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PDE

PDE (phosphodiesterases) catalyze the hydrolysis of cGMP and/or cAMP. Stimulus such as light, neurotransmitter and hormone trigger PDE to regulate various biological response including vascular smooth muscle proliferation/contraction, hormone secretion and plate aggregation etc.

Items 1-10 of 54

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  1. Nortadalafil
    A3665 Nortadalafil
    Summary: PDE5 inhibitor
      ≥32.7 mg/mL
  2. Olprinone Hydrochloride
    A3683 Olprinone Hydrochloride
    Summary: Phosphodiesterase 3 (PDE3) inhibitor, selective
      insoluble in EtOH; ≥13.2 mg/mL
  3. PF-04447943
    A3713 PF-04447943
    Summary: PDE9 inhibitor
      Soluble in DMSO
  4. Zardaverine
    A3950 Zardaverine
    Summary: PDE III and IV inhibitor
      Soluble in DMSO
  5. Apremilast (CC-10004)
    A4317 Apremilast (CC-10004)
    Target: Phosphodiesterases (PDEs)
    Summary: PDE4 inhibitor
      ≥23.05 mg/mL
  6. Roflumilast
    A4319 Roflumilast
    Summary: PDE-4 inhibitor
      insoluble in H2O; ≥20.2 mg/mL
  7. Sildenafil Citrate
    A4321 Sildenafil Citrate
    Target: Phosphodiesterases (PDEs)
    Summary: Treat erectile dysfunction and PAH
      ≥25.35 mg/mL
  8. Vardenafil HCl Trihydrate
    A4323 Vardenafil HCl Trihydrate
    Target: Phosphodiesterases (PDEs)
    Summary: PDE5 inhibitor, potent and selective
      ≥13.3 mg/mL
  9. PF-2545920
    A4325 PF-2545920
    Target: Phosphodiesterases (PDEs)
    Summary: PDE10A inhibitor,potent and selective
      insoluble in H2O; ≥19.35 mg/mL
  10. Tadalafil
    A4327 Tadalafil
    Target: Phosphodiesterases (PDEs)
    Summary: PDE5 inhibitor
      insoluble in H2O; insoluble in EtOH; ≥16.6 mg/mL

Items 1-10 of 54

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