L-Arginine (hydrochloride)
L-Arginine (hydrochloride) is the biological precursor of NO which serves as an important signal and effector molecule in animals. L-Arginine is a substrate for NO synthase which catalyzes the oxidation of L-arginine to NO and L-citrulline. NO released by vascular endothelial cells results in relaxation of strips of vascular tissue, as well as inhibition of platelet aggregation and platelet adhesion. L-arginine can be utilized by vascular endothelial cells for NO synthesis, and thereby serves as a potent vasodilator.
References:
1. Stuehr DJ. Enzymes of the L-arginine to nitric oxide pathway. Journal of Nutrition, 2004, 134(10 Suppl): 2748S-2751S.
2. Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature, 1988, 333(6174): 664-666.
3. Morikawa E, Moskowitz MA, Huang Z, et al. L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke, 1994, 25(2): 429-435.
| Storage | Store at -20°C |
| M.Wt | 210.66 |
| Cas No. | 1119-34-2 |
| Formula | C6H15ClN4O2 |
| Synonyms | (S)-(+)-Arginine hydrochloride |
| Solubility | insoluble in EtOH; insoluble in DMSO; ≥72.8 mg/mL in H2O |
| Chemical Name | (S)-2-amino-5-guanidinopentanoic acid hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | NC(NCCC[C@H](N)C(O)=O)=N.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[2] | |
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Cell lines |
Porcine aortic endothelial cells |
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Reaction Conditions |
10 μM L-arginine for 24 h incubation |
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Applications |
Release of NO from the endothelial cells induced by bradykinin and the calcium ionophore A23187 was reversibly enhanced by infusions of L-arginine and L-citrulline, but not D-arginine or other close structural analogues. This enhancement was due to the formation of NO from the terminal guanidino nitrogen atom(s) of L-arginine. |
| Animal experiment:[3] | |
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Animal models |
Normotensive Sprague-Dawley rats and spontaneously hypertensive rats |
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Dosage form |
30 and 300 mg/kg Intravenous (i.v.) administration |
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Applications |
L-Arginine induced dilation of pial arterioles and increased regional cerebral blood flow in normotensive Sprague-Dawley rats. L-Arginine (300 mg/kg, i.v.) also reduced infarction volume by 35% and 28% in normotensive Sprague-Dawley rats and spontaneously hypertensive rats subjected to middle cerebral artery occlusion, respectively. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Stuehr DJ. Enzymes of the L-arginine to nitric oxide pathway. Journal of Nutrition, 2004, 134(10 Suppl): 2748S-2751S. 2. Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature, 1988, 333(6174): 664-666. 3. Morikawa E, Moskowitz MA, Huang Z, et al. L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke, 1994, 25(2): 429-435. |
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