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Signaling Pathways

Items 101-110 of 118

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  1. MAZ51
    C3342 MAZ51
    Target: VEGFR
    Summary: VEGFR3 antagonist
      insoluble in EtOH; insoluble in H2O; ≥31.4 mg/mL
  2. Altiratinib
    B5832 Altiratinib
     1 Citation
    Target: FLT3|VEGFR|Trk Receptors|c-MET|Tie-2
    Summary: c-MET/TIE-2/VEGFR inhibitor
      ≥21.55 mg/mL
  3. AZD2932
    B5835 AZD2932
    Target: FLT3|VEGFR|PDGFR|c-Kit
    Summary: inhibitor of VEGFR-2, PDGFRβ, Flt-3, and c-Kit
      Soluble in DMSO
  4. Pexidartinib (PLX3397)
    B5854 Pexidartinib (PLX3397)
     3 Citation
    Target: FLT3|c-Kit|CSF1R
    Summary: CSF-1R inhibitor
      insoluble in EtOH; insoluble in H2O; ≥20.9 mg/mL
  5. Entrectinib
    B5859 Entrectinib
    Target: Trk Receptors|ALK|ROS1
    Summary: Orally active inhibitor of ALK kinase
      ≥28.05 mg/mL
  6. EGF816
    B5889 EGF816
     2 Citation
    Target: EGFR
    Summary: Novel covalent inhibitor of mutant-selective EGFR
      Soluble in DMSO
  7. TP-0903
    B5940 TP-0903
    Target: AXL
    Summary: AXL receptor tyrosine kinase inhibitor, anti-cancer agent
      ≥25.8 mg/mL
  8. MLR 1023
    B5648 MLR 1023
    Target: Lyn kinase
    Summary: allosteric activator of Lyn kinase
  9. KB SRC 4
    B5673 KB SRC 4
    Target: Src
    Summary: c-Src inhibitor
      <11.1 mg/mL
  10. ANA 12
    B5712 ANA 12
     1 Citation
    Target: Trk Receptors
    Summary: TrkB receptor antagonist
      insoluble in H2O; insoluble in EtOH; ≥10.175 mg/mL

Items 101-110 of 118

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  1. Category Tyrosine Kinase Remove This Item
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Category
  1. Bcr-Abl 5item
  2. Axl 4item
  3. ALK 9item
  4. Broad Spectrum Protein Kinase Inhibitor 1 item
  5. c-FMS 1 item
  6. c-Kit 3item
  7. c-MET 13item
  8. c-RET 2item
  9. CSF-1R 3item
  10. EGFR 14item
  11. EphB4 1 item
  12. FAK 4item
  13. FGFR 8item
  14. FLT3 7item
  15. HER2 5item
  16. IGF1R 4item
  17. IRAK 3item
  18. ITK 1 item
  19. LRRK2 4item
  20. PDGFR 12item
  21. Pyk2 2item
  22. Spleen Tyrosine Kinase (Syk) 6item
  23. Src 7item
  24. Tie-2 2item
  25. Trk 4item
  26. VEGFR 19item
Reversibility
  1. Reversible 8item
  2. Irreversible 4item
Target
  1. Cyclin-Dependent Kinases 1 item
  2. Raf 3item
  3. Aurora Kinases 1 item
  4. CSF-1R 2item
  5. MER 1 item
  6. FLT3 9item
  7. Eph Receptors 2item
  8. VEGFR 25item
  9. PDGFR 16item
  10. c-Kit 7item
  11. RET 3item
  12. IRAK 3item
  13. Bcr-Abl 8item
  14. FGFR 9item
  15. Insulin-like growth factor receptors(IGFRs) 1 item
  16. MET 7item
  17. Src 7item
  18. Trk Receptors 5item
  19. EGFR 14item
  20. FAK 4item
  21. BMP and Other Activin Receptors 3item
  22. JAK 2item
  23. Syk 6item
  24. ErbB 2item
  25. c-MET 8item
  26. PKC 1 item
  27. Ca2 /calmodulin-dependent protein kinases (CaMKs) 1 item
  28. Lyn 1 item
  29. HER2 2item
  30. Pyk2 3item
  31. LRRK2 4item
  32. S1P receptors 1 item
  33. Insulin and Insulin-like Receptors 2item
  34. ALK 4item
  35. ROS1 2item
  36. PKG 1 item
  37. PKA 1 item
  38. Myosin light chain kinases (MLCKs) 1 item
  39. Insulin-like growth factors (IGFs) 1 item
  40. CSF1R 1 item
  41. Tie-2 3item
  42. RSK 1 item
  43. p70 S6K 1 item
  44. Ron 1 item
  45. c-Fyn 1 item
  46. Insulin Receptors 1 item
  47. IRG-1R 1 item
  48. ZAP-70 1 item
  49. Flk-1 1 item
  50. TAM kinase 1 item
  51. AXL 1 item
  52. c-Fms tyrosine kinase 1 item
  53. Lyn kinase 1 item
  54. ITK 1 item
  55. DCLK2 1 item
  56. tropomyosin receptor kinase 1 item
  57. Insulin Receptor 1 item
Reported Experiments
  1. Animal Experiments 106item
  2. Cell Experiments 62item
Related Disease
  1. Acute Myelogenous Leukemia 1 item
  2. Acute Myeloid Leukemia 5item
  3. Adrenocortical Carcinoma 1 item
  4. Advanced Renal Cell Carcinoma 1 item
  5. Autoimmune Diseases 1 item
  6. Bladder Cancer 4item
  7. Bladder Carcinoma 1 item
  8. Breast Cancer 20item
  9. Cancer 84item
  10. Cervical Cancer 1 item
  11. Cholangiocarcinoma 1 item
  12. Chronic Lymphocytic Leukemia 1 item
  13. Clear Cell Renal Cell Carcinoma 1 item
  14. Colon Cancer 3item
  15. Colon Carcinoma 3item
  16. Colorectal Cancer 12item
  17. Glioblastoma 9item
  18. Glioma 4item
  19. Hepatocellular Carcinoma 3item
  20. Leukemia 2item
  21. Liver Cancer 2item
  22. Lung Cancer 8item
  23. Lung Carcinoma 4item
  24. Lymphoma 5item
  25. Melanoma 3item
  26. Multiple Myeloma 5item
  27. Myeloma 1 item
  28. Neuroblastoma 2item
  29. Non-small Cell Lung Cancer 6item
  30. Ovarian Cancer 7item
  31. Pancreatic Cancer 12item
  32. Prostate Cancer 8item
  33. Pulmonary Arterial Hypertension 1 item
  34. Renal Cancer 2item
  35. Renal Cell Carcinoma 4item
  36. Rheumatoid Arthritis 2item
  37. Thyroid Cancer 4item