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Signaling Pathways

Items 21-30 of 143

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  1. Linifanib (ABT-869)
    A2949 Linifanib (ABT-869)
    Target: VEGFR|PDGFR
    Summary: VEGFR/PDGFR inhibitor
      insoluble in H2O; insoluble in EtOH; ≥18.75 mg/mL
  2. BMS-754807
    A1185 BMS-754807
    Target: Insulin and Insulin-like Receptors
    Summary: IGF-1R/InsR inhibitor,potent and selective
      ≥23.05 mg/mL
  3. Imatinib Mesylate (STI571)
    A1805 Imatinib Mesylate (STI571)
    Target: PDGFR|c-Kit|Bcr-Abl
    Summary: Abl/c-kit/PDGFR inhibitor
      ≥29.5 mg/mL
  4. Dovitinib (TKI-258, CHIR-258)
    A2168 Dovitinib (TKI-258, CHIR-258)
     2 Citation
    Target: FLT3|VEGFR|PDGFR|c-Kit|FGFR
    Summary: Multitargeted RTK inhibitor
      insoluble in H2O; insoluble in EtOH; ≥36.35 mg/mL
  5. Cediranib (AZD217)
    A1882 Cediranib (AZD217)
    Target: VEGFR
    Summary: VEGFR inhibitor receptor,highly potent
      ≥22.52 mg/mL
  6. CP-724714
    A2412 CP-724714
    Target: VEGFR|PDGFR|Bcr-Abl|Src|EGFR|c-MET|Insulin Receptors|IRG-1R
    Summary: HER2 inhibitor,potent and selective
      ≥23.5 mg/mL
  7. Tivozanib (AV-951)
    A2251 Tivozanib (AV-951)
    Target: VEGFR
    Summary: VEGFR inhibitor,potent and selective
      ≥22.75 mg/mL
  8. Brivanib (BMS-540215)
    A2597 Brivanib (BMS-540215)
    Target: VEGFR|FGFR|Flk1
    Summary: VEGFR-2 inhibitor,ATP-competitive
      insoluble in H2O; ≥18.5 mg/mL
  9. Lenvatinib (E7080)
    A2174 Lenvatinib (E7080)
    Target: VEGFR|PDGFR|RET
    Summary: VEGFR inhibitor
      ≥21.35 mg/mL
  10. MGCD-265
    A5057 MGCD-265
    Target: VEGFR|c-MET
    Summary: Met/Flt/Flk/Ron/Tie-2 inhibitor
      ≥25.9 mg/mL

Items 21-30 of 143

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Category
  1. Bcr-Abl 8item
  2. Axl 5item
  3. ALK 10item
  4. c-FMS 1 item
  5. c-Kit 4item
  6. c-MET 14item
  7. c-RET 4item
  8. CSF-1R 3item
  9. EGFR 21item
  10. FAK 5item
  11. FGFR 10item
  12. FLT3 9item
  13. HER2 10item
  14. IGF1R 4item
  15. Insulin Receptor 1 item
  16. IRAK 1 item
  17. ITK 1 item
  18. LRRK2 5item
  19. PDGFR 12item
  20. Pyk2 2item
  21. Spleen Tyrosine Kinase (Syk) 6item
  22. Src 8item
  23. Tie-2 2item
  24. Trk 4item
  25. VEGFR 30item
Specificity
  1. Selective 106item
Reversibility
  1. Reversible 9item
  2. Irreversible 8item
Target
  1. Histone Deacetylases (HDACs) 1 item
  2. Raf 5item
  3. Aurora Kinases 3item
  4. CSF-1R 4item
  5. MER 1 item
  6. FLT3 12item
  7. Eph Receptors 1 item
  8. VEGFR 37item
  9. PDGFR 21item
  10. c-Kit 12item
  11. RET 3item
  12. IRAK 1 item
  13. Bcr-Abl 10item
  14. FGFR 15item
  15. Insulin-like growth factor receptors(IGFRs) 1 item
  16. MET 7item
  17. Src 9item
  18. Trk Receptors 5item
  19. STAT 1 item
  20. EGFR 21item
  21. FAK 5item
  22. BMP and Other Activin Receptors 2item
  23. JAK 2item
  24. Syk 6item
  25. ErbB 5item
  26. c-MET 8item
  27. PKC 1 item
  28. Lyn 2item
  29. HER2 3item
  30. Pyk2 3item
  31. LRRK2 5item
  32. S1P receptors 1 item
  33. Insulin and Insulin-like Receptors 3item
  34. ALK 6item
  35. ROS1 2item
  36. Insulin-like growth factors (IGFs) 1 item
  37. CSF1R 1 item
  38. Angiotensin-Converting Enzymes (ACEs) 1 item
  39. Tie-2 4item
  40. RSK 1 item
  41. p70 S6K 1 item
  42. Ron 1 item
  43. 5-Lipoxygenases 1 item
  44. Insulin Receptors 2item
  45. IRG-1R 1 item
  46. ZAP-70 1 item
  47. Flk-1 1 item
  48. c-RET 2item
  49. TAM kinase 1 item
  50. KDR 1 item
  51. Fyn kinase 1 item
  52. AXL 1 item
  53. c-Fms tyrosine kinase 1 item
  54. insulin 1 item
  55. Lyn kinase 1 item
  56. Mer tyrosine kinase 1 item
  57. ErbB-2 1 item
  58. ITK 1 item
  59. DCLK2 1 item
  60. PTK 1 item
  61. Flk1 1 item
  62. YES 1 item
  63. Fyn 1 item
  64. enoyl-acyl-carrier protein reductase 1 item
  65. tropomyosin receptor kinase 1 item
  66. Insulin Receptor 1 item
Related Disease
  1. Acute Myelogenous Leukemia 1 item
  2. Acute Myeloid Leukemia 5item
  3. Adrenocortical Carcinoma 1 item
  4. Advanced Renal Cell Carcinoma 1 item
  5. Autoimmune Diseases 1 item
  6. Bladder Cancer 4item
  7. Bladder Carcinoma 1 item
  8. Breast Cancer 22item
  9. Cancer 106item
  10. Cervical Cancer 1 item
  11. Cholangiocarcinoma 1 item
  12. Chronic Lymphocytic Leukemia 1 item
  13. Clear Cell Renal Cell Carcinoma 1 item
  14. Colon Cancer 4item
  15. Colon Carcinoma 3item
  16. Colorectal Cancer 12item
  17. Glioblastoma 9item
  18. Glioma 4item
  19. Hepatocellular Carcinoma 3item
  20. Leukemia 3item
  21. Liver Cancer 2item
  22. Lung Cancer 7item
  23. Lung Carcinoma 4item
  24. Lymphoma 5item
  25. Melanoma 2item
  26. Multiple Myeloma 5item
  27. Myeloma 1 item
  28. Neuroblastoma 2item
  29. Non-small Cell Lung Cancer 6item
  30. Ovarian Cancer 8item
  31. Pancreatic Cancer 12item
  32. Prostate Cancer 8item
  33. Pulmonary Arterial Hypertension 1 item
  34. Renal Cancer 2item
  35. Renal Cell Carcinoma 4item
  36. Rheumatoid Arthritis 2item
  37. Thyroid Cancer 4item