JWH 133
JWH 133 is a synthetic cannabinoid (CB) with Ki values of 3.4 nM and 677 nM for the peripheral CB2 receptor and central CB1 receptor, respectively[1].
JWH 133 inhibits tumor growth in mice, promoting apoptosis and destroying angiogenesis[2]. JWH 133 also inhibits inflammation of experimental colitis and pancreatitis in mice and in vitro models[3].
References:
[1]. Huffman J W, Liddle J, Yu S, et al. 3-(1',1'-Dimethylbutyl)-1-deoxy-Δ8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorganic & Medicinal Chemistry, 1999, 7: 2905-2914.
[2]. Casanova M L, Blázquez C, Martínez-Palacio J, et al. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. Journal of Clinical Investigation, 2003, 111(1): 43-50.
[3]. Kimball E S, Schneider C R, Wallace N H, et al. Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium. American Journal of Physiology and Gastrointestinal Liver Physiology, 2006, 291(2): G364-G371.
| Physical Appearance | A solution in methyl acetate. To change the solvent, simply evaporate the acetate containing under a gentle stream of nitrogen and immediately add the solvent of choice. |
| Storage | Store at -20°C |
| M.Wt | 312.49 |
| Cas No. | 259869-55-1 |
| Formula | C22H32O |
| Solubility | Soluble in DMSO |
| Chemical Name | (6aR,10aR)-6,6,9-trimethyl-3-(2-methylpentan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromene |
| SDF | Download SDF |
| Canonical SMILES | CCCC(C)(C1=CC2=C([C@H]3[C@@H](CC=C(C3)C)C(C)(O2)C)C=C1)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
