DL-threo-2-methylisocitrate sodium
DL-threo-2-methylisocitrate sodium is a substrate of isocitratelyase 1(ICL1).
ICL1 had dual activity for both threo-D(s)L(s)-isocitrate (ICA) and DL-threo-2-methylisocitrate (MICA). Using Michaelis-Menten non-linear least squares fit, the Km of purified recombinant ICL1 for threo-D(s)L(s)-isocitrate (ICA) was determined to be 188 mM with akcatof 5.24 s-1 .The Km of ICL2 for MICA was greater than 15 mM which was too high to be determained accurately due to the limitations of the solubility of MICA. The Kcat/Km for ICL1, a measureforcatalyticefficiency, was 2.79 × 104 M-1 s-1 and 1.74 ×103 M-1 s-1, for ICA and MICA respectively.
Reference:
[1]. Gould TA1,van de Langemheen H,Muoz-Elías EJ,McKinney JD,Sacchettini JC. Dual role of isocitratelyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis.Mol Microbiol.2006 Aug;61(4):940-7.
| Storage | Store at -20°C |
| M.Wt | 544.19 |
| Formula | C14H14Na6O14 |
| Solubility | Soluble in DMSO |
| Chemical Name | sodium (2R,3S)-3-hydroxybutane-1,2,3-tricarboxylate |
| SDF | Download SDF |
| Canonical SMILES | C[C@](C([O-])=O)(O)[C@@](C([O-])=O)([H])CC([O-])=O.C[C@](C([O-])=O)(O)[C@@](C([O-])=O)([H])CC([O-])=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
