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Search results for: 'research area pi3k akt signaling pi3k inhibitors'

Items 411-420 of 964

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  1. MLN4924
    B1036 MLN4924
     5 Citation
    Target: NAE|Ubiquitin-activating Enzyme E1|SUMOylation
    Summary: NAE inhibitor
      ≥22.18 mg/mL
  2. PF-2545920
    A4325 PF-2545920
    Target: Phosphodiesterases (PDEs)
    Summary: PDE10A inhibitor,potent and selective
      insoluble in H2O; ≥19.35 mg/mL
  3. VX-745
    A8686 VX-745
    Target: p38
    Summary: P38α inhibitor,highly potent and selective
      ≥21.8 mg/mL
  4. Imatinib (STI571)
    B2171 Imatinib (STI571)
    Target: PDGFR|c-Kit|Bcr-Abl
    Summary: Protein-tyrosine kinase inhibitor
      ≥24.68 mg/mL
  5. Mitoxantrone HCl
    B2114 Mitoxantrone HCl
    Target: Pim|Topoisomerases|USP|HIV Integrases
    Summary: Topoisomerase II inhibitor, anti-neoplastic drug
      insoluble in EtOH; ≥51.53 mg/mL
  6. WWL 70
    A8891 WWL 70
    Summary: α/β-hydrolase domain 6 inhibitor
      insoluble in EtOH; insoluble in H2O; ≥14.45 mg/mL
  7. R428
    A8329 R428
     10 Citation
    Summary: Selective Axl inhibitor
      ≥25 mg/mL
  8. JZL184
    B1958 JZL184
    Target: MAGL
    Summary: MAGL inhibitor, potent and selective
      insoluble in H2O; insoluble in EtOH; ≥20.35 mg/mL
  9. LDN 57444
    A4003 LDN 57444
    Target: UCH
    Summary: UCH-L1 inhibitor,reversible competitve
      insoluble in EtOH; insoluble in H2O; ≥16.7 mg/mL
  10. Lonafarnib
    A4379 Lonafarnib
    Target: FPTase
    Summary: Ftase inhibitor,potent and selective
      ≥31.95 mg/mL

Items 411-420 of 964

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  1. Signaling Pathways 928item
  2. Natural Products 7item
  3. Lab Reagents 3item
Specificity
  1. Selective 683item
  2. Non-Selective 5item
Reversibility
  1. Reversible 54item
  2. Irreversible 31item
Target
  1. Caspases 8item
  2. Cyclin-Dependent Kinases 25item
  3. Proteasome 12item
  4. Cathepsins 9item
  5. Histone Deacetylases (HDACs) 32item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 13item
  8. Bcl-2 8item
  9. PI3K 36item
  10. CXCR 3item
  11. Raf 13item
  12. Aurora Kinases 20item
  13. Bcl-xl 2item
  14. CSF-1R 4item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. Gap Junctions 1 item
  18. MDM2 1 item
  19. EZH2 4item
  20. mTOR 20item
  21. Bromodomains 6item
  22. AP-1 1 item
  23. MMP 7item
  24. Thymidine Phosphorylases 1 item
  25. Androgen Receptors 4item
  26. Peptidylprolyl isomerases 1 item
  27. Acyl coenzyme A: cholesterol acyltransferases 1 item
  28. Myosin II ATPases 1 item
  29. DT-diaphorases 1 item
  30. Voltage-gated Potassium (KV) Channels 1 item
  31. MER 1 item
  32. FLT3 19item
  33. GSK-3 10item
  34. Factor Xa 4item
  35. P-glycoprotein (P-gp) 5item
  36. PLK 10item
  37. Chk 7item
  38. Eph Receptors 2item
  39. VEGFR 40item
  40. PDGFR 25item
  41. c-Kit 13item
  42. RET 4item
  43. IRAK 1 item
  44. Bromodomain-containing proteins(BRDs) 1 item
  45. Phosphodiesterases (PDEs) 16item
  46. Mcl-1 6item
  47. Hydrolase 1 item
  48. Thymidylate Synthase 3item
  49. p38 9item
  50. PKB 1 item
  51. JNK 3item
  52. SGK 1 item
  53. Bcr-Abl 13item
  54. Kynurenine-3-monooxygenase 1 item
  55. MEK 13item
  56. PORCN 1 item
  57. DOT1L 3item
  58. FGFR 17item
  59. Nrf2 2item
  60. Insulin-like growth factor receptors(IGFRs) 1 item
  61. Pim 4item
  62. GABAB Receptors 1 item
  63. Sir2-like Family Deacetylases (Sirtuins) 3item
  64. Voltage-gated Sodium (NaV) Channels 1 item
  65. Deubiquitinating enzymes (DUBs) 3item
  66. Smoothened 4item
  67. Neuraminidases (NA) 2item
  68. MET 7item
  69. Src 14item
  70. Trk Receptors 6item
  71. Integrins 1 item
  72. Aminopeptidases 3item
  73. NMDA Receptors 1 item
  74. STAT 10item
  75. ATP Citrate Lyases 1 item
  76. Microtubules/Tubulins 4item
  77. EGFR 23item
  78. Hedgehog 1 item
  79. Reverse Transcriptases 6item
  80. ROCK 9item
  81. BTK 1 item
  82. RIP kinases 1 item
  83. Monocyte chemotactic proteins 1 item
  84. PAK 3item
  85. Hypoxia Inducible Factors (HIFs) 2item
  86. Tankyrases 1 item
  87. Inositol Phosphatases 1 item
  88. FAK 7item
  89. BMP and Other Activin Receptors 3item
  90. JAK 20item
  91. p300 1 item
  92. Stearoyl-CoA 9-desaturase (SCD-1) 2item
  93. Syk 7item
  94. EZH1 2item
  95. DNA-PK 7item
  96. HSP90 12item
  97. AMPK 2item
  98. Gutathione S-transferase 1 item
  99. PDHK 1 item
  100. Angiotensin AT2 Receptors 1 item
  101. Notch 1 item
  102. S-nitrosoglutathione reductase 1 item
  103. CFTR 2item
  104. TNKS 1 item
  105. Topoisomerases 12item
  106. Cytochrome P450 (CYP450) 8item
  107. thrombin 1 item
  108. Ksp 2item
  109. Renin 1 item
  110. Influenza viruses 1 item
  111. ErbB 5item
  112. S6 kinases 1 item
  113. Toll-like receptors (TLRs) 3item
  114. Adenosine Kinases 2item
  115. Serine Proteases 2item
  116. DNA Methyltransferases 2item
  117. Survivin 1 item
  118. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  119. ERK 8item
  120. HMG-CoA Reductases 6item
  121. c-MET 8item
  122. BMI-1 1 item
  123. PKC 13item
  124. Calpains 5item
  125. Ubiquitin-specific proteases 1 item
  126. HCV Proteases 3item
  127. Ca2 /calmodulin-dependent protein kinases (CaMKs) 6item
  128. MLK3 1 item
  129. O-GlcNAcase 1 item
  130. CREBBP 1 item
  131. EP300 1 item
  132. Lyn 2item
  133. SGLT 1 item
  134. RAD51 2item
  135. Trypsins 1 item
  136. HER2 3item
  137. Pyk2 3item
  138. USP 1 item
  139. 5-HT2 Receptors 4item
  140. LRRK2 6item
  141. Voltage-gated Calcium Channels (CaV) 2item
  142. DGAT 2item
  143. Insulin and Insulin-like Receptors 4item
  144. PARP 7item
  145. CB1 Receptors 1 item
  146. Melanocortin (MC) Receptors 1 item
  147. Pyruvate dehydrogenases (PDH) 2item
  148. ALK 10item
  149. ROS1 2item
  150. Sphingosine kinases (SphKs) 3item
  151. Trypsin 1 item
  152. Chymotrypsin 1 item
  153. Kallikrein 1 item
  154. Trypsinogen 1 item
  155. Monocarboxylate transporters (MCTs) 2item
  156. CETP 2item
  157. Dehydrogenase 1 item
  158. PKG 2item
  159. PKA 6item
  160. Myosin light chain kinases (MLCKs) 2item
  161. HIV-1 gp120 1 item
  162. D1 and D5 Receptors 1 item
  163. D2 Receptors 3item
  164. D3 Receptors 2item
  165. 5-HT1 Receptors 2item
  166. 5-HT7 Receptors 1 item
  167. MELK 1 item
  168. Serotonin reuptake 1 item
  169. Insulin-like growth factors (IGFs) 1 item
  170. CSF1R 1 item
  171. Bromodomain and Extra-Terminal motif (BET) 1 item
  172. Lactate Dehydrogenases (LDH) 2item
  173. MK2 2item
  174. Fatty-acid-binding proteins (FABPs) 1 item
  175. Angiotensin-Converting Enzymes (ACEs) 6item
  176. Tie-2 5item
  177. RSK 3item
  178. p70 S6K 1 item
  179. phosphatases 2item
  180. Autophagy 4item
  181. ATM/ATR 5item
  182. COX 12item
  183. CK1 1 item
  184. CK2 2item
  185. HIPK2 1 item
  186. HIPK3 1 item
  187. HIV Integrases 2item
  188. Squalene epoxidases 2item
  189. PRAK 1 item
  190. MAPKAP-K2 1 item
  191. Delayed rectifier outward potassium current (IKr) 1 item
  192. GpIIb/IIIa receptor 1 item
  193. Guanine nucleotide exchange factors (GEFs) 1 item
  194. 20S proteasomal chymotrypsin 1 item
  195. Geranylgeranyltransferase I 1 item
  196. Farnesyltransferase 1 item
  197. Nampt 3item
  198. eIF4F 1 item
  199. Cdc42 1 item
  200. SRPK1 1 item
  201. P2X Receptors 1 item
  202. Glutaminases 2item
  203. Carbonic Anhydrases 7item
  204. Ron 1 item
  205. G9a 1 item
  206. BLM 1 item
  207. HSV 1 item
  208. NADPH Oxidases 3item
  209. Calcium-activated chloride channels (CaCC) 1 item
  210. GPR35 1 item
  211. Aldehyde Dehydrogenases 1 item
  212. Synthases/Synthetases 2item
  213. MAGL 1 item
  214. Histamine H1 Receptors 3item
  215. Na /K ATPases 3item
  216. P110 1 item
  217. Hck 2item
  218. Inositol-requiring enzyme 1 (IRE1) 2item
  219. Na /K /Cl- Symporters (NKCCs) 2item
  220. GABAA Receptors 1 item
  221. Phospholipases 1 item
  222. Monoamine oxidases (MAOs) 1 item
  223. Organic anion transporters (OATs) 1 item
  224. TRP Channel 1 item
  225. RNA Polymerases 2item
  226. Norepinephrine transporter 1 item
  227. 5-HT Transporters 3item
  228. Xanthine oxidoreductases 1 item
  229. Dihydroorotate dehydrogenase 1 item
  230. Histone Demethylases 1 item
  231. MNK 2item
  232. 5-Lipoxygenases 1 item
  233. NO Donors / Precursors 2item
  234. CB2 Receptors 1 item
  235. HIV-1 reverse transcriptase 1 item
  236. IL Receptors 2item
  237. CCL2 1 item
  238. Noradrenaline reuptake 1 item
  239. Norepinephrine transporters 1 item
  240. Calcium-Activated Potassium (KCa) Channels 2item
  241. AChE 3item
  242. Insulin Receptors 1 item
  243. IRG-1R 1 item
  244. cAMP 1 item
  245. Sulfonylurea receptors 1 item
  246. Cdc2-like kinase (Clk) 1 item
  247. eEF-2 1 item
  248. Inward Rectifier Potassium (Kir) Channels 3item
  249. Cdc7 1 item
  250. CMV 1 item
  251. ZAP-70 1 item
  252. Catechol O-Methyltransferase (COMT) 2item
  253. fibrinolysis 1 item
  254. Angiotensin AT1 Receptors 1 item
  255. D4 Receptors 1 item
  256. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  257. NMDA receptor 1 item
  258. HBV Proteases 1 item
  259. Hydroxylases 2item
  260. Flk-1 1 item
  261. Papains 1 item
  262. Protein Arginine Methyltransferases 1 item
  263. IMPDH 1 item
  264. Na /Ca2 Exchangers (NCXs) 1 item
  265. NAE 2item
  266. Ubiquitin-activating Enzyme E1 2item
  267. SUMOylation 1 item
  268. ATGL 1 item
  269. BACE 2item
  270. Cytidine deaminases 1 item
  271. angiogenesis 1 item
  272. Glucagon Receptors 1 item
  273. 15-PGDH 1 item
  274. DPP-4 5item
  275. c-RET 3item
  276. Nonstructural protein 5B (NS5B) 1 item
  277. p70 rsk 3item
  278. voltage-gated chloride channels 1 item
  279. FPTase 1 item
  280. Microtubule/Tubulin 1 item
  281. VEGFR3/FLT4 1 item
  282. NTRK1/TRKA 1 item
  283. CSF-1R/c-Fms 1 item
  284. Tryptophan hydroxylases (TPH) 2item
  285. ADAMs 1 item
  286. NMPRTase 1 item
  287. Bfl-1 1 item
  288. TAM kinase 1 item
  289. p53-MDM2 interaction 1 item
  290. nuclear export 1 item
  291. CRM1 1 item
  292. PTP 1 item
  293. KDR 2item
  294. Fyn kinase 1 item
  295. Trypsin-like protease 1 item
  296. AXL 1 item
  297. Glyoxalase I 1 item
  298. ERAD 1 item
  299. Dipeptidyl-peptidase II 1 item
  300. p53 4item
  301. metalloprotease 1 item
  302. HDAC 2item
  303. 5-HT receptors 1 item
  304. sodium channel 3item
  305. c-Fms tyrosine kinase 1 item
  306. human lyase 1 item
  307. insulin 1 item
  308. Ub-conjugating enzyme (E2) complex 1 item
  309. Smoothened receptor 1 item
  310. cysteine protease 2item
  311. IKK 1 item
  312. MSK 1 item
  313. gp120-CD4 interaction 1 item
  314. HCV polymerase 2item
  315. Ftase 1 item
  316. PC-PLC 2item
  317. Elastases 1 item
  318. Antibiotic 1 item
  319. Mer tyrosine kinase 1 item
  320. Hec1 1 item
  321. neprilysin 1 item
  322. GLI 1 item
  323. decarboxylase 1 item
  324. HMGCR 1 item
  325. ErbB-2 1 item
  326. adrenergic receptor 2item
  327. 5-HT4 Receptor 1 item
  328. sterol demethylase 1 item
  329. PDK-1 1 item
  330. GAPDH 1 item
  331. Histone Acetyltransferases (HATs) 2item
  332. complex I of the mitochondrial electron transport chain 1 item
  333. F1 Fo-ATPase 1 item
  334. Prk 1 item
  335. potassium channel 1 item
  336. calcium channel 1 item
  337. Ribonucleotide Reductases 1 item
  338. Trx 1 item
  339. Tyrosinases 1 item
  340. HSP70 1 item
  341. ICAM 1 item
  342. ITK 1 item
  343. HIF-PH 1 item
  344. NUAK 1 item
  345. Rho 1 item
  346. Ubiquitin E3 Ligases 1 item
  347. DCLK2 1 item
  348. FAAH 1 item
  349. PTK 1 item
  350. integrase 1 item
  351. NOS 2item
  352. TYK2 2item
  353. MUSK 1 item
  354. MAP3K 1 item
  355. GPR3 1 item
  356. Adenosine Deaminases 2item
  357. mitochondrial pyruvate carrier (MPC) 1 item
  358. Thrombin Receptor 1 item
  359. prolactin secretion 1 item
  360. gonadotropin release 1 item
  361. DprE 1 item
  362. carnitine reabsorption 1 item
  363. Histamine receptors 1 item
  364. GluR 1 item
  365. 5-HT receptor 1 item
  366. dopamine receptors 1 item
  367. AMPA receptor 1 item
  368. 5-alpha Reductases 1 item
  369. Flk1 2item
  370. p21 1 item
  371. Prostaglandin synthesis 1 item
  372. Protein Tyrosine Phosphatases 1 item
  373. alkaline phosphatases 1 item
  374. ATPases 1 item
  375. glutamate release 1 item
  376. PAFR 1 item
  377. Aromatases 2item
  378. DHFR 1 item
  379. GARFT 1 item
  380. FGR 1 item
  381. YES 2item
  382. Fyn 2item
  383. ARG 1 item
  384. Autotaxin 1 item
  385. UCH 1 item
  386. RHA 1 item
  387. HCV NS3-4A protease 1 item
  388. TRPC channel 1 item
  389. PKD 1 item
  390. Pyruvate kinases 1 item
  391. Thioredoxin Reductases 1 item
  392. enoyl-acyl-carrier protein reductase 1 item
  393. SHIP 1 item
  394. FKBP 1 item
  395. MCL1 1 item
  396. Bcl-w 1 item
  397. glutathione peroxidase 4 1 item
  398. S-adenosylhomocysteine hydrolase 1 item
  399. Rho-kinase 1 item
  400. tropomyosin receptor kinase 1 item
  401. LSD 1 item
  402. DDX3 1 item
  403. PRMT 1 item
  404. ACE 1 item
  405. GLP 1 item
  406. SK 1 item
  407. MST 1 item
  408. PPK 1 item
  409. c-Syk 1 item
  410. CDK1/CyclinB 1 item
  411. NHE 1 item
  412. IDO 2item
  413. Tph 1 item
  414. PIM1 kinase 1 item
  415. phospholipase A2 1 item
  416. reverse transcriptase 1 item
  417. epoxide hydrolase 1 item
  418. Serotonin (5-HT) reuptake 1 item
  419. Cholesterol absorption 1 item
  420. Vascular Disrupting Agents (VDA) 1 item
  421. Androgen Receptor 1 item
  422. Substance P/NK1 Receptor 1 item
  423. gp120/CD4 1 item
  424. ATM 1 item
  425. Sirtuin 1 item
  426. NE 1 item
  427. PIKfyve 1 item
  428. Bax 1 item
  429. Glycogen Phosphorylases 1 item
  430. MTH1 1 item
  431. PTEN 1 item
  432. Insulin Receptor 1 item
  433. NS3/4a Proteases 1 item
  434. Ca2 -ATPases 1 item
  435. p90 S6K 1 item
  436. Dynamins 1 item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 2item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 5item
  7. Acute Myeloid Leukemia 25item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Biliary Cancer 1 item
  13. Bladder Cancer 11item
  14. Bladder Carcinoma 4item
  15. Bladder Diseases 2item
  16. B-lymphoid Malignancies 1 item
  17. Brain Injuries Studies 3item
  18. Breast Cancer 113item
  19. Cancer 502item
  20. Candida Peritonitis 1 item
  21. Candidemia 1 item
  22. Castration-resistant Prostate Cancer 1 item
  23. Cervical Cancer 6item
  24. Cholangiocarcinoma 2item
  25. Chronic Lymphocytic Leukemia 8item
  26. Chronic Myeloproliferative Disorders 1 item
  27. Clear Cell Renal Cell Carcinoma 2item
  28. Cocaine-Related Disorders 2item
  29. Colon Cancer 42item
  30. Colon Carcinoma 7item
  31. Colorectal Cancer 40item
  32. Depression 2item
  33. Diabetes 7item
  34. Diffuse Large B-cell Lymphoma 1 item
  35. Dyskinesia 1 item
  36. Dyslipidemia 2item
  37. Epilepsy 4item
  38. Erectile Dysfunction 4item
  39. Friedreich's Ataxia 2item
  40. Fungal Infection 1 item
  41. Fungi 1 item
  42. Glioblastoma 30item
  43. Glioma 17item
  44. HCV 4item
  45. Heart Failure 4item
  46. Hepatic Cancer 2item
  47. Hepatitis C 4item
  48. Hepatocellular Carcinoma 7item
  49. HIV 13item
  50. HIV Infections 9item
  51. Hypercholesterolemia 3item
  52. Immunological Diseases 1 item
  53. Inflammation 1 item
  54. Inflammatory Bowel Disease 1 item
  55. Inflammatory Diseases 15item
  56. Influenza 3item
  57. Kidney Injury Studies 2item
  58. Leukemia 24item
  59. Liver Cancer 3item
  60. Lung Cancer 40item
  61. Lung Carcinoma 4item
  62. Lymphoma 28item
  63. Mantle Cell Lymphoma 2item
  64. Medulloblastoma 1 item
  65. Melanoma 31item
  66. Mixed Lineage Leukemia 3item
  67. Multiple Myeloma 21item
  68. Myelofibrosis 2item
  69. Myeloma 6item
  70. Neuroblastoma 13item
  71. Neurocognitive Disorders 1 item
  72. Neuronal Protection 1 item
  73. Non-small Cell Lung Cancer 26item
  74. Non-small Cell Lung Carcinoma 2item
  75. Obsessive-Compulsive Disorder 1 item
  76. Osteoporosis 2item
  77. Ovarian Cancer 34item
  78. Pancreatic Cancer 47item
  79. Pancreatic Carcinoma 3item
  80. Prostate Cancer 50item
  81. Psoriasis 4item
  82. Psoriasis Vulgaris 1 item
  83. Pulmonary Arterial Hypertension 2item
  84. Pulmonary Fibrosis 2item
  85. Renal Cancer 4item
  86. Renal Cell Carcinoma 8item
  87. Rheumatoid Arthritis 14item
  88. Sarcoma 1 item
  89. Schizophrenia 8item
  90. Sleep Disorders 2item
  91. Soft Tissue Sarcoma 1 item
  92. Squamous Cell Carcinoma 2item
  93. Testicular Cancer 2item
  94. Thyroid Cancer 6item
  95. Tuberculosis 1 item
  96. Type 2 Diabetes 12item