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Signaling Pathways

Items 41-50 of 143

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  1. PD168393
    A2024 PD168393
    Target: PDGFR|FGFR|EGFR|PKC|insulin
    Summary: EGFR inhibitor
  2. GW2580
    A1655 GW2580
     1 Citation
    Target: CSF-1R
    Summary: CFMS kinase/CSF-1R inhibitor,selective and ATP-competitive
      ≥36.6 mg/mL
  3. Butein
    A2689 Butein
    Target: Src|STAT|EGFR|Angiotensin-Converting Enzymes (ACEs)|5-Lipoxygenases|PTK|enoyl-acyl-carrier protein reductase
    Summary: Protein kinase inhibitor
      insoluble in H2O; ≥13.6 mg/mL
  4. GNF-5837
    A8303 GNF-5837
    Target: Trk Receptors
    Summary: Pan-Trk inhibitor
      insoluble in EtOH; insoluble in H2O; ≥17 mg/mL
  5. Crenolanib (CP-868596)
    A8307 Crenolanib (CP-868596)
     1 Citation
    Target: FLT3|PDGFR
    Summary: PDGFR-β inhibitor,potent and selective
      ≥22.2 mg/mL
  6. PF-562271
    A8310 PF-562271
     1 Citation
    Target: FAK|Pyk2
    Summary: ATP-competitive FAK inhibitor, reversible
      ≥25.35 mg/mL
  7. RAF265
    A8313 RAF265
    Target: Raf|VEGFR
    Summary: Multiple intracellular kinases inhibitor
      ≥25.9 mg/mL
  8. Dacomitinib (PF299804, PF299)
    A8319 Dacomitinib (PF299804, PF299)
    Target: ErbB
    Summary: HER inhibitor
      ≥23.5 mg/mL
  9. PF-00562271
    A8320 PF-00562271
    Target: FAK|Pyk2
    Summary: FAK/Pyk2 inhibitor,potent and ATP-competitive
      insoluble in EtOH; insoluble in H2O; ≥11.1 mg/mL
  10. Neratinib (HKI-272)
    A8322 Neratinib (HKI-272)
     1 Citation
    Target: EGFR
    Summary: HER2/EGFR inhibitor,potent and irreversible
      insoluble in H2O; ≥13.93 mg/mL

Items 41-50 of 143

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  1. Category Tyrosine Kinase Remove This Item
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Category
  1. Bcr-Abl 8item
  2. Axl 5item
  3. ALK 10item
  4. c-FMS 1 item
  5. c-Kit 4item
  6. c-MET 14item
  7. c-RET 4item
  8. CSF-1R 3item
  9. EGFR 21item
  10. FAK 5item
  11. FGFR 10item
  12. FLT3 9item
  13. HER2 10item
  14. IGF1R 4item
  15. Insulin Receptor 1 item
  16. IRAK 1 item
  17. ITK 1 item
  18. LRRK2 5item
  19. PDGFR 12item
  20. Pyk2 2item
  21. Spleen Tyrosine Kinase (Syk) 6item
  22. Src 8item
  23. Tie-2 2item
  24. Trk 4item
  25. VEGFR 30item
Specificity
  1. Selective 106item
Reversibility
  1. Reversible 9item
  2. Irreversible 8item
Target
  1. Histone Deacetylases (HDACs) 1 item
  2. Raf 5item
  3. Aurora Kinases 3item
  4. CSF-1R 4item
  5. MER 1 item
  6. FLT3 12item
  7. Eph Receptors 1 item
  8. VEGFR 37item
  9. PDGFR 21item
  10. c-Kit 12item
  11. RET 3item
  12. IRAK 1 item
  13. Bcr-Abl 10item
  14. FGFR 15item
  15. Insulin-like growth factor receptors(IGFRs) 1 item
  16. MET 7item
  17. Src 9item
  18. Trk Receptors 5item
  19. STAT 1 item
  20. EGFR 21item
  21. FAK 5item
  22. BMP and Other Activin Receptors 2item
  23. JAK 2item
  24. Syk 6item
  25. ErbB 5item
  26. c-MET 8item
  27. PKC 1 item
  28. Lyn 2item
  29. HER2 3item
  30. Pyk2 3item
  31. LRRK2 5item
  32. S1P receptors 1 item
  33. Insulin and Insulin-like Receptors 3item
  34. ALK 6item
  35. ROS1 2item
  36. Insulin-like growth factors (IGFs) 1 item
  37. CSF1R 1 item
  38. Angiotensin-Converting Enzymes (ACEs) 1 item
  39. Tie-2 4item
  40. RSK 1 item
  41. p70 S6K 1 item
  42. Ron 1 item
  43. 5-Lipoxygenases 1 item
  44. Insulin Receptors 2item
  45. IRG-1R 1 item
  46. ZAP-70 1 item
  47. Flk-1 1 item
  48. c-RET 2item
  49. TAM kinase 1 item
  50. KDR 1 item
  51. Fyn kinase 1 item
  52. AXL 1 item
  53. c-Fms tyrosine kinase 1 item
  54. insulin 1 item
  55. Lyn kinase 1 item
  56. Mer tyrosine kinase 1 item
  57. ErbB-2 1 item
  58. ITK 1 item
  59. DCLK2 1 item
  60. PTK 1 item
  61. Flk1 1 item
  62. YES 1 item
  63. Fyn 1 item
  64. enoyl-acyl-carrier protein reductase 1 item
  65. tropomyosin receptor kinase 1 item
  66. Insulin Receptor 1 item
Related Disease
  1. Acute Myelogenous Leukemia 1 item
  2. Acute Myeloid Leukemia 5item
  3. Adrenocortical Carcinoma 1 item
  4. Advanced Renal Cell Carcinoma 1 item
  5. Autoimmune Diseases 1 item
  6. Bladder Cancer 4item
  7. Bladder Carcinoma 1 item
  8. Breast Cancer 22item
  9. Cancer 106item
  10. Cervical Cancer 1 item
  11. Cholangiocarcinoma 1 item
  12. Chronic Lymphocytic Leukemia 1 item
  13. Clear Cell Renal Cell Carcinoma 1 item
  14. Colon Cancer 4item
  15. Colon Carcinoma 3item
  16. Colorectal Cancer 12item
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  24. Lymphoma 5item
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  26. Multiple Myeloma 5item
  27. Myeloma 1 item
  28. Neuroblastoma 2item
  29. Non-small Cell Lung Cancer 6item
  30. Ovarian Cancer 8item
  31. Pancreatic Cancer 12item
  32. Prostate Cancer 8item
  33. Pulmonary Arterial Hypertension 1 item
  34. Renal Cancer 2item
  35. Renal Cell Carcinoma 4item
  36. Rheumatoid Arthritis 2item
  37. Thyroid Cancer 4item