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Signaling Pathways

Items 161-170 of 1060

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  1. VX-661
    A2664 VX-661
    Target: CFTR
    Summary: F508del CFTR corrector
      ≥21.8 mg/mL
  2. LY2835219
    A1794 LY2835219
    Target: Cyclin-Dependent Kinases
    Summary: CDK4/6 inhibitor,potent and selective
      ≥30.15 mg/mL
  3. Duvelisib (IPI-145, INK1197)
    A1720 Duvelisib (IPI-145, INK1197)
    Target: PI3K
    Summary: PI3K-δ/PI3K-γ inhibitor
      ≥20.84 mg/mL
  4. ZCL278
    A8300 ZCL278
     1 Citation
    Target: Cdc42
    Summary: Selective Cdc42 inhibitor
      ≥29.25 mg/mL
  5. GW788388
    A8301 GW788388
    Summary: ALK5 inhibitor,potent and selective
      ≥21.25 mg/mL
  6. Tenovin-6
    A8302 Tenovin-6
    Target: Sir2-like Family Deacetylases (Sirtuins)
    Summary: SIRT inhibitor and p53 activator
      ≥22.75 mg/mL
  7. GNF-5837
    A8303 GNF-5837
    Target: Trk Receptors
    Summary: Pan-Trk inhibitor
      insoluble in EtOH; insoluble in H2O; ≥17 mg/mL
  8. FR 180204
    A8304 FR 180204
    Target: ERK
    Summary: ERK inhibitor
      insoluble in H2O; ≥10.25 mg/mL
  9. MOG (35-55)
    A8306 MOG (35-55)
     1 Citation
    Summary: Minor component of CNS myelin
      ≥32.25 mg/mL
  10. Crenolanib (CP-868596)
    A8307 Crenolanib (CP-868596)
     1 Citation
    Target: FLT3|PDGFR
    Summary: PDGFR-β inhibitor,potent and selective
      ≥22.2 mg/mL

Items 161-170 of 1060

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  1. Proteases 80item
  2. Apoptosis 51item
  3. Chromatin/Epigenetics 108item
  4. Metabolism 79item
  5. MAPK Signaling 46item
  6. Tyrosine Kinase 118item
  7. DNA Damage/DNA Repair 72item
  8. PI3K/Akt/mTOR Signaling 64item
  9. Microbiology & Virology 45item
  10. Cell Cycle/Checkpoint 80item
  11. Ubiquitination/ Proteasome 35item
  12. JAK/STAT Signaling 33item
  13. TGF-β / Smad Signaling 35item
  14. Angiogenesis 10item
  15. GPCR/G protein 88item
  16. Stem Cell 32item
  17. Membrane Transporter/Ion Channel 57item
  18. Cancer Biology 2item
  19. Endocrinology and Hormones 28item
  20. Neuroscience 63item
  21. Obesity, Appetite Control & Diabetes 3item
  22. Other Signal Transduction 5item
  23. Others 106item
  24. Immunology/Inflammation 17item
  25. Cardiovascular 3item
Reversibility
  1. Reversible 56item
  2. Irreversible 29item
Target
  1. Caspases 11item
  2. Cyclin-Dependent Kinases 26item
  3. Adenosine A2A Receptors 5item
  4. Proteasome 11item
  5. Cathepsins 11item
  6. Histone Deacetylases (HDACs) 27item
  7. Inhibitor of apoptosis proteins (IAP) 3item
  8. Akt 6item
  9. Bcl-2 6item
  10. PI3K 27item
  11. CXCR 6item
  12. Raf 10item
  13. Aurora Kinases 14item
  14. Bcl-xl 3item
  15. CSF-1R 2item
  16. Glycoproteins 1 item
  17. p97 1 item
  18. Gap Junctions 3item
  19. MDM2 2item
  20. EZH2 6item
  21. mTOR 15item
  22. Bromodomains 5item
  23. AP-1 3item
  24. MMP 10item
  25. Thymidine Phosphorylases 1 item
  26. Androgen Receptors 4item
  27. Peptidylprolyl isomerases 1 item
  28. Acyl coenzyme A: cholesterol acyltransferases 1 item
  29. Myosin II ATPases 1 item
  30. DT-diaphorases 1 item
  31. Voltage-gated Potassium (KV) Channels 2item
  32. MER 1 item
  33. FLT3 12item
  34. GSK-3 9item
  35. Factor Xa 3item
  36. Farnesoid X receptors (FXRs) 1 item
  37. LPA Receptors 3item
  38. P-glycoprotein (P-gp) 6item
  39. PLK 7item
  40. Chk 8item
  41. ULK1 1 item
  42. Eph Receptors 3item
  43. VEGFR 26item
  44. PDGFR 19item
  45. c-Kit 7item
  46. RET 3item
  47. IRAK 3item
  48. Bromodomain-containing proteins(BRDs) 1 item
  49. Phosphodiesterases (PDEs) 10item
  50. Mcl-1 5item
  51. Hydrolase 1 item
  52. Thymidylate Synthase 2item
  53. p38 9item
  54. PKB 1 item
  55. 3-phosphoglycerate dehydrogenase 1 item
  56. JNK 6item
  57. SGK 2item
  58. Bcr-Abl 10item
  59. Kynurenine-3-monooxygenase 1 item
  60. MEK 15item
  61. PORCN 1 item
  62. DOT1L 3item
  63. FGFR 9item
  64. Nrf2 2item
  65. Insulin-like growth factor receptors(IGFRs) 1 item
  66. CGRP receptors 2item
  67. Pim 4item
  68. GABAB Receptors 2item
  69. Liver X receptors (LXRs) 2item
  70. Glucagon-like peptide 1 (GLP-1) receptors 2item
  71. Sir2-like Family Deacetylases (Sirtuins) 4item
  72. Voltage-gated Sodium (NaV) Channels 8item
  73. Deubiquitinating enzymes (DUBs) 4item
  74. PP1 1 item
  75. PP2A 1 item
  76. Smoothened 5item
  77. Eukaryotic elongation factors 1 item
  78. Ribosomal s6 kinases (RSK) 1 item
  79. Neuraminidases (NA) 2item
  80. MET 7item
  81. Glucan synthase 1 item
  82. Src 9item
  83. RARs 9item
  84. Trk Receptors 6item
  85. Integrins 1 item
  86. Aminopeptidases 2item
  87. NMDA Receptors 2item
  88. STAT 6item
  89. ATP Citrate Lyases 1 item
  90. Microtubules/Tubulins 7item
  91. Estrogen and Related Receptors 5item
  92. EGFR 15item
  93. Hedgehog 1 item
  94. Reverse Transcriptases 1 item
  95. ROCK 7item
  96. BTK 2item
  97. Purinergic (P2Y) Receptors 1 item
  98. RIP kinases 1 item
  99. PAK 3item
  100. Hypoxia Inducible Factors (HIFs) 2item
  101. Tankyrases 1 item
  102. Inositol Phosphatases 1 item
  103. FAK 5item
  104. BMP and Other Activin Receptors 4item
  105. JAK 13item
  106. p300 1 item
  107. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  108. Syk 7item
  109. Progesterone Receptors 3item
  110. EZH1 2item
  111. DNA-PK 6item
  112. HSP90 10item
  113. AMPK 5item
  114. Gutathione S-transferase 1 item
  115. CCR 2item
  116. PDHK 1 item
  117. Angiotensin AT2 Receptors 2item
  118. eIF4E/eIF3G interaction 1 item
  119. Notch 1 item
  120. S-nitrosoglutathione reductase 1 item
  121. CFTR 4item
  122. TNKS 1 item
  123. Topoisomerases 8item
  124. Cytochrome P450 (CYP450) 10item
  125. M3 Receptors 2item
  126. thrombin 1 item
  127. Ksp 1 item
  128. Ribosomes 1 item
  129. Renin 2item
  130. HIV proteases 1 item
  131. Pepsins 1 item
  132. Influenza viruses 1 item
  133. ErbB 2item
  134. Ferroptosis 1 item
  135. S6 kinases 1 item
  136. Toll-like receptors (TLRs) 3item
  137. Adenosine Kinases 2item
  138. Actin 2item
  139. DNA Methyltransferases 4item
  140. Epac 1 item
  141. Calcitonin and Related Receptors 1 item
  142. Survivin 1 item
  143. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  144. ERK 5item
  145. HMG-CoA Reductases 5item
  146. Vacuolar-type ATPase 1 item
  147. c-MET 8item
  148. BMI-1 1 item
  149. PKC 7item
  150. Calpains 5item
  151. CysLT1 1 item
  152. Ubiquitin-specific proteases 1 item
  153. M1 Receptors 1 item
  154. HCV Proteases 3item
  155. Ca2 /calmodulin-dependent protein kinases (CaMKs) 8item
  156. MLK3 1 item
  157. SMYD2 1 item
  158. CREBBP 2item
  159. EP300 2item
  160. Protease-Activated Receptors 1 item
  161. Lyn 1 item
  162. SGLT 2item
  163. RAD51 1 item
  164. Trypsins 1 item
  165. HER2 2item
  166. Pyk2 3item
  167. USP 2item
  168. 5-HT2 Receptors 12item
  169. LRRK2 4item
  170. Calcium ionophores 1 item
  171. S1P receptors 3item
  172. Voltage-gated Calcium Channels (CaV) 6item
  173. Calcium chelator 1 item
  174. DGAT 2item
  175. Insulin and Insulin-like Receptors 4item
  176. PARP 4item
  177. Prostaglandin EP receptors 1 item
  178. CB1 Receptors 1 item
  179. Melanocortin (MC) Receptors 1 item
  180. Pyruvate dehydrogenases (PDH) 1 item
  181. ALK 5item
  182. ROS1 2item
  183. Sphingosine kinases (SphKs) 2item
  184. Trypsin 1 item
  185. Chymotrypsin 1 item
  186. Kallikrein 1 item
  187. Trypsinogen 1 item
  188. KRAS G12C 1 item
  189. GTPases 1 item
  190. Monocarboxylate transporters (MCTs) 1 item
  191. CETP 2item
  192. NK1 Receptors 1 item
  193. Dehydrogenase 1 item
  194. PKG 1 item
  195. PKA 1 item
  196. Myosin light chain kinases (MLCKs) 2item
  197. GPR30 2item
  198. BCPCF efflux 1 item
  199. HIV-1 gp120 1 item
  200. D1 and D5 Receptors 4item
  201. D2 Receptors 7item
  202. D3 Receptors 4item
  203. 5-HT1 Receptors 6item
  204. 5-HT7 Receptors 2item
  205. CaM-KK 1 item
  206. Valosin-containing protein (VCP) 1 item
  207. AdipoR1 1 item
  208. AdipoR2 1 item
  209. MELK 1 item
  210. Serotonin reuptake 1 item
  211. Insulin-like growth factors (IGFs) 1 item
  212. Pancreatic and duodenal homeobox 1 (PDX1) 1 item
  213. AMPA 1 item
  214. Clk 1 item
  215. TBK1 1 item
  216. MARK1 1 item
  217. NUAK1 2item
  218. Integrin-ligand interactions 1 item
  219. CSF1R 1 item
  220. Bromodomain and Extra-Terminal motif (BET) 1 item
  221. NUAK2 1 item
  222. Na /H Exchangers (NHEs) 1 item
  223. Lactate Dehydrogenases (LDH) 2item
  224. MK2 3item
  225. Fatty-acid-binding proteins (FABPs) 1 item
  226. 5-HT3 Receptors 2item
  227. Angiotensin-Converting Enzymes (ACEs) 2item
  228. Tie-2 4item
  229. RSK 2item
  230. p70 S6K 1 item
  231. Free Fatty Acid Receptors 3item
  232. phosphatases 2item
  233. ROS and Other Gaseous Donors 1 item
  234. Autophagy 3item
  235. ATM/ATR 7item
  236. Acetylcholine 1 item
  237. Mixed lineage kinase domain-like protein (MLKL) 1 item
  238. COX 7item
  239. C5a receptors 1 item
  240. Heparanases 1 item
  241. Folate Analogue 1 item
  242. YAP 1 item
  243. CK1 1 item
  244. IDH2 1 item
  245. Histamine H4 Receptors 2item
  246. Farnesyl Diphosphate Synthases 1 item
  247. CK2 3item
  248. HIPK2 1 item
  249. HIPK3 1 item
  250. HIV Integrases 1 item
  251. Cryptochromes 1 item
  252. G-quadruplexes 1 item
  253. Squalene epoxidases 2item
  254. PRAK 1 item
  255. MAPKAP-K2 1 item
  256. Delayed rectifier outward potassium current (IKr) 1 item
  257. Melatonin Receptors 2item
  258. 20S proteasomal chymotrypsin 1 item
  259. Geranylgeranyltransferase I 1 item
  260. Farnesyltransferase 1 item
  261. NAT10 1 item
  262. Nampt 2item
  263. eIF4F 1 item
  264. Cdc42 1 item
  265. SRPK1 1 item
  266. P2X Receptors 2item
  267. Glutaminases 1 item
  268. Carbonic Anhydrases 6item
  269. Ron 1 item
  270. AP endonucleases 1 item
  271. G9a 2item
  272. BLM 1 item
  273. HSV 2item
  274. Adenosine A2B Receptors 1 item
  275. NADPH Oxidases 2item
  276. Glutamate (Metabotropic) Group I Receptors 3item
  277. Calcium-activated chloride channels (CaCC) 1 item
  278. GPR35 1 item
  279. Aldehyde Dehydrogenases 2item
  280. Synthases/Synthetases 4item
  281. MAGL 1 item
  282. NPY Receptors 1 item
  283. c-Fyn 1 item
  284. Leukotriene and Related Receptors 1 item
  285. TAK1 1 item
  286. Histamine H1 Receptors 9item
  287. RAR/RXR 1 item
  288. Sigma Receptors 1 item
  289. Na /K ATPases 2item
  290. P110 1 item
  291. Hck 1 item
  292. Inositol-requiring enzyme 1 (IRE1) 1 item
  293. SETD7 1 item
  294. Na /K /Cl- Symporters (NKCCs) 1 item
  295. GABAA Receptors 1 item
  296. iNOS 1 item
  297. Histamine H2 Receptors 1 item
  298. Phospholipases 1 item
  299. TRP Channel 3item
  300. RNA Polymerases 3item
  301. Norepinephrine transporter 1 item
  302. 5-HT Transporters 3item
  303. Ionophores 2item
  304. Xanthine oxidoreductases 1 item
  305. Dihydroorotate dehydrogenase 1 item
  306. Guanylyl Cyclases 1 item
  307. FoxM1 1 item
  308. Histone Demethylases 1 item
  309. Apoptosis Inducers 1 item
  310. M2 Receptors 1 item
  311. MNK 1 item
  312. NO Donors / Precursors 1 item
  313. CB2 Receptors 2item
  314. Glucocorticoid Receptors 2item
  315. HIV-1 reverse transcriptase 1 item
  316. IL Receptors 2item
  317. CCL2 1 item
  318. Norepinephrine transporters 1 item
  319. 15-lipoxygenases 1 item
  320. Calcium-Activated Potassium (KCa) Channels 2item
  321. 5-HT4 Receptors 1 item
  322. AChE 2item
  323. Insulin Receptors 1 item
  324. IRG-1R 1 item
  325. Proton Pump 1 item
  326. cAMP 1 item
  327. Sulfonylurea receptors 1 item
  328. eEF-2 1 item
  329. Inward Rectifier Potassium (Kir) Channels 5item
  330. Arp2/3 complex 1 item
  331. Peptidoglycan synthesis 1 item
  332. CRTH2 1 item
  333. Cdc7 1 item
  334. calcium chelator 1 item
  335. Nuclear Receptors 1 item
  336. CMV 2item
  337. ZAP-70 1 item
  338. Catechol O-Methyltransferase (COMT) 2item
  339. fibrinolysis 1 item
  340. Angiotensin AT1 Receptors 3item
  341. D4 Receptors 2item
  342. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  343. Aldosterone receptor 1 item
  344. HBV Proteases 1 item
  345. Flk-1 1 item
  346. Adenine receptors 1 item
  347. Papains 1 item
  348. RNA synthesis 1 item
  349. Protein Arginine Methyltransferases 1 item
  350. IMPDH 1 item
  351. Na /Ca2 Exchangers (NCXs) 1 item
  352. NAE 2item
  353. Ubiquitin-activating Enzyme E1 1 item
  354. SUMOylation 1 item
  355. ATGL 1 item
  356. BACE 1 item
  357. Cytidine deaminases 1 item
  358. GPR40 1 item
  359. Adenylyl Cyclases 1 item
  360. angiogenesis 1 item
  361. Glucagon Receptors 1 item
  362. 15-PGDH 1 item
  363. DPP-4 4item
  364. DREADD Ligands 1 item
  365. PP4 1 item
  366. c-RET 1 item
  367. Nonstructural protein 5B (NS5B) 1 item
  368. ETA Receptors 2item
  369. ETB Receptors 1 item
  370. p70 rsk 1 item
  371. FPTase 1 item
  372. Retinoic acid-related Orphan Receptors (RORs) 1 item
  373. ADAMs 1 item
  374. TAM kinase 1 item
  375. p53-MDM2 interaction 1 item
  376. nuclear export 1 item
  377. CRM1 1 item
  378. endothelin receptor 1 item
  379. PARs 1 item
  380. AXL 1 item
  381. Protein polybromo-1 1 item
  382. SMARCA4 1 item
  383. SMARCA2 1 item
  384. Dipeptidyl-peptidase II 1 item
  385. adrenoceptor 2item
  386. HDAC 1 item
  387. 5-HT6 Receptor 1 item
  388. c-Fms tyrosine kinase 1 item
  389. PAR 1 item
  390. human lyase 1 item
  391. Ub-conjugating enzyme (E2) complex 1 item
  392. PPAR 2item
  393. STK 1 item
  394. IKK 1 item
  395. MSK 1 item
  396. HCV polymerase 2item
  397. Lyn kinase 1 item
  398. Ftase 1 item
  399. PC-PLC 1 item
  400. Elastases 1 item
  401. P97 ATPase 1 item
  402. NTPDases 1 item
  403. cannabinoid receptor 1 item
  404. Calcium-Sensing Receptors (CaSRs) 1 item
  405. Rev-Erb Receptors 1 item
  406. telomerase 1 item
  407. Prostanoid Receptors 1 item
  408. Histone Acetyltransferases (HATs) 1 item
  409. Retinoid X receptors (RXR) 1 item
  410. F1 Fo-ATPase 1 item
  411. ITK 1 item
  412. NOD1 1 item
  413. NUAK 1 item
  414. DCLK2 1 item
  415. FAAH 1 item
  416. TYK2 1 item
  417. Lck 1 item
  418. NOP Receptors 1 item
  419. Aromatases 1 item
  420. PKD 1 item
  421. SHIP 1 item
  422. MCL1 1 item
  423. Bcl-w 1 item
  424. tropomyosin receptor kinase 1 item
  425. LSD 1 item
  426. PRMT 1 item
  427. GLP 1 item
  428. SK 1 item
  429. MST 1 item
  430. IDO 1 item
  431. FXR 1 item
  432. Serotonin (5-HT) reuptake 1 item
  433. Androgen Receptor 1 item
  434. Substance P/NK1 Receptor 1 item
  435. gp120/CD4 1 item
  436. ATM 2item
  437. Sirtuin 1 item
  438. NE 1 item
  439. CRF1 Receptors 1 item
  440. PIKfyve 1 item
  441. Glycogen Phosphorylases 1 item
  442. MTH1 1 item
  443. Insulin Receptor 1 item
Reported Experiments
  1. Animal Experiments 914item
  2. Cell Experiments 634item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 1 item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 6item
  7. Acute Myeloid Leukemia 30item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Bacterial Infectios 1 item
  13. Biliary Cancer 1 item
  14. Bladder Cancer 11item
  15. Bladder Carcinoma 4item
  16. Bladder Diseases 2item
  17. B-lymphoid Malignancies 1 item
  18. Brain Injuries Studies 3item
  19. Breast Cancer 135item
  20. Cancer 498item
  21. Candida Peritonitis 1 item
  22. Candidemia 1 item
  23. Castration-resistant Prostate Cancer 1 item
  24. Cervical Cancer 6item
  25. Cholangiocarcinoma 2item
  26. Chronic Lymphocytic Leukemia 8item
  27. Chronic Myeloproliferative Disorders 1 item
  28. Clear Cell Renal Cell Carcinoma 2item
  29. Cocaine Abuse 1 item
  30. Cocaine-Related Disorders 2item
  31. Colon Cancer 48item
  32. Colon Carcinoma 7item
  33. Colorectal Cancer 45item
  34. Depression 2item
  35. Diabetes 10item
  36. Diffuse Large B-cell Lymphoma 1 item
  37. Dyskinesia 1 item
  38. Dyslipidemia 2item
  39. Epilepsy 3item
  40. Erectile Dysfunction 3item
  41. Friedreich's Ataxia 1 item
  42. Fungal Infection 3item
  43. Glioblastoma 36item
  44. Glioma 20item
  45. HCV 3item
  46. Heart Failure 1 item
  47. Hepatic Cancer 2item
  48. Hepatitis C 3item
  49. Hepatocellular Carcinoma 8item
  50. HIV 5item
  51. HIV Infections 13item
  52. Hypercholesterolemia 2item
  53. Immunological Diseases 1 item
  54. Immunosuppressive Therapy 1 item
  55. Inflammation 1 item
  56. Inflammatory Bowel Disease 1 item
  57. Inflammatory Diseases 22item
  58. Influenza 2item
  59. Kidney Injury Studies 2item
  60. Leukemia 29item
  61. Liver Cancer 5item
  62. Lung Cancer 50item
  63. Lung Carcinoma 4item
  64. Lymphoma 38item
  65. Mantle Cell Lymphoma 2item
  66. Medulloblastoma 1 item
  67. Melanoma 42item
  68. Mixed Lineage Leukemia 3item
  69. Multidrug Resistance Studies 1 item
  70. Multiple Myeloma 26item
  71. Myelofibrosis 2item
  72. Myeloma 8item
  73. Narcolepsy 1 item
  74. Neuroblastoma 15item
  75. Neurocognitive Disorders 1 item
  76. Neuronal Protection 1 item
  77. Non-small Cell Lung Cancer 28item
  78. Non-small Cell Lung Carcinoma 3item
  79. Obsessive-Compulsive Disorder 1 item
  80. Osteoporosis 3item
  81. Ovarian Cancer 40item
  82. Pain Relief 1 item
  83. Pancreatic Cancer 51item
  84. Pancreatic Carcinoma 3item
  85. Prostate Cancer 62item
  86. Psoriasis 6item
  87. Psoriasis Vulgaris 1 item
  88. Pulmonary Arterial Hypertension 2item
  89. Pulmonary Fibrosis 2item
  90. Renal Cancer 5item
  91. Renal Cell Carcinoma 11item
  92. Rheumatoid Arthritis 16item
  93. Sarcoma 1 item
  94. Schizophrenia 10item
  95. Sleep Disorders 2item
  96. Soft Tissue Sarcoma 1 item
  97. Squamous Cell Carcinoma 3item
  98. Testicular Cancer 2item
  99. Thyroid Cancer 6item
  100. Tuberculosis 2item
  101. Type 2 Diabetes 26item