Metabolism
Serine/threonine kinase AMPK upregulates glucose uptake by promoting the expression and function of glucose transporters. AMPK is activated by increased AMP/ATP ratio, resulting from cellular and environmental stress, e.g. low glucose, heat shock, hypoxia and ischemia. AMPK activation positively modulates signaling transductions that refill ATP levels. Moreover, it also stimulates catabolic processes such as fatty acid oxidation and glycolysis through inhibition of ACC and activation of PFK2. AMPK negatively regulates various proteins which are important to ATP-consuming mechanisms, e.g. mTORC2, glycogen synthase, SREBP-1, and TSC2, causing the downregulation/inhibition of gluconeogenesis and glycogen, lipid and protein synthesis.
-
C4385 HalopemideSummary: phospholipase D (PLD) inhibitor
-
C4371 BW 755CSummary: dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways
-
C4426 Simvastatin (sodium salt)Summary: HMG-CoA reductase inhibitor
-
C4880 6,7-dihydroxy BergamottinSummary: potent inhibitor of CYP3A4
-
C4497 6-AminonicotinamideSummary: 6-phosphogluconate dehydrogenase inhibitor
-
C4429 4-phenyl-5-methyl-1,2,3-ThiadiazoleSummary: CYP2B4 and CYP2E1 inhibitor
-
C4945 Perhexiline (maleate)Summary: CPT1 and CPT2 inhibitor
-
B7843 Sodium molybdateSummary: An acid phosphatase inhibitor
-
B7844 Sodium tartrateSummary: Acid phosphatases inhibitor
-
B7845 ImidazoleSummary: Alkaline phosphatases inhibitor