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Signaling Pathways

Items 251-260 of 351

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  1. CH5183284 (Debio-1347)
    B4985 CH5183284 (Debio-1347)
    Summary: selective and orally available FGFR inhibitor
      ≥35.6 mg/mL
  2. PLX647
    B5816 PLX647
    Summary: dual inhibitor of FMS and KIT kinases
  3. Altiratinib
    B5832 Altiratinib
     1 Citation
    Target: FLT3|VEGFR|Trk Receptors|c-MET|Tie-2
    Summary: c-MET/TIE-2/VEGFR inhibitor
      ≥21.55 mg/mL
  4. AZD2932
    B5835 AZD2932
    Target: FLT3|VEGFR|PDGFR|c-Kit
    Summary: inhibitor of VEGFR-2, PDGFRβ, Flt-3, and c-Kit
      Soluble in DMSO
  5. SU6656
    B5839 SU6656
    Target: Src|Lyn|YES|Fyn
    Summary: Src tyrosine kinases inhibitor
      insoluble in H2O; insoluble in EtOH; ≥18.55 mg/mL
  6. CTX0294885
    B5843 CTX0294885
    Target: Kinases
    Summary: Pan-kinase inhibitor
      ≥21.9 mg/mL
  7. Pexidartinib (PLX3397)
    B5854 Pexidartinib (PLX3397)
     3 Citation
    Target: FLT3|c-Kit|CSF1R
    Summary: CSF-1R inhibitor
      insoluble in EtOH; insoluble in H2O; ≥20.9 mg/mL
  8. Entrectinib
    B5859 Entrectinib
    Target: Trk Receptors|ALK|ROS1
    Summary: Orally active inhibitor of ALK kinase
      ≥28.05 mg/mL
  9. Fruquintinib(HMPL-013)
    B5864 Fruquintinib(HMPL-013)
    Target: VEGFR
    Summary: Potent and selective inhibitor of VEGFR 1, 2, 3
      insoluble in H2O; insoluble in EtOH; ≥6.35 mg/mL
  10. EGF816
    B5889 EGF816
     2 Citation
    Target: EGFR
    Summary: Novel covalent inhibitor of mutant-selective EGFR
      Soluble in DMSO

Items 251-260 of 351

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  1. Category Tyrosine Kinase Remove This Item
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Category
  1. Bcr-Abl 19item
  2. Ack1 1 item
  3. Axl 6item
  4. ALK 21item
  5. BMX Kinase 1 item
  6. Broad Spectrum Protein Kinase Inhibitor 9item
  7. c-FMS 2item
  8. c-Kit 7item
  9. c-MET 24item
  10. c-RET 7item
  11. CSF-1R 3item
  12. DDR1/DDR2 Receptor 1 item
  13. EGFR 69item
  14. EphB4 1 item
  15. FAK 10item
  16. FGFR 17item
  17. FLT3 19item
  18. HER2 14item
  19. IGF1R 9item
  20. Insulin Receptor 6item
  21. IRAK 6item
  22. ITK 1 item
  23. Lck 1 item
  24. LRRK2 9item
  25. PDGFR 24item
  26. PTKs/RTKs 3item
  27. Pyk2 3item
  28. ROR 6item
  29. Spleen Tyrosine Kinase (Syk) 12item
  30. Src 24item
  31. Tie-2 2item
  32. Trk 11item
  33. VEGFR 55item
Specificity
  1. Selective 118item
Reversibility
  1. Reversible 9item
  2. Irreversible 8item
Target
  1. Cyclin-Dependent Kinases 1 item
  2. Histone Deacetylases (HDACs) 1 item
  3. Raf 5item
  4. Aurora Kinases 3item
  5. CSF-1R 4item
  6. MER 1 item
  7. FLT3 12item
  8. Eph Receptors 2item
  9. VEGFR 37item
  10. PDGFR 23item
  11. c-Kit 12item
  12. RET 3item
  13. IRAK 5item
  14. Bcr-Abl 12item
  15. FGFR 15item
  16. Insulin-like growth factor receptors(IGFRs) 1 item
  17. MET 7item
  18. Src 12item
  19. Trk Receptors 5item
  20. STAT 1 item
  21. EGFR 23item
  22. FAK 5item
  23. BMP and Other Activin Receptors 3item
  24. JAK 2item
  25. Syk 6item
  26. ErbB 5item
  27. Kinases 1 item
  28. c-MET 8item
  29. PKC 2item
  30. Ca2 /calmodulin-dependent protein kinases (CaMKs) 1 item
  31. Lyn 2item
  32. HER2 3item
  33. Pyk2 3item
  34. LRRK2 5item
  35. S1P receptors 1 item
  36. Insulin and Insulin-like Receptors 3item
  37. ALK 6item
  38. ROS1 2item
  39. PKG 1 item
  40. PKA 1 item
  41. Myosin light chain kinases (MLCKs) 1 item
  42. Insulin-like growth factors (IGFs) 1 item
  43. CSF1R 1 item
  44. Angiotensin-Converting Enzymes (ACEs) 1 item
  45. Tie-2 4item
  46. RSK 1 item
  47. p70 S6K 1 item
  48. Ron 1 item
  49. c-Fyn 1 item
  50. 5-Lipoxygenases 1 item
  51. Insulin Receptors 2item
  52. IRG-1R 1 item
  53. ZAP-70 1 item
  54. Flk-1 1 item
  55. c-RET 2item
  56. TAM kinase 1 item
  57. KDR 1 item
  58. Fyn kinase 1 item
  59. Abl kinases 1 item
  60. AXL 1 item
  61. c-Fms tyrosine kinase 1 item
  62. insulin 1 item
  63. Lyn kinase 1 item
  64. Mer tyrosine kinase 1 item
  65. ErbB-2 1 item
  66. ITK 1 item
  67. DCLK2 1 item
  68. PTK 1 item
  69. Flk1 1 item
  70. YES 1 item
  71. Fyn 1 item
  72. enoyl-acyl-carrier protein reductase 1 item
  73. tropomyosin receptor kinase 1 item
  74. Insulin Receptor 1 item
Reported Experiments
  1. Animal Experiments 143item
  2. Cell Experiments 101item
Related Disease
  1. Acute Myelogenous Leukemia 1 item
  2. Acute Myeloid Leukemia 5item
  3. Adrenocortical Carcinoma 1 item
  4. Advanced Renal Cell Carcinoma 1 item
  5. Autoimmune Diseases 1 item
  6. Bladder Cancer 4item
  7. Bladder Carcinoma 1 item
  8. Breast Cancer 22item
  9. Cancer 110item
  10. Cervical Cancer 1 item
  11. Cholangiocarcinoma 1 item
  12. Chronic Lymphocytic Leukemia 1 item
  13. Clear Cell Renal Cell Carcinoma 1 item
  14. Colon Cancer 4item
  15. Colon Carcinoma 3item
  16. Colorectal Cancer 12item
  17. Glioblastoma 9item
  18. Glioma 4item
  19. Hepatocellular Carcinoma 3item
  20. Leukemia 3item
  21. Liver Cancer 2item
  22. Lung Cancer 8item
  23. Lung Carcinoma 4item
  24. Lymphoma 5item
  25. Melanoma 3item
  26. Multiple Myeloma 5item
  27. Myeloma 1 item
  28. Neuroblastoma 2item
  29. Non-small Cell Lung Cancer 6item
  30. Ovarian Cancer 8item
  31. Pancreatic Cancer 12item
  32. Prostate Cancer 8item
  33. Pulmonary Arterial Hypertension 1 item
  34. Renal Cancer 2item
  35. Renal Cell Carcinoma 4item
  36. Rheumatoid Arthritis 2item
  37. Thyroid Cancer 4item