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  • Search results for: 'p53 and mdm2 proteins interaction inhibitor chiral'

Search results for: 'p53 and mdm2 proteins interaction inhibitor chiral'

Items 391-400 of 3728

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  1. ITF2357 (Givinostat)
    A4093 ITF2357 (Givinostat)
     2 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: HDAC inhibitor
      ≥23.8 mg/mL
  2. Empagliflozin (BI 10773)
    A4601 Empagliflozin (BI 10773)
     2 Citation
    Summary: SGLT-2 inhibitor for oral treatment of type 2 diabetes
      insoluble in H2O; ≥20.75 mg/mL
  3. Etomoxir
    A3404 Etomoxir
    Summary: (CPT)-1 and DGAT activity inhibitor
      ≥32.7 mg/mL
  4. Dasatinib hydrochloride
    A3351 Dasatinib hydrochloride
    Summary: Multi-BCR/Abl and Src kinase inhibitor, oral active
      insoluble in EtOH; insoluble in H2O; ≥8.41 mg/mL
  5. PD153035 hydrochloride
    A8199 PD153035 hydrochloride
     1 Citation
    Target: EGFR
    Summary: Potent EGFR inhibitor
      insoluble in EtOH; insoluble in H2O; ≥3.97 mg/mL
  6. Valproic acid sodium salt (Sodium valproate)
    A4099 Valproic acid sodium salt (Sodium valproate)
    Target: Histone Deacetylases (HDACs)
    Summary: HDAC inhibitor
      ≥8.35 mg/mL
  7. Calcineurin Autoinhibitory Peptide
    A4532 Calcineurin Autoinhibitory Peptide
    Summary: CaMKII inhibitor
      Soluble to 1 mg/mL
  8. PCI-24781 (CRA-024781)
    A4098 PCI-24781 (CRA-024781)
    Target: Histone Deacetylases (HDACs)
    Summary: Pan-HDAC inhibitor
      insoluble in H2O; insoluble in EtOH; ≥11.75 mg/mL
  9. 4EGI-1
    B3696 4EGI-1
     2 Citation
    Target: eIF4E/eIF3G interaction
    Summary: Competitive eIF4E/eIF4G interaction inhibitor
      ≥22.56 mg/mL
  10. AICAR
    A8184 AICAR
     3 Citation
    Target: AMPK
    Summary: AMPK activator
      insoluble in EtOH; ≥12.9 mg/mL

Items 391-400 of 3728

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Reversibility
  1. Reversible 65item
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Target
  1. Caspases 14item
  2. Cyclin-Dependent Kinases 33item
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  4. Cathepsins 11item
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  48. Hydrolase 1 item
  49. Thymidylate Synthase 3item
  50. p38 9item
  51. PKB 1 item
  52. 3-phosphoglycerate dehydrogenase 1 item
  53. JNK 7item
  54. SGK 2item
  55. Bcr-Abl 15item
  56. Kynurenine-3-monooxygenase 1 item
  57. MEK 16item
  58. DOT1L 3item
  59. FGFR 17item
  60. Nrf2 2item
  61. Pim 5item
  62. Sir2-like Family Deacetylases (Sirtuins) 3item
  63. Deubiquitinating enzymes (DUBs) 5item
  64. Smoothened 4item
  65. Neuraminidases (NA) 2item
  66. MET 7item
  67. Src 18item
  68. Trk Receptors 7item
  69. Integrins 1 item
  70. Aminopeptidases 3item
  71. NMDA Receptors 1 item
  72. STAT 12item
  73. ATP Citrate Lyases 1 item
  74. Microtubules/Tubulins 5item
  75. Estrogen and Related Receptors 1 item
  76. EGFR 25item
  77. Hedgehog 1 item
  78. Reverse Transcriptases 7item
  79. ROCK 12item
  80. BTK 2item
  81. RIP kinases 1 item
  82. Monocyte chemotactic proteins 1 item
  83. PAK 3item
  84. PD-1/PD-L1 interaction 1 item
  85. Hypoxia Inducible Factors (HIFs) 2item
  86. Tankyrases 1 item
  87. Inositol Phosphatases 1 item
  88. FAK 7item
  89. BMP and Other Activin Receptors 4item
  90. JAK 22item
  91. p300 1 item
  92. Stearoyl-CoA 9-desaturase (SCD-1) 2item
  93. Syk 7item
  94. EZH1 2item
  95. DNA-PK 8item
  96. HSP90 12item
  97. AMPK 2item
  98. Gutathione S-transferase 2item
  99. PDHK 1 item
  100. Angiotensin AT2 Receptors 1 item
  101. eIF4E/eIF3G interaction 1 item
  102. Notch 1 item
  103. S-nitrosoglutathione reductase 1 item
  104. CFTR 4item
  105. TNKS 1 item
  106. Topoisomerases 15item
  107. Cytochrome P450 (CYP450) 8item
  108. M3 Receptors 1 item
  109. thrombin 1 item
  110. Ksp 2item
  111. Ribosomes 1 item
  112. Renin 2item
  113. HIV proteases 1 item
  114. Pepsins 1 item
  115. Influenza viruses 1 item
  116. ErbB 5item
  117. Ferroptosis 1 item
  118. S6 kinases 1 item
  119. Toll-like receptors (TLRs) 3item
  120. Adenosine Kinases 2item
  121. Actin 2item
  122. Serine Proteases 2item
  123. DNA Methyltransferases 3item
  124. Survivin 1 item
  125. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  126. ERK 8item
  127. HMG-CoA Reductases 6item
  128. Vacuolar-type ATPase 1 item
  129. Kinases 1 item
  130. c-MET 8item
  131. BMI-1 1 item
  132. PKC 16item
  133. Calpains 6item
  134. Ubiquitin-specific proteases 1 item
  135. HCV Proteases 3item
  136. Ca2 /calmodulin-dependent protein kinases (CaMKs) 7item
  137. MLK3 1 item
  138. SMYD2 1 item
  139. O-GlcNAcase 1 item
  140. CREBBP 2item
  141. EP300 2item
  142. Protease-Activated Receptors 1 item
  143. Lyn 2item
  144. SGLT 1 item
  145. RAD51 2item
  146. Trypsins 1 item
  147. HER2 3item
  148. Pyk2 3item
  149. USP 3item
  150. 5-HT2 Receptors 4item
  151. LRRK2 6item
  152. Voltage-gated Calcium Channels (CaV) 2item
  153. DGAT 2item
  154. Insulin and Insulin-like Receptors 4item
  155. PARP 9item
  156. CB1 Receptors 1 item
  157. Melanocortin (MC) Receptors 1 item
  158. Pyruvate dehydrogenases (PDH) 2item
  159. ALK 10item
  160. ROS1 2item
  161. Sphingosine kinases (SphKs) 3item
  162. Trypsin 1 item
  163. Chymotrypsin 1 item
  164. Kallikrein 1 item
  165. Trypsinogen 1 item
  166. KRAS G12C 1 item
  167. GTPases 1 item
  168. Monocarboxylate transporters (MCTs) 2item
  169. CETP 2item
  170. Dehydrogenase 1 item
  171. PKG 3item
  172. PKA 7item
  173. Myosin light chain kinases (MLCKs) 3item
  174. HIV-1 gp120 1 item
  175. D1 and D5 Receptors 1 item
  176. D2 Receptors 3item
  177. D3 Receptors 2item
  178. 5-HT1 Receptors 2item
  179. 5-HT7 Receptors 1 item
  180. CaM-KK 1 item
  181. Valosin-containing protein (VCP) 1 item
  182. MELK 1 item
  183. Serotonin reuptake 1 item
  184. Insulin-like growth factors (IGFs) 1 item
  185. Clk 1 item
  186. TBK1 1 item
  187. MARK1 1 item
  188. NUAK1 2item
  189. Integrin-ligand interactions 1 item
  190. CSF1R 1 item
  191. Bromodomain and Extra-Terminal motif (BET) 1 item
  192. NUAK2 1 item
  193. Na /H Exchangers (NHEs) 1 item
  194. Lactate Dehydrogenases (LDH) 3item
  195. MK2 4item
  196. Fatty-acid-binding proteins (FABPs) 1 item
  197. Angiotensin-Converting Enzymes (ACEs) 6item
  198. Tie-2 5item
  199. RSK 3item
  200. p70 S6K 1 item
  201. Granzyme B 1 item
  202. Free Fatty Acid Receptors 2item
  203. phosphatases 2item
  204. Autophagy 4item
  205. ATM/ATR 8item
  206. Mixed lineage kinase domain-like protein (MLKL) 1 item
  207. COX 12item
  208. Heparanases 1 item
  209. CK1 2item
  210. IDH2 1 item
  211. Farnesyl Diphosphate Synthases 1 item
  212. CK2 3item
  213. HIPK2 1 item
  214. HIPK3 1 item
  215. HIV Integrases 3item
  216. Cryptochromes 1 item
  217. Squalene epoxidases 2item
  218. PRAK 1 item
  219. MAPKAP-K2 1 item
  220. Delayed rectifier outward potassium current (IKr) 1 item
  221. GpIIb/IIIa receptor 1 item
  222. Guanine nucleotide exchange factors (GEFs) 1 item
  223. 20S proteasomal chymotrypsin 1 item
  224. Geranylgeranyltransferase I 1 item
  225. Farnesyltransferase 1 item
  226. NAT10 1 item
  227. Nampt 3item
  228. eIF4F 1 item
  229. Cdc42 1 item
  230. SRPK1 1 item
  231. P2X Receptors 1 item
  232. Glutaminases 2item
  233. Carbonic Anhydrases 7item
  234. Ron 1 item
  235. AP endonucleases 1 item
  236. G9a 2item
  237. BLM 1 item
  238. HSV 2item
  239. NADPH Oxidases 3item
  240. Calcium-activated chloride channels (CaCC) 1 item
  241. GPR35 1 item
  242. Urokinases 1 item
  243. Aldehyde Dehydrogenases 1 item
  244. Synthases/Synthetases 3item
  245. MAGL 1 item
  246. c-Fyn 1 item
  247. TAK1 1 item
  248. Histamine H1 Receptors 2item
  249. Na /K ATPases 3item
  250. P110 1 item
  251. Hck 2item
  252. Inositol-requiring enzyme 1 (IRE1) 3item
  253. SETD7 1 item
  254. Na /K /Cl- Symporters (NKCCs) 2item
  255. GABAA Receptors 2item
  256. Phospholipases 1 item
  257. Monoamine oxidases (MAOs) 1 item
  258. Organic anion transporters (OATs) 1 item
  259. TRP Channel 1 item
  260. RNA Polymerases 2item
  261. DYRK 2item
  262. Norepinephrine transporter 1 item
  263. 5-HT Transporters 3item
  264. Xanthine oxidoreductases 1 item
  265. Dihydroorotate dehydrogenase 1 item
  266. FoxM1 1 item
  267. Histone Demethylases 1 item
  268. Apoptosis Inducers 1 item
  269. MNK 2item
  270. 5-Lipoxygenases 1 item
  271. NO Donors / Precursors 2item
  272. CB2 Receptors 1 item
  273. HIV-1 reverse transcriptase 1 item
  274. IL Receptors 2item
  275. CCL2 1 item
  276. Noradrenaline reuptake 1 item
  277. Norepinephrine transporters 1 item
  278. Calcium-Activated Potassium (KCa) Channels 2item
  279. AChE 3item
  280. Insulin Receptors 1 item
  281. IRG-1R 1 item
  282. Proton Pump 1 item
  283. cAMP 1 item
  284. Sulfonylurea receptors 1 item
  285. Cdc2-like kinase (Clk) 1 item
  286. eEF-2 1 item
  287. Inward Rectifier Potassium (Kir) Channels 3item
  288. Arp2/3 complex 1 item
  289. Cdc7 1 item
  290. CMV 1 item
  291. ZAP-70 1 item
  292. Catechol O-Methyltransferase (COMT) 2item
  293. fibrinolysis 1 item
  294. Angiotensin AT1 Receptors 1 item
  295. D4 Receptors 1 item
  296. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  297. NMDA receptor 1 item
  298. HBV Proteases 1 item
  299. Hydroxylases 2item
  300. Flk-1 1 item
  301. Papains 2item
  302. Protein Arginine Methyltransferases 1 item
  303. IMPDH 1 item
  304. Na /Ca2 Exchangers (NCXs) 1 item
  305. NAE 2item
  306. Ubiquitin-activating Enzyme E1 2item
  307. SUMOylation 1 item
  308. ATGL 1 item
  309. BACE 2item
  310. Cytidine deaminases 1 item
  311. GPR40 1 item
  312. angiogenesis 1 item
  313. Glucagon Receptors 1 item
  314. 15-PGDH 1 item
  315. DPP-4 5item
  316. PP4 1 item
  317. c-RET 3item
  318. Nonstructural protein 5B (NS5B) 1 item
  319. p70 rsk 3item
  320. voltage-gated chloride channels 1 item
  321. FPTase 1 item
  322. Microtubule/Tubulin 1 item
  323. VEGFR3/FLT4 1 item
  324. NTRK1/TRKA 1 item
  325. CSF-1R/c-Fms 1 item
  326. Menin-MLL 2item
  327. Tryptophan hydroxylases (TPH) 2item
  328. ADAMs 1 item
  329. NMPRTase 1 item
  330. Bfl-1 1 item
  331. TAM kinase 1 item
  332. p53-MDM2 interaction 2item
  333. nuclear export 1 item
  334. CRM1 1 item
  335. PTP 1 item
  336. KDR 2item
  337. Fyn kinase 1 item
  338. Abl kinases 1 item
  339. Trypsin-like protease 1 item
  340. AXL 1 item
  341. Glyoxalase I 1 item
  342. dCTP Pyrophosphatases 1 item
  343. Protein polybromo-1 1 item
  344. SMARCA4 1 item
  345. SMARCA2 1 item
  346. ERAD 1 item
  347. Dipeptidyl-peptidase II 1 item
  348. p53 7item
  349. metalloprotease 1 item
  350. HDAC 2item
  351. KDM 2item
  352. 5-HT receptors 1 item
  353. sodium channel 3item
  354. c-Fms tyrosine kinase 1 item
  355. human lyase 1 item
  356. insulin 1 item
  357. Ub-conjugating enzyme (E2) complex 1 item
  358. Smoothened receptor 1 item
  359. quinone oxidoreductase 1 item
  360. cysteine protease 2item
  361. haspin kinase 1 item
  362. STK 1 item
  363. HDM2 ubiquitin ligase 1 item
  364. USP1/USF1 complex 1 item
  365. IKK 1 item
  366. MSK 1 item
  367. gp120-CD4 interaction 1 item
  368. HCV polymerase 3item
  369. Ftase 1 item
  370. Subtilisin/Kex2p-like proprotein convertase 1 item
  371. PC-PLC 2item
  372. Elastases 1 item
  373. P97 ATPase 1 item
  374. Glucosidases 1 item
  375. NTPDases 1 item
  376. Mer tyrosine kinase 1 item
  377. Hec1 1 item
  378. neprilysin 1 item
  379. GLI 1 item
  380. decarboxylase 1 item
  381. HMGCR 1 item
  382. AAT 1 item
  383. ErbB-2 1 item
  384. adrenergic receptor 2item
  385. 5-HT4 Receptor 1 item
  386. sterol demethylase 1 item
  387. PDK-1 1 item
  388. GAPDH 1 item
  389. telomerase 1 item
  390. Histone Acetyltransferases (HATs) 3item
  391. complex I of the mitochondrial electron transport chain 1 item
  392. F1 Fo-ATPase 1 item
  393. Prk 1 item
  394. potassium channel 1 item
  395. calcium channel 1 item
  396. Ribonucleotide Reductases 1 item
  397. Trx 1 item
  398. Tyrosinases 1 item
  399. HSP70 1 item
  400. ICAM 1 item
  401. ITK 1 item
  402. HIF-PH 1 item
  403. NOD1 1 item
  404. NUAK 1 item
  405. Rho 1 item
  406. Ubiquitin E3 Ligases 1 item
  407. DCLK2 1 item
  408. FAAH 1 item
  409. PTK 1 item
  410. integrase 1 item
  411. L3MBTL 1 item
  412. NOS 2item
  413. MDMX 1 item
  414. TYK2 2item
  415. MUSK 1 item
  416. MAP3K 1 item
  417. GPR3 1 item
  418. Lck 1 item
  419. Adenosine Deaminases 2item
  420. mitochondrial pyruvate carrier (MPC) 1 item
  421. prolactin secretion 1 item
  422. gonadotropin release 1 item
  423. DprE 1 item
  424. carnitine reabsorption 1 item
  425. Histamine receptors 1 item
  426. GluR 1 item
  427. 5-HT receptor 1 item
  428. dopamine receptors 1 item
  429. AMPA receptor 1 item
  430. 5-alpha Reductases 1 item
  431. Flk1 2item
  432. p21 1 item
  433. DNA Ligases 1 item
  434. Prostaglandin synthesis 1 item
  435. Protein Tyrosine Phosphatases 1 item
  436. alkaline phosphatases 1 item
  437. ATPases 1 item
  438. glutamate release 1 item
  439. PAFR 1 item
  440. Aromatases 2item
  441. DHFR 1 item
  442. GARFT 1 item
  443. PHF 1 item
  444. FGR 1 item
  445. YES 2item
  446. Fyn 2item
  447. ARG 1 item
  448. Autotaxin 1 item
  449. UCH 1 item
  450. RHA 1 item
  451. HCV NS3-4A protease 1 item
  452. PKD 1 item
  453. Pyruvate kinases 1 item
  454. Thioredoxin Reductases 1 item
  455. enoyl-acyl-carrier protein reductase 1 item
  456. SHIP 1 item
  457. FKBP 1 item
  458. MCL1 1 item
  459. Bcl-w 1 item
  460. glutathione peroxidase 4 1 item
  461. NADH oxidase 1 item
  462. S-adenosylhomocysteine hydrolase 1 item
  463. Rho-kinase 1 item
  464. tropomyosin receptor kinase 1 item
  465. LSD 1 item
  466. DDX3 1 item
  467. PRMT 1 item
  468. ACE 1 item
  469. GLP 1 item
  470. SK 1 item
  471. MST 1 item
  472. PPK 1 item
  473. c-Syk 1 item
  474. CDK1/CyclinB 1 item
  475. NHE 1 item
  476. IDO 2item
  477. Tph 1 item
  478. PIM1 kinase 1 item
  479. phospholipase A2 1 item
  480. reverse transcriptase 1 item
  481. epoxide hydrolase 1 item
  482. Serotonin (5-HT) reuptake 1 item
  483. Cholesterol absorption 1 item
  484. Vascular Disrupting Agents (VDA) 1 item
  485. Androgen Receptor 1 item
  486. Substance P/NK1 Receptor 1 item
  487. gp120/CD4 1 item
  488. Histone Methyltransferase 1 item
  489. ATM 2item
  490. Sirtuin 1 item
  491. NE 1 item
  492. PIKfyve 1 item
  493. Bax 1 item
  494. Glycogen Phosphorylases 1 item
  495. RGS 1 item
  496. MTH1 1 item
  497. PTEN 1 item
  498. Insulin Receptor 1 item
  499. NS3/4a Proteases 1 item
  500. Ca2 -ATPases 1 item
Reported Experiments
  1. Animal Experiments 981item
  2. Cell Experiments 793item
Related Disease
  1. Abscesses And Esophageal Candidiasis 1 item
  2. Acne 1 item
  3. Acute Disseminated Candidiasis 1 item
  4. Acute Kidney Injury 2item
  5. Acute Lung Injury 1 item
  6. Acute Myelogenous Leukemia 6item
  7. Acute Myeloid Leukemia 26item
  8. Acute Renal Failure 1 item
  9. Adrenocortical Carcinoma 4item
  10. Advanced Renal Cell Carcinoma 1 item
  11. Anesthesia 1 item
  12. Autoimmune Diseases 1 item
  13. Biliary Cancer 1 item
  14. Bladder Cancer 11item
  15. Bladder Carcinoma 4item
  16. Bladder Diseases 2item
  17. B-lymphoid Malignancies 1 item
  18. Brain Injuries Studies 3item
  19. Breast Cancer 123item
  20. Cancer 553item
  21. Candida Peritonitis 1 item
  22. Candidemia 1 item
  23. Castration-resistant Prostate Cancer 1 item
  24. Cervical Cancer 6item
  25. Cholangiocarcinoma 2item
  26. Chronic Lymphocytic Leukemia 8item
  27. Chronic Myeloproliferative Disorders 1 item
  28. Clear Cell Renal Cell Carcinoma 2item
  29. Cocaine-Related Disorders 2item
  30. Colon Cancer 49item
  31. Colon Carcinoma 7item
  32. Colorectal Cancer 43item
  33. Depression 2item
  34. Diabetes 9item
  35. Diffuse Large B-cell Lymphoma 1 item
  36. Dyskinesia 1 item
  37. Dyslipidemia 2item
  38. Epilepsy 4item
  39. Erectile Dysfunction 4item
  40. Friedreich's Ataxia 2item
  41. Fungal Infection 1 item
  42. Fungi 1 item
  43. Glioblastoma 32item
  44. Glioma 18item
  45. HCV 5item
  46. Heart Failure 3item
  47. Hepatic Cancer 2item
  48. Hepatitis C 4item
  49. Hepatocellular Carcinoma 7item
  50. HIV 14item
  51. HIV Infections 10item
  52. Hypercholesterolemia 3item
  53. Immunological Diseases 1 item
  54. Inflammation 1 item
  55. Inflammatory Bowel Disease 1 item
  56. Inflammatory Diseases 16item
  57. Influenza 3item
  58. Kidney Injury Studies 2item
  59. Leukemia 28item
  60. Liver Cancer 4item
  61. Lung Cancer 45item
  62. Lung Carcinoma 4item
  63. Lymphoma 31item
  64. Mantle Cell Lymphoma 2item
  65. Medulloblastoma 1 item
  66. Melanoma 35item
  67. Mixed Lineage Leukemia 3item
  68. Multiple Myeloma 24item
  69. Myelofibrosis 2item
  70. Myeloma 6item
  71. Neuroblastoma 13item
  72. Neurocognitive Disorders 1 item
  73. Neuronal Protection 1 item
  74. Non-small Cell Lung Cancer 27item
  75. Non-small Cell Lung Carcinoma 2item
  76. Obsessive-Compulsive Disorder 1 item
  77. Osteoporosis 3item
  78. Ovarian Cancer 36item
  79. Pancreatic Cancer 50item
  80. Pancreatic Carcinoma 3item
  81. Prostate Cancer 56item
  82. Psoriasis 4item
  83. Psoriasis Vulgaris 1 item
  84. Pulmonary Arterial Hypertension 2item
  85. Pulmonary Fibrosis 2item
  86. Renal Cancer 4item
  87. Renal Cell Carcinoma 8item
  88. Rheumatoid Arthritis 14item
  89. Sarcoma 1 item
  90. Schizophrenia 8item
  91. Sleep Disorders 2item
  92. Soft Tissue Sarcoma 1 item
  93. Squamous Cell Carcinoma 2item
  94. Testicular Cancer 2item
  95. Thyroid Cancer 6item
  96. Tuberculosis 1 item
  97. Type 2 Diabetes 13item