PPAR
The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.
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A3453 GW1929Target: PPARSummary: Potent PPARγ agonist
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A3536 L-165041Target: PPARSummary: PPARβ/δ agonist,cell permeable,potent and selective
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A3893 TroglitazoneTarget: PPARSummary: Selective PPARγ agonist
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A4300 GW96621 CitationSummary: PPARγ antagonist
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A4302 Rosiglitazone maleateTarget: Insulin and Insulin-like ReceptorsSummary: PPARγ agonist,high-affinity and selective,potent insulin sensitizer
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A4303 GSK3787Summary: PPARβ/δ antagonist,novel and irreversible
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A4304 RosiglitazoneSummary: Potent PPARγ agonist
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A4305 WY-14643 (Pirinixic Acid)1 CitationTarget: PPARSummary: PPARα agonist,selective and highly potent
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A4306 CiprofibrateSummary: PPARα agonist
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A4309 GW5015161 CitationSummary: PPARδ agonist,selective and potent