O; ≥18.5 mg/mL
  6. BAY 87-2243
    B1115 BAY 87-2243
    Target: Hypoxia Inducible Factors (HIFs)
    Summary: HIF-1 inhibitor,potent and selective
  7. AZD-9291
    B1104 AZD-9291
     1 Citation
    Target: EGFR
    Summary: Mutated forms EGFR inhibitor
      ≥24.98 mg/mL
  8. Sabutoclax
    A4199 Sabutoclax
     2 Citation
    Target: Bcl-2|Mcl-1|Bfl-1
    Summary: pan-Bcl-2 inhibitor
      insoluble in H2O; ≥205.6 mg/mL
  9. Etoposide
    A1971 Etoposide
     4 Citation
    Target: Topoisomerases
    Summary: Topo II inhibitor
      ≥29.45 mg/mL
  10. Reparixin L-lysine salt
    A3753 Reparixin L-lysine salt
     1 Citation
    Target: CXCR
    Summary: CXCR1/CXCR2 inhibitor
      insoluble in DMSO; ≥16.67 mg/mL

Items 241-250 of 545

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Category
  1. Signaling Pathways 533item
  2. Natural Products 2item
  3. Lab Reagents 1 item
Specificity
  1. Selective 430item
  2. Non-Selective 2item
Reversibility
  1. Reversible 28item
  2. Irreversible 22item
Target
  1. Caspases 3item
  2. Cyclin-Dependent Kinases 25item
  3. Proteasome 9item
  4. Cathepsins 2item
  5. Histone Deacetylases (HDACs) 25item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 11item
  8. Bcl-2 7item
  9. PI3K 26item
  10. CXCR 1 item
  11. Raf 11item
  12. Aurora Kinases 18item
  13. Bcl-xl 2item
  14. CSF-1R 4item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. MDM2 1 item
  18. EZH2 5item
  19. mTOR 15item
  20. Bromodomains 5item
  21. MMP 3item
  22. Thymidine Phosphorylases 1 item
  23. Androgen Receptors 3item
  24. DT-diaphorases 1 item
  25. FLT3 12item
  26. GSK-3 5item
  27. P-glycoprotein (P-gp) 5item
  28. PLK 9item
  29. Chk 5item
  30. ULK1 1 item
  31. Eph Receptors 3item
  32. VEGFR 36item
  33. PDGFR 21item
  34. c-Kit 10item
  35. RET 4item
  36. Bromodomain-containing proteins(BRDs) 1 item
  37. Phosphodiesterases (PDEs) 3item
  38. Mcl-1 5item
  39. Thymidylate Synthase 3item
  40. p38 3item
  41. 3-phosphoglycerate dehydrogenase 1 item
  42. JNK 1 item
  43. SGK 2item
  44. Bcr-Abl 8item
  45. MEK 11item
  46. PORCN 1 item
  47. DOT1L 3item
  48. FGFR 13item
  49. Insulin-like growth factor receptors(IGFRs) 1 item
  50. Pim 4item
  51. Sir2-like Family Deacetylases (Sirtuins) 2item
  52. Deubiquitinating enzymes (DUBs) 4item
  53. Smoothened 4item
  54. Ribosomal s6 kinases (RSK) 1 item
  55. MET 7item
  56. Src 8item
  57. Trk Receptors 5item
  58. Integrins 1 item
  59. Aminopeptidases 2item
  60. STAT 9item
  61. Microtubules/Tubulins 4item
  62. EGFR 20item
  63. Hedgehog 1 item
  64. ROCK 1 item
  65. PAK 3item
  66. Hypoxia Inducible Factors (HIFs) 2item
  67. FAK 7item
  68. BMP and Other Activin Receptors 2item
  69. JAK 12item
  70. p300 1 item
  71. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  72. Syk 4item
  73. EZH1 1 item
  74. DNA-PK 5item
  75. HSP90 12item
  76. Gutathione S-transferase 1 item
  77. eIF4E/eIF3G interaction 1 item
  78. Notch 1 item
  79. TNKS 1 item
  80. Topoisomerases 10item
  81. Cytochrome P450 (CYP450) 4item
  82. Ksp 1 item
  83. ErbB 5item
  84. DNA Methyltransferases 3item
  85. Survivin 1 item
  86. ERK 4item
  87. HMG-CoA Reductases 2item
  88. Vacuolar-type ATPase 1 item
  89. c-MET 7item
  90. BMI-1 1 item
  91. PKC 10item
  92. Calpains 2item
  93. Ubiquitin-specific proteases 1 item
  94. Ca2 /calmodulin-dependent protein kinases (CaMKs) 2item
  95. SMYD2 1 item
  96. CREBBP 1 item
  97. EP300 1 item
  98. Lyn 1 item
  99. RAD51 2item
  100. HER2 2item
  101. Pyk2 3item
  102. USP 1 item
  103. 5-HT2 Receptors 1 item
  104. Insulin and Insulin-like Receptors 2item
  105. PARP 3item
  106. Pyruvate dehydrogenases (PDH) 1 item
  107. ALK 8item
  108. ROS1 2item
  109. Sphingosine kinases (SphKs) 2item
  110. KRAS G12C 1 item
  111. Monocarboxylate transporters (MCTs) 1 item
  112. Dehydrogenase 1 item
  113. PKG 2item
  114. PKA 5item
  115. Myosin light chain kinases (MLCKs) 1 item
  116. D1 and D5 Receptors 1 item
  117. D2 Receptors 1 item
  118. D3 Receptors 1 item
  119. Valosin-containing protein (VCP) 1 item
  120. MELK 1 item
  121. Insulin-like growth factors (IGFs) 1 item
  122. Integrin-ligand interactions 1 item
  123. CSF1R 1 item
  124. Bromodomain and Extra-Terminal motif (BET) 1 item
  125. MK2 2item
  126. Angiotensin-Converting Enzymes (ACEs) 1 item
  127. Tie-2 4item
  128. RSK 2item
  129. p70 S6K 1 item
  130. Autophagy 3item
  131. ATM/ATR 6item
  132. COX 2item
  133. Heparanases 1 item
  134. CK1 1 item
  135. IDH2 1 item
  136. CK2 1 item
  137. HIPK2 1 item
  138. HIPK3 1 item
  139. HIV Integrases 1 item
  140. PRAK 1 item
  141. MAPKAP-K2 1 item
  142. Guanine nucleotide exchange factors (GEFs) 1 item
  143. 20S proteasomal chymotrypsin 1 item
  144. Geranylgeranyltransferase I 1 item
  145. Farnesyltransferase 1 item
  146. Nampt 3item
  147. eIF4F 1 item
  148. Cdc42 1 item
  149. Glutaminases 2item
  150. Carbonic Anhydrases 1 item
  151. Ron 1 item
  152. BLM 1 item
  153. Aldehyde Dehydrogenases 1 item
  154. Synthases/Synthetases 2item
  155. P110 1 item
  156. Hck 1 item
  157. Inositol-requiring enzyme 1 (IRE1) 1 item
  158. DYRK 1 item
  159. Norepinephrine transporter 1 item
  160. 5-HT Transporters 1 item
  161. Histone Demethylases 1 item
  162. MNK 1 item
  163. HIV-1 reverse transcriptase 1 item
  164. Calcium-Activated Potassium (KCa) Channels 1 item
  165. Insulin Receptors 1 item
  166. IRG-1R 1 item
  167. cAMP 1 item
  168. Sulfonylurea receptors 1 item
  169. eEF-2 1 item
  170. Cdc7 1 item
  171. CMV 1 item
  172. ZAP-70 1 item
  173. Catechol O-Methyltransferase (COMT) 1 item
  174. fibrinolysis 1 item
  175. D4 Receptors 1 item
  176. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  177. Flk-1 1 item
  178. Papains 1 item
  179. Protein Arginine Methyltransferases 1 item
  180. NAE 2item
  181. Ubiquitin-activating Enzyme E1 1 item
  182. SUMOylation 1 item
  183. BACE 1 item
  184. Cytidine deaminases 1 item
  185. angiogenesis 1 item
  186. DPP-4 1 item
  187. c-RET 2item
  188. p70 rsk 2item
  189. VEGFR3/FLT4 1 item
  190. NTRK1/TRKA 1 item
  191. CSF-1R/c-Fms 1 item
  192. NMPRTase 1 item
  193. Bfl-1 1 item
  194. TAM kinase 1 item
  195. p53-MDM2 interaction 1 item
  196. nuclear export 1 item
  197. CRM1 1 item
  198. KDR 2item
  199. AXL 1 item
  200. Glyoxalase I 1 item
  201. ERAD 1 item
  202. p53 2item
  203. HDAC 1 item
  204. human lyase 1 item
  205. insulin 1 item
  206. Ub-conjugating enzyme (E2) complex 1 item
  207. Smoothened receptor 1 item
  208. Antibiotic 1 item
  209. Hec1 1 item
  210. GLI 1 item
  211. ErbB-2 1 item
  212. PDK-1 1 item
  213. Prk 1 item
  214. Ribonucleotide Reductases 1 item
  215. Trx 1 item
  216. HSP70 1 item
  217. TYK2 1 item
  218. MUSK 1 item
  219. MAP3K 1 item
  220. Adenosine Deaminases 1 item
  221. Flk1 2item
  222. DHFR 1 item
  223. GARFT 1 item
  224. RHA 1 item
  225. MCL1 1 item
  226. Bcl-w 1 item
  227. tropomyosin receptor kinase 1 item
  228. LSD 1 item
  229. DDX3 1 item
  230. SK 1 item
  231. PPK 1 item
  232. c-Syk 1 item
  233. CDK1/CyclinB 1 item
  234. IDO 1 item
  235. PIM1 kinase 1 item
  236. phospholipase A2 1 item
  237. Substance P/NK1 Receptor 1 item
  238. Bax 1 item
Reported Experiments
  1. Animal Experiments 502item
  2. Cell Experiments 348item