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Signaling Pathways

Signaling Pathways

A8340 Cyclopamine

1 Citation

Target: Smoothened

Summary: Hedgehog (Hh) signaling Inhibitor

insoluble in EtOH; insoluble in H2O; ≥6.86 mg/mL
A8345 PF-562271 HCl

Target: FAK|Pyk2

Summary: FAK/Pyk2 inhibitor

≥26.35 mg/mL
A8346 BYL-719

1 Citation

Target: PI3K

Summary: Selective PI3Kα inhibitor

≥22.07 mg/mL
A8374 AZD8330

Target: MEK

Summary: MEK 1/2 inhibitor

≥23.05 mg/mL
A8464 LY2109761

4 Citation

Summary: TβRI/II kinase inhibitor

≥22.1 mg/mL
A8476 MK-2461

Target: FLT3|PDGFR|MET|Ron

Summary: C-Met (WT/mutants) inhibitor

≥24.8 mg/mL
A8551 INK 128 (MLN0128)

4 Citation

Target: mTOR

Summary: MTOR(TORC-1/-2) inhibitor,potent and selective

insoluble in H2O; ≥15.45 mg/mL
B2307 LGK-974

1 Citation

Summary: PORCN inhibitor,potent and specific

insoluble in H2O; ≥19.8 mg/mL
B1288 Rigosertib

Target: PI3K|PLK

Summary: PI3K/PLK1 inhibitor

Soluble in DMSO
B1621 TAK-733

Target: MEK

Summary: MEK allosteric site inhibitor

≥25.2 mg/mL