Active Human Caspases Group IV

Caspases are groups of enzymes that involved apoptosis, necrosis and inflammation. These groups can be speperated in to three major classes based on their substrate specificities : Group I (caspase-1,-4,-5), Group II (caspase-2,-3,-7), and Group III (caspase-6,-8,-9,-10). Group I caspases are implicated in the inflammatory cytokines production. Group II are effectors and Group III are upstream activators that mediates apoptosis. The Active Human Caspases Group IV are recombinant caspases that expressed in E.coli and are useful in screening caspase inhibitors, studying enzyme kinetics, determining substrate specificity, and as a positive control in caspase activity assays.