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Signaling Pathways

Items 61-70 of 88

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  1. THZ1
    A8882 THZ1
     12 Citation
    Target: Cyclin-Dependent Kinases
    Summary: Covalent CDK7 inhibitor,potent and selective
      ≥28.3 mg/mL
  2. Fasudil
    B3523 Fasudil
    Target: ROCK|PKC|PKG|PKA|Myosin light chain kinases (MLCKs)
    Summary: calcium antagonist
      Soluble in DMSO
  3. NMS-1286937
    B4094 NMS-1286937
    Target: PLK
    Summary: PLK1 inhibitor, orally bioavailable
      insoluble in H2O; insoluble in EtOH; ≥13.33 mg/mL
  4. Y-27632 dihydrochloride
    A3008 Y-27632 dihydrochloride
     19 Citation
    Target: ROCK
    Summary: ROCK1 inhibitor
      ≥111.2 mg/mL
  5. VX-680 (MK-0457,Tozasertib)
    A4111 VX-680 (MK-0457,Tozasertib)
    Target: Aurora Kinases
    Summary: Aurora kinase inhibitor
      ≥23.25 mg/mL
  6. Barasertib (AZD1152-HQPA)
    A4112 Barasertib (AZD1152-HQPA)
     3 Citation
    Target: Aurora Kinases
    Summary: Aurora Kinase B inhibitor, Potent and selective
      ≥25.4 mg/mL
  7. ENMD-2076
    A4130 ENMD-2076
    Target: Aurora Kinases|FLT3|RET|Src|VEGFR3/FLT4|NTRK1/TRKA|CSF-1R/c-Fms
    Summary: Selective Aurora A/Flt3 inhibitor
      insoluble in H2O; ≥18.75 mg/mL
  8. CCT137690
    A4132 CCT137690
    Target: Aurora Kinases
    Summary: Aurora A/B/C inhibitor
      insoluble in H2O; insoluble in EtOH; ≥6.89 mg/mL
  9. MLN8054
    A4114 MLN8054
    Target: Aurora Kinases
    Summary: Aurora A inhibitor
      insoluble in EtOH; insoluble in H2O; ≥39.05 mg/mL
  10. JNJ-7706621
    A4115 JNJ-7706621
     1 Citation
    Target: Cyclin-Dependent Kinases|Aurora Kinases
    Summary: Potent CDK/Aurora kinase inhibitor
      insoluble in EtOH; insoluble in H2O; ≥19.7 mg/mL

Items 61-70 of 88

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Category
  1. ATM/ATR 3item
  2. Aurora Kinase 18item
  3. Cdc42 1 item
  4. Cdc7 1 item
  5. Chk 7item
  6. CRM1 1 item
  7. Cyclin-Dependent Kinases 21item
  8. E1 enzyme 1 item
  9. Ksp 2item
  10. Microtubule/Tubulin 8item
  11. Mitotic 1 item
  12. RAD51 2item
  13. ROCK 7item
  14. Rho 3item
  15. PAK1 2item
  16. PAK4 1 item
  17. PERK 1 item
  18. PLK 9item
  19. PTEN 1 item
Specificity
  1. Selective 60item
Reversibility
  1. Reversible 7item
  2. Irreversible 1 item
Target
  1. Cyclin-Dependent Kinases 23item
  2. PI3K 1 item
  3. Aurora Kinases 17item
  4. FLT3 5item
  5. GSK-3 1 item
  6. PLK 10item
  7. Chk 7item
  8. VEGFR 1 item
  9. PDGFR 1 item
  10. RET 1 item
  11. Bromodomain-containing proteins(BRDs) 1 item
  12. FGFR 1 item
  13. Src 2item
  14. Microtubules/Tubulins 4item
  15. ROCK 7item
  16. PAK 3item
  17. JAK 1 item
  18. Ksp 2item
  19. PKC 1 item
  20. RAD51 2item
  21. LRRK2 1 item
  22. PKG 1 item
  23. PKA 1 item
  24. Myosin light chain kinases (MLCKs) 1 item
  25. MK2 1 item
  26. ATM/ATR 3item
  27. Farnesyl Diphosphate Synthases 1 item
  28. Cdc42 1 item
  29. Hck 1 item
  30. Cdc7 1 item
  31. Ubiquitin-activating Enzyme E1 1 item
  32. Microtubule/Tubulin 3item
  33. VEGFR3/FLT4 1 item
  34. NTRK1/TRKA 1 item
  35. CSF-1R/c-Fms 1 item
  36. nuclear export 1 item
  37. CRM1 1 item
  38. Hec1 1 item
  39. Histone Acetyltransferases (HATs) 1 item
  40. Rho 1 item
  41. FGR 1 item
  42. YES 1 item
  43. Fyn 1 item
  44. ARG 1 item
  45. Rho-kinase 1 item
  46. PTEN 1 item
Related Disease
  1. Acute Myeloid Leukemia 6item
  2. B-lymphoid Malignancies 1 item
  3. Breast Cancer 12item
  4. Cancer 68item
  5. Cervical Cancer 1 item
  6. Chronic Lymphocytic Leukemia 2item
  7. Colon Cancer 8item
  8. Colon Carcinoma 1 item
  9. Colorectal Cancer 4item
  10. Glioblastoma 2item
  11. Glioma 2item
  12. Leukemia 1 item
  13. Liver Cancer 1 item
  14. Lung Cancer 6item
  15. Lymphoma 3item
  16. Mantle Cell Lymphoma 1 item
  17. Melanoma 2item
  18. Multiple Myeloma 1 item
  19. Neuroblastoma 1 item
  20. Non-small Cell Lung Carcinoma 1 item
  21. Ovarian Cancer 8item
  22. Pancreatic Cancer 7item
  23. Prostate Cancer 4item
  24. Renal Cell Carcinoma 1 item
  25. Thyroid Cancer 1 item