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Signaling Pathways

Items 41-50 of 250

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  1. MK-8776 (SCH-900776)
    A8477 MK-8776 (SCH-900776)
    Target: Chk
    Summary: Chk1 inhibitor,potent and selective
      insoluble in H2O; insoluble in EtOH; ≥18.8 mg/mL
  2. PHA-848125
    A8501 PHA-848125
    Target: Cyclin-Dependent Kinases
    Summary: CDK inhibitor,potent and ATP-competitive
      ≥23.05 mg/mL
  3. BMS265246
    A8385 BMS265246
    Target: Cyclin-Dependent Kinases
    Summary: CDK1/2 inhibitor,potent and selective
      insoluble in H2O; insoluble in EtOH; ≥17.25 mg/mL
  4. CHIR-124
    A8394 CHIR-124
    Target: FLT3|GSK-3|Chk|PDGFR
    Summary: Chk1 inhibitor,novel and potent
      insoluble in H2O; ≥10.5 mg/mL
  5. Dinaciclib (SCH727965)
    A8412 Dinaciclib (SCH727965)
     2 Citation
    Target: Cyclin-Dependent Kinases
    Summary: Potent CDK inhibitor
  6. BI6727 (Volasertib)
    A8558 BI6727 (Volasertib)
     1 Citation
    Summary: Plk inhibitor,highly potent
      insoluble in H2O; ≥10.31 mg/mL
  7. Purvalanol B
    A8565 Purvalanol B
     1 Citation
    Target: Cyclin-Dependent Kinases
    Summary: CDK1/CDK2/CDK4 inhibitor
      ≥21.65 mg/mL
  8. CGK733
    A8624 CGK733
    Target: ATM/ATR
    Summary: ATM/ATR inhibitor,potent and selective
      ≥27.8 mg/mL
  9. CP-466722
    A8625 CP-466722
    Target: ATM
    Summary: ATM inhibitor,potent and reversible
      ≥4.36 mg/mL
  10. ETP-46464
    A8626 ETP-46464
    Target: PI3K|mTOR|DNA-PK|ATM/ATR
    Summary: ATR inhibitor,potent and selective
      ≥16.13 mg/mL

Items 41-50 of 250

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Category
  1. ATM/ATR 9item
  2. Aurora Kinase 28item
  3. Cdc42 4item
  4. Cdc7 2item
  5. Chk 15item
  6. c-Myc 3item
  7. CRM1 4item
  8. Cyclin-Dependent Kinases 65item
  9. E1 enzyme 1 item
  10. G-quadruplex 3item
  11. Haspin 1 item
  12. HMTase 1 item
  13. Kinesin 7item
  14. Ksp 4item
  15. Microtubule/Tubulin 33item
  16. Mps1 3item
  17. Mitotic 7item
  18. RAD51 3item
  19. ROCK 16item
  20. Rho 12item
  21. PAK1 4item
  22. PAK4 2item
  23. PERK 4item
  24. PLK 18item
  25. PTEN 2item
  26. Wee1 1 item
Specificity
  1. Selective 80item
Reversibility
  1. Reversible 9item
  2. Irreversible 2item
Target
  1. Cyclin-Dependent Kinases 30item
  2. PI3K 2item
  3. Aurora Kinases 20item
  4. mTOR 1 item
  5. FLT3 5item
  6. GSK-3 1 item
  7. PLK 11item
  8. Chk 8item
  9. VEGFR 1 item
  10. PDGFR 1 item
  11. RET 1 item
  12. Bromodomain-containing proteins(BRDs) 1 item
  13. MEK 1 item
  14. FGFR 1 item
  15. Voltage-gated Sodium (NaV) Channels 1 item
  16. Src 3item
  17. Microtubules/Tubulins 5item
  18. ROCK 10item
  19. PAK 3item
  20. JAK 1 item
  21. DNA-PK 1 item
  22. Ksp 2item
  23. PKC 1 item
  24. RAD51 2item
  25. LRRK2 1 item
  26. KRAS G12C 1 item
  27. PKG 1 item
  28. PKA 1 item
  29. Myosin light chain kinases (MLCKs) 1 item
  30. Clk 1 item
  31. MK2 1 item
  32. ATM/ATR 6item
  33. Farnesyl Diphosphate Synthases 1 item
  34. G-quadruplexes 1 item
  35. Cdc42 1 item
  36. Hck 1 item
  37. Arp2/3 complex 1 item
  38. Cdc7 1 item
  39. Ubiquitin-activating Enzyme E1 1 item
  40. Microtubule/Tubulin 3item
  41. VEGFR3/FLT4 1 item
  42. NTRK1/TRKA 1 item
  43. CSF-1R/c-Fms 1 item
  44. nuclear export 1 item
  45. CRM1 1 item
  46. Hec1 1 item
  47. Histone Acetyltransferases (HATs) 1 item
  48. Rho 1 item
  49. Lck 1 item
  50. FGR 1 item
  51. YES 1 item
  52. Fyn 1 item
  53. ARG 1 item
  54. Rho-kinase 1 item
  55. ATM 1 item
  56. PTEN 1 item
Reported Experiments
  1. Animal Experiments 88item
  2. Cell Experiments 71item
Related Disease
  1. Acute Myeloid Leukemia 7item
  2. B-lymphoid Malignancies 1 item
  3. Breast Cancer 16item
  4. Cancer 77item
  5. Cervical Cancer 1 item
  6. Chronic Lymphocytic Leukemia 2item
  7. Colon Cancer 10item
  8. Colon Carcinoma 1 item
  9. Colorectal Cancer 5item
  10. Glioblastoma 2item
  11. Glioma 2item
  12. Leukemia 1 item
  13. Liver Cancer 1 item
  14. Lung Cancer 7item
  15. Lymphoma 4item
  16. Mantle Cell Lymphoma 1 item
  17. Melanoma 2item
  18. Multiple Myeloma 1 item
  19. Neuroblastoma 1 item
  20. Non-small Cell Lung Carcinoma 1 item
  21. Ovarian Cancer 10item
  22. Pancreatic Cancer 7item
  23. Prostate Cancer 5item
  24. Renal Cell Carcinoma 1 item
  25. Thyroid Cancer 1 item