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Signaling Pathways

Items 41-50 of 624

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  1. Regorafenib
    A8236 Regorafenib
     4 Citation
    Target: Raf|VEGFR|PDGFR|c-Kit|RET
    Summary: Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1
      ≥25.04 mg/mL
  2. PP 1
    A8215 PP 1
    Target: Src|EGFR|JAK|ZAP-70
    Summary: Src family tyrosine kinase inhibitor
  3. Sorafenib Tosylate
    A8245 Sorafenib Tosylate
     1 Citation
    Target: Raf|VEGFR
    Summary: Raf kinases and tyrosine kinases inhibitor
      ≥31.85 mg/mL
  4. Afatinib (BIBW2992)
    A8247 Afatinib (BIBW2992)
     1 Citation
    Target: EGFR
    Summary: Irreversible EGFR/HER2 inhibitor
      ≥24.3 mg/mL
  5. SB 431542
    A8249 SB 431542
     2 Citation
    Summary: ALK inhibitor
  6. LY 294002
    A8250 LY 294002
     16 Citation
    Target: PI3K
    Summary: Potent PI3K inhibitor
  7. Nintedanib (BIBF 1120)
    A8252 Nintedanib (BIBF 1120)
     3 Citation
    Target: VEGFR|PDGFR|FGFR
    Summary: VEGFR/PDGFR/FGFR inhibitor
      insoluble in H2O; insoluble in EtOH; ≥5.34 mg/mL
  8. PD 173074
    A8253 PD 173074
    Target: VEGFR|FGFR
    Summary: FGFR inhibitor
      ≥26.18 mg/mL
  9. Sunitinib malate
    A8255 Sunitinib malate
     2 Citation
    Target: VEGFR
    Summary: VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor
      ≥26.65 mg/mL
  10. SP 600125
    A4604 SP 600125
     7 Citation
    Target: JNK
    Summary: JNK1/2/3 inhibitor
      insoluble in H2O; ≥11 mg/mL

Items 41-50 of 624

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  1. Proteases 35item
  2. Apoptosis 46item
  3. Chromatin/Epigenetics 86item
  4. Metabolism 37item
  5. MAPK Signaling 27item
  6. Tyrosine Kinase 110item
  7. DNA Damage/DNA Repair 68item
  8. PI3K/Akt/mTOR Signaling 51item
  9. Microbiology & Virology 6item
  10. Cell Cycle/Checkpoint 77item
  11. Ubiquitination/ Proteasome 31item
  12. JAK/STAT Signaling 35item
  13. TGF-β / Smad Signaling 24item
  14. Angiogenesis 6item
  15. GPCR/G protein 18item
  16. Stem Cell 27item
  17. Membrane Transporter/Ion Channel 10item
  18. Endocrinology and Hormones 14item
  19. Neuroscience 10item
  20. Others 40item
  21. Immunology/Inflammation 7item
Specificity
  1. Selective 498item
  2. Non-Selective 2item
Reversibility
  1. Reversible 30item
  2. Irreversible 23item
Target
  1. Caspases 4item
  2. Cyclin-Dependent Kinases 25item
  3. Proteasome 9item
  4. Cathepsins 2item
  5. Histone Deacetylases (HDACs) 24item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 11item
  8. Bcl-2 8item
  9. PI3K 26item
  10. CXCR 4item
  11. Raf 11item
  12. Aurora Kinases 18item
  13. Bcl-xl 2item
  14. CSF-1R 4item
  15. Glycoproteins 1 item
  16. p97 1 item
  17. MDM2 2item
  18. EZH2 5item
  19. mTOR 15item
  20. Bromodomains 5item
  21. AP-1 1 item
  22. MMP 3item
  23. Thymidine Phosphorylases 1 item
  24. Androgen Receptors 4item
  25. DT-diaphorases 1 item
  26. FLT3 12item
  27. GSK-3 5item
  28. LPA Receptors 3item
  29. P-glycoprotein (P-gp) 6item
  30. PLK 9item
  31. Chk 5item
  32. ULK1 1 item
  33. Eph Receptors 3item
  34. VEGFR 37item
  35. PDGFR 21item
  36. c-Kit 10item
  37. RET 4item
  38. Bromodomain-containing proteins(BRDs) 1 item
  39. Phosphodiesterases (PDEs) 3item
  40. Mcl-1 5item
  41. Thymidylate Synthase 3item
  42. p38 3item
  43. 3-phosphoglycerate dehydrogenase 1 item
  44. JNK 1 item
  45. SGK 2item
  46. Bcr-Abl 8item
  47. MEK 11item
  48. PORCN 1 item
  49. DOT1L 3item
  50. FGFR 13item
  51. Nrf2 1 item
  52. Insulin-like growth factor receptors(IGFRs) 1 item
  53. Pim 3item
  54. Liver X receptors (LXRs) 1 item
  55. Sir2-like Family Deacetylases (Sirtuins) 3item
  56. Deubiquitinating enzymes (DUBs) 4item
  57. PP1 1 item
  58. PP2A 1 item
  59. Smoothened 5item
  60. Ribosomal s6 kinases (RSK) 1 item
  61. MET 7item
  62. Src 9item
  63. RARs 6item
  64. Trk Receptors 5item
  65. Integrins 1 item
  66. Aminopeptidases 2item
  67. STAT 6item
  68. Microtubules/Tubulins 7item
  69. Estrogen and Related Receptors 5item
  70. EGFR 20item
  71. Hedgehog 1 item
  72. ROCK 1 item
  73. PAK 3item
  74. Hypoxia Inducible Factors (HIFs) 2item
  75. FAK 6item
  76. BMP and Other Activin Receptors 2item
  77. JAK 12item
  78. p300 1 item
  79. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  80. Syk 4item
  81. Progesterone Receptors 2item
  82. EZH1 1 item
  83. DNA-PK 5item
  84. HSP90 12item
  85. AMPK 2item
  86. Gutathione S-transferase 1 item
  87. CCR 1 item
  88. eIF4E/eIF3G interaction 1 item
  89. Notch 1 item
  90. TNKS 1 item
  91. Topoisomerases 10item
  92. Cytochrome P450 (CYP450) 5item
  93. Ksp 1 item
  94. ErbB 5item
  95. Actin 1 item
  96. DNA Methyltransferases 3item
  97. Survivin 1 item
  98. ERK 4item
  99. HMG-CoA Reductases 2item
  100. Vacuolar-type ATPase 1 item
  101. c-MET 7item
  102. BMI-1 1 item
  103. PKC 11item
  104. Calpains 2item
  105. Ubiquitin-specific proteases 1 item
  106. Ca2 /calmodulin-dependent protein kinases (CaMKs) 2item
  107. SMYD2 1 item
  108. CREBBP 1 item
  109. EP300 1 item
  110. Lyn 1 item
  111. SGLT 1 item
  112. RAD51 2item
  113. HER2 2item
  114. Pyk2 3item
  115. 5-HT2 Receptors 2item
  116. Voltage-gated Calcium Channels (CaV) 2item
  117. Calcium chelator 1 item
  118. Insulin and Insulin-like Receptors 2item
  119. PARP 3item
  120. Pyruvate dehydrogenases (PDH) 1 item
  121. ALK 7item
  122. ROS1 2item
  123. Sphingosine kinases (SphKs) 2item
  124. KRAS G12C 1 item
  125. Monocarboxylate transporters (MCTs) 1 item
  126. Dehydrogenase 1 item
  127. PKG 2item
  128. PKA 5item
  129. Myosin light chain kinases (MLCKs) 1 item
  130. GPR30 2item
  131. D1 and D5 Receptors 1 item
  132. D2 Receptors 2item
  133. D3 Receptors 1 item
  134. Valosin-containing protein (VCP) 1 item
  135. MELK 1 item
  136. Insulin-like growth factors (IGFs) 1 item
  137. Integrin-ligand interactions 1 item
  138. CSF1R 1 item
  139. Bromodomain and Extra-Terminal motif (BET) 1 item
  140. MK2 2item
  141. 5-HT3 Receptors 1 item
  142. Angiotensin-Converting Enzymes (ACEs) 1 item
  143. Tie-2 4item
  144. RSK 2item
  145. p70 S6K 1 item
  146. Autophagy 4item
  147. ATM/ATR 6item
  148. COX 4item
  149. Heparanases 1 item
  150. Folate Analogue 1 item
  151. YAP 1 item
  152. CK1 1 item
  153. IDH2 1 item
  154. Farnesyl Diphosphate Synthases 1 item
  155. CK2 2item
  156. HIPK2 1 item
  157. HIPK3 1 item
  158. G-quadruplexes 1 item
  159. PRAK 1 item
  160. MAPKAP-K2 1 item
  161. 20S proteasomal chymotrypsin 1 item
  162. Geranylgeranyltransferase I 1 item
  163. Farnesyltransferase 1 item
  164. Nampt 3item
  165. eIF4F 1 item
  166. Cdc42 1 item
  167. P2X Receptors 2item
  168. Glutaminases 2item
  169. Carbonic Anhydrases 1 item
  170. Ron 1 item
  171. BLM 1 item
  172. Aldehyde Dehydrogenases 1 item
  173. Synthases/Synthetases 3item
  174. MAGL 1 item
  175. Histamine H1 Receptors 1 item
  176. RAR/RXR 1 item
  177. P110 1 item
  178. Hck 1 item
  179. Inositol-requiring enzyme 1 (IRE1) 1 item
  180. iNOS 1 item
  181. Histamine H2 Receptors 1 item
  182. RNA Polymerases 1 item
  183. Norepinephrine transporter 1 item
  184. 5-HT Transporters 1 item
  185. Guanylyl Cyclases 1 item
  186. FoxM1 1 item
  187. Histone Demethylases 1 item
  188. Apoptosis Inducers 1 item
  189. MNK 1 item
  190. Glucocorticoid Receptors 1 item
  191. HIV-1 reverse transcriptase 1 item
  192. Calcium-Activated Potassium (KCa) Channels 1 item
  193. Insulin Receptors 1 item
  194. IRG-1R 1 item
  195. cAMP 1 item
  196. Sulfonylurea receptors 1 item
  197. eEF-2 1 item
  198. Cdc7 1 item
  199. CMV 1 item
  200. ZAP-70 1 item
  201. Catechol O-Methyltransferase (COMT) 1 item
  202. fibrinolysis 1 item
  203. D4 Receptors 1 item
  204. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  205. Flk-1 1 item
  206. Papains 1 item
  207. RNA synthesis 1 item
  208. Protein Arginine Methyltransferases 1 item
  209. NAE 2item
  210. Ubiquitin-activating Enzyme E1 1 item
  211. SUMOylation 1 item
  212. BACE 1 item
  213. Cytidine deaminases 1 item
  214. angiogenesis 1 item
  215. DPP-4 1 item
  216. PP4 1 item
  217. c-RET 2item
  218. p70 rsk 2item
  219. Microtubule/Tubulin 2item
  220. VEGFR3/FLT4 1 item
  221. NTRK1/TRKA 1 item
  222. CSF-1R/c-Fms 1 item
  223. NMPRTase 1 item
  224. Bfl-1 1 item
  225. TAM kinase 1 item
  226. p53-MDM2 interaction 1 item
  227. nuclear export 1 item
  228. CRM1 1 item
  229. KDR 2item
  230. AXL 1 item
  231. Glyoxalase I 1 item
  232. p53 4item
  233. HDAC 1 item
  234. LOX 1 item
  235. Adenylyl cyclase 1 item
  236. Quinone reductase 1 item
  237. human lyase 1 item
  238. insulin 1 item
  239. Ub-conjugating enzyme (E2) complex 1 item
  240. Smoothened receptor 1 item
  241. HDM2 ubiquitin ligase 1 item
  242. Antibiotic 1 item
  243. Hec1 1 item
  244. DNA Alkylating 2item
  245. GLI 1 item
  246. ErbB-2 1 item
  247. PDK-1 1 item
  248. Prk 1 item
  249. Ribonucleotide Reductases 1 item
  250. Trx 1 item
  251. HSP70 1 item
  252. TYK2 1 item
  253. MUSK 1 item
  254. MAP3K 1 item
  255. Adenosine Deaminases 1 item
  256. Flk1 2item
  257. DHFR 1 item
  258. GARFT 1 item
  259. RHA 1 item
  260. MCL1 1 item
  261. Bcl-w 1 item
  262. tropomyosin receptor kinase 1 item
  263. LSD 1 item
  264. DDX3 1 item
  265. SK 1 item
  266. PPK 1 item
  267. c-Syk 1 item
  268. CDK1/CyclinB 1 item
  269. IDO 1 item
  270. PIM1 kinase 1 item
  271. phospholipase A2 1 item
  272. Substance P/NK1 Receptor 1 item
  273. Bax 1 item
Reported Experiments
  1. Animal Experiments 578item
  2. Cell Experiments 394item