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Immunology/Inflammation

The innate immune system is triggered when microbial pathogens are targeted by pattern recognition receptors such as Toll-like receptors (TLRs) that recognize the pathogen-associated molecular patterns. The activated TLRs initiate a cascade of interaction between various intracellular signaling adaptors including MyD88, IRAKs, and TRAF6, resulting the activation of the MAP kinase, NF-κB, and IRF signaling pathways, which mediate inflammation through the production of inflammatory cytokines, chemokines, type I IFN, and antimicrobial peptides.

The adaptive immune system consists of B and T lymphocytes which mediate humoral immunity (e.g. antibody response) and cell-mediated immunity, respectively. B cell receptor and T cell receptor signaling is responsible for activation of Src family tyrosine kinases, such as Blk, Fyn, and Lyn in B cells and Fyn and Lck in T cells, resulting phosphorylation of the receptor-associated ITAM motifs. Phosphorylated ITAMs serve as the docking sites for Syk family tyrosine kinases, e.g. Syk in B cells and Zap-70 in T cells. Activated Syk kinases then propagate the signals via phosphorylation of downstream proteins. Furthermore, lymphocyte receptor signaling facilitates B and T cell development, differentiation, proliferation and survival.

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  1. hemagglutinin (332-340) [Influenza A virus]
    A1141 hemagglutinin (332-340) [Influenza A virus]
    Summary: Partial antigenic glycoprotein
      ≥97 mg/mL
  2. hemagglutinin precursor (114-122) amide [Influenza A virus]
    A1142 hemagglutinin precursor (114-122) amide [Influenza A virus]
    Summary: Partial antigenic glycoprotein
      ≥110.1 mg/mL
  3. MHC class II antigen (45-57) [Homo sapiens]
    A1081 MHC class II antigen (45-57) [Homo sapiens]
    Summary: Major histocompatibility complex
      ≥164.2 mg/mL
  4. ovalbumin (324-338) [Gallus gallus]/[Coturnix coturnix]
    A1082 ovalbumin (324-338) [Gallus gallus]/[Coturnix coturnix]
    Summary: Triggers immuno response
      ≥156 mg/mL
  5. transferrin fragment
    A1093 transferrin fragment
    Summary: Transferrin fragment
      ≥182.4 mg/mL
  6. egg white lysozyme (19-36) [Gallus gallus]
    A1065 egg white lysozyme (19-36) [Gallus gallus]
    Summary: Dissolution of cell wall
      insoluble in H2O; insoluble in EtOH; ≥402.3 mg/mL
  7. ferritin heavy chain fragment [Multiple species]
    A1069 ferritin heavy chain fragment [Multiple species]
    Summary: Ferritin heavy chain fragment
      ≥107.7 mg/mL
  8. IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]
    A1070 IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]
    Summary: IgG light chain region
      ≥81 mg/mL
  9. immunoglobulin light chain variable region fragment [Homo sapiens]
    A1071 immunoglobulin light chain variable region fragment [Homo sapiens]
    Summary: Immunoglobulin light chain fragment
      ≥86.4 mg/mL
  10. immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus]
    A1072 immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus]
    Summary: Immunoglobulin light chain fragment
      ≥112.2 mg/mL

Items 1-10 of 135

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