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  • Search results for: 'cdk4 inhibitor'

Search results for: 'cdk4 inhibitor'

Items 191-200 of 3287

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  1. PCI-24781 (CRA-024781)
    A4098 PCI-24781 (CRA-024781)
    Target: Histone Deacetylases (HDACs)
    Summary: Pan-HDAC inhibitor
      insoluble in H2O; insoluble in EtOH; ≥11.75 mg/mL
  2. Tariquidar
    A8208 Tariquidar
     2 Citation
    Target: P-glycoprotein (P-gp)
    Summary: P-glycoprotein inhibitor,potent and non-competitive
      insoluble in H2O; insoluble in EtOH; ≥16.17 mg/mL
  3. CGS 21680
    A3304 CGS 21680
    Summary: Adenosine A2 receptor agonists,potent and selective
      ≥19.25 mg/mL
  4. GS-9620
    A3444 GS-9620
    Target: Toll-like receptors (TLRs)
    Summary: TLR-7 agonist
      insoluble in H2O; ≥20.55 mg/mL
  5. Laropiprant
    A3538 Laropiprant
    Summary: DP1 receptor antagonist,potent and selective
      Soluble in DMSO
  6. SCH 527123
    A3802 SCH 527123
     5 Citation
    Target: CXCR
    Summary: CXCR1 and CXCR2 receptors antagonist
  7. LEE011
    A8641 LEE011
    Target: Cyclin-Dependent Kinases
    Summary: CDK4/6 inhibitor
      insoluble in H2O; insoluble in EtOH; ≥10.88 mg/mL
  8. Clasto-Lactacystin β-lactone
    A2578 Clasto-Lactacystin β-lactone
    Target: Proteasome
    Summary: Proteasome inhibitor
      Soluble in DMSO
  9. Palbociclib (PD0332991) Isethionate
    A8335 Palbociclib (PD0332991) Isethionate
     1 Citation
    Target: Cyclin-Dependent Kinases
    Summary: CDK4/6 inhibitor,highly selective
      ≥28.7 mg/mL
  10. GDC-0941
    A8210 GDC-0941
     10 Citation
    Target: PI3K
    Summary: PI3K inhibitor,potent and selective
      ≥25.7 mg/mL

Items 191-200 of 3287

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  1. Selective 803item
  2. Non-Selective 5item
Reversibility
  1. Reversible 65item
  2. Irreversible 39item
Target
  1. Caspases 14item
  2. Cyclin-Dependent Kinases 33item
  3. Proteasome 14item
  4. Cathepsins 11item
  5. Histone Deacetylases (HDACs) 37item
  6. Inhibitor of apoptosis proteins (IAP) 2item
  7. Akt 13item
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  9. PI3K 37item
  10. CXCR 3item
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  27. Acyl coenzyme A: cholesterol acyltransferases 1 item
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  29. DT-diaphorases 1 item
  30. Voltage-gated Potassium (KV) Channels 2item
  31. MER 1 item
  32. FLT3 19item
  33. GSK-3 11item
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  36. PLK 11item
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  48. Hydrolase 1 item
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  50. p38 9item
  51. PKB 1 item
  52. 3-phosphoglycerate dehydrogenase 1 item
  53. JNK 7item
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  55. Bcr-Abl 15item
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  57. MEK 16item
  58. PORCN 1 item
  59. DOT1L 3item
  60. FGFR 17item
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  62. Insulin-like growth factor receptors(IGFRs) 1 item
  63. Pim 5item
  64. Sir2-like Family Deacetylases (Sirtuins) 3item
  65. Voltage-gated Sodium (NaV) Channels 1 item
  66. Deubiquitinating enzymes (DUBs) 5item
  67. Smoothened 4item
  68. Ribosomal s6 kinases (RSK) 1 item
  69. Neuraminidases (NA) 2item
  70. MET 7item
  71. Src 18item
  72. Trk Receptors 6item
  73. Integrins 1 item
  74. Aminopeptidases 3item
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  76. STAT 11item
  77. ATP Citrate Lyases 1 item
  78. Microtubules/Tubulins 5item
  79. EGFR 25item
  80. Hedgehog 1 item
  81. Reverse Transcriptases 7item
  82. ROCK 12item
  83. BTK 2item
  84. RIP kinases 1 item
  85. Monocyte chemotactic proteins 1 item
  86. PAK 3item
  87. PD-1/PD-L1 interaction 1 item
  88. Hypoxia Inducible Factors (HIFs) 2item
  89. Tankyrases 1 item
  90. Inositol Phosphatases 1 item
  91. FAK 7item
  92. BMP and Other Activin Receptors 4item
  93. JAK 22item
  94. p300 1 item
  95. Stearoyl-CoA 9-desaturase (SCD-1) 2item
  96. Syk 7item
  97. EZH1 2item
  98. DNA-PK 8item
  99. HSP90 12item
  100. AMPK 2item
  101. Gutathione S-transferase 2item
  102. PDHK 1 item
  103. Angiotensin AT2 Receptors 1 item
  104. eIF4E/eIF3G interaction 1 item
  105. Notch 1 item
  106. S-nitrosoglutathione reductase 1 item
  107. CFTR 2item
  108. TNKS 1 item
  109. Topoisomerases 14item
  110. Cytochrome P450 (CYP450) 8item
  111. M3 Receptors 1 item
  112. thrombin 1 item
  113. Ksp 2item
  114. Ribosomes 1 item
  115. Renin 2item
  116. HIV proteases 1 item
  117. Pepsins 1 item
  118. Influenza viruses 1 item
  119. ErbB 5item
  120. Ferroptosis 1 item
  121. S6 kinases 1 item
  122. Toll-like receptors (TLRs) 3item
  123. Adenosine Kinases 2item
  124. Actin 2item
  125. Serine Proteases 2item
  126. DNA Methyltransferases 3item
  127. Survivin 1 item
  128. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  129. ERK 8item
  130. HMG-CoA Reductases 6item
  131. Vacuolar-type ATPase 1 item
  132. Kinases 1 item
  133. c-MET 8item
  134. BMI-1 1 item
  135. PKC 15item
  136. Calpains 6item
  137. Ubiquitin-specific proteases 1 item
  138. HCV Proteases 3item
  139. Ca2 /calmodulin-dependent protein kinases (CaMKs) 7item
  140. MLK3 1 item
  141. SMYD2 1 item
  142. O-GlcNAcase 1 item
  143. CREBBP 2item
  144. EP300 2item
  145. Protease-Activated Receptors 1 item
  146. Lyn 2item
  147. SGLT 1 item
  148. RAD51 2item
  149. Trypsins 1 item
  150. HER2 3item
  151. Pyk2 3item
  152. USP 3item
  153. 5-HT2 Receptors 4item
  154. LRRK2 6item
  155. Voltage-gated Calcium Channels (CaV) 2item
  156. DGAT 2item
  157. Insulin and Insulin-like Receptors 4item
  158. PARP 9item
  159. CB1 Receptors 1 item
  160. Pyruvate dehydrogenases (PDH) 2item
  161. ALK 10item
  162. ROS1 2item
  163. Sphingosine kinases (SphKs) 3item
  164. Trypsin 1 item
  165. Chymotrypsin 1 item
  166. Kallikrein 1 item
  167. Trypsinogen 1 item
  168. KRAS G12C 1 item
  169. GTPases 1 item
  170. Monocarboxylate transporters (MCTs) 2item
  171. CETP 2item
  172. Dehydrogenase 1 item
  173. PKG 3item
  174. PKA 7item
  175. Myosin light chain kinases (MLCKs) 3item
  176. HIV-1 gp120 1 item
  177. D1 and D5 Receptors 1 item
  178. D2 Receptors 3item
  179. D3 Receptors 2item
  180. 5-HT1 Receptors 2item
  181. 5-HT7 Receptors 1 item
  182. CaM-KK 1 item
  183. Valosin-containing protein (VCP) 1 item
  184. MELK 1 item
  185. Serotonin reuptake 1 item
  186. Insulin-like growth factors (IGFs) 1 item
  187. Clk 1 item
  188. TBK1 1 item
  189. MARK1 1 item
  190. NUAK1 2item
  191. Integrin-ligand interactions 1 item
  192. CSF1R 1 item
  193. Bromodomain and Extra-Terminal motif (BET) 1 item
  194. NUAK2 1 item
  195. Na /H Exchangers (NHEs) 1 item
  196. Lactate Dehydrogenases (LDH) 3item
  197. MK2 4item
  198. Fatty-acid-binding proteins (FABPs) 1 item
  199. Angiotensin-Converting Enzymes (ACEs) 6item
  200. Tie-2 5item
  201. RSK 3item
  202. p70 S6K 1 item
  203. Granzyme B 1 item
  204. phosphatases 2item
  205. Autophagy 4item
  206. ATM/ATR 8item
  207. Mixed lineage kinase domain-like protein (MLKL) 1 item
  208. COX 12item
  209. Heparanases 1 item
  210. CK1 2item
  211. IDH2 1 item
  212. CK2 3item
  213. HIPK2 1 item
  214. HIPK3 1 item
  215. HIV Integrases 3item
  216. Squalene epoxidases 2item
  217. PRAK 1 item
  218. MAPKAP-K2 1 item
  219. Delayed rectifier outward potassium current (IKr) 1 item
  220. GpIIb/IIIa receptor 1 item
  221. Guanine nucleotide exchange factors (GEFs) 1 item
  222. 20S proteasomal chymotrypsin 1 item
  223. Geranylgeranyltransferase I 1 item
  224. Farnesyltransferase 1 item
  225. NAT10 1 item
  226. Nampt 3item
  227. eIF4F 1 item
  228. Cdc42 1 item
  229. SRPK1 1 item
  230. P2X Receptors 1 item
  231. Glutaminases 2item
  232. Carbonic Anhydrases 7item
  233. Ron 1 item
  234. AP endonucleases 1 item
  235. G9a 2item
  236. BLM 1 item
  237. HSV 2item
  238. NADPH Oxidases 3item
  239. Calcium-activated chloride channels (CaCC) 1 item
  240. GPR35 1 item
  241. Urokinases 1 item
  242. Aldehyde Dehydrogenases 1 item
  243. Synthases/Synthetases 3item
  244. MAGL 1 item
  245. c-Fyn 1 item
  246. TAK1 1 item
  247. Histamine H1 Receptors 2item
  248. Na /K ATPases 3item
  249. P110 1 item
  250. Hck 2item
  251. Inositol-requiring enzyme 1 (IRE1) 3item
  252. SETD7 1 item
  253. Na /K /Cl- Symporters (NKCCs) 2item
  254. GABAA Receptors 1 item
  255. Phospholipases 1 item
  256. Monoamine oxidases (MAOs) 1 item
  257. Organic anion transporters (OATs) 1 item
  258. TRP Channel 1 item
  259. RNA Polymerases 2item
  260. DYRK 2item
  261. Norepinephrine transporter 1 item
  262. 5-HT Transporters 3item
  263. Xanthine oxidoreductases 1 item
  264. Dihydroorotate dehydrogenase 1 item
  265. Histone Demethylases 1 item
  266. MNK 2item
  267. 5-Lipoxygenases 1 item
  268. NO Donors / Precursors 2item
  269. CB2 Receptors 1 item
  270. HIV-1 reverse transcriptase 1 item
  271. IL Receptors 2item
  272. CCL2 1 item
  273. Noradrenaline reuptake 1 item
  274. Norepinephrine transporters 1 item
  275. Calcium-Activated Potassium (KCa) Channels 2item
  276. AChE 3item
  277. Insulin Receptors 1 item
  278. IRG-1R 1 item
  279. Proton Pump 1 item
  280. cAMP 1 item
  281. Sulfonylurea receptors 1 item
  282. Cdc2-like kinase (Clk) 1 item
  283. eEF-2 1 item
  284. Inward Rectifier Potassium (Kir) Channels 3item
  285. Arp2/3 complex 1 item
  286. Cdc7 1 item
  287. CMV 1 item
  288. ZAP-70 1 item
  289. Catechol O-Methyltransferase (COMT) 2item
  290. fibrinolysis 1 item
  291. Angiotensin AT1 Receptors 1 item
  292. D4 Receptors 1 item
  293. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  294. NMDA receptor 1 item
  295. HBV Proteases 1 item
  296. Hydroxylases 2item
  297. Flk-1 1 item
  298. Papains 2item
  299. Protein Arginine Methyltransferases 1 item
  300. IMPDH 1 item
  301. Na /Ca2 Exchangers (NCXs) 1 item
  302. NAE 2item
  303. Ubiquitin-activating Enzyme E1 2item
  304. SUMOylation 1 item
  305. ATGL 1 item
  306. BACE 2item
  307. Cytidine deaminases 1 item
  308. angiogenesis 1 item
  309. Glucagon Receptors 1 item
  310. 15-PGDH 1 item
  311. DPP-4 5item
  312. c-RET 3item
  313. Nonstructural protein 5B (NS5B) 1 item
  314. p70 rsk 3item
  315. voltage-gated chloride channels 1 item
  316. FPTase 1 item
  317. Microtubule/Tubulin 1 item
  318. VEGFR3/FLT4 1 item
  319. NTRK1/TRKA 1 item
  320. CSF-1R/c-Fms 1 item
  321. Menin-MLL 2item
  322. Tryptophan hydroxylases (TPH) 2item
  323. ADAMs 1 item
  324. NMPRTase 1 item
  325. Bfl-1 1 item
  326. TAM kinase 1 item
  327. p53-MDM2 interaction 2item
  328. nuclear export 1 item
  329. CRM1 1 item
  330. PTP 1 item
  331. KDR 2item
  332. Fyn kinase 1 item
  333. Abl kinases 1 item
  334. Trypsin-like protease 1 item
  335. AXL 1 item
  336. Glyoxalase I 1 item
  337. dCTP Pyrophosphatases 1 item
  338. Protein polybromo-1 1 item
  339. SMARCA4 1 item
  340. SMARCA2 1 item
  341. ERAD 1 item
  342. Dipeptidyl-peptidase II 1 item
  343. p53 4item
  344. metalloprotease 1 item
  345. HDAC 2item
  346. KDM 2item
  347. 5-HT receptors 1 item
  348. sodium channel 3item
  349. c-Fms tyrosine kinase 1 item
  350. human lyase 1 item
  351. insulin 1 item
  352. Ub-conjugating enzyme (E2) complex 1 item
  353. Smoothened receptor 1 item
  354. quinone oxidoreductase 1 item
  355. cysteine protease 2item
  356. haspin kinase 1 item
  357. STK 1 item
  358. USP1/USF1 complex 1 item
  359. IKK 1 item
  360. MSK 1 item
  361. gp120-CD4 interaction 1 item
  362. HCV polymerase 3item
  363. Ftase 1 item
  364. Subtilisin/Kex2p-like proprotein convertase 1 item
  365. PC-PLC 2item
  366. Elastases 1 item
  367. P97 ATPase 1 item
  368. NTPDases 1 item
  369. Mer tyrosine kinase 1 item
  370. Hec1 1 item
  371. neprilysin 1 item
  372. GLI 1 item
  373. decarboxylase 1 item
  374. HMGCR 1 item
  375. AAT 1 item
  376. ErbB-2 1 item
  377. adrenergic receptor 2item
  378. 5-HT4 Receptor 1 item
  379. sterol demethylase 1 item
  380. PDK-1 1 item
  381. GAPDH 1 item
  382. telomerase 1 item
  383. Histone Acetyltransferases (HATs) 3item
  384. complex I of the mitochondrial electron transport chain 1 item
  385. F1 Fo-ATPase 1 item
  386. Prk 1 item
  387. potassium channel 1 item
  388. calcium channel 1 item
  389. Ribonucleotide Reductases 1 item
  390. Trx 1 item
  391. Tyrosinases 1 item
  392. HSP70 1 item
  393. ICAM 1 item
  394. ITK 1 item
  395. HIF-PH 1 item
  396. NOD1 1 item
  397. NUAK 1 item
  398. Rho 1 item
  399. Ubiquitin E3 Ligases 1 item
  400. DCLK2 1 item
  401. FAAH 1 item
  402. PTK 1 item
  403. integrase 1 item
  404. L3MBTL 1 item
  405. NOS 2item
  406. MDMX 1 item
  407. TYK2 2item
  408. MUSK 1 item
  409. MAP3K 1 item
  410. GPR3 1 item
  411. Lck 1 item
  412. Adenosine Deaminases 2item
  413. mitochondrial pyruvate carrier (MPC) 1 item
  414. prolactin secretion 1 item
  415. gonadotropin release 1 item
  416. DprE 1 item
  417. carnitine reabsorption 1 item
  418. Histamine receptors 1 item
  419. GluR 1 item
  420. 5-HT receptor 1 item
  421. dopamine receptors 1 item
  422. AMPA receptor 1 item
  423. 5-alpha Reductases 1 item
  424. Flk1 2item
  425. p21 1 item
  426. DNA Ligases 1 item
  427. Prostaglandin synthesis 1 item
  428. Protein Tyrosine Phosphatases 1 item
  429. alkaline phosphatases 1 item
  430. ATPases 1 item
  431. glutamate release 1 item
  432. PAFR 1 item
  433. Aromatases 2item
  434. DHFR 1 item
  435. GARFT 1 item
  436. PHF 1 item
  437. FGR 1 item
  438. YES 2item
  439. Fyn 2item
  440. ARG 1 item
  441. Autotaxin 1 item
  442. UCH 1 item
  443. RHA 1 item
  444. HCV NS3-4A protease 1 item
  445. PKD 1 item
  446. Pyruvate kinases 1 item
  447. Thioredoxin Reductases 1 item
  448. enoyl-acyl-carrier protein reductase 1 item
  449. SHIP 1 item
  450. MCL1 1 item
  451. Bcl-w 1 item
  452. glutathione peroxidase 4 1 item
  453. NADH oxidase 1 item
  454. S-adenosylhomocysteine hydrolase 1 item
  455. Rho-kinase 1 item
  456. tropomyosin receptor kinase 1 item
  457. LSD 1 item
  458. DDX3 1 item
  459. PRMT 1 item
  460. ACE 1 item
  461. GLP 1 item
  462. SK 1 item
  463. MST 1 item
  464. PPK 1 item
  465. c-Syk 1 item
  466. CDK1/CyclinB 1 item
  467. NHE 1 item
  468. IDO 2item
  469. Tph 1 item
  470. PIM1 kinase 1 item
  471. phospholipase A2 1 item
  472. reverse transcriptase 1 item
  473. epoxide hydrolase 1 item
  474. Serotonin (5-HT) reuptake 1 item
  475. Cholesterol absorption 1 item
  476. Vascular Disrupting Agents (VDA) 1 item
  477. Androgen Receptor 1 item
  478. Substance P/NK1 Receptor 1 item
  479. gp120/CD4 1 item
  480. Histone Methyltransferase 1 item
  481. ATM 2item
  482. Sirtuin 1 item
  483. NE 1 item
  484. PIKfyve 1 item
  485. Bax 1 item
  486. Glycogen Phosphorylases 1 item
  487. RGS 1 item
  488. MTH1 1 item
  489. PTEN 1 item
  490. Insulin Receptor 1 item
  491. NS3/4a Proteases 1 item
  492. Ca2 -ATPases 1 item
  493. p90 S6K 1 item
  494. Dynamins 1 item
Reported Experiments
  1. Animal Experiments 950item
  2. Cell Experiments 766item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 2item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 6item
  7. Acute Myeloid Leukemia 26item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Autoimmune Diseases 1 item
  12. Biliary Cancer 1 item
  13. Bladder Cancer 11item
  14. Bladder Carcinoma 4item
  15. Bladder Diseases 2item
  16. B-lymphoid Malignancies 1 item
  17. Brain Injuries Studies 3item
  18. Breast Cancer 120item
  19. Cancer 542item
  20. Candida Peritonitis 1 item
  21. Candidemia 1 item
  22. Castration-resistant Prostate Cancer 1 item
  23. Cervical Cancer 6item
  24. Cholangiocarcinoma 2item
  25. Chronic Lymphocytic Leukemia 8item
  26. Chronic Myeloproliferative Disorders 1 item
  27. Clear Cell Renal Cell Carcinoma 2item
  28. Cocaine-Related Disorders 2item
  29. Colon Cancer 48item
  30. Colon Carcinoma 7item
  31. Colorectal Cancer 43item
  32. Depression 2item
  33. Diabetes 8item
  34. Diffuse Large B-cell Lymphoma 1 item
  35. Dyskinesia 1 item
  36. Dyslipidemia 2item
  37. Epilepsy 4item
  38. Erectile Dysfunction 4item
  39. Friedreich's Ataxia 2item
  40. Fungal Infection 1 item
  41. Fungi 1 item
  42. Glioblastoma 32item
  43. Glioma 18item
  44. HCV 5item
  45. Heart Failure 3item
  46. Hepatic Cancer 2item
  47. Hepatitis C 4item
  48. Hepatocellular Carcinoma 7item
  49. HIV 14item
  50. HIV Infections 10item
  51. Hypercholesterolemia 3item
  52. Immunological Diseases 1 item
  53. Inflammation 1 item
  54. Inflammatory Bowel Disease 1 item
  55. Inflammatory Diseases 16item
  56. Influenza 3item
  57. Kidney Injury Studies 2item
  58. Leukemia 27item
  59. Liver Cancer 3item
  60. Lung Cancer 44item
  61. Lung Carcinoma 4item
  62. Lymphoma 31item
  63. Mantle Cell Lymphoma 2item
  64. Medulloblastoma 1 item
  65. Melanoma 35item
  66. Mixed Lineage Leukemia 3item
  67. Multiple Myeloma 24item
  68. Myelofibrosis 2item
  69. Myeloma 6item
  70. Neuroblastoma 13item
  71. Neurocognitive Disorders 1 item
  72. Neuronal Protection 1 item
  73. Non-small Cell Lung Cancer 27item
  74. Non-small Cell Lung Carcinoma 2item
  75. Obsessive-Compulsive Disorder 1 item
  76. Osteoporosis 3item
  77. Ovarian Cancer 36item
  78. Pancreatic Cancer 49item
  79. Pancreatic Carcinoma 3item
  80. Prostate Cancer 55item
  81. Psoriasis 4item
  82. Psoriasis Vulgaris 1 item
  83. Pulmonary Arterial Hypertension 2item
  84. Pulmonary Fibrosis 2item
  85. Renal Cancer 4item
  86. Renal Cell Carcinoma 8item
  87. Rheumatoid Arthritis 14item
  88. Sarcoma 1 item
  89. Schizophrenia 8item
  90. Sleep Disorders 2item
  91. Soft Tissue Sarcoma 1 item
  92. Squamous Cell Carcinoma 2item
  93. Testicular Cancer 2item
  94. Thyroid Cancer 6item
  95. Tuberculosis 1 item
  96. Type 2 Diabetes 12item