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MEK1/2

MEK1/2, also known as MAPKK (mitogen-activated protein kinase kinase), is a kinase enzyme which phosphorylates MAPK (mitogen-activated protein kinase).

Items 1-10 of 37

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  1. Cobimetinib
    A3321 Cobimetinib
     3 Citation
    Summary: Selective MEK inhibitor
      ≥26.55 mg/mL
  2. Cobimetinib (racemate)
    A3322 Cobimetinib (racemate)
    Summary: Selective MEK inhibitor
      Soluble in DMSO
  3. Cobimetinib (R-enantiomer)
    A3323 Cobimetinib (R-enantiomer)
    Summary: Selective MEK inhibitor
      Soluble in DMSO
  4. MEK inhibitor
    A3594 MEK inhibitor
    Summary: Potent MEK inhibitor, Antitumor agent
      Soluble in DMSO
  5. SCH772984
    A3805 SCH772984
     7 Citation
    Summary: ERK1 and ERK2 inhibitor
      insoluble in EtOH; insoluble in H2O; ≥14.7 mg/mL
  6. Trametinib DMSO solvate
    A3887 Trametinib DMSO solvate
     1 Citation
    Target: MEK
    Summary: Allosteric MEK1/MEK2 kinase inhibitor
      insoluble in EtOH; insoluble in H2O; ≥11.2 mg/mL
  7. Refametinib
    B1267 Refametinib
    Target: MEK
    Summary: MEK 1/ MEK 2 inhibitor
      insoluble in H2O; ≥151.8 mg/mL
  8. GDC-0623
    B1135 GDC-0623
    Target: MEK
    Summary: MEK1 inhibitor, potent and ATP-uncompetitive
      insoluble in H2O; ≥16.85 mg/mL
  9. AZD8330
    A8374 AZD8330
    Target: MEK
    Summary: MEK 1/2 inhibitor
      ≥23.05 mg/mL
  10. RO4987655
    B3261 RO4987655
    Summary: MEK inhibitor
      insoluble in H2O; insoluble in EtOH; ≥56.6 mg/mL

Items 1-10 of 37

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