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Signaling Pathways

Items 1-10 of 80

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  1. CCT241533
    A3291 CCT241533
    Target: Chk
    Summary: Potent Chk2 inhibitor
      Soluble in DMSO
  2. THZ2
    A8717 THZ2
     1 Citation
    Target: Cyclin-Dependent Kinases
    Summary: CDK7 inhibitor
      ≥28.3 mg/mL
  3. TC-A 2317 hydrochloride
    A4489 TC-A 2317 hydrochloride
    Target: Aurora Kinases
    Summary: Aurora kinase A inhibitor,potent and selective
      <39.29 mg/mL
  4. BI 2536
    A3965 BI 2536
     1 Citation
    Target: PLK|Bromodomain-containing proteins(BRDs)
    Summary: Plk1 inhibitor,potent and ATP-competitive
      insoluble in H2O; ≥13.04 mg/mL
  5. ABT-751 (E7010)
    A1493 ABT-751 (E7010)
     1 Citation
    Target: Microtubules/Tubulins
    Summary: Inhibitor of microtubule polymerization,antimitotic
      insoluble in H2O; ≥18.55 mg/mL
  6. SNS-032 (BMS-387032)
    A1980 SNS-032 (BMS-387032)
     2 Citation
    Target: Cyclin-Dependent Kinases
    Summary: CDK inhibitor
      insoluble in H2O; ≥19.05 mg/mL
  7. Epothilone B (EPO906, Patupilone)
    A1630 Epothilone B (EPO906, Patupilone)
    Target: Microtubules/Tubulins
    Summary: Microtubule stabilizing macrolide
      ≥25.4 mg/mL
  8. Rigosertib sodium salt
    A1404 Rigosertib sodium salt
     1 Citation
    Target: PLK
    Summary: Plk1 inhibitor
      ≥23.65 mg/mL
  9. Zoledronic Acid
    A1352 Zoledronic Acid
    Target: Farnesyl Diphosphate Synthases
    Summary: Potent nitrogen-containing bisphosphonates
      insoluble in DMSO; insoluble in H2O; insoluble in EtOH
  10. GSK429286A
    A5611 GSK429286A
    Target: ROCK
    Summary: Selective ROCK1/ROCK2 inhibitor
      ≥21.6 mg/mL

Items 1-10 of 80

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Category
  1. ATM/ATR 5item
  2. Aurora Kinase 13item
  3. Cdc42 1 item
  4. Cdc7 1 item
  5. Chk 8item
  6. CRM1 1 item
  7. Cyclin-Dependent Kinases 24item
  8. G-quadruplex 1 item
  9. Ksp 1 item
  10. Microtubule/Tubulin 5item
  11. Mitotic 1 item
  12. RAD51 1 item
  13. ROCK 6item
  14. Rho 3item
  15. PAK1 2item
  16. PAK4 1 item
  17. PERK 1 item
  18. PLK 7item
Reversibility
  1. Reversible 8item
  2. Irreversible 2item
Target
  1. Cyclin-Dependent Kinases 24item
  2. PI3K 1 item
  3. Aurora Kinases 13item
  4. FLT3 2item
  5. GSK-3 1 item
  6. PLK 7item
  7. Chk 8item
  8. PDGFR 1 item
  9. Bromodomain-containing proteins(BRDs) 1 item
  10. MEK 1 item
  11. Voltage-gated Sodium (NaV) Channels 1 item
  12. Src 1 item
  13. Microtubules/Tubulins 4item
  14. ROCK 6item
  15. PAK 3item
  16. Ksp 1 item
  17. RAD51 1 item
  18. KRAS G12C 1 item
  19. Clk 1 item
  20. MK2 1 item
  21. ATM/ATR 5item
  22. Farnesyl Diphosphate Synthases 1 item
  23. G-quadruplexes 1 item
  24. Cdc42 1 item
  25. Arp2/3 complex 1 item
  26. Cdc7 1 item
  27. nuclear export 1 item
  28. CRM1 1 item
  29. Lck 1 item
  30. ATM 1 item
Reported Experiments
  1. Animal Experiments 60item
  2. Cell Experiments 39item
Related Disease
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  2. B-lymphoid Malignancies 1 item
  3. Breast Cancer 16item
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  21. Ovarian Cancer 10item
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