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  • Search results for: 'research area pi3k akt signaling pi3k inhibitors'

Search results for: 'research area pi3k akt signaling pi3k inhibitors'

Items 611-620 of 810

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  1. JNJ-7706621
    A4115 JNJ-7706621
     1 Citation
    Target: Cyclin-Dependent Kinases|Aurora Kinases
    Summary: Potent CDK/Aurora kinase inhibitor
      insoluble in EtOH; insoluble in H2O; ≥19.7 mg/mL
  2. MK-0752
    A4006 MK-0752
     1 Citation
    Summary: γ-secretase inhibitor
      ≥22.15 mg/mL
  3. Rivaroxaban
    A4338 Rivaroxaban
    Target: Factor Xa
    Summary: Factor Xa inhibitor
      insoluble in H2O; insoluble in EtOH; ≥13.9 mg/mL
  4. ABT-263 (Navitoclax)
    A3007 ABT-263 (Navitoclax)
     15 Citation
    Target: Bcl-2|Bcl-w
    Summary: Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w
      ≥48.73 mg/mL
  5. Paroxetine HCl
    B2252 Paroxetine HCl
     1 Citation
    Target: 5-HT Transporters
    Summary: Antidepressant agents
  6. AR-42 (OSU-HDAC42)
    A4104 AR-42 (OSU-HDAC42)
     2 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: HDAC inhibitor,novel and potent
      insoluble in EtOH; insoluble in H2O; ≥15.62 mg/mL
  7. Trametinib DMSO solvate
    A3887 Trametinib DMSO solvate
     1 Citation
    Target: MEK
    Summary: Allosteric MEK1/MEK2 kinase inhibitor
      insoluble in EtOH; insoluble in H2O; ≥11.2 mg/mL
  8. Lurasidone HCl
    B1477 Lurasidone HCl
    Target: 5-HT2 Receptors|D2 Receptors|5-HT1 Receptors|5-HT7 Receptors
    Summary: Dopamine D2/5-HT2A/5-HT7/5-HT1A inhibitor
      insoluble in H2O; insoluble in EtOH; ≥11.11 mg/mL
  9. Tariquidar methanesulfonate, hydrate
    A3859 Tariquidar methanesulfonate, hydrate
    Target: P-glycoprotein (P-gp)
    Summary: P-glycoprotein inhibitor, potent and selective
      insoluble in H2O; insoluble in EtOH; ≥56.2 mg/mL
  10. PSI-6206
    A8189 PSI-6206
     3 Citation
    Target: HCV polymerase
    Summary: Inhibitor of HCV RNA polymerase,potent and selective
      ≥13.1 mg/mL

Items 611-620 of 810

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Category
  1. Signaling Pathways 780item
  2. Natural Products 2item
  3. Kits 1 item
  4. Peptides 1 item
  5. Peptides & Proteins 1 item
  6. Lab Reagents 3item
Reversibility
  1. Reversible 54item
  2. Irreversible 26item
Target
  1. Caspases 11item
  2. Cyclin-Dependent Kinases 26item
  3. Proteasome 11item
  4. Cathepsins 11item
  5. Histone Deacetylases (HDACs) 28item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 6item
  8. Bcl-2 5item
  9. PI3K 27item
  10. CXCR 3item
  11. Raf 10item
  12. Aurora Kinases 14item
  13. Bcl-xl 3item
  14. CSF-1R 2item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. Gap Junctions 1 item
  18. MDM2 1 item
  19. EZH2 6item
  20. mTOR 15item
  21. Bromodomains 5item
  22. AP-1 1 item
  23. MMP 8item
  24. Thymidine Phosphorylases 1 item
  25. Androgen Receptors 3item
  26. Peptidylprolyl isomerases 1 item
  27. Acyl coenzyme A: cholesterol acyltransferases 1 item
  28. Myosin II ATPases 1 item
  29. DT-diaphorases 1 item
  30. Voltage-gated Potassium (KV) Channels 1 item
  31. MER 1 item
  32. FLT3 12item
  33. GSK-3 9item
  34. Factor Xa 3item
  35. P-glycoprotein (P-gp) 5item
  36. PLK 7item
  37. Chk 8item
  38. ULK1 1 item
  39. Eph Receptors 3item
  40. VEGFR 25item
  41. PDGFR 19item
  42. c-Kit 7item
  43. RET 3item
  44. IRAK 3item
  45. Bromodomain-containing proteins(BRDs) 1 item
  46. Phosphodiesterases (PDEs) 10item
  47. Mcl-1 5item
  48. Hydrolase 1 item
  49. Thymidylate Synthase 2item
  50. p38 9item
  51. PKB 1 item
  52. 3-phosphoglycerate dehydrogenase 1 item
  53. JNK 6item
  54. SGK 2item
  55. Bcr-Abl 10item
  56. Kynurenine-3-monooxygenase 1 item
  57. MEK 15item
  58. PORCN 1 item
  59. DOT1L 3item
  60. FGFR 9item
  61. Nrf2 1 item
  62. Insulin-like growth factor receptors(IGFRs) 1 item
  63. Pim 5item
  64. GABAB Receptors 1 item
  65. Sir2-like Family Deacetylases (Sirtuins) 2item
  66. Deubiquitinating enzymes (DUBs) 4item
  67. Smoothened 4item
  68. Ribosomal s6 kinases (RSK) 1 item
  69. Neuraminidases (NA) 1 item
  70. MET 7item
  71. Src 9item
  72. Trk Receptors 6item
  73. Integrins 1 item
  74. Aminopeptidases 2item
  75. STAT 7item
  76. ATP Citrate Lyases 1 item
  77. Microtubules/Tubulins 4item
  78. EGFR 15item
  79. Hedgehog 1 item
  80. Reverse Transcriptases 1 item
  81. ROCK 7item
  82. BTK 2item
  83. RIP kinases 1 item
  84. Monocyte chemotactic proteins 1 item
  85. PAK 3item
  86. Hypoxia Inducible Factors (HIFs) 2item
  87. Tankyrases 1 item
  88. Inositol Phosphatases 1 item
  89. FAK 5item
  90. BMP and Other Activin Receptors 4item
  91. JAK 13item
  92. p300 1 item
  93. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  94. Syk 7item
  95. EZH1 2item
  96. DNA-PK 6item
  97. HSP90 10item
  98. AMPK 2item
  99. Gutathione S-transferase 1 item
  100. PDHK 1 item
  101. Angiotensin AT2 Receptors 1 item
  102. eIF4E/eIF3G interaction 1 item
  103. Notch 1 item
  104. S-nitrosoglutathione reductase 1 item
  105. CFTR 2item
  106. TNKS 1 item
  107. Topoisomerases 7item
  108. Cytochrome P450 (CYP450) 5item
  109. thrombin 1 item
  110. Ksp 1 item
  111. Ribosomes 1 item
  112. Renin 2item
  113. HIV proteases 1 item
  114. Pepsins 1 item
  115. Influenza viruses 1 item
  116. ErbB 2item
  117. Ferroptosis 1 item
  118. S6 kinases 1 item
  119. Toll-like receptors (TLRs) 2item
  120. Adenosine Kinases 2item
  121. Actin 1 item
  122. DNA Methyltransferases 3item
  123. Survivin 1 item
  124. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  125. ERK 5item
  126. HMG-CoA Reductases 5item
  127. Vacuolar-type ATPase 1 item
  128. c-MET 8item
  129. BMI-1 1 item
  130. PKC 7item
  131. Calpains 6item
  132. Ubiquitin-specific proteases 1 item
  133. HCV Proteases 3item
  134. Ca2 /calmodulin-dependent protein kinases (CaMKs) 7item
  135. MLK3 1 item
  136. SMYD2 1 item
  137. O-GlcNAcase 1 item
  138. CREBBP 2item
  139. EP300 2item
  140. Lyn 1 item
  141. SGLT 1 item
  142. RAD51 1 item
  143. Trypsins 1 item
  144. HER2 2item
  145. Pyk2 3item
  146. USP 3item
  147. 5-HT2 Receptors 4item
  148. LRRK2 4item
  149. Voltage-gated Calcium Channels (CaV) 1 item
  150. DGAT 2item
  151. Insulin and Insulin-like Receptors 3item
  152. PARP 5item
  153. CB1 Receptors 1 item
  154. Melanocortin (MC) Receptors 1 item
  155. Pyruvate dehydrogenases (PDH) 1 item
  156. ALK 5item
  157. ROS1 2item
  158. Sphingosine kinases (SphKs) 2item
  159. Trypsin 1 item
  160. Chymotrypsin 1 item
  161. Kallikrein 1 item
  162. Trypsinogen 1 item
  163. KRAS G12C 1 item
  164. GTPases 1 item
  165. Monocarboxylate transporters (MCTs) 1 item
  166. CETP 2item
  167. Dehydrogenase 1 item
  168. PKG 1 item
  169. PKA 1 item
  170. Myosin light chain kinases (MLCKs) 2item
  171. HIV-1 gp120 1 item
  172. D1 and D5 Receptors 1 item
  173. D2 Receptors 3item
  174. D3 Receptors 2item
  175. 5-HT1 Receptors 2item
  176. 5-HT7 Receptors 1 item
  177. CaM-KK 1 item
  178. Valosin-containing protein (VCP) 1 item
  179. MELK 1 item
  180. Serotonin reuptake 1 item
  181. Insulin-like growth factors (IGFs) 1 item
  182. Clk 1 item
  183. TBK1 1 item
  184. MARK1 1 item
  185. NUAK1 2item
  186. Integrin-ligand interactions 1 item
  187. CSF1R 1 item
  188. Bromodomain and Extra-Terminal motif (BET) 1 item
  189. NUAK2 1 item
  190. Na /H Exchangers (NHEs) 1 item
  191. Lactate Dehydrogenases (LDH) 2item
  192. MK2 3item
  193. Fatty-acid-binding proteins (FABPs) 1 item
  194. Angiotensin-Converting Enzymes (ACEs) 4item
  195. Tie-2 4item
  196. RSK 2item
  197. p70 S6K 1 item
  198. Granzyme B 1 item
  199. phosphatases 1 item
  200. Autophagy 2item
  201. ATM/ATR 7item
  202. Mixed lineage kinase domain-like protein (MLKL) 1 item
  203. COX 6item
  204. Heparanases 1 item
  205. CK1 1 item
  206. IDH2 1 item
  207. CK2 3item
  208. HIPK2 1 item
  209. HIPK3 1 item
  210. HIV Integrases 2item
  211. Squalene epoxidases 2item
  212. PRAK 1 item
  213. MAPKAP-K2 1 item
  214. Delayed rectifier outward potassium current (IKr) 1 item
  215. GpIIb/IIIa receptor 1 item
  216. Guanine nucleotide exchange factors (GEFs) 1 item
  217. 20S proteasomal chymotrypsin 1 item
  218. Geranylgeranyltransferase I 1 item
  219. Farnesyltransferase 1 item
  220. NAT10 1 item
  221. Nampt 2item
  222. eIF4F 1 item
  223. Cdc42 1 item
  224. SRPK1 1 item
  225. P2X Receptors 1 item
  226. Glutaminases 1 item
  227. Carbonic Anhydrases 6item
  228. Ron 1 item
  229. AP endonucleases 1 item
  230. G9a 2item
  231. BLM 1 item
  232. HSV 2item
  233. NADPH Oxidases 2item
  234. Calcium-activated chloride channels (CaCC) 1 item
  235. GPR35 1 item
  236. Aldehyde Dehydrogenases 1 item
  237. Synthases/Synthetases 3item
  238. MAGL 1 item
  239. c-Fyn 1 item
  240. TAK1 1 item
  241. Histamine H1 Receptors 1 item
  242. Na /K ATPases 2item
  243. P110 1 item
  244. Hck 1 item
  245. Inositol-requiring enzyme 1 (IRE1) 2item
  246. SETD7 1 item
  247. Na /K /Cl- Symporters (NKCCs) 1 item
  248. GABAA Receptors 1 item
  249. Phospholipases 1 item
  250. Organic anion transporters (OATs) 1 item
  251. TRP Channel 1 item
  252. RNA Polymerases 1 item
  253. DYRK 1 item
  254. Norepinephrine transporter 1 item
  255. 5-HT Transporters 3item
  256. Xanthine oxidoreductases 1 item
  257. Dihydroorotate dehydrogenase 1 item
  258. Histone Demethylases 1 item
  259. MNK 1 item
  260. NO Donors / Precursors 2item
  261. CB2 Receptors 1 item
  262. HIV-1 reverse transcriptase 1 item
  263. IL Receptors 2item
  264. CCL2 1 item
  265. Noradrenaline reuptake 1 item
  266. Norepinephrine transporters 1 item
  267. Calcium-Activated Potassium (KCa) Channels 1 item
  268. AChE 2item
  269. Insulin Receptors 1 item
  270. IRG-1R 1 item
  271. Proton Pump 1 item
  272. cAMP 1 item
  273. Sulfonylurea receptors 1 item
  274. Cdc2-like kinase (Clk) 1 item
  275. eEF-2 1 item
  276. Inward Rectifier Potassium (Kir) Channels 2item
  277. Arp2/3 complex 1 item
  278. Cdc7 1 item
  279. CMV 1 item
  280. ZAP-70 1 item
  281. Catechol O-Methyltransferase (COMT) 2item
  282. fibrinolysis 1 item
  283. D4 Receptors 1 item
  284. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  285. HBV Proteases 1 item
  286. Flk-1 1 item
  287. Papains 1 item
  288. Protein Arginine Methyltransferases 1 item
  289. IMPDH 1 item
  290. Na /Ca2 Exchangers (NCXs) 1 item
  291. NAE 2item
  292. Ubiquitin-activating Enzyme E1 1 item
  293. SUMOylation 1 item
  294. ATGL 1 item
  295. BACE 1 item
  296. Cytidine deaminases 1 item
  297. angiogenesis 1 item
  298. Glucagon Receptors 1 item
  299. 15-PGDH 1 item
  300. DPP-4 4item
  301. c-RET 1 item
  302. Nonstructural protein 5B (NS5B) 1 item
  303. p70 rsk 1 item
  304. FPTase 1 item
  305. ADAMs 1 item
  306. TAM kinase 1 item
  307. p53-MDM2 interaction 1 item
  308. nuclear export 1 item
  309. CRM1 1 item
  310. AXL 1 item
  311. Protein polybromo-1 1 item
  312. SMARCA4 1 item
  313. SMARCA2 1 item
  314. Dipeptidyl-peptidase II 1 item
  315. HDAC 1 item
  316. c-Fms tyrosine kinase 1 item
  317. human lyase 1 item
  318. Ub-conjugating enzyme (E2) complex 1 item
  319. STK 1 item
  320. IKK 1 item
  321. MSK 1 item
  322. HCV polymerase 2item
  323. Ftase 1 item
  324. PC-PLC 1 item
  325. Elastases 1 item
  326. P97 ATPase 1 item
  327. NTPDases 1 item
  328. telomerase 1 item
  329. Histone Acetyltransferases (HATs) 1 item
  330. F1 Fo-ATPase 1 item
  331. ITK 1 item
  332. NOD1 1 item
  333. NUAK 1 item
  334. DCLK2 1 item
  335. FAAH 1 item
  336. TYK2 1 item
  337. Lck 1 item
  338. Aromatases 1 item
  339. PKD 1 item
  340. SHIP 1 item
  341. MCL1 1 item
  342. Bcl-w 1 item
  343. tropomyosin receptor kinase 1 item
  344. LSD 1 item
  345. PRMT 1 item
  346. GLP 1 item
  347. SK 1 item
  348. MST 1 item
  349. IDO 1 item
  350. Serotonin (5-HT) reuptake 1 item
  351. Androgen Receptor 1 item
  352. Substance P/NK1 Receptor 1 item
  353. gp120/CD4 1 item
  354. ATM 2item
  355. Sirtuin 1 item
  356. NE 1 item
  357. PIKfyve 1 item
  358. Glycogen Phosphorylases 1 item
  359. RGS 1 item
  360. MTH1 1 item
  361. Insulin Receptor 1 item
Reported Experiments
  1. Animal Experiments 683item
  2. Cell Experiments 473item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 1 item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 6item
  7. Acute Myeloid Leukemia 26item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Biliary Cancer 1 item
  13. Bladder Cancer 10item
  14. Bladder Carcinoma 4item
  15. Bladder Diseases 2item
  16. B-lymphoid Malignancies 1 item
  17. Brain Injuries Studies 3item
  18. Breast Cancer 115item
  19. Cancer 430item
  20. Candida Peritonitis 1 item
  21. Candidemia 1 item
  22. Castration-resistant Prostate Cancer 1 item
  23. Cervical Cancer 5item
  24. Cholangiocarcinoma 2item
  25. Chronic Lymphocytic Leukemia 8item
  26. Chronic Myeloproliferative Disorders 1 item
  27. Clear Cell Renal Cell Carcinoma 2item
  28. Cocaine-Related Disorders 2item
  29. Colon Cancer 46item
  30. Colon Carcinoma 7item
  31. Colorectal Cancer 42item
  32. Depression 2item
  33. Diabetes 7item
  34. Diffuse Large B-cell Lymphoma 1 item
  35. Dyskinesia 1 item
  36. Dyslipidemia 2item
  37. Epilepsy 2item
  38. Erectile Dysfunction 3item
  39. Friedreich's Ataxia 2item
  40. Fungal Infection 1 item
  41. Glioblastoma 32item
  42. Glioma 18item
  43. HCV 3item
  44. Heart Failure 1 item
  45. Hepatic Cancer 2item
  46. Hepatitis C 3item
  47. Hepatocellular Carcinoma 7item
  48. HIV 4item
  49. HIV Infections 9item
  50. Hypercholesterolemia 2item
  51. Immunological Diseases 1 item
  52. Inflammation 1 item
  53. Inflammatory Bowel Disease 1 item
  54. Inflammatory Diseases 14item
  55. Influenza 2item
  56. Kidney Injury Studies 1 item
  57. Leukemia 23item
  58. Liver Cancer 3item
  59. Lung Cancer 44item
  60. Lung Carcinoma 4item
  61. Lymphoma 31item
  62. Mantle Cell Lymphoma 2item
  63. Medulloblastoma 1 item
  64. Melanoma 34item
  65. Mixed Lineage Leukemia 3item
  66. Multiple Myeloma 24item
  67. Myelofibrosis 2item
  68. Myeloma 6item
  69. Neuroblastoma 13item
  70. Neurocognitive Disorders 1 item
  71. Neuronal Protection 1 item
  72. Non-small Cell Lung Cancer 26item
  73. Non-small Cell Lung Carcinoma 2item
  74. Obsessive-Compulsive Disorder 1 item
  75. Osteoporosis 2item
  76. Ovarian Cancer 35item
  77. Pancreatic Cancer 49item
  78. Pancreatic Carcinoma 3item
  79. Prostate Cancer 54item
  80. Psoriasis 4item
  81. Psoriasis Vulgaris 1 item
  82. Pulmonary Arterial Hypertension 2item
  83. Pulmonary Fibrosis 2item
  84. Renal Cancer 4item
  85. Renal Cell Carcinoma 8item
  86. Rheumatoid Arthritis 14item
  87. Sarcoma 1 item
  88. Schizophrenia 7item
  89. Sleep Disorders 2item
  90. Soft Tissue Sarcoma 1 item
  91. Squamous Cell Carcinoma 2item
  92. Testicular Cancer 2item
  93. Thyroid Cancer 6item
  94. Type 2 Diabetes 12item