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Search results for: 'signal transduction'

Items 51-60 of 240

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  1. Dabrafenib Mesylate (GSK-2118436)
    A3347 Dabrafenib Mesylate (GSK-2118436)
    Target: Raf
    Summary: Inhibitor of BRAF(V600) mutants
      ≥30.75 mg/mL
  2. GDC-0941 dimethanesulfonate
    A3432 GDC-0941 dimethanesulfonate
    Summary: PI3K inhibitor
      insoluble in H2O; insoluble in EtOH; ≥207.6 mg/mL
  3. SB 203580
    A8254 SB 203580
     9 Citation
    Target: p38|PKB
    Summary: P38 MAP kinase inhibitor
      insoluble in H2O; ≥18.872 mg/mL
  4. LY2940680
    A8651 LY2940680
    Target: Smoothened receptor
    Summary: Hedgehog/SMO antagonist,inhibits Hh signaling
  5. A 77-01
    A3132 A 77-01
    Summary: Potent ALK5 inhibitor
      insoluble in H2O; ≥14.3 mg/mL
  6. SB-505124 hydrochloride
    A3799 SB-505124 hydrochloride
    Target: ALK
    Summary: ALK5/ALK4/ALK7 inhibitor in TGF-β/activin signalling,selective
  7. TAK-632
    A8226 TAK-632
    Target: Raf
    Summary: Pan-RAF inhibitor,potent and selective
      ≥27.75 mg/mL
  8. AZD6244 (Selumetinib)
    A8207 AZD6244 (Selumetinib)
     3 Citation
    Summary: MEK inhibitor
      ≥22.88 mg/mL
  9. GDC-0879
    A5071 GDC-0879
     1 Citation
    Target: Raf
    Summary: B-Raf inhibitor,potent and selective
      insoluble in EtOH; insoluble in H2O; ≥16.7 mg/mL
  10. PD184352 (CI-1040)
    A1792 PD184352 (CI-1040)
    Target: MEK
    Summary: Selective MEK inhibitor
      ≥47.9 mg/mL

Items 51-60 of 240

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  1. Category Signaling Pathways Remove This Item
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Category
  1. Proteases 4item
  2. Apoptosis 8item
  3. Chromatin/Epigenetics 8item
  4. Metabolism 4item
  5. MAPK Signaling 34item
  6. Tyrosine Kinase 16item
  7. DNA Damage/DNA Repair 5item
  8. PI3K/Akt/mTOR Signaling 57item
  9. Cell Cycle/Checkpoint 4item
  10. Ubiquitination/ Proteasome 2item
  11. JAK/STAT Signaling 13item
  12. TGF-β / Smad Signaling 22item
  13. GPCR/G protein 2item
  14. Stem Cell 38item
  15. Membrane Transporter/Ion Channel 2item
  16. Cancer Biology 12item
  17. Endocrinology and Hormones 16item
  18. Neuroscience 15item
  19. Obesity, Appetite Control & Diabetes 4item
  20. Other Signal Transduction 42item
  21. Others 8item
  22. Immunology/Inflammation 6item
  23. Cardiovascular 24item
Specificity
  1. Selective 81item
  2. Non-Selective 1 item
Reversibility
  1. Reversible 7item
  2. Irreversible 1 item
Target
  1. Cyclin-Dependent Kinases 1 item
  2. Akt 9item
  3. PI3K 13item
  4. Raf 8item
  5. mTOR 8item
  6. Androgen Receptors 1 item
  7. GSK-3 7item
  8. P-glycoprotein (P-gp) 1 item
  9. VEGFR 4item
  10. PDGFR 1 item
  11. Phosphodiesterases (PDEs) 1 item
  12. p38 4item
  13. PKB 1 item
  14. JNK 4item
  15. MEK 5item
  16. PORCN 1 item
  17. FGFR 1 item
  18. GABAB Receptors 1 item
  19. Smoothened 1 item
  20. NMDA Receptors 1 item
  21. STAT 6item
  22. EGFR 2item
  23. Hedgehog 1 item
  24. BMP and Other Activin Receptors 2item
  25. JAK 3item
  26. Syk 1 item
  27. DNA-PK 1 item
  28. HSP90 1 item
  29. TNKS 1 item
  30. Toll-like receptors (TLRs) 1 item
  31. ERK 2item
  32. PKC 6item
  33. Melanocortin (MC) Receptors 1 item
  34. ALK 1 item
  35. PKG 1 item
  36. PKA 4item
  37. RSK 1 item
  38. NO Donors / Precursors 1 item
  39. IL Receptors 1 item
  40. AChE 1 item
  41. BACE 1 item
  42. p70 rsk 1 item
  43. sodium channels 1 item
  44. Smoothened receptor 1 item
  45. Nrf2/ARE signal 1 item
  46. PPAR 1 item
  47. Antibiotic 1 item
  48. Prk 1 item
  49. ICAM 1 item
  50. Rho 1 item
  51. Thrombin Receptor 1 item
  52. prolactin secretion 1 item
  53. gonadotropin release 1 item
  54. FKBP 1 item
Reported Experiments
  1. Animal Experiments 107item
  2. Cell Experiments 83item
Related Disease
  1. Acute Myelogenous Leukemia 1 item
  2. Acute Myeloid Leukemia 2item
  3. Bladder Cancer 1 item
  4. Breast Cancer 18item
  5. Cancer 68item
  6. Cervical Cancer 2item
  7. Colon Cancer 8item
  8. Colon Carcinoma 1 item
  9. Colorectal Cancer 9item
  10. Glioblastoma 10item
  11. Glioma 3item
  12. Heart Failure 1 item
  13. Leukemia 6item
  14. Liver Cancer 1 item
  15. Lung Cancer 6item
  16. Lymphoma 2item
  17. Melanoma 6item
  18. Multiple Myeloma 1 item
  19. Myeloma 1 item
  20. Neuroblastoma 2item
  21. Non-small Cell Lung Cancer 5item
  22. Ovarian Cancer 6item
  23. Pancreatic Cancer 7item
  24. Pancreatic Carcinoma 2item
  25. Prostate Cancer 10item
  26. Pulmonary Arterial Hypertension 1 item
  27. Pulmonary Fibrosis 1 item
  28. Renal Cancer 1 item
  29. Rheumatoid Arthritis 2item
  30. Thyroid Cancer 2item
  31. Type 2 Diabetes 1 item