Endocrinology and Hormones
There are three types of hormones based on their chemical composition: Amines (e.g. dopamine, adrenalin and noradrenalin); Steroids (e.g. estrogen, testosterone and glucocorticoids); Peptides (e.g. the peptide hormones insulin, ghrelin and vasopressin). Peptide hormones produced by secretory nervous tissue are known as neuropeptides. For example, thyroid hormone plays important parts in development, homeostasis and metabolism, while cortisol is essential for growth, nutrient supply and immune function. Moreover, the regulation of blood glucose involves several pancreatic peptide insulin and its counter regulatory hormone, glucagon, as well as cortisol, growth hormone and epinephrine.
Dysregulations in endocrine system are implicated in diseases such as Acromegaly, Cushing Syndrome, Diabetes, Dwarfism, Graves Disease, Hermaphroditism, Delayed and Precocious Puberty and Thyroid Diseases.
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A1115 Peptide YY(3-36), PYY, humanTarget: NPY ReceptorsSummary: Y2R agonist
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A5065 Bicalutamide1 CitationTarget: Androgen ReceptorsSummary: Androgen receptor antagonist
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A1659 DutasterideTarget: 5-alpha ReductasesSummary: 5-alpha-reductase inhibitor
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A3517 JDTicSummary: Opioid antagonist
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A3518 JDTic 2HClSummary: κ-opioid receptor antagonist
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A4326 TAK-700 (Orteronel)2 CitationTarget: human lyaseSummary: Human 17,20-lyase inhibitor
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A3190 ASC-J9Summary: AR degradation enhancer,antiumor agent
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B1382 AnastrozoleTarget: AromatasesSummary: Aromatase inhibitor
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B1513 Toremifene CitrateTarget: Estrogen and Related ReceptorsSummary: Oral selective estrogen receptor modulator (SERM)
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B1534 AZD1981Target: CRTH2Summary: CRTh2 antagonist,potent and selective