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Signaling Pathways

Signaling Pathways

A1718 Posaconazole

Target: Cytochrome P450 (CYP450)|sterol demethylase

Summary: Sterol C14ɑ demethylase inhibitor

≥35.04 mg/mL
A2822 AC480 (BMS-599626)

Target: EGFR

Summary: HER1/2 inhibitor,selective and efficacious

≥28.35 mg/mL
A1684 Aprepitant

Target: Substance P/NK1 Receptor

Summary: Substance P (SP) inhibitor

≥26.72 mg/mL
A2415 Acitretin

Target: RARs

Summary: Metabolite of etretinate

insoluble in EtOH; insoluble in H2O; ≥16.32 mg/mL
A1302 GSK1904529A

Target: Insulin and Insulin-like Receptors

Summary: Selective IGF-1R/IR inhibitor

≥42.6 mg/mL
A1987 Ki16425

4 Citation

Target: LPA Receptors

Summary: LPA receptor antagonist

≥23.75 mg/mL
A2487 Odanacatib (MK-0822)

Target: Cathepsins

Summary: Cathepsin K,potent and selective

insoluble in EtOH; insoluble in H2O; ≥17.7 mg/mL
A2278 NVP-AEW541

Target: Insulin Receptor

Summary: IGF-IR inhibitor, novel, potent and selective

≥22 mg/mL
A1352 Zoledronic Acid

Target: Farnesyl Diphosphate Synthases

Summary: Potent nitrogen-containing bisphosphonates

insoluble in DMSO; insoluble in H2O; insoluble in EtOH
A5166 Ondansetron HCl

Target: 5-HT3 Receptors

Summary: 5-HT3 receptor antagonist

insoluble in EtOH; insoluble in H2O; ≥33.04 mg/mL