Cell Counting Kit-8 (CCK-8)
Catalog No.
K1018
Used in cell proliferation assay and cytotoxicity assay
Featured Products
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- 3. Yu Zhang, Xiyou Du, et al. "A Vanadium-Based Nanoplatform Synergizing Ferroptotic-like Therapy with Glucose Metabolism Intervention for Enhanced Cancer Cell Death and Antitumor Immunity." ACS Nano. 2023 Jun 5. PMID: 37272777
- 4. Zhechuan Zhang, Yuanfeng Zhang, et al. "P4HA3 promotes clear cell renal cell carcinoma progression via the PI3K/AKT/GSK3β pathway." Med Oncol. 2023 Jan 2;40(2):70. PMID: 36588128
- 5. Chuchu Lin, Chenyi Huang, et al. "Biodegradable calcium sulfide-based nanomodulators for H2S-boosted Ca2+-involved synergistic cascade cancer therapy." Acta Pharm Sin B. 2022 Dec;12(12):4472-4485. PMID: 36561996
- 6. J. Li, Q. Tian, et al. "A novel liposome-loaded injectable hydrogel for enhanced treatment of choroidal neovascularization by sub-tenon's injection." Materials Today Nano. Volume 20, December 2022, 100264.
- 7. Cheng Wei, Xiaoyang Zhang, et al. "LncRNA HOXA11-AS promotes glioma malignant phenotypes and reduces its sensitivity to ROS via Tpl2-MEK1/2-ERK1/2 pathway." Cell Death Dis. 2022 Nov 9;13(11):942. PMID: 36351895
- 8. Zheng Liu, Xing Luo, et al. "Enzyme-Enhanced Codelivery of Doxorubicin and Bcl-2 Inhibitor by Electrospun Nanofibers for Synergistic Inhibition of Prostate Cancer Recurrence." Pharmaceuticals (Basel). 2022 Oct 10;15(10):1244. PMID: 36297356
- 9. Qiong Wang, Junxiu Chen, et al. "MiR-29c-3p and MiR-223-3p regulate the proliferation and drug resistance of oral squamous cell carcinoma by targeting ANGPTL4." Front Oral Maxillofac Med 2022. Vol 4 (December 30, 2022).
- 10. Dejuan Sun, Yueying Yang, et al. "Identification of ADP-ribosylation factor 6 as the cellular target of withangulatin A against TNBC cells by ferroptosis." Research Square. October 14th, 2022.
- 11. Haiyan Wang, Hanqing Lin, et al. "miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress." Research Square. September 28th, 2022.
- 12. Qianying Jia, Qinggong Jia, et al. "A promoting nitric oxide-releasing coating containing copper ion on ZE21B alloy for potential vascular stent application." Journal of Magnesium and Alloys. 28 September 2022.
- 13. Qin Tang, Yue-ming Chen, et al. "Increased Expression of NXPH4 Correlates with Immune Cell Infiltration and Unfavorable Prognosis in Hepatocellular Carcinoma." J Oncol. 2022 Oct 6;2022:5005747. PMID: 36245978
- 14. Yuan Li, Qingya Dang, et al. "Restoration of Mitochondrial Function Is Essential in the Endothelium-Dependent Vasodilation Induced by Acacetin in Hypertensive Rats." Int J Mol Sci. 2022 Sep 26;23(19):11350. PMID: 36232649
- 15. Yufei Long, Tuotuo Chong, et al. "FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer." J Exp Clin Cancer Res. 2022 Oct 13;41(1):301. PMID: 36229838
- 16. Chen Chen, Heng Zhang, et al. "Shenxian-Shengmai Oral Liquid Evoke Autophagy of Fibroblast to Attenuate Sinoatrial Node Fibrosis in Sick Sinus Syndrome Mice via the AKT/mTOR Pathway." Evid Based Complement Alternat Med. 2022 Sep 28;2022:5219277. PMID: 36212944
- 17. Xiaolong Tang, Yahang Liang, et al. "Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer." Cell Death Dis. 2022 Oct 4;13(10):848. PMID: 36195596
- 18. Jun-Dan Wang, Jue-Qiong Xu, et al. "Mutant C/EBPα p30 alleviates immunosuppression of CD8+ T cells by inhibiting autophagy-associated secretion of IL-1β in AML." Cell Prolif. 2022 Dec;55(12):e13331. PMID: 36124714
- 19. Wei Zhu, Xiaofen Zhang, et al. "Profiles of Acetylation Regulation Genes Contribute to Malignant Progression and Have a Clinical Prognostic Impact on Liver Cancer." Dis Markers. 2022 Sep 10;2022:1724301. PMID: 36124029
- 20. Ruo-Wen Xiao, Fang Wang, et al. "Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication." EBioMedicine. 2022 Oct;84:104267. PMID: 36116213
- 21. LIJUN LI, ZHIHAO WEN, et al. "LIS1 interacts with CLIP170 to promote tumor growth and metastasis via the Cdc42 signaling pathway in salivary gland adenoid cystic carcinoma." Int J Oncol. 2022 Oct;61(4):129. PMID: 36102310
- 22. Lijuan Bian, Xi Rui, et al. "Profile of chimeric RNAs and TMPRSS2-ERG e2e4 isoform in neuroendocrine prostate cancer." Cell Biosci. 2022 Sep 10;12(1):153. PMID: 36088396
- 23. Zijuan Wu, Danling Gu, et al. "CircRIC8B regulates the lipid metabolism of chronic lymphocytic leukemia through miR199b-5p/LPL axis." Exp Hematol Oncol. 2022 Sep 5;11(1):51. PMID: 36064433
- 24. Anne Behre, Joshua W Tashman, et al. "3D Bioprinted Patient‐Specific Extracellular Matrix Scaffolds for Soft Tissue Defects." Adv Healthc Mater. 2022 Sep 5;e2200866. PMID: 36063047
- 25. Peng Ye, Zhanhu Mi, et al. "miR-3960 from Mesenchymal Stem Cell-Derived Extracellular Vesicles Inactivates SDC1/Wnt/ β-Catenin Axis to Relieve Chondrocyte Injury in Osteoarthritis by Targeting PHLDA2." Stem Cells Int. 2022 Aug 25;2022:9455152. PMID: 36061148
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- 28. Caiji Lin, Zheng Zeng, et al. "Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota." Phytomedicine. 2022 Nov;106:154401. PMID: 36029647
- 29. Qing Zhang, Yue Zhou, et al. "Low-dose orlistat promotes the therapeutic effect of oxaliplatin in colorectal cancer." Biomed Pharmacother. 2022 Sep;153:113426. PMID: 36017794
- 30. Xin Ming, Huan Chen, et al. "Porcine Enteric Coronavirus PEDV Induces the ROS-ATM and Caspase7-CAD-γH2AX Signaling Pathways to Foster Its Replication." Viruses. 2022 Aug 15;14(8):1782. PMID: 36016404
- 31. Wang Liao, Xinyi Cao, et al. "Pea Protein-Derived Peptides Inhibit Hepatic Glucose Production via the Gluconeogenic Signaling in the AML-12 Cells." Int J Environ Res Public Health. 2022 Aug 18;19(16):10254. PMID: 36011893
- 32. Xin Shen, Weiwen Zhu, et al. "Macrophage miR-149-5p induction is a key driver and therapeutic target for BRONJ." JCI Insight. 2022 Aug 22;7(16):e159865. PMID: 35993364
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- 36. Xiaoli Liu, Huikun Zhang, et al. "Knockdown of Girdin Induced Apoptosis of Glioblastoma Cells via the Mitochondrion Signaling Pathway." Neuroscience. 2022 Sep 15;500:95-105. PMID: 35952993
- 37. Li‑Ming Xu, Ya‑Jing Yuan, et al. "LINC00665 knockdown confers sensitivity in irradiated non-small cell lung cancer cells through the miR-582-5p/UCHL3/AhR axis." J Transl Med. 2022 Aug 2;20(1):350. PMID: 35918714
- 38. Chunhua Tian, Jing Su, et al. "lncRNA NBAT1 Inhibits Cell Metastasis and Promotes Apoptosis in Endometrial Cancer by Sponging miR-21-5p to Regulate PTEN." Comput Math Methods Med. 2022 Jul 20;2022:9304392. PMID: 35912140
- 39. Xiaoyu Feng, Wenfeng Hu, et al. "Taurine Ameliorates Iron Overload-Induced Hepatocyte Injury via the Bcl-2/VDAC1-Mediated Mitochondrial Apoptosis Pathway." Oxid Med Cell Longev. 2022 Jul 16;2022:4135752. PMID: 35879990
- 40. Qi Dong, Dan Zu, et al. "Construction of antibacterial nano-silver embedded bioactive hydrogel to repair infectious skin defects." Biomater Res. 2022 Jul 25;26(1):36. PMID: 35879746
- 41. Thomas Später, Marisa Assunção, et al. "Engineering microparticles based on solidified stem cell secretome with an augmented pro-angiogenic factor portfolio for therapeutic angiogenesis." Bioact Mater. 2022 Apr 2;17:526-541. PMID: 35846945
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- 44. Yang Liu, Libo He, et al. "Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway." iScience. 2022 Jun 6;25(7):104533. PMID: 35784791
- 45. Chengtao Sun, Mengzhen Li, et al. "IDO1 plays a tumor-promoting role via MDM2-mediated suppression of the p53 pathway in diffuse large B-cell lymphoma." Cell Death Dis. 2022 Jun 27;13(6):572. PMID: 35760783
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- 49. Zhicheng Cao, Hongmei Wang, et al. "Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration." Bioact Mater. 2022 May 31;20:221-242. PMID: 35702612
- 50. Yanlin Wu, Xuan Li, et al. "Multiscale design of stiffening and ROS scavenging hydrogels for the augmentation of mandibular bone regeneration." Bioact Mater. 2022 May 23;20:111-125. PMID: 35663335
- 51. Haiyan Xing, Qiang Liu, et al. "Cadmium mediates pyroptosis of human dermal lymphatic endothelial cells in a NLRP3 inflammasome-dependent manner." J Toxicol Sci. 2022;47(6):237-247. PMID: 35650140
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- 54. Jieping Zhang, Shaomin Zou, et al. "3,3'-Diindolylmethane Enhances Fluorouracil Sensitivity via Inhibition of Pyrimidine Metabolism in Colorectal Cancer." Metabolites. 2022 Apr 30;12(5):410. PMID: 35629914
- 55. Wei Wang, Xiaolong Liang, et al. "NOX4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the Nrf2 signaling pathway." J Nanobiotechnology. 2022 May 23;20(1):241. PMID: 35606794
- 56. Qing Liu, Qiyao Li, et al. "circ-Pank1 promotes dopaminergic neuron neurodegeneration through modulating miR-7a-5p/α-syn pathway in Parkinson's disease." Cell Death Dis. 2022 May 19;13(5):477. PMID: 35589691
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- 58. He Ding, Zhiqiang Li, et al. "FTO Alleviates CdCl2-Induced Apoptosis and Oxidative Stress via the AKT/Nrf2 Pathway in Bovine Granulosa Cells." Int J Mol Sci. 2022 Apr 29;23(9):4948. PMID: 35563339
- 59. Yanxue Wang, Shuo Luan, et al. "The Combined Use of Platelet-Rich Plasma Clot Releasate and Allogeneic Human Umbilical Cord Mesenchymal Stem Cells Rescue Glucocorticoid-Induced Osteonecrosis of the Femoral Head." Stem Cells Int. 2022 May 2;2022:7432665. PMID: 35547633
- 60. Jianqiang Zhu, Leyi Liu, et al. "Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium." Environ Pollut. 2022 Aug 1;306:119421. PMID: 35533959
- 61. Luqiao Wang, Zijuan Wu, et al. "Single-cell profiling-guided combination therapy of c-Fos and histone deacetylase inhibitors in diffuse large B-cell lymphoma." Clin Transl Med. 2022 May;12(5):e798. PMID: 35522945
- 62. Xi Wang, Mengmeng Zhang, et al. "Exosomal AFAP1-AS1 binds to microRNA-15a-5p to promote the proliferation, migration, and invasion of ectopic endometrial stromal cells in endometriosis." Reprod Biol Endocrinol. 2022 May 5;20(1):77. PMID: 35513844
- 63. Haojie Chen, Jia Luo, et al. "Non-drug efflux function of ABCC5 promotes enzalutamide resistance in castration-resistant prostate cancer via upregulation of P65/AR-V7." Cell Death Discov. 2022 May 3;8(1):241. PMID: 35504877
- 64. Wei Yu, Weidong Liu, et al. "High Level of Uric Acid Promotes Atherosclerosis by Targeting NRF2-Mediated Autophagy Dysfunction and Ferroptosis." Oxid Med Cell Longev. 2022 Apr 18;2022:9304383. PMID: 35480874
- 65. Tianli Wu, Hui Tang, et al. "METTL3-m6 A methylase regulates the osteogenic potential of bone marrow mesenchymal stem cells in osteoporotic rats via the Wnt signalling pathway." Cell Prolif. 2022 May;55(5):e13234. PMID: 35470497
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- 67. Xinyu Zhou, Nanqu Huang, et al. "Icaritin attenuates 6-OHDA-induced MN9D cell damage by inhibiting oxidative stress." PeerJ. 2022 Apr 12;10:e13256. PMID: 35433120
- 68. Chang Kong, Xuqing Ni, et al. "ICA69 aggravates ferroptosis causing septic cardiac dysfunction via STING trafficking." Cell Death Discov. 2022 Apr 9;8(1):187. PMID: 35397620
- 69. Xiaohua Zhu, YingYing Xie, et al. "NAP1L1 promotes tumor proliferation through HDGF/C-JUN signaling in ovarian cancer." BMC Cancer. 2022 Mar 29;22(1):339. PMID: 35351053
- 70. Zaiyong Zhang, Jianhao Li, et al. "Regulatory Mechanism of circEIF4G2 Targeting miR-26a in Acute Myocardial Infarction." J Healthc Eng. 2022 Mar 16;2022:5308372. PMID: 35340248
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- 72. Haixia Wu, Youliang Yan, et al. "miR-4324 inhibits ovarian cancer progression by targeting FEN1." J Ovarian Res. 2022 Mar 4;15(1):32. PMID: 35246224
- 73. Ying Liu, Guangwei Ma, et al. "Global chromosome rearrangement induced by CRISPR-Cas9 reshapes the genome and transcriptome of human cells." Nucleic Acids Res. 2022 Apr 8;50(6):3456-3474. PMID: 35244719
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| 100 tests | 1 mL x 1 |
| 500 tests | 5 mL x 1 |
| 1000 tests | 5 mL x 2 |
| 3000 tests | 5 mL x 6 |
| 10000 tests | 5 mL x 20 |
| Store at -20°C away from light. | |
Our product Cell Counting Kit-8 (CCK-8) provide a more convenient and sensitive method for the research of cell number determination and cell proliferationtotoxicity assay than previous ways. The kit utilizes a highly water-soluble tetrazolium salt, WST-8, which produces a water-soluble formazan dye upon reduction in the presence of an electron mediator. The amount of the formazan generated by dehydrogenases is directly in proportion to the numbers of living cells. The detection sensitivity by CCK-8 is higher than other tetrazolium salts such as MTT, XTT, MTS or WST-1.
More Sensitive than MTT, MTS, or WST-1
No Toxicity to Cell
Simpler Steps, No organic solvents required
Stable One Bottle Solution, ready-to-use
Advantages
Store at -20°C away from light.