ERK5-in-1
Catalog No.
B8388
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ERK5-IN-1 is a potent and selective ERK5 inhibitor. In vitro, ERK5-IN-1 effectively inhibits ERK5 biochemically with an IC50 of 162 nM. In cell experiments, ERK5-IN-1 has a cellular EC50 for inhibiting epidermal growth factor induced ERK5 autophosphorylation of 0.09 μM. In cell-based analysis, it is at least 30 times more selective for ERK5 than LRRK2. It is also ERK5 selective for a group of other kinases. Available Oral Bioavailability.
| Storage | Store at -20°C |
| M.Wt | 459.54 |
| Cas No. | 1234479-76-5 |
| Formula | C25H29N7O2 |
| Solubility | ≥111.4 mg/mL in DMSO; ≥22.12 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | 2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one |
| SDF | Download SDF |
| Canonical SMILES | CN(C1=CN=C(NC2=C(OC)C=C(N3CCN(C)CC3)C=C2)N=C1N(C)C4=C5C=CC=C4)C5=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
