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Hedgehog

Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.

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  1. GANT 58
    A3429 GANT 58
    Summary: GLI antagonist,novel and potent
  2. PF-5274857
    A8500 PF-5274857
    Summary: Smo antagonist,potent and selective
      insoluble in EtOH; ≥17.6 mg/mL
  3. CHIR-99021 (CT99021) HCl
    A8396 CHIR-99021 (CT99021) HCl
    Target: GSK-3
    Summary: GSK-3α/β inhibitor
      ≥25.1 mg/mL
  4. LY2940680
    A8651 LY2940680
    Target: Smoothened receptor
    Summary: Hedgehog/SMO antagonist,inhibits Hh signaling
  5. JK 184
    A8652 JK 184
    Summary: Hh signaling inhibitor
      Soluble in DMSO
  6. SANT-2
    A8653 SANT-2
    Summary: Hedgehog signaling inhibitor
      Soluble in DMSO
  7. HPI 1
    A8654 HPI 1
    Summary: Hh signaling inhibitor
      Soluble in DMSO
  8. Ciliobrevin A
    A8655 Ciliobrevin A
    Summary: Hh pathway antagonist
      Soluble in DMSO
  9. Jervine
    A8656 Jervine
    Summary: Hedgehog signaling Inhibitor
      soluble in DMSO or ethanol
  10. AY 9944 dihydrochloride
    A8658 AY 9944 dihydrochloride
    Summary: Hedgehog Inhibitor
      Soluble in H2O

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